Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.2818 | 0.2791 |
Schistosoma mansoni | zinc finger protein | 0.0155 | 0.2818 | 0.2818 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.2818 | 0.2791 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0155 | 0.2818 | 0.2558 |
Echinococcus granulosus | geminin | 0.0156 | 0.2858 | 0.2599 |
Schistosoma mansoni | tar DNA-binding protein | 0.0058 | 0.035 | 0.035 |
Onchocerca volvulus | 0.0155 | 0.2818 | 0.2818 | |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0155 | 0.2818 | 0.2558 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0155 | 0.2818 | 0.2818 |
Loa Loa (eye worm) | brahma associated protein | 0.0435 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0155 | 0.2818 | 0.2818 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0155 | 0.2818 | 0.2558 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0155 | 0.2818 | 0.2558 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0155 | 0.2818 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0219 | 0.4475 | 0.4274 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0219 | 0.4475 | 0.4274 |
Schistosoma mansoni | fusion | 0.0155 | 0.2818 | 0.2818 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.2818 | 0.2791 |
Schistosoma mansoni | RNA binding protein | 0.0155 | 0.2818 | 0.2818 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0435 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0435 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0058 | 0.035 | 0.035 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0155 | 0.2818 | 0.2558 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0155 | 0.2818 | 0.5 |
Chlamydia trachomatis | SWIB complex protein | 0.0435 | 1 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0435 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0058 | 0.035 | 0.035 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0155 | 0.2818 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0155 | 0.2818 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0155 | 0.2818 | 0.5 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0435 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0058 | 0.035 | 0.035 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0155 | 0.2818 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0155 | 0.2818 | 0.5 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0435 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0156 | 0.2858 | 0.2858 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0155 | 0.2818 | 0.2818 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0155 | 0.2818 | 0.2818 |
Schistosoma mansoni | hypothetical protein | 0.0435 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0155 | 0.2818 | 0.5 |
Schistosoma mansoni | brg-1 associated factor | 0.0435 | 1 | 1 |
Onchocerca volvulus | 0.0155 | 0.2818 | 0.2818 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0155 | 0.2818 | 0.5 |
Brugia malayi | RNA binding protein | 0.0058 | 0.035 | 0.035 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0435 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0435 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0155 | 0.2818 | 0.5 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0155 | 0.2818 | 0.5 |
Onchocerca volvulus | 0.0155 | 0.2818 | 0.2818 | |
Chlamydia trachomatis | DNA topoisomerase I | 0.0435 | 1 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0155 | 0.2818 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0155 | 0.2818 | 0.2818 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0155 | 0.2818 | 0.2558 |
Loa Loa (eye worm) | RNA binding protein | 0.0058 | 0.035 | 0.0313 |
Schistosoma mansoni | hypothetical protein | 0.0156 | 0.2858 | 0.2858 |
Onchocerca volvulus | 0.0155 | 0.2818 | 0.2818 | |
Onchocerca volvulus | 0.0435 | 1 | 1 | |
Brugia malayi | TAR-binding protein | 0.0058 | 0.035 | 0.035 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0435 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0219 | 0.4475 | 0.4475 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0435 | 1 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0155 | 0.2818 | 0.5 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0155 | 0.2818 | 0.2818 |
Loa Loa (eye worm) | TAR-binding protein | 0.0058 | 0.035 | 0.0313 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0155 | 0.2818 | 0.2818 |
Schistosoma mansoni | tar DNA-binding protein | 0.0058 | 0.035 | 0.035 |
Leishmania major | hypothetical protein, conserved | 0.0155 | 0.2818 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.2818 | 0.2791 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0435 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0058 | 0.035 | 0.0313 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0155 | 0.2818 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0046 | 0.0038 | 0.0038 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0155 | 0.2818 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0435 | 1 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0435 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0435 | 1 | 0.5 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0435 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0058 | 0.035 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.4475 | 0.4454 |
Echinococcus multilocularis | geminin | 0.0156 | 0.2858 | 0.2599 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0046 | 0.0038 | 0.0038 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0435 | 1 | 0.5 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0155 | 0.2818 | 0.5 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0155 | 0.2818 | 0.2558 |
Brugia malayi | YY1-associated factor 2 | 0.0155 | 0.2818 | 0.2818 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.2818 | 0.2791 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0435 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0155 | 0.2818 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0155 | 0.2818 | 0.5 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0155 | 0.2818 | 0.2558 |
Brugia malayi | brahma associated protein 60 kDa | 0.0435 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0435 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.612 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.