Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0401 | 0.104 | 0.4632 |
Trichomonas vaginalis | beta-glucosidase, putative | 0.0131 | 0.0252 | 0.0443 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0401 | 0.104 | 0.2252 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0275 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0704 | 0.1921 | 0.1921 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.1199 | 0.3365 | 0.3295 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.1043 | 0.2908 | 0.2833 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0243 | 0.0243 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.1199 | 0.3365 | 0.3665 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1079 | 0.3014 | 0.6781 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0774 | 0.2125 | 0.2125 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1024 | 0.2853 | 0.6413 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.156 | 0.4416 | 0.4416 |
Brugia malayi | Ceramide glucosyltransferase | 0.1199 | 0.3365 | 0.3365 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.156 | 0.4416 | 1 |
Brugia malayi | Amylo-alpha-1,6-glucosidase family protein | 0.0126 | 0.0238 | 0.0238 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0401 | 0.104 | 0.4732 |
Brugia malayi | Trehalase family protein | 0.0128 | 0.0243 | 0.0243 |
Loa Loa (eye worm) | amylo-alpha-1,6-glucosidase | 0.0061 | 0.005 | 0.005 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0774 | 0.2125 | 0.2042 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0243 | 0.0243 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.3477 | 1 | 1 |
Trypanosoma brucei | glucosidase, putative | 0.0774 | 0.2125 | 1 |
Echinococcus multilocularis | glycogen debranching enzyme | 0.0126 | 0.0238 | 0.0135 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0774 | 0.2125 | 0.4742 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0126 | 0.0238 | 0.041 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0243 | 0.0243 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.1024 | 0.2853 | 0.3844 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0401 | 0.104 | 0.4253 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0744 | 0.2038 | 0.4543 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.3477 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0774 | 0.2125 | 1 |
Treponema pallidum | hypothetical protein | 0.0044 | 0 | 0.5 |
Brugia malayi | Trehalase family protein | 0.0128 | 0.0243 | 0.0243 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1024 | 0.2853 | 0.6413 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.1043 | 0.2908 | 0.2833 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.156 | 0.4416 | 1 |
Trichomonas vaginalis | glycoside hydrolases, putative | 0.0131 | 0.0252 | 0.0443 |
Loa Loa (eye worm) | trehalase | 0.0128 | 0.0243 | 0.0243 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.1199 | 0.3365 | 0.3665 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.156 | 0.4416 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0401 | 0.104 | 0.2252 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0774 | 0.2125 | 0.4742 |
Echinococcus granulosus | glycogen debranching enzyme | 0.0126 | 0.0238 | 0.0135 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1024 | 0.2853 | 0.6413 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.156 | 0.4416 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0243 | 0.0243 |
Trypanosoma brucei | lysosomal alpha-mannosidase precursor, putative | 0.008 | 0.0104 | 0.0187 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0774 | 0.2125 | 0.2042 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0544 | 0.1455 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0401 | 0.104 | 0.2252 |
Loa Loa (eye worm) | hypothetical protein | 0.0401 | 0.104 | 0.104 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.156 | 0.4416 | 1 |
Loa Loa (eye worm) | trehalase | 0.0128 | 0.0243 | 0.0243 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0401 | 0.104 | 0.2252 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0774 | 0.2125 | 0.4742 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0774 | 0.2125 | 0.2125 |
Schistosoma mansoni | hypothetical protein | 0.0091 | 0.0136 | 0.0035 |
Loa Loa (eye worm) | TRE-1 protein | 0.0128 | 0.0243 | 0.0243 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0401 | 0.104 | 0.2252 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.1043 | 0.2908 | 0.3151 |
Loa Loa (eye worm) | TRE-2 protein | 0.0128 | 0.0243 | 0.0243 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1024 | 0.2853 | 0.6413 |
Echinococcus granulosus | beta galactosidase | 0.0139 | 0.0275 | 0.0172 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1024 | 0.2853 | 0.6413 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1024 | 0.2853 | 0.6413 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0774 | 0.2125 | 0.4742 |
Brugia malayi | hypothetical protein | 0.0128 | 0.0243 | 0.0243 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0774 | 0.2125 | 0.4742 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.1199 | 0.3365 | 0.4599 |
Echinococcus multilocularis | beta galactosidase | 0.0139 | 0.0275 | 0.0172 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.156 | 0.4416 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.0342 | 0.0267 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0774 | 0.2125 | 0.4742 |
Schistosoma mansoni | beta-galactosidase | 0.0139 | 0.0275 | 0.0192 |
Schistosoma mansoni | alpha-glucosidase | 0.3135 | 0.9002 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0401 | 0.104 | 0.104 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.1199 | 0.3365 | 0.3365 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0774 | 0.2125 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0401 | 0.104 | 0.2252 |
Echinococcus granulosus | bile acid beta glucosidase | 0.1043 | 0.2908 | 0.2833 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.1043 | 0.2908 | 0.3151 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.0238 | 0.0238 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.3477 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0774 | 0.2125 | 0.4742 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1079 | 0.3014 | 0.6781 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1024 | 0.2853 | 0.6413 |
Schistosoma mansoni | alpha glucosidase | 0.0774 | 0.2125 | 0.2271 |
Onchocerca volvulus | 0.2458 | 0.7032 | 1 | |
Brugia malayi | Trehalase family protein | 0.0128 | 0.0243 | 0.0243 |
Trichomonas vaginalis | trehalase, putative | 0.0128 | 0.0243 | 0.0422 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0114 | 0.0114 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0401 | 0.104 | 0.2252 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0774 | 0.2125 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.3135 | 0.9002 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0401 | 0.104 | 0.2252 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.1043 | 0.2908 | 0.2833 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.3477 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0243 | 0.0243 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0128 | 0.0243 | 0.0422 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0774 | 0.2125 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0275 | 0.0275 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0126 | 0.0238 | 0.041 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.1199 | 0.3365 | 0.3295 |
Loa Loa (eye worm) | trehalase | 0.0128 | 0.0243 | 0.0243 |
Brugia malayi | Trehalase family protein | 0.0128 | 0.0243 | 0.0243 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0401 | 0.104 | 0.4632 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0744 | 0.2038 | 0.954 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0058 | 0.0058 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0401 | 0.104 | 0.1174 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.156 | 0.4416 | 0.4416 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0774 | 0.2125 | 0.4742 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0774 | 0.2125 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.532 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.434 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.427 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.363 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.304 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.043 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.