Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Homo sapiens | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | fusion | 0.0109 | 0.3407 | 0.3407 |
Schistosoma mansoni | zinc finger protein | 0.0109 | 0.3407 | 0.3407 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.1248 | 0.1195 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0109 | 0.3407 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0109 | 0.3407 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0109 | 0.3407 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0196 | 0.0196 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.1248 | 0.1195 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0109 | 0.3407 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0109 | 0.3407 | 0.3367 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0109 | 0.3407 | 0.3367 |
Leishmania major | hypothetical protein, conserved | 0.0109 | 0.3407 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.115 | 0.1097 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0109 | 0.3407 | 0.5 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0109 | 0.3407 | 0.5 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0009 | 0.006 | 0.006 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0196 | 0.0137 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.006 | 0.006 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0196 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.3407 | 0.3367 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0109 | 0.3407 | 0.3367 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0109 | 0.3407 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1052 | 0.0999 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.006 | 0.006 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0196 | 0.0196 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0109 | 0.3407 | 0.3367 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.1384 | 0.1384 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0109 | 0.3407 | 0.3367 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.115 | 0.1097 |
Leishmania major | hypothetical protein, conserved | 0.0109 | 0.3407 | 0.5 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0109 | 0.3407 | 0.3367 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0109 | 0.3407 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0196 | 0.0137 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0109 | 0.3407 | 0.5 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0109 | 0.3407 | 0.3367 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0109 | 0.3407 | 0.3367 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0196 | 0.0137 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0109 | 0.3407 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.1248 | 0.1195 |
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.3407 | 0.3407 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0109 | 0.3407 | 0.3367 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.3407 | 0.3367 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0109 | 0.3407 | 0.3367 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0196 | 0.0137 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0109 | 0.3407 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.1248 | 0.1195 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0009 | 0.006 | 0.006 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0109 | 0.3407 | 0.5 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0109 | 0.3407 | 0.3407 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.3407 | 0.3367 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0109 | 0.3407 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0109 | 0.3407 | 0.3367 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0109 | 0.3407 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.3407 | 0.3367 |
Brugia malayi | YY1-associated factor 2 | 0.0109 | 0.3407 | 0.3367 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0109 | 0.3407 | 0.3367 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0009 | 0.006 | 0.006 |
Leishmania major | hypothetical protein, conserved | 0.0109 | 0.3407 | 0.5 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0109 | 0.3407 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.3407 | 0.3367 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0196 | 0.0137 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0109 | 0.3407 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.1384 | 0.1384 |
Schistosoma mansoni | RNA binding protein | 0.0109 | 0.3407 | 0.3407 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | < 0.1 nM | Displacement of [125I]MIP-1alpha from human recombinant CCR5 expressed in CHO cells | ChEMBL. | 22266038 |
IC50 (binding) | = 1.2 uM | Displacement of 3,7-Bis[2-(4-nitro[3,5-3H]phenyl)ethyl]-3,7-diazabicyclo[3.3.1]nonane from human ERG expressed in HEK cells after 3 hrs | ChEMBL. | 22266038 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.