Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | zinc finger protein | 0.0155 | 0.2763 | 0.2763 |
Leishmania major | hypothetical protein, conserved | 0.0155 | 0.2763 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0155 | 0.2763 | 0.5 |
Onchocerca volvulus | 0.0155 | 0.2763 | 0.2763 | |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.2763 | 0.2763 |
Onchocerca volvulus | 0.0155 | 0.2763 | 0.2763 | |
Echinococcus multilocularis | tumor protein p63 | 0.0327 | 0.7188 | 0.6114 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0155 | 0.2763 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0155 | 0.2763 | 0.2763 |
Leishmania major | hypothetical protein, conserved | 0.0155 | 0.2763 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.0327 | 0.7188 | 0.6114 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0155 | 0.2763 | 0.5 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0155 | 0.2763 | 0.5 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0155 | 0.2763 | 0.2763 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0155 | 0.2763 | 0.5 |
Schistosoma mansoni | fusion | 0.0155 | 0.2763 | 0.2763 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.2763 | 0.2763 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0155 | 0.2763 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.2763 | 0.2763 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.2763 | 0.2763 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0155 | 0.2763 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0155 | 0.2763 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.2763 | 0.2763 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0155 | 0.2763 | 0.5 |
Schistosoma mansoni | RNA binding protein | 0.0155 | 0.2763 | 0.2763 |
Onchocerca volvulus | 0.0155 | 0.2763 | 0.2763 | |
Leishmania major | hypothetical protein, conserved | 0.0155 | 0.2763 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0155 | 0.2763 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0155 | 0.2763 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0155 | 0.2763 | 0.5 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0155 | 0.2763 | 0.2763 |
Onchocerca volvulus | 0.0155 | 0.2763 | 0.2763 | |
Leishmania major | hypothetical protein, conserved | 0.0155 | 0.2763 | 0.5 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0155 | 0.2763 | 0.5 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0155 | 0.2763 | 0.5 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0155 | 0.2763 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.