Detailed information for compound 1618342

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 206.241 | Formula: C11H14N2O2
  • H donors: 1 H acceptors: 2 LogP: 1.77 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CC(=CC(=O)C1)Nc1noc(c1)C
  • InChi: 1S/C11H14N2O2/c1-7-3-9(6-10(14)4-7)12-11-5-8(2)15-13-11/h5-7H,3-4H2,1-2H3,(H,12,13)
  • InChiKey: ZLBGHLUPVWCOIT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0334 0.0351
Echinococcus multilocularis nostrin 0.0019 0.0125 0.0125
Echinococcus granulosus tyrosine protein kinase Fyn 0.0192 0.5558 0.5558
Loa Loa (eye worm) TK/ABL protein kinase 0.0025 0.0334 0.0351
Echinococcus granulosus endophilin A3 0.0019 0.0125 0.0125
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0019 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0131
Onchocerca volvulus 0.0019 0.014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0025 0.0334 0.0351
Brugia malayi hypothetical protein 0.0019 0.014 0.0021
Brugia malayi SWIB/MDM2 domain containing protein 0.0318 0.952 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0192 0.5558 0.5558
Leishmania major hypothetical protein, conserved 0.0113 0.3091 1
Loa Loa (eye worm) TK protein kinase 0.0173 0.4974 0.5225
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0019 0.0125 0.0125
Echinococcus granulosus tyrosine protein kinase shark 0.0025 0.0334 0.0334
Echinococcus granulosus suppressor of cytokine signaling 7 0.0019 0.014 0.014
Loa Loa (eye worm) brahma associated protein 0.0318 0.952 1
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0319 0.0207
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0173 0.4974 0.4974
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0334 0.0351
Echinococcus multilocularis SWI:SNF matrix associated 0.0318 0.952 0.952
Echinococcus multilocularis SH2 domain containing protein 7 0.0019 0.014 0.014
Onchocerca volvulus 0.0019 0.014 0.0016
Schistosoma mansoni tyrosine kinase 0.0192 0.5558 0.5783
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0334 0.0351
Echinococcus multilocularis SH2 motif 0.0019 0.014 0.014
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0113 0.3091 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0038 0.0724 0.0724
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0334 0.0351
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0019 0.0125 0.0125
Brugia malayi SRC-1 0.0192 0.5558 0.5785
Brugia malayi brahma associated protein 60 kDa 0.0318 0.952 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0154 0.4375 0.4375
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.3091 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.3091 0.3246
Onchocerca volvulus 0.0113 0.3091 0.3157
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0192 0.5558 0.5558
Loa Loa (eye worm) SH2 domain-containing protein 0.0019 0.014 0.0147
Schistosoma mansoni nck2/grb4 0.0038 0.0724 0.0637
Echinococcus multilocularis SWI:SNF matrix associated 0.0318 0.952 0.952
Brugia malayi STAT protein, DNA binding domain containing protein 0.0019 0.014 0.0021
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0019 0.014 0.0016
Brugia malayi SH2 domain containing protein 0.0019 0.014 0.0021
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0019 0.0125 0.0125
Schistosoma mansoni hypothetical protein 0.0113 0.3091 0.3157
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0019 0.0125 0.0125
Brugia malayi hypothetical protein 0.0025 0.0334 0.0228
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0113 0.3091 0.316
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0113 0.3091 0.316
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0019 0.0125 0.0125
Onchocerca volvulus 0.0025 0.0334 0.0223
Echinococcus granulosus tyrosine protein kinase Srms 0.0025 0.0334 0.0334
Echinococcus granulosus N chimaerin 0.0019 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0147
Brugia malayi Protein kinase domain containing protein 0.0025 0.0334 0.0228
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0131
Onchocerca volvulus 0.0049 0.1072 0.1008
Schistosoma mansoni RNA binding protein 0.0113 0.3091 0.3157
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0192 0.5558 0.5558
Brugia malayi Protein kinase domain containing protein 0.0025 0.0334 0.0228
Echinococcus multilocularis expressed protein 0.0019 0.0125 0.0125
Echinococcus granulosus tyrosine protein kinase Blk 0.0173 0.4974 0.4974
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0019 0.014 0.0016
Echinococcus multilocularis c src tyrosine kinase 0.0044 0.0918 0.0918
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0038 0.0724 0.076
Echinococcus granulosus SH2 domain containing protein 7 0.0019 0.014 0.014
Onchocerca volvulus 0.0019 0.014 0.0016
Schistosoma mansoni TRABID protein (C64 family) 0.0113 0.3091 0.3157
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0131
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0113 0.3091 1
Schistosoma mansoni hypothetical protein 0.0318 0.952 1
Onchocerca volvulus 0.0025 0.0334 0.0223
Loa Loa (eye worm) guanylate kinase 0.0019 0.0125 0.0131
Echinococcus granulosus intersectin 2 0.0019 0.0125 0.0125
Echinococcus granulosus suppressor of cytokine signaling 6 0.0019 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0131
Echinococcus multilocularis tyrosine protein kinase shark 0.0025 0.0334 0.0334
Schistosoma mansoni tyrosine kinase 0.0025 0.0334 0.0223
Echinococcus granulosus nostrin 0.0019 0.0125 0.0125
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0192 0.5558 0.5558
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0125 0.0005
Schistosoma mansoni SH2A 0.0019 0.014 0.0016
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0334 0.0351
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0192 0.5558 0.5558
Onchocerca volvulus 0.0113 0.3091 0.3157
Echinococcus granulosus tyrosine protein kinase Fyn 0.0192 0.5558 0.5558
Loa Loa (eye worm) STAT protein 0.0019 0.014 0.0147
Trypanosoma brucei hypothetical protein, conserved 0.0113 0.3091 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0131
Loa Loa (eye worm) p53BP2 0.0019 0.0125 0.0131
Brugia malayi SH2 domain containing protein 0.0019 0.014 0.0021
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0019 0.014 0.014
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0019 0.014 0.0035
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0113 0.3091 0.3091
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0125 0.0005
Loa Loa (eye worm) hypothetical protein 0.0113 0.3091 0.3246
Loa Loa (eye worm) protein-tyrosine kinase 0.0019 0.0125 0.0131
Brugia malayi brahma associated protein 60 kDa 0.0318 0.952 1
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0019 0.0125 0.0125
Schistosoma mansoni fusion 0.0113 0.3091 0.3157
Loa Loa (eye worm) hypothetical protein 0.0113 0.3091 0.3246
Schistosoma mansoni GTPase activating protein 0.0019 0.014 0.0016
Schistosoma mansoni signal transduction protein lnk-related 0.0019 0.014 0.0016
Schistosoma mansoni brg-1 associated factor 0.0318 0.952 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0019 0.014 0.0016
Echinococcus granulosus tyrosine protein kinase Lyn 0.0192 0.5558 0.5558
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0019 0.014 0.0147
Brugia malayi Myosin tail family protein 0.0019 0.0125 0.0005
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0019 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0147
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0318 0.952 1
Leishmania major hypothetical protein, conserved 0.0113 0.3091 1
Brugia malayi tRNA modification GTPase TrmE family protein 0.0019 0.014 0.0021
Echinococcus multilocularis signal transduction protein lnk realted 0.0019 0.014 0.014
Echinococcus granulosus SHC transforming protein 3 0.0019 0.014 0.014
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0019 0.014 0.014
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0019 0.014 0.0016
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0192 0.5558 0.5558
Schistosoma mansoni tensin-related 0.0019 0.014 0.0016
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0334 0.0351
Schistosoma mansoni tensin 0.0019 0.014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0147
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0019 0.0125 0.0125
Brugia malayi SH2 domain containing protein 0.0019 0.014 0.0021
Echinococcus multilocularis endophilin A3 0.0019 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0147
Onchocerca volvulus 0.0025 0.0334 0.0223
Leishmania major hypothetical protein, conserved 0.0113 0.3091 1
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0113 0.3091 0.3091
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0019 0.014 0.0147
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0038 0.0724 0.0637
Entamoeba histolytica SH2 domain containing protein 0.0019 0.014 0.0035
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0019 0.014 0.014
Brugia malayi Sex muscle abnormal protein 5 0.0038 0.0724 0.0642
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0318 0.952 0.952
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0019 0.014 0.014
Echinococcus granulosus expressed conserved protein 0.0019 0.014 0.014
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0019 0.014 0.0021
Echinococcus multilocularis 0.0019 0.014 0.014
Schistosoma mansoni tyrosine kinase 0.0025 0.0334 0.0223
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0025 0.0334 0.0334
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0025 0.0334 0.0334
Onchocerca volvulus 0.0025 0.0334 0.0223
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0334 0.0351
Schistosoma mansoni tensin 0.0019 0.014 0.0016
Echinococcus multilocularis tyrosine protein kinase Abl 0.0044 0.0918 0.0918
Schistosoma mansoni suppressor of cytokine signaling 0.0019 0.014 0.0016
Schistosoma mansoni tensin-related 0.0019 0.014 0.0016
Brugia malayi Src substrate cortactin 0.0019 0.0125 0.0005
Echinococcus granulosus NCK adaptor protein 0.0038 0.0724 0.0724
Onchocerca volvulus 0.0025 0.0334 0.0223
Entamoeba histolytica protein kinase, putative 0.0154 0.4375 1
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0019 0.014 0.014
Brugia malayi cytokine inducible SH2-containing protein 5 0.0019 0.014 0.0021
Schistosoma mansoni vav2 0.0019 0.014 0.0016
Echinococcus granulosus tyrosine protein kinase Fyn 0.0192 0.5558 0.5558
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0113 0.3091 1
Echinococcus granulosus SWI:SNF matrix associated 0.0318 0.952 0.952
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0019 0.014 0.014
Brugia malayi protein-tyrosine kinase 0.0173 0.4974 0.5164
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0019 0.014 0.014
Brugia malayi RhoGAP domain containing protein 0.0019 0.014 0.0021
Onchocerca volvulus 0.0025 0.0334 0.0223
Trypanosoma cruzi WLM domain containing protein, putative 0.0113 0.3091 1
Chlamydia trachomatis DNA topoisomerase I 0.0318 0.952 0.5
Echinococcus multilocularis tyrosine protein kinase HCK 0.0154 0.4375 0.4375
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0318 0.952 1
Echinococcus granulosus Spectrin alpha actinin 0.0019 0.0125 0.0125
Brugia malayi SH2 domain containing protein 0.0025 0.0334 0.0228
Loa Loa (eye worm) SH2 domain-containing protein 0.0019 0.014 0.0147
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0192 0.5558 0.5558
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0044 0.0918 0.0918
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0131
Brugia malayi Tensin 0.0019 0.014 0.0021
Leishmania major hypothetical protein, conserved 0.0113 0.3091 1
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0019 0.0125 0.0125
Brugia malayi SH2 domain containing protein 0.0019 0.014 0.0021
Onchocerca volvulus 0.0019 0.014 0.0016
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0167 0.4779 0.4779
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0019 0.014 0.0147
Echinococcus multilocularis intersectin 2 0.0019 0.0125 0.0125
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0192 0.5558 0.5558
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0147
Echinococcus multilocularis SHC transforming protein 3 0.0019 0.014 0.014
Brugia malayi Fes/CIP4 homology domain containing protein 0.0019 0.0125 0.0005
Echinococcus granulosus tyrosine protein kinase Src42A 0.0167 0.4779 0.4779
Schistosoma mansoni tensin 0.0019 0.014 0.0016
Echinococcus granulosus SH2 motif 0.0019 0.014 0.014
Brugia malayi Variant SH3 domain containing protein 0.0038 0.0724 0.0642
Brugia malayi Variant SH3 domain containing protein 0.0038 0.0724 0.0642
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.1072 0.1008
Echinococcus granulosus tyrosine kinase 0.0173 0.4974 0.4974
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0147
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0113 0.3091 0.316
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0147
Echinococcus multilocularis tyrosine kinase 0.0025 0.0334 0.0334
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0125 0.0005
Brugia malayi Variant SH3 domain containing protein 0.0019 0.014 0.0021
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0113 0.3091 1
Echinococcus granulosus fch and double sh3 domains protein 2 0.0019 0.0125 0.0125
Loa Loa (eye worm) SRC-1 0.0192 0.5558 0.5838
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0192 0.5558 0.5558
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0113 0.3091 1
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0125 0.0005
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0125 0.0005
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0019 0.0125 0.0131
Brugia malayi protein-tyrosine kinase 0.0019 0.0125 0.0005
Brugia malayi Protein kinase domain containing protein 0.0025 0.0334 0.0228
Brugia malayi YY1-associated factor 2 0.0113 0.3091 0.316
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0019 0.014 0.014
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0334 0.0351
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0044 0.0918 0.0918
Echinococcus granulosus tyrosine protein kinase Src42A 0.0192 0.5558 0.5558
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0318 0.952 1
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0334 0.0351
Echinococcus granulosus expressed protein 0.0019 0.0125 0.0125
Onchocerca volvulus 0.0019 0.014 0.0016
Schistosoma mansoni hypothetical protein 0.0019 0.014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0147
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0334 0.0351
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0019 0.014 0.0016
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0019 0.014 0.014
Brugia malayi SH2 domain containing protein 0.0019 0.014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0147
Schistosoma mansoni suppressor of cytokine signaling 0.0019 0.014 0.0016
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0019 0.014 0.014
Echinococcus multilocularis tyrosine protein kinase Srms 0.0173 0.4974 0.4974
Entamoeba histolytica protein kinase, putative 0.0019 0.014 0.0035
Echinococcus multilocularis SH2 motif 0.0019 0.014 0.014
Schistosoma mansoni hypothetical protein 0.0019 0.014 0.0016
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0113 0.3091 1
Brugia malayi Variant SH3 domain containing protein 0.0019 0.014 0.0021
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0318 0.952 1
Echinococcus granulosus epidermal growth factor receptor kinase 0.0019 0.0125 0.0125
Schistosoma mansoni tyrosine kinase 0.0192 0.5558 0.5783
Brugia malayi Spectrin alpha chain 0.0019 0.0125 0.0005
Echinococcus granulosus zinc finger protein Ran binding 0.0113 0.3091 0.3091
Echinococcus multilocularis SH2 motif 0.0019 0.014 0.014
Onchocerca volvulus 0.0113 0.3091 0.3157
Brugia malayi Protein kinase domain containing protein 0.0025 0.0334 0.0228
Onchocerca volvulus 0.0318 0.952 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0147
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0018 0.012 0.0126
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0019 0.014 0.0016
Echinococcus multilocularis transfer RNA-Ala 0.0019 0.0125 0.0125
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0038 0.0724 0.076
Schistosoma mansoni hypothetical protein 0.0318 0.952 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0131
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0147
Echinococcus multilocularis Spectrin alpha actinin 0.0019 0.0125 0.0125
Leishmania major hypothetical protein, conserved 0.0113 0.3091 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0192 0.5558 0.5558
Trypanosoma cruzi WLM domain containing protein, putative 0.0113 0.3091 1
Schistosoma mansoni growth factor receptor-bound protein 0.0038 0.0724 0.0637
Loa Loa (eye worm) hypothetical protein 0.0049 0.1072 0.1126
Echinococcus multilocularis tyrosine protein kinase Blk 0.0173 0.4974 0.4974
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0019 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0113 0.3091 0.3246
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0019 0.014 0.0147
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0113 0.3091 0.316
Echinococcus multilocularis tensin 0.0019 0.014 0.014
Brugia malayi Peripheral plasma membrane protein CASK 0.0019 0.0125 0.0005
Echinococcus granulosus Zinc finger RanBP2 type 0.0113 0.3091 0.3091
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0025 0.0334 0.0493
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0044 0.0918 0.0845
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0318 0.952 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0318 0.952 0.952
Echinococcus granulosus c src tyrosine kinase 0.0044 0.0918 0.0918
Loa Loa (eye worm) TK protein kinase 0.0154 0.4375 0.4596
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0113 0.3091 0.3091
Brugia malayi SH2 domain containing protein 0.0019 0.014 0.0021
Trypanosoma brucei hypothetical protein, conserved 0.0113 0.3091 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0025 0.0334 0.0334
Brugia malayi Protein kinase domain containing protein 0.0025 0.0334 0.0228
Schistosoma mansoni tyrosine kinase 0.0044 0.0918 0.0845
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.3091 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.3091 0.3246
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0318 0.952 0.5
Schistosoma mansoni adapter molecule crk 0.0038 0.0724 0.0637
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0147
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0019 0.0125 0.0125
Echinococcus granulosus SH2 domain containing adapter protein F 0.0019 0.014 0.014
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0173 0.4974 0.4974
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0019 0.0125 0.0131
Chlamydia trachomatis SWIB complex protein 0.0318 0.952 0.5
Loa Loa (eye worm) thyroid receptor interactor 0.0019 0.0125 0.0131
Onchocerca volvulus 0.0019 0.014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0147
Loa Loa (eye worm) hypothetical protein 0.0038 0.0724 0.076
Echinococcus granulosus ring and YY1 binding protein 0.0113 0.3091 0.3091
Echinococcus granulosus growth factor receptor bound protein 2 0.0038 0.0724 0.0724
Schistosoma mansoni zinc finger protein 0.0113 0.3091 0.3157
Echinococcus multilocularis tensin 0.0019 0.014 0.014
Brugia malayi Tyrosine-protein kinase abl-1 0.0044 0.0918 0.0849
Brugia malayi Guanylate kinase family protein 0.0019 0.0125 0.0005
Echinococcus multilocularis NCK adaptor protein 0.0038 0.0724 0.0724
Onchocerca volvulus 0.0113 0.3091 0.3157
Echinococcus granulosus src region 0.0019 0.0125 0.0125
Echinococcus multilocularis zinc finger protein Ran binding 0.0113 0.3091 0.3091
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0147
Schistosoma mansoni tyrosine kinase 0.0044 0.0918 0.0845
Schistosoma mansoni hypothetical protein 0.0318 0.952 1
Brugia malayi SH2 domain containing protein 0.0025 0.0334 0.0228
Echinococcus granulosus tensin 0.0019 0.014 0.014
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0019 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0131
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0019 0.014 0.014
Echinococcus multilocularis ring and YY1 binding protein 0.0113 0.3091 0.3091
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0318 0.952 0.952
Echinococcus granulosus hypothetical protein 0.0019 0.014 0.014
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0192 0.5558 0.5558
Plasmodium vivax hypothetical protein, conserved 0.0318 0.952 0.5
Echinococcus granulosus tyrosine kinase 0.0025 0.0334 0.0334
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0192 0.5558 0.5558
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0125 0.0005
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0113 0.3091 0.3157
Trichomonas vaginalis conserved hypothetical protein 0.0318 0.952 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0113 0.3091 1
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0019 0.0125 0.0125
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.3091 1
Echinococcus granulosus signal transduction protein lnk realted 0.0019 0.014 0.014
Schistosoma mansoni shc transforming protein 0.0019 0.014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0131
Echinococcus multilocularis N chimaerin 0.0019 0.014 0.014
Loa Loa (eye worm) SH2 domain-containing protein 0.0019 0.014 0.0147
Brugia malayi SH2 domain containing protein 0.0019 0.014 0.0021
Echinococcus granulosus tyrosine protein kinase ABL1 0.0025 0.0334 0.0334
Echinococcus granulosus SH2 motif 0.0019 0.014 0.014
Schistosoma mansoni growth factor receptor-bound protein 0.0038 0.0724 0.0637
Brugia malayi SH3 domain containing protein 0.0019 0.0125 0.0005

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Anticonvulsant activity in CF1 mouse assessed as protection against subcutaneous pentylenetetrazole-induced seizure at 300 mg/kg, ip after 30 mins ChEMBL. 22417639
Activity (functional) Anticonvulsant activity in CF1 mouse assessed as protection against maximal electroshock-induced seizure at 300 mg/kg, ip after 1 hr ChEMBL. 22417639
Activity (ADMET) Neurotoxicity in CF1 mouse at 300 mg/kg, ip after 15 mins by rotarod test ChEMBL. 22417639
Activity (functional) Anticonvulsant activity in CF1 mouse assessed as protection against maximal electroshock-induced seizure at 100 mg/kg, ip after 15 mins ChEMBL. 22417639
Activity (ADMET) Neurotoxicity in CF1 mouse at 100 mg/kg, ip after 30 mins by rotarod test ChEMBL. 22417639

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.