Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cysteine peptidase, putative | 0.0022 | 0.0018 | 0.0045 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0022 | 0.0018 | 0.0045 |
Leishmania major | hypothetical protein, conserved | 0.0193 | 0.0441 | 0.1073 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-4 | 0.0193 | 0.0441 | 0.1113 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0022 | 0.0018 | 0.0045 |
Brugia malayi | Cathepsin L-like precursor | 0.0022 | 0.0018 | 0.0045 |
Onchocerca volvulus | Cathepsin F homolog | 0.0022 | 0.0018 | 0.0401 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.1621 | 0.3968 | 0.3957 |
Entamoeba histolytica | cysteine protease, putative | 0.0022 | 0.0018 | 0.0045 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E type, putative | 0.0193 | 0.0441 | 0.0713 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E type, putative | 0.0193 | 0.0441 | 0.0713 |
Onchocerca volvulus | 0.0022 | 0.0018 | 0.0401 | |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.1621 | 0.3968 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.2524 | 0.6196 | 1 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E type 5 | 0.0193 | 0.0441 | 0.1073 |
Onchocerca volvulus | 0.0022 | 0.0018 | 0.0401 | |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.1545 | 0.3778 | 0.3491 |
Plasmodium vivax | dipeptidyl aminopeptidase 3, putative | 0.1545 | 0.3778 | 0.3767 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.0425 |
Loa Loa (eye worm) | eukaryotic translation initiation factor 4E-1 | 0.0193 | 0.0441 | 0.1113 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0022 | 0.0018 | 0.0018 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.0713 |
Onchocerca volvulus | 0.0022 | 0.0018 | 0.0401 | |
Plasmodium vivax | translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.0425 |
Loa Loa (eye worm) | translation initiation factor 4E | 0.1621 | 0.3968 | 1 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.1545 | 0.3778 | 0.3491 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0022 | 0.0018 | 0.0045 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.0713 |
Loa Loa (eye worm) | fibroinase | 0.0022 | 0.0018 | 0.0045 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-4 | 0.0193 | 0.0441 | 0.1073 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Brugia malayi | Eukaryotic translation initiation factor 4E type 3, putative | 0.0193 | 0.0441 | 0.1113 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0022 | 0.0018 | 0.0045 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0022 | 0.0018 | 0.0045 |
Trypanosoma cruzi | eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative | 0.0193 | 0.0441 | 0.1113 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0022 | 0.0018 | 0.0045 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.1621 | 0.3968 | 0.6404 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0193 | 0.0441 | 0.0713 |
Leishmania major | eukaryotic translation initiation factor, putative | 0.0193 | 0.0441 | 0.1073 |
Plasmodium falciparum | dipeptidyl aminopeptidase 3 | 0.1545 | 0.3778 | 0.3767 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.1621 | 0.3968 | 0.6404 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0022 | 0.0018 | 0.0045 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0022 | 0.0018 | 0.0045 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.1621 | 0.3968 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0022 | 0.0018 | 0.0018 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E type, putative | 0.0193 | 0.0441 | 0.0713 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-2 | 0.0193 | 0.0441 | 0.1073 |
Trypanosoma cruzi | eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative | 0.0193 | 0.0441 | 0.1113 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Brugia malayi | Cathepsin L-like precursor | 0.0022 | 0.0018 | 0.0045 |
Loa Loa (eye worm) | ctsf protein | 0.0022 | 0.0018 | 0.0045 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0022 | 0.0018 | 0.0045 |
Brugia malayi | Cathepsin L-like precursor | 0.0022 | 0.0018 | 0.0045 |
Plasmodium vivax | hypothetical protein, conserved | 0.0193 | 0.0441 | 0.0425 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Brugia malayi | translation initiation factor 4E | 0.1621 | 0.3968 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0022 | 0.0018 | 0.0045 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.0713 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Leishmania major | eukaryotic translation initiation factor-like protein | 0.1621 | 0.3968 | 1 |
Toxoplasma gondii | cathepsin CPC2 | 0.1545 | 0.3778 | 0.3767 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-3 | 0.0193 | 0.0441 | 0.1073 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0193 | 0.0441 | 0.0713 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E type, putative | 0.0193 | 0.0441 | 0.0713 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.1621 | 0.3968 | 1 |
Onchocerca volvulus | 0.0022 | 0.0018 | 0.0401 | |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-3 | 0.0193 | 0.0441 | 0.1113 |
Onchocerca volvulus | Cathepsin L homolog | 0.0022 | 0.0018 | 0.0401 |
Giardia lamblia | Encystation-specific protease | 0.1545 | 0.3778 | 0.3491 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.1113 |
Brugia malayi | eukaryotic translation initiation factor 4E-1 | 0.0193 | 0.0441 | 0.1113 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E type | 0.0193 | 0.0441 | 0.1113 |
Brugia malayi | Cathepsin L-like precursor | 0.0022 | 0.0018 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0018 | 0.0045 |
Echinococcus granulosus | cathepsin l1 | 0.0022 | 0.0018 | 0.0045 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Loa Loa (eye worm) | eukaryotic translation initiation factor 4E type 3 | 0.0193 | 0.0441 | 0.1113 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.1621 | 0.3968 | 0.6404 |
Entamoeba histolytica | hypothetical protein | 0.0193 | 0.0441 | 0.1113 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E type 5, putative | 0.0193 | 0.0441 | 0.1113 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.1621 | 0.3968 | 1 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-4 | 0.0193 | 0.0441 | 0.1113 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-1 | 0.1621 | 0.3968 | 1 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.0713 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.0713 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Onchocerca volvulus | Putative eukaryotic translation initiation factor 4e | 0.0193 | 0.0441 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0022 | 0.0018 | 0.0045 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trichomonas vaginalis | hypothetical protein | 0.0193 | 0.0441 | 0.0713 |
Entamoeba histolytica | eukaryotic initiation factor 4E, putative | 0.0193 | 0.0441 | 0.1113 |
Onchocerca volvulus | Cathepsin L homolog | 0.0022 | 0.0018 | 0.0401 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.0193 | 0.0441 | 0.0425 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.1113 |
Onchocerca volvulus | 0.0022 | 0.0018 | 0.0401 | |
Leishmania major | eukaryotic translation initiation factor-like | 0.1621 | 0.3968 | 1 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E | 0.0193 | 0.0441 | 0.0425 |
Leishmania major | hypothetical protein, conserved | 0.0193 | 0.0441 | 0.1073 |
Toxoplasma gondii | hypothetical protein | 0.0193 | 0.0441 | 0.0425 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.0713 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0022 | 0.0018 | 0.0045 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.1113 |
Onchocerca volvulus | 0.0022 | 0.0018 | 0.0401 | |
Entamoeba histolytica | hypothetical protein | 0.0193 | 0.0441 | 0.1113 |
Leishmania major | eukaryotic translation initiation factor eIF-4E, putative | 0.1621 | 0.3968 | 1 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E type, putative | 0.0193 | 0.0441 | 0.0713 |
Brugia malayi | Cathepsin L-like precursor | 0.0022 | 0.0018 | 0.0045 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.0713 |
Loa Loa (eye worm) | cysteine protease | 0.0022 | 0.0018 | 0.0045 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.0713 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0193 | 0.0441 | 0.0713 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.1621 | 0.3968 | 0.6404 |
Schistosoma mansoni | eukaryotic translation initiation factor 4e | 0.1621 | 0.3968 | 0.3968 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E | 0.1621 | 0.3968 | 1 |
Entamoeba histolytica | eukaryotic initiation factor 4E, putative | 0.0193 | 0.0441 | 0.1113 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Onchocerca volvulus | 0.0022 | 0.0018 | 0.0401 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Leishmania major | eukaryotic translation initiation factor 4e, putative | 0.0193 | 0.0441 | 0.1073 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Echinococcus multilocularis | eukaryotic translation initiation factor 4E | 0.1621 | 0.3968 | 1 |
Entamoeba histolytica | translation initiation factor 4e, putative | 0.0193 | 0.0441 | 0.1113 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E type 5, putative | 0.0193 | 0.0441 | 0.1113 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | > 100 uM | Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay | ChEMBL. | 22325804 |
IC50 (functional) | > 100 uM | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method | ChEMBL. | 22325804 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.