Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | eukaryotic initiation factor 4E, putative | 0.0193 | 0.0441 | 0.1113 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Onchocerca volvulus | 0.0022 | 0.0018 | 0.0401 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Leishmania major | eukaryotic translation initiation factor 4e, putative | 0.0193 | 0.0441 | 0.1073 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E type 5, putative | 0.0193 | 0.0441 | 0.1113 |
Echinococcus multilocularis | eukaryotic translation initiation factor 4E | 0.1621 | 0.3968 | 1 |
Entamoeba histolytica | translation initiation factor 4e, putative | 0.0193 | 0.0441 | 0.1113 |
Brugia malayi | Cathepsin L-like precursor | 0.0022 | 0.0018 | 0.0045 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.0713 |
Loa Loa (eye worm) | cysteine protease | 0.0022 | 0.0018 | 0.0045 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.0713 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0193 | 0.0441 | 0.0713 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.1621 | 0.3968 | 0.6404 |
Schistosoma mansoni | eukaryotic translation initiation factor 4e | 0.1621 | 0.3968 | 0.3968 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E | 0.1621 | 0.3968 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0022 | 0.0018 | 0.0045 |
Onchocerca volvulus | 0.0022 | 0.0018 | 0.0401 | |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.1113 |
Entamoeba histolytica | hypothetical protein | 0.0193 | 0.0441 | 0.1113 |
Leishmania major | eukaryotic translation initiation factor eIF-4E, putative | 0.1621 | 0.3968 | 1 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E type, putative | 0.0193 | 0.0441 | 0.0713 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.0713 |
Onchocerca volvulus | Putative eukaryotic translation initiation factor 4e | 0.0193 | 0.0441 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.0713 |
Trichomonas vaginalis | hypothetical protein | 0.0193 | 0.0441 | 0.0713 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Brugia malayi | Cathepsin L-like precursor | 0.0022 | 0.0018 | 0.0045 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Entamoeba histolytica | eukaryotic initiation factor 4E, putative | 0.0193 | 0.0441 | 0.1113 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.0193 | 0.0441 | 0.0425 |
Onchocerca volvulus | Cathepsin L homolog | 0.0022 | 0.0018 | 0.0401 |
Leishmania major | eukaryotic translation initiation factor-like | 0.1621 | 0.3968 | 1 |
Onchocerca volvulus | 0.0022 | 0.0018 | 0.0401 | |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.1113 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E | 0.0193 | 0.0441 | 0.0425 |
Toxoplasma gondii | hypothetical protein | 0.0193 | 0.0441 | 0.0425 |
Leishmania major | hypothetical protein, conserved | 0.0193 | 0.0441 | 0.1073 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E type 5, putative | 0.0193 | 0.0441 | 0.1113 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-4 | 0.0193 | 0.0441 | 0.1113 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.1621 | 0.3968 | 1 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-1 | 0.1621 | 0.3968 | 1 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.0713 |
Onchocerca volvulus | Cathepsin L homolog | 0.0022 | 0.0018 | 0.0401 |
Giardia lamblia | Encystation-specific protease | 0.1545 | 0.3778 | 0.3491 |
Brugia malayi | eukaryotic translation initiation factor 4E-1 | 0.0193 | 0.0441 | 0.1113 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.1113 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E type | 0.0193 | 0.0441 | 0.1113 |
Brugia malayi | Cathepsin L-like precursor | 0.0022 | 0.0018 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0018 | 0.0045 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Echinococcus granulosus | cathepsin l1 | 0.0022 | 0.0018 | 0.0045 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.1621 | 0.3968 | 0.6404 |
Entamoeba histolytica | hypothetical protein | 0.0193 | 0.0441 | 0.1113 |
Loa Loa (eye worm) | eukaryotic translation initiation factor 4E type 3 | 0.0193 | 0.0441 | 0.1113 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.1621 | 0.3968 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E type, putative | 0.0193 | 0.0441 | 0.0713 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0193 | 0.0441 | 0.0713 |
Onchocerca volvulus | 0.0022 | 0.0018 | 0.0401 | |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-3 | 0.0193 | 0.0441 | 0.1113 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.0713 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Toxoplasma gondii | cathepsin CPC2 | 0.1545 | 0.3778 | 0.3767 |
Leishmania major | eukaryotic translation initiation factor-like protein | 0.1621 | 0.3968 | 1 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-3 | 0.0193 | 0.0441 | 0.1073 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Brugia malayi | Cathepsin L-like precursor | 0.0022 | 0.0018 | 0.0045 |
Brugia malayi | Cathepsin L-like precursor | 0.0022 | 0.0018 | 0.0045 |
Plasmodium vivax | hypothetical protein, conserved | 0.0193 | 0.0441 | 0.0425 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0022 | 0.0018 | 0.0045 |
Loa Loa (eye worm) | ctsf protein | 0.0022 | 0.0018 | 0.0045 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0022 | 0.0018 | 0.0045 |
Brugia malayi | translation initiation factor 4E | 0.1621 | 0.3968 | 1 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.1621 | 0.3968 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0022 | 0.0018 | 0.0018 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E type, putative | 0.0193 | 0.0441 | 0.0713 |
Trypanosoma cruzi | eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative | 0.0193 | 0.0441 | 0.1113 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-2 | 0.0193 | 0.0441 | 0.1073 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.1621 | 0.3968 | 0.6404 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0193 | 0.0441 | 0.0713 |
Leishmania major | eukaryotic translation initiation factor, putative | 0.0193 | 0.0441 | 0.1073 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0022 | 0.0018 | 0.0045 |
Plasmodium falciparum | dipeptidyl aminopeptidase 3 | 0.1545 | 0.3778 | 0.3767 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.1621 | 0.3968 | 0.6404 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0022 | 0.0018 | 0.0045 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Brugia malayi | Eukaryotic translation initiation factor 4E type 3, putative | 0.0193 | 0.0441 | 0.1113 |
Trypanosoma cruzi | eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative | 0.0193 | 0.0441 | 0.1113 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0022 | 0.0018 | 0.0045 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0022 | 0.0018 | 0.0045 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0022 | 0.0018 | 0.0045 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0022 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | eukaryotic translation initiation factor 4E-1 | 0.0193 | 0.0441 | 0.1113 |
Plasmodium vivax | dipeptidyl aminopeptidase 3, putative | 0.1545 | 0.3778 | 0.3767 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.0425 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Plasmodium vivax | translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.0425 |
Onchocerca volvulus | 0.0022 | 0.0018 | 0.0401 | |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.0713 |
Loa Loa (eye worm) | translation initiation factor 4E | 0.1621 | 0.3968 | 1 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.1545 | 0.3778 | 0.3491 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0022 | 0.0018 | 0.0045 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0193 | 0.0441 | 0.0713 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-4 | 0.0193 | 0.0441 | 0.1073 |
Loa Loa (eye worm) | fibroinase | 0.0022 | 0.0018 | 0.0045 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Onchocerca volvulus | Cathepsin F homolog | 0.0022 | 0.0018 | 0.0401 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E type, putative | 0.0193 | 0.0441 | 0.0713 |
Entamoeba histolytica | cysteine protease, putative | 0.0022 | 0.0018 | 0.0045 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.1621 | 0.3968 | 0.3957 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.1621 | 0.3968 | 1 |
Onchocerca volvulus | 0.0022 | 0.0018 | 0.0401 | |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E type, putative | 0.0193 | 0.0441 | 0.0713 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.2524 | 0.6196 | 1 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E type 5 | 0.0193 | 0.0441 | 0.1073 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.1545 | 0.3778 | 0.3491 |
Onchocerca volvulus | 0.0022 | 0.0018 | 0.0401 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0022 | 0.0018 | 0.0045 |
Leishmania major | hypothetical protein, conserved | 0.0193 | 0.0441 | 0.1073 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0022 | 0.0018 | 0.0045 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0022 | 0.0018 | 0.0029 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0022 | 0.0018 | 0.0045 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-4 | 0.0193 | 0.0441 | 0.1113 |
Brugia malayi | Cathepsin L-like precursor | 0.0022 | 0.0018 | 0.0045 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | > 100 uM | Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay | ChEMBL. | 22325804 |
IC50 (functional) | > 100 uM | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method | ChEMBL. | 22325804 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.