Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0489 | 0.306 | 0.0839 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0489 | 0.306 | 0.5 |
Onchocerca volvulus | 0.0489 | 0.306 | 0.306 | |
Schistosoma mansoni | RNA binding protein | 0.0489 | 0.306 | 0.306 |
Onchocerca volvulus | 0.0489 | 0.306 | 0.306 | |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0489 | 0.306 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0489 | 0.306 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0489 | 0.306 | 0.5 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0489 | 0.306 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0489 | 0.306 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0489 | 0.306 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0489 | 0.306 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0489 | 0.306 | 0.306 |
Schistosoma mansoni | zinc finger protein | 0.0489 | 0.306 | 0.306 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0489 | 0.306 | 0.5 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0489 | 0.306 | 0.0839 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.306 | 0.306 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.306 | 0.306 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0489 | 0.306 | 0.0839 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0489 | 0.306 | 0.2128 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0489 | 0.306 | 0.5 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0489 | 0.306 | 0.0839 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0489 | 0.306 | 0.306 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0489 | 0.306 | 0.5 |
Schistosoma mansoni | fusion | 0.0489 | 0.306 | 0.306 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0489 | 0.306 | 0.2128 |
Brugia malayi | YY1-associated factor 2 | 0.0489 | 0.306 | 0.2128 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0489 | 0.306 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.0673 | 0.4499 | 0.2739 |
Leishmania major | hypothetical protein, conserved | 0.0489 | 0.306 | 0.5 |
Onchocerca volvulus | 0.0489 | 0.306 | 0.306 | |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.306 | 0.306 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0489 | 0.306 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0673 | 0.4499 | 0.2739 |
Leishmania major | hypothetical protein, conserved | 0.0489 | 0.306 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0489 | 0.306 | 0.5 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0489 | 0.306 | 0.0839 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.025 | 0.1184 | 0.1184 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0489 | 0.306 | 0.2128 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0489 | 0.306 | 0.0839 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0489 | 0.306 | 0.5 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0489 | 0.306 | 0.306 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0489 | 0.306 | 0.0839 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0489 | 0.306 | 0.0839 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.306 | 0.306 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0489 | 0.306 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0489 | 0.306 | 0.2128 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.025 | 0.1184 | 0.1184 |
Leishmania major | hypothetical protein, conserved | 0.0489 | 0.306 | 0.5 |
Onchocerca volvulus | 0.0489 | 0.306 | 0.306 | |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.306 | 0.306 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.193 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.125 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.