Detailed information for compound 1620587

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 444.302 | Formula: C19H14BrN3O3S
  • H donors: 1 H acceptors: 3 LogP: 5.43 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc2c(c1)sc(n2)/N=C/c1nc(oc1O)c1ccc(cc1)Br
  • InChi: 1S/C19H14BrN3O3S/c1-2-25-13-7-8-14-16(9-13)27-19(23-14)21-10-15-18(24)26-17(22-15)11-3-5-12(20)6-4-11/h3-10,24H,2H2,1H3/b21-10+
  • InChiKey: LLFSHORTUJRLHA-UFFVCSGVSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0061 0.0506 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0092 0.0068
Plasmodium falciparum plasmepsin III 0.0024 0.0128 0.0059
Echinococcus multilocularis 0.0018 0.0069 0.0052
Mycobacterium leprae Probable lipase LipE 0.0043 0.0329 0.6497
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0329 0.1212
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0079 0.0062
Trypanosoma cruzi hypothetical protein, conserved 0.0353 0.3484 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.034 0.0323
Brugia malayi Eukaryotic aspartyl protease family protein 0.0024 0.0128 0.0111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0448 0.0432
Plasmodium falciparum plasmepsin X 0.0024 0.0128 0.0059
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0079 0.0062
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0329 0.6497
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0329 0.076
Trichomonas vaginalis hypothetical protein 0.0018 0.0069 0.0045
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0069 0.4553
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0123 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0092 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0602 0.1561
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0079 0.0028
Plasmodium falciparum plasmepsin II 0.0101 0.091 0.0846
Loa Loa (eye worm) hypothetical protein 0.0043 0.0329 0.0312
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0123 0.0214
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.067 0.176
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0018 0.0069 0.0045
Leishmania major hypothetical protein, conserved 0.0018 0.0069 0.0079
Leishmania major cathepsin L-like protease 0.002 0.0092 0.0146
Loa Loa (eye worm) fibroinase 0.002 0.0092 0.0075
Leishmania major hypothetical protein, conserved 0.0353 0.3484 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0353 0.3484 1
Onchocerca volvulus Protein neuralized homolog 0.0018 0.0069 0.0045
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0069 0.4553
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0092 0.0068
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0069 0.0057
Trypanosoma brucei Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0069 0.0057
Loa Loa (eye worm) RiNg Finger protein family member 0.0018 0.0069 0.0052
Leishmania major hypothetical protein, conserved 0.0018 0.0069 0.0079
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0329 0.0306
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0448 0.0432
Leishmania major hypothetical protein, conserved 0.0018 0.0069 0.0079
Plasmodium falciparum plasmepsin I 0.0101 0.091 0.0846
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0329 0.0306
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0448 0.0432
Schistosoma mansoni fusion 0.0353 0.3484 0.3472
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0024 0.0128 0.0111
Loa Loa (eye worm) hypothetical protein 0.0353 0.3484 0.3472
Brugia malayi Cathepsin L-like precursor 0.002 0.0092 0.0075
Brugia malayi hypothetical protein 0.0018 0.0069 0.0052
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0069 0.0052
Brugia malayi aspartic protease BmAsp-1, identical 0.0024 0.0128 0.0111
Echinococcus granulosus ring and YY1 binding protein 0.0353 0.3484 0.3472
Plasmodium falciparum plasmepsin VII 0.0024 0.0128 0.0059
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0018 0.0069 0.0052
Onchocerca volvulus Cathepsin L homolog 0.002 0.0092 0.0068
Schistosoma mansoni hypothetical protein 0.0353 0.3484 0.3472
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0329 0.1212
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0079 0.0062
Loa Loa (eye worm) hypothetical protein 0.0039 0.028 0.0263
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0069 0.4553
Brugia malayi B-box zinc finger family protein 0.0018 0.0069 0.0052
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0101 0.091 0.0894
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0052
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0024 0.0128 0.0111
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0061 0.0506 1
Brugia malayi jmjC domain containing protein 0.0019 0.0079 0.0062
Loa Loa (eye worm) hypothetical protein 0.0043 0.0329 0.0312
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0024 0.0128 0.0111
Plasmodium vivax plasmepsin IV, putative 0.0101 0.091 0.0846
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0069 0.0057
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0024 0.0006
Onchocerca volvulus 0.002 0.0092 0.0068
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0609 0.0593
Trypanosoma brucei ring finger containing protein 0.0018 0.0069 0.0057
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0329 0.0312
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0079 0.001
Leishmania major cathepsin L-like protease 0.0077 0.067 0.1826
Leishmania major hypothetical protein, conserved 0.0018 0.0069 0.0079
Echinococcus granulosus phd:f box containing protein 0.0019 0.0079 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Brugia malayi Cathepsin L-like precursor 0.0014 0.0024 0.0006
Brugia malayi hypothetical protein 0.0024 0.0128 0.0111
Echinococcus granulosus Zinc finger RanBP2 type 0.0353 0.3484 0.3472
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger) containing protein, putative 0.0018 0.0069 0.0057
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0079 0.0062
Leishmania major hypothetical protein, conserved 0.0018 0.0069 0.0079
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0353 0.3484 0.3472
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0018 0.0069 0.0052
Brugia malayi Zinc finger, C2H2 type family protein 0.0018 0.0069 0.0052
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0024 0.0128 0.0111
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0381 0.0364
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0329 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0079 0.0062
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0079 0.0062
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0329 0.0312
Leishmania major hypothetical protein 0.0018 0.0069 0.0079
Trypanosoma brucei unspecified product 0.0023 0.0123 0.0214
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0018 0.0069 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0092 0.0068
Onchocerca volvulus Cathepsin F homolog 0.002 0.0092 0.0068
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.034 0.0323
Mycobacterium ulcerans lipase LipD 0.0043 0.0329 0.6497
Leishmania major DNA repair protein-like protein 0.0018 0.0069 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0092 0.0068
Loa Loa (eye worm) aspartyl protease 6 0.0024 0.0128 0.0111
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0092 0.6842
Entamoeba histolytica SPRY domain protein 0.0018 0.0069 0.4553
Onchocerca volvulus 0.002 0.0092 0.0068
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2714 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0092 0.0068
Echinococcus multilocularis RING finger protein 185 0.0018 0.0069 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0123 0.0214
Brugia malayi jmjC domain containing protein 0.0019 0.0079 0.0062
Leishmania major hypothetical protein, conserved 0.0353 0.3484 1
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0069 0.4553
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0448 0.0432
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.067 0.1807
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0018 0.0069 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0123 0.0214
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0079 0.0062
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0069 0.4553
Schistosoma mansoni memapsin-2 (A01 family) 0.0024 0.0128 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0092 0.0068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0092 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0069 0.0057
Schistosoma mansoni zinc finger protein 0.0018 0.0069 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.067 0.1807
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0069 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0092 0.0068
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0069 0.0057
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0092 0.0075
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0079 0.0062
Toxoplasma gondii ABC1 family protein 0.0043 0.0329 0.0261
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8369 0.8366
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0079 0.0062
Echinococcus multilocularis ring finger protein 113a 0.0018 0.0069 0.0052
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0092 0.0075
Echinococcus granulosus cell growth regulator with ring finger domain 0.0018 0.0069 0.0052
Onchocerca volvulus 0.0018 0.0069 0.0045
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0018 0.0069 0.0052
Onchocerca volvulus 0.0353 0.3484 0.3468
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.034 0.0323
Trichomonas vaginalis ankyrin, putative 0.0018 0.0069 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.067 0.1807
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0024 0.0128 0.0111
Mycobacterium ulcerans hypothetical protein 0.0043 0.0329 0.6497
Trichomonas vaginalis receptor histidine kinase, putative 0.0014 0.0033 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0123 0.0214
Trichomonas vaginalis esterase, putative 0.0043 0.0329 0.0306
Leishmania major hypothetical protein, conserved 0.0018 0.0069 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0123 0.0214
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0092 0.0075
Leishmania major hypothetical protein, conserved 0.0353 0.3484 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0092 0.0068
Leishmania major cathepsin L-like protease 0.0077 0.067 0.1826
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0062
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0079 0.0062
Echinococcus granulosus dna polymerase kappa 0.0023 0.0123 0.0106
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0052
Onchocerca volvulus 0.002 0.0092 0.0068
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0123 0.0106
Schistosoma mansoni cathepsin D (A01 family) 0.0297 0.2904 0.2892
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0062
Onchocerca volvulus 0.0024 0.0128 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0092 0.0068
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0092 0.0075
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0018 0.0069 0.0045
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0101 0.091 0.0894
Trypanosoma brucei hypothetical protein, conserved 0.0353 0.3484 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0437 0.042
Echinococcus multilocularis ring finger protein 170 0.0018 0.0069 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0092 0.0068
Leishmania major hypothetical protein, unknown function 0.0018 0.0069 0.0079
Loa Loa (eye worm) beta-lactamase 0.0043 0.0329 0.0312
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0024 0.0128 0.0111
Onchocerca volvulus 0.0353 0.3484 0.3468
Brugia malayi hypothetical protein 0.0024 0.0128 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Leishmania major cathepsin L-like protease 0.002 0.0092 0.0146
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0018 0.0069 0.0052
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0018 0.0069 0.0045
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0609 0.0593
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0123 1
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0069 0.0057
Echinococcus granulosus ring finger protein 113a 0.0018 0.0069 0.0052
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0079 0.0062
Trichomonas vaginalis ankyrin, putative 0.0018 0.0069 0.0045
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0018 0.0069 0.0052
Trypanosoma brucei predicted zinc finger protein 0.0018 0.0069 0.0057
Brugia malayi Cathepsin L-like precursor 0.0014 0.0024 0.0006
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0092 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0123 0.0214
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0018 0.0069 0.0045
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0448 0.0432
Brugia malayi YY1-associated factor 2 0.0353 0.3484 0.3472
Plasmodium falciparum plasmepsin VI 0.0101 0.091 0.0846
Plasmodium vivax aspartyl protease, putative 0.0024 0.0128 0.0059
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0079 0.001
Schistosoma mansoni mind bomb 0.0018 0.0069 0.0052
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0079 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0123 0.0214
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0329 0.1212
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0018 0.0069 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.067 0.1807
Trichomonas vaginalis sensor histidine kinase, putative 0.0014 0.0033 0.0009
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8369 0.8366
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0024 0.0006
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0123 0.0237
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0018 0.0069 0.0052
Onchocerca volvulus 0.002 0.0092 0.0068
Leishmania major cathepsin L-like protease 0.002 0.0092 0.0146
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0123 0.0455
Loa Loa (eye worm) cysteine protease 0.002 0.0092 0.0075
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0609 0.0593
Leishmania major hypothetical protein, conserved 0.0018 0.0069 0.0079
Onchocerca volvulus 0.0018 0.0069 0.0045
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0069 0.0057
Echinococcus granulosus dna polymerase eta 0.0054 0.0437 0.042
Schistosoma mansoni hypothetical protein 0.0018 0.0069 0.0052
Onchocerca volvulus 0.0043 0.0329 0.0306
Loa Loa (eye worm) hypothetical protein 0.0101 0.091 0.0894
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0024 0.0128 0.0111
Brugia malayi Cathepsin L-like precursor 0.002 0.0092 0.0075
Schistosoma mansoni ring finger protein 151 0.0018 0.0069 0.0052
Mycobacterium tuberculosis Conserved protein 0.0043 0.0329 0.1212
Plasmodium vivax aspartyl proteinase, putative 0.0024 0.0128 0.0059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0092 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0092 0.0068
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0061 0.0506 0.1865
Leishmania major cysteine peptidase A (CPA) 0.002 0.0092 0.0146
Giardia lamblia DINP protein human, muc B family 0.0023 0.0123 1
Onchocerca volvulus 0.002 0.0092 0.0068
Leishmania major hypothetical protein, conserved 0.0018 0.0069 0.0079
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0123 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.067 0.1807
Loa Loa (eye worm) RING finger protein 20 0.0018 0.0069 0.0052
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.067 0.176
Trichomonas vaginalis ankyrin, putative 0.0018 0.0069 0.0045
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0101 0.091 0.0888
Brugia malayi Neuralized family protein 0.0018 0.0069 0.0052
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0437 0.1076
Onchocerca volvulus Cathepsin L homolog 0.002 0.0092 0.0068
Mycobacterium tuberculosis Conserved protein 0.0043 0.0329 0.1212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0092 0.0068
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0353 0.3484 0.3472
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0092 0.0075
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0329 0.0306
Echinococcus granulosus cathepsin l1 0.0014 0.0024 0.0006
Onchocerca volvulus 0.0353 0.3484 0.3468
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0079 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0123 0.0214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.067 0.1807
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0123 0.0214
Brugia malayi Cathepsin L-like precursor 0.002 0.0092 0.0075
Onchocerca volvulus 0.002 0.0092 0.0068
Onchocerca volvulus 0.0043 0.0329 0.0306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0092 0.0068
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0353 0.3484 1
Leishmania major DNA polymerase eta, putative 0.0038 0.0273 0.0671
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0448 0.0432
Echinococcus multilocularis zinc finger protein Ran binding 0.0353 0.3484 0.3472
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0329 0.0812
Plasmodium falciparum plasmepsin VIII, putative 0.0024 0.0128 0.0059
Onchocerca volvulus 0.0018 0.0069 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.067 0.1807
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0123 0.0455
Echinococcus multilocularis ring and YY1 binding protein 0.0353 0.3484 0.3472
Brugia malayi hypothetical protein 0.0018 0.0069 0.0052
Echinococcus multilocularis cysteine protease 0.002 0.0092 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0092 0.0068
Onchocerca volvulus 0.01 0.0901 0.0879
Leishmania major hypothetical protein, conserved 0.0018 0.0069 0.0079
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0329 0.0312
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0381 0.0364
Loa Loa (eye worm) hypothetical protein 0.0353 0.3484 0.3472
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0069 0.0057
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0079 0.0062
Entamoeba histolytica hypothetical protein 0.0018 0.0069 0.4553
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0353 0.3484 1
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0092 0.0075
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0503 0.1269
Trypanosoma cruzi hypothetical protein, conserved 0.0353 0.3484 1
Brugia malayi hypothetical protein 0.0018 0.0069 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.067 0.1807
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0329 0.076
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0448 0.0432
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0101 0.091 0.0894
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0448 0.0432
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0329 0.1212
Loa Loa (eye worm) hypothetical protein 0.0043 0.0329 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0018 0.0069 0.0045
Brugia malayi RING zinc finger protein 0.0018 0.0069 0.0052
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0018 0.0069 0.0045
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0353 0.3484 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0123 0.0106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.067 0.1807
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.067 0.176
Toxoplasma gondii aspartyl protease ASP1 0.0101 0.091 0.0846
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0123 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.034 0.0323
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0092 0.0023
Brugia malayi jmjC domain containing protein 0.0019 0.0079 0.0062
Schistosoma mansoni TRABID protein (C64 family) 0.0353 0.3484 0.3472
Toxoplasma gondii cathepsin CPL 0.002 0.0092 0.0023
Brugia malayi Cathepsin L-like precursor 0.002 0.0092 0.0075
Echinococcus granulosus cathepsin l1 0.002 0.0092 0.0075
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0123 0.2439
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0329 0.0312
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0079 0.0062
Brugia malayi RING finger protein 20 0.0018 0.0069 0.0052
Leishmania major hypothetical protein, conserved 0.0018 0.0069 0.0079
Brugia malayi beta-lactamase family protein 0.0043 0.0329 0.0312
Schistosoma mansoni hypothetical protein 0.0018 0.0069 0.0052
Leishmania major hypothetical protein, conserved 0.0018 0.0069 0.0079
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0123 0.0106
Trypanosoma cruzi hypothetical protein, conserved 0.0353 0.3484 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Brugia malayi hypothetical protein 0.0018 0.0069 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0092 0.0068
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0123 0.0159
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0052
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0092 0.0075
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0123 0.2439
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0018 0.0069 0.0045
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0006
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0329 0.0261
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0018 0.0069 0.0052
Plasmodium vivax aspartyl protease, putative 0.0024 0.0128 0.0059
Brugia malayi beta-lactamase family protein 0.0043 0.0329 0.0312
Echinococcus multilocularis cysteine protease 0.002 0.0092 0.0075
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0448 0.0432
Leishmania major DNA polymerase eta, putative 0.0054 0.0437 0.1147
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Echinococcus granulosus tumor protein p63 0.0681 0.6822 0.6816
Loa Loa (eye worm) hypothetical protein 0.01 0.0901 0.0885
Schistosoma mansoni hypothetical protein 0.0018 0.0069 0.0052
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0092 0.0067
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0052
Loa Loa (eye worm) hypothetical protein 0.0024 0.0128 0.0111
Plasmodium falciparum plasmepsin IX 0.0024 0.0128 0.0059
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0101 0.091 0.0846
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0079 0.0085
Plasmodium vivax aspartyl protease, putative 0.0024 0.0128 0.0059
Loa Loa (eye worm) hypothetical protein 0.0043 0.0329 0.0312
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0609 0.0593
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0092 0.0068
Mycobacterium tuberculosis Conserved protein 0.0043 0.0329 0.1212
Echinococcus multilocularis tumor protein p63 0.0681 0.6822 0.6816
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0052
Leishmania major hypothetical protein, conserved 0.0018 0.0069 0.0079
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0069 0.4553
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Toxoplasma gondii ran binding protein 0.0353 0.3484 0.3438
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0018 0.0069 0.0052
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0079 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0062
Onchocerca volvulus 0.002 0.0092 0.0068
Toxoplasma gondii aspartyl protease ASP3 0.0024 0.0128 0.0059
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0123 0.0106
Plasmodium vivax vivapain-2 0.002 0.0092 0.0023
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0123 0.0106
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0052
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0092 0.0075
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.9854 0.9854
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0092 0.0075
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0018 0.0069 0.0052
Loa Loa (eye worm) hypothetical protein 0.002 0.0092 0.0075
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0329 0.0312
Brugia malayi cathepsin L-like precursor 0.0014 0.0024 0.0006
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0018 0.0069 0.0045
Trypanosoma brucei SNF2 family N-terminal domain/Ring finger domain containing protein, putative 0.0018 0.0069 0.0057
Brugia malayi aspartic protease BmAsp-2, identical 0.0024 0.0128 0.0111
Onchocerca volvulus 0.0043 0.0329 0.0306
Trypanosoma cruzi WLM domain containing protein, putative 0.0353 0.3484 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0123 0.0106
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0609 0.0593
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0353 0.3484 0.3472
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0123 0.0214
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0018 0.0069 0.0045
Loa Loa (eye worm) hypothetical protein 0.0353 0.3484 0.3472
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0052
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0018 0.0069 0.0052
Loa Loa (eye worm) hypothetical protein 0.0043 0.0329 0.0312
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0353 0.3484 0.3472
Trypanosoma cruzi WLM domain containing protein, putative 0.0353 0.3484 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0092 0.0075
Trypanosoma brucei hypothetical protein, conserved 0.0353 0.3484 1
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8369 0.8366
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Leishmania major hypothetical protein, conserved 0.0019 0.0079 0.0108
Leishmania major DNA polymerase kappa, putative 0.0023 0.0123 0.0237
Brugia malayi hypothetical protein 0.0018 0.0069 0.0052
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0353 0.3484 1
Leishmania major hypothetical protein, conserved 0.0353 0.3484 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0052
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0353 0.3484 0.3438
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0069 0.0057
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0123 0.01
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0123 0.0159
Onchocerca volvulus Putative RING finger protein 207 0.0018 0.0069 0.0045
Onchocerca volvulus 0.0018 0.0069 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0092 0.0068
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0014 0.0033 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0092 0.0075
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0273 0.0205
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0069 0.4553
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0092 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.067 0.1807
Loa Loa (eye worm) hypothetical protein 0.0353 0.3484 0.3472
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0079 0.0062
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0014 0.0033 0.0009
Plasmodium falciparum plasmepsin IV 0.0101 0.091 0.0846
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0437 0.1126
Brugia malayi Cathepsin L-like precursor 0.002 0.0092 0.0075
Trypanosoma brucei DNA repair protein, putative 0.0018 0.0069 0.0057
Schistosoma mansoni peter pan-related 0.0018 0.0069 0.0052
Loa Loa (eye worm) hypothetical protein 0.0024 0.0128 0.0111
Leishmania major hypothetical protein, conserved 0.0353 0.3484 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0273 0.0597
Loa Loa (eye worm) hypothetical protein 0.0043 0.0329 0.0312
Onchocerca volvulus 0.0024 0.0128 0.0104
Entamoeba histolytica hypothetical protein 0.0018 0.0069 0.4553
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0353 0.3484 1
Schistosoma mansoni rnf5 0.0018 0.0069 0.0052
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0123 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0069 0.4553
Toxoplasma gondii aspartyl protease 0.0024 0.0128 0.0059
Brugia malayi Zinc finger protein 183 homolog 0.0018 0.0069 0.0052
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0353 0.3484 0.3438
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0079 0.0028
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0006
Schistosoma mansoni RNA binding protein 0.0353 0.3484 0.3472
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0018 0.0069 0.0045
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0014 0.0033 0.0009
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0353 0.3484 0.3468
Plasmodium falciparum plasmepsin V 0.0024 0.0128 0.0059
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0329 0.1212
Echinococcus granulosus ring finger protein 170 0.0018 0.0069 0.0052
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0024 0.0128 0.0111
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0609 0.0593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0092 0.0068
Leishmania major cathepsin L-like protease 0.002 0.0092 0.0146
Schistosoma mansoni zinc finger protein 0.0353 0.3484 0.3472
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0329 0.0306
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0092 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Loa Loa (eye worm) ctsf protein 0.002 0.0092 0.0075
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0014 0.0033 0.0009
Echinococcus granulosus zinc finger protein Ran binding 0.0353 0.3484 0.3472
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0329 0.1212
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0329 0.6497
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0329 0.6497
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0123 0.0159
Schistosoma mansoni cathepsin D (A01 family) 0.0297 0.2904 0.2892
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0101 0.091 0.0894
Schistosoma mansoni cellular tumor antigen P53 0.01 0.0901 0.0885
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0014 0.0033 0.0009
Echinococcus granulosus RING finger protein 185 0.0018 0.0069 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0052
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0092 0.0023
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0123 0.0106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.067 0.1807
Echinococcus multilocularis dna polymerase eta 0.0054 0.0437 0.042
Leishmania major cathepsin L-like protease 0.0077 0.067 0.1826
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0079 0.0062
Onchocerca volvulus 0.0018 0.0069 0.0045
Plasmodium vivax vivapain-2 0.002 0.0092 0.0023
Plasmodium vivax JmjC domain containing protein 0.0019 0.0079 0.001
Loa Loa (eye worm) hypothetical protein 0.0353 0.3484 0.3472
Onchocerca volvulus 0.0018 0.0069 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Trichomonas vaginalis receptor histidine kinase, putative 0.0014 0.0033 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0092 0.0068
Entamoeba histolytica cysteine protease, putative 0.002 0.0092 0.6842
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Leishmania major hypothetical protein, conserved 0.0043 0.0329 0.0833
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0024 0.0128 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0092 0.0068
Brugia malayi hypothetical protein 0.0018 0.0069 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Brugia malayi jmjC domain containing protein 0.0071 0.0609 0.0593
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0329 0.0306
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0609 0.0593
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0092 0.6842
Leishmania major hypothetical protein, conserved 0.0018 0.0069 0.0079
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.067 0.176
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0092 0.0068
Brugia malayi Pepsin A precursor 0.0024 0.0128 0.0111
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0609 0.0593
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0329 0.1212
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.031 0.0286
Leishmania major cathepsin L-like protease 0.002 0.0092 0.0146
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0123 0.01
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0437 0.042
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0353 0.3484 0.3472
Onchocerca volvulus RING finger protein 141 homolog 0.0018 0.0069 0.0045
Schistosoma mansoni DNA polymerase eta 0.0054 0.0437 0.042
Plasmodium vivax aspartyl proteinase, putative 0.0101 0.091 0.0846
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0353 0.3484 0.3472
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0353 0.3484 1
Brugia malayi jmjC domain containing protein 0.0019 0.0079 0.0062
Plasmodium vivax plasmepsin V, putative 0.0024 0.0128 0.0059
Onchocerca volvulus 0.0353 0.3484 0.3468
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0353 0.3484 0.3472
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0024 0.0128 0.0059
Brugia malayi jmjC domain containing protein 0.0071 0.0609 0.0593
Trichomonas vaginalis ion channel nompc, putative 0.0018 0.0069 0.0045
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0061 0.0506 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.031 0.0286
Brugia malayi beta-lactamase 0.0043 0.0329 0.0312
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0069 0.0057
Schistosoma mansoni peter pan-related 0.0018 0.0069 0.0052
Mycobacterium ulcerans beta-lactamase 0.0043 0.0329 0.6497
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0069 0.0045

Activities

Activity type Activity value Assay description Source Reference
EC50 (ADMET) = 0.16 um PUBCHEM_BIOASSAY: Confirmation Dose Response screen for compounds that protect hERG from block by proarrhythmic agents. (Class of assay: confirmatory) [Related pubchem assays: 1511 (Primary HTS assay for 305616 compounds.)] ChEMBL. No reference
EC50 (functional) > 53 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 3.5481 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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