Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.0085 | 0.6018 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0141 | 0.0541 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0064 | 0.4545 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.1044 | 0.6248 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0085 | 0.6018 |
Leishmania major | GTP-binding protein, putative | 0.0021 | 0.0032 | 0.2267 |
Mycobacterium ulcerans | NADH dehydrogenase subunit H | 0.1433 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.1107 | 0.6634 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0085 | 0.6018 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0141 | 0.0141 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.1652 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0232 | 0.1523 | 0.1523 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0141 | 0.0638 |
Wolbachia endosymbiont of Brugia malayi | NADH dehydrogenase subunit H | 0.1433 | 1 | 0.5 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0032 | 0.0123 |
Brugia malayi | RNA, U transporter 1 | 0.0081 | 0.0454 | 0.1741 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0064 | 0.4545 |
Echinococcus multilocularis | snurportin 1 | 0.0303 | 0.2022 | 0.9153 |
Mycobacterium tuberculosis | Possible formate hydrogenlyase HycD (FHL) | 0.0386 | 0.2608 | 0.2608 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0141 | 1 |
Schistosoma mansoni | ran | 0.0021 | 0.0032 | 0.0032 |
Brugia malayi | MH2 domain containing protein | 0.0124 | 0.0757 | 0.2902 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0141 | 0.0541 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0047 | 0.0093 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0108 | 0.0108 |
Schistosoma mansoni | importin beta-1 | 0.0028 | 0.0085 | 0.0085 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.1044 | 0.6248 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0097 | 0.0097 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0141 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0064 | 0.7552 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0089 | 0.0089 |
Echinococcus granulosus | snurportin 1 | 0.0303 | 0.2022 | 0.2022 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.1652 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0319 | 0.0319 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0319 | 0.0319 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0141 | 0.0141 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0141 | 0.0673 |
Onchocerca volvulus | 0.0239 | 0.1571 | 0.5872 | |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0064 | 0.4545 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0064 | 0.0246 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0141 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.0319 | 0.1224 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.1044 | 0.6248 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0097 | 0.0097 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.0591 | 0.2266 |
Schistosoma mansoni | hypothetical protein | 0.0329 | 0.221 | 0.221 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0032 | 0.2267 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0141 | 0.0541 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0141 | 0.0141 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0032 | 0.0032 |
Brugia malayi | hypothetical protein | 0.0386 | 0.2608 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.021 | 0.1367 | 0.5241 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0047 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0367 | 0.1409 |
Schistosoma mansoni | ran | 0.0021 | 0.0032 | 0.0032 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0108 | 0.0489 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0097 | 0.044 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0303 | 0.2022 | 0.7756 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0032 | 0.0123 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0141 | 0.0141 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0064 | 0.4545 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0141 | 0.0541 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0032 | 0.2267 |
Trichomonas vaginalis | set domain proteins, putative | 0.0239 | 0.1571 | 0.9503 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0141 | 0.0141 |
Brugia malayi | NADH dehydrogenase subunit 1, identical | 0.0386 | 0.2608 | 1 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0021 | 0.0032 | 0.2267 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0085 | 0.0325 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0124 | 0.0757 | 0.2902 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0064 | 0.0246 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0141 | 0.0141 |
Onchocerca volvulus | 0.0386 | 0.2608 | 1 | |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.0319 | 0.0319 |
Echinococcus granulosus | importin subunit beta 1 | 0.0028 | 0.0085 | 0.0085 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.0108 | 0.0414 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0141 | 1 |
Onchocerca volvulus | 0.0036 | 0.0141 | 0.0175 | |
Echinococcus granulosus | geminin | 0.0329 | 0.221 | 0.221 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.0319 | 0.1444 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0141 | 0.0673 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.0319 | 0.1224 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.1107 | 0.6634 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0164 | 0.1044 | 0.3772 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0141 | 0.0673 |
Onchocerca volvulus | 0.0036 | 0.0141 | 0.0175 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0141 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.1652 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0108 | 0.0108 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0141 | 0.0141 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0141 | 0.0541 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0591 | 0.2266 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0032 | 0.0145 |
Brugia malayi | RNA binding protein | 0.0062 | 0.0319 | 0.1224 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0047 | 0.0093 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0108 | 0.0108 |
Schistosoma mansoni | NADH dehydrogenase subunit 1 | 0.0386 | 0.2608 | 0.2608 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.1652 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0141 | 0.0541 |
Mycobacterium ulcerans | formate hydrogenlyase HycD | 0.0386 | 0.2608 | 0.2502 |
Brugia malayi | Pre-SET motif family protein | 0.021 | 0.1367 | 0.5241 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0141 | 0.0541 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.1044 | 0.6248 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.0319 | 0.1224 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0064 | 0.4545 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.0319 | 0.1224 |
Onchocerca volvulus | 0.0386 | 0.2608 | 1 | |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.0108 | 0.0489 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0047 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0141 | 0.0673 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0032 | 0.2267 |
Onchocerca volvulus | 0.0036 | 0.0141 | 0.0175 | |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0108 | 0.0414 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0141 | 0.0541 |
Loa Loa (eye worm) | NADH dehydrogenase subunit 1 | 0.0386 | 0.2608 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0097 | 0.6892 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0097 | 0.0373 |
Brugia malayi | hypothetical protein | 0.0016 | 0 | 0.0002 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0141 | 0.0541 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0032 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0097 | 0.0097 |
Schistosoma mansoni | hypothetical protein | 0.0329 | 0.221 | 0.221 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.025 | 0.1652 | 0.6334 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0021 | 0.0032 | 0.2267 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0108 | 0.0108 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0047 | 0.3331 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0141 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.0591 | 0.2266 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0097 | 0.0373 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.0108 | 0.0414 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0064 | 0.4545 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0141 | 0.0541 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0319 | 0.0319 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0097 | 0.6892 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0097 | 0.044 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0047 | 0.3331 |
Brugia malayi | Importin beta-1 subunit | 0.0028 | 0.0085 | 0.0325 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0108 | 0.0414 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0319 | 0.0319 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0032 | 0.3767 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0141 | 0.0673 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0064 | 0.7552 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.025 | 0.1652 | 0.6334 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0319 | 0.0319 |
Schistosoma mansoni | hypothetical protein | 0.1433 | 1 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0028 | 0.0085 | 0.0384 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0141 | 0.0141 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0141 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.1044 | 0.6248 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) | 0.1433 | 1 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0141 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.0591 | 0.2266 |
Brugia malayi | NADH dehydrogenase subunit 1 | 0.0386 | 0.2608 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0141 | 0.0673 |
Schistosoma mansoni | hypothetical protein | 0.0303 | 0.2022 | 0.2022 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0141 | 0.0541 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.0367 | 0.1409 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.1044 | 0.6248 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0141 | 0.0141 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.1652 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.1652 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.1044 | 0.6248 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0108 | 0.0489 |
Echinococcus multilocularis | geminin | 0.0329 | 0.221 | 1 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.0085 | 0.6018 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0124 | 0.0757 | 0.2902 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0141 | 0.0141 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0141 | 0.0141 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0085 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.0319 | 0.1224 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0097 | 0.0097 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0097 | 0.0097 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0141 | 0.0541 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0367 | 0.0367 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1.56 ug ml-1 | Minimum inhibitory concentration towards C. neoformans | ChEMBL. | 15125956 |
MIC (functional) | = 1.56 ug ml-1 | Minimum inhibitory concentration towards C. neoformans | ChEMBL. | 15125956 |
MIC (functional) | = 3.125 ug ml-1 | Minimum inhibitory concentration towards C. albicans | ChEMBL. | 15125956 |
MIC (functional) | = 3.125 ug ml-1 | Minimum inhibitory concentration towards T. mentagraphytes | ChEMBL. | 15125956 |
MIC (functional) | = 3.125 ug ml-1 | Minimum inhibitory concentration towards M. cannis | ChEMBL. | 15125956 |
MIC (functional) | = 3.125 ug ml-1 | Minimum inhibitory concentration towards C. albicans | ChEMBL. | 15125956 |
MIC (functional) | = 12.5 ug ml-1 | Minimum inhibitory concentration towards T. tumefaciens | ChEMBL. | 15125956 |
MIC (functional) | > 50 ug ml-1 | Minimum inhibitory concentration towards A. fumigatus | ChEMBL. | 15125956 |
MIC (functional) | > 50 ug ml-1 | Minimum inhibitory concentration towards S. aureus | ChEMBL. | 15125956 |
MIC (functional) | > 50 ug ml-1 | Minimum inhibitory concentration towards P. aeruginosa | ChEMBL. | 15125956 |
MIC (functional) | = 50 ug ml-1 | Minimum inhibitory concentration towards K. pneumoniae | ChEMBL. | 15125956 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.