Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | eukaryotic translation initiation factor-like protein | 0.056 | 0.5447 | 1 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.0388 | 0.3579 | 0.523 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-1 | 0.056 | 0.5447 | 1 |
Brugia malayi | hypothetical protein | 0.0286 | 0.2468 | 0.3776 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.056 | 0.5447 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0067 | 0.0092 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0067 | 0.0092 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0067 | 0.0092 | 0.5 |
Brugia malayi | Eukaryotic translation initiation factor 4E type 3, putative | 0.0067 | 0.0092 | 0.0141 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E | 0.056 | 0.5447 | 0.7988 |
Brugia malayi | translation initiation factor 4E | 0.056 | 0.5447 | 0.8333 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0684 | 0.6795 | 1 |
Leishmania major | eukaryotic translation initiation factor eIF-4E, putative | 0.056 | 0.5447 | 1 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.056 | 0.5447 | 1 |
Schistosoma mansoni | eukaryotic translation initiation factor 4e | 0.056 | 0.5447 | 0.8016 |
Onchocerca volvulus | Putative eukaryotic translation initiation factor 4e | 0.0067 | 0.0092 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.2468 | 0.3544 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.2468 | 0.3564 |
Leishmania major | eukaryotic translation initiation factor-like | 0.056 | 0.5447 | 1 |
Brugia malayi | Raf kinase | 0.066 | 0.6536 | 1 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0684 | 0.6795 | 0.5745 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.056 | 0.5447 | 1 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.056 | 0.5447 | 1 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E | 0.0067 | 0.0092 | 0.5 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0684 | 0.6795 | 1 |
Giardia lamblia | Translation elongation factor | 0.0067 | 0.0092 | 0.5 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.056 | 0.5447 | 1 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.056 | 0.5447 | 1 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E, putative | 0.0067 | 0.0092 | 0.5 |
Loa Loa (eye worm) | raf kinase | 0.0681 | 0.6759 | 1 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.056 | 0.5447 | 1 |
Brugia malayi | eukaryotic translation initiation factor 4E-1 | 0.0067 | 0.0092 | 0.0141 |
Plasmodium vivax | translation initiation factor 4E, putative | 0.0067 | 0.0092 | 0.5 |
Echinococcus multilocularis | eukaryotic translation initiation factor 4E | 0.056 | 0.5447 | 0.3955 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.056 | 0.5447 | 1 |
Loa Loa (eye worm) | translation initiation factor 4E | 0.056 | 0.5447 | 0.8032 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.056 | 0.5447 | 1 |
Giardia lamblia | hypothetical protein | 0.0067 | 0.0092 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of MMP9 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 30 mins by spectrofluorimetry | ChEMBL. | 22386984 | |
IC50 (binding) | > 500 uM | Inhibition of full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr prior substrate addition measured after 30 mins by spectrofluorimetry | ChEMBL. | 22386984 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.