Detailed information for compound 1622607

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 680.713 | Formula: C34H36N10O6
  • H donors: 2 H acceptors: 8 LogP: 7.07 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1nc(OCCOc2nc(OC)nc(n2)Nc2ccc(c(c2)OCC=C(C)C)C#N)nc(n1)Nc1ccc(c(c1)OCC=C(C)C)C#N
  • InChi: 1S/C34H36N10O6/c1-21(2)11-13-47-27-17-25(9-7-23(27)19-35)37-29-39-31(45-5)43-33(41-29)49-15-16-50-34-42-30(40-32(44-34)46-6)38-26-10-8-24(20-36)28(18-26)48-14-12-22(3)4/h7-12,17-18H,13-16H2,1-6H3,(H,37,39,41,43)(H,38,40,42,44)
  • InChiKey: ZRBACUSQUZDMCY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Cysteine protease 0.0207 0.0826 0.2181
Plasmodium falciparum serine repeat antigen 1 0.0207 0.0826 0.3084
Loa Loa (eye worm) hypothetical protein 0.0245 0.099 0.099
Schistosoma mansoni cathepsin F (C01 family) 0.0576 0.2412 0.2412
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Trypanosoma cruzi cruzipain precursor, putative 0.0819 0.3453 0.3441
Echinococcus multilocularis cathepsin L cysteine protease 0.0629 0.2636 0.2636
Giardia lamblia Cathepsin B precursor 0.0868 0.3664 1
Schistosoma mansoni cathepsin C 0.0207 0.0826 0.0826
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0179 0.0179
Brugia malayi calpain 7 0.002 0.0026 0.0026
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0035 0.0059
Giardia lamblia Cathepsin B precursor 0.0868 0.3664 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0328 0.0328
Schistosoma mansoni calpain C (C02 family) 0.002 0.0026 0.0026
Onchocerca volvulus 0.0027 0.0054 0.0078
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.168 0.168
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0026 0.001
Echinococcus multilocularis inhibitor of apoptosis protein 0.0537 0.2244 0.2244
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0207 0.0826 0.2181
Leishmania major cathepsin L-like protease 0.0629 0.2636 0.4231
Echinococcus multilocularis calpain 5 0.002 0.0026 0.0026
Brugia malayi Cathepsin L-like precursor 0.0052 0.0164 0.0164
Giardia lamblia Cathepsin B precursor 0.0207 0.0826 0.2181
Schistosoma mansoni hypothetical protein 0.084 0.3544 0.3544
Loa Loa (eye worm) hypothetical protein 0.1635 0.6956 0.6956
Giardia lamblia Cysteine protease 0.0207 0.0826 0.2181
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0207 0.0826 0.0826
Echinococcus granulosus cpg binding protein 0.003 0.0068 0.0068
Brugia malayi Cathepsin L-like precursor 0.0629 0.2636 0.2636
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Schistosoma mansoni hypothetical protein 0.0537 0.2244 0.2244
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0216 0.0216
Giardia lamblia Cathepsin L precursor 0.0207 0.0826 0.2181
Loa Loa (eye worm) hypothetical protein 0.0629 0.2636 0.2636
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0207 0.0826 0.0826
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0455 0.189 0.189
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0207 0.0826 0.3084
Schistosoma mansoni acetylcholine receptor subunit beta 0.021 0.0839 0.0839
Plasmodium vivax calpain, putative 0.002 0.0026 0.0024
Schistosoma mansoni smad 0.0024 0.0042 0.0042
Leishmania major histone deacetylase, putative 0.0046 0.0136 0.0188
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.021 0.0839 0.0839
Echinococcus multilocularis cysteine protease 0.0629 0.2636 0.2636
Plasmodium falciparum serine repeat antigen 7 0.0207 0.0826 0.3084
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.1635 0.6956 0.6956
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.1635 0.6956 0.6956
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0035 0.0035
Schistosoma mansoni nAChR subunit 0.0455 0.189 0.189
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0629 0.2636 0.7169
Schistosoma mansoni hypothetical protein 0.0406 0.168 0.168
Loa Loa (eye worm) LGC-31 protein 0.0455 0.189 0.189
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.021 0.0839 0.0839
Brugia malayi cathepsin Z-like cysteine proteinase 0.0207 0.0826 0.0826
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0629 0.2636 0.7169
Brugia malayi prolyl oligopeptidase family protein 0.0171 0.0672 0.0672
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Entamoeba histolytica hypothetical protein 0.0025 0.0045 0.0037
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0537 0.2244 0.2244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Trypanosoma cruzi cysteine protease, putative 0.0259 0.1051 0.1033
Toxoplasma gondii preprocathepsin c precursor, putative 0.0207 0.0826 0.2256
Schistosoma mansoni nAChR subunit 0.0455 0.189 0.189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Echinococcus multilocularis smad 0.0024 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0046 0.0136 0.0136
Toxoplasma gondii cathepsin CPL 0.0629 0.2636 0.7196
Schistosoma mansoni cathepsin S (C01 family) 0.0207 0.0826 0.0826
Trypanosoma cruzi cysteine peptidase, putative 0.0819 0.3453 0.3441
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Echinococcus granulosus cathepsin l1 0.0629 0.2636 0.2636
Loa Loa (eye worm) hypothetical protein 0.0245 0.099 0.099
Schistosoma mansoni P2X receptor subunit 0.0068 0.0233 0.0233
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0245 0.099 0.099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.1051 0.28
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Brugia malayi Papain family cysteine protease containing protein 0.0259 0.1051 0.1051
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0455 0.189 0.189
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0455 0.189 0.189
Onchocerca volvulus 0.0027 0.0054 0.0078
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0207 0.0826 0.3084
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2345 1 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0207 0.0826 0.0826
Loa Loa (eye worm) hypothetical protein 0.0537 0.2244 0.2244
Brugia malayi Papain family cysteine protease containing protein 0.0207 0.0826 0.0826
Entamoeba histolytica hypothetical protein 0.0207 0.0826 0.3043
Onchocerca volvulus 0.021 0.0839 0.1206
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0026 0.001
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0216 0.0216
Brugia malayi hypothetical protein 0.021 0.0839 0.0839
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.0948 0.0948
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0455 0.189 0.189
Leishmania major cysteine peptidase A (CPA) 0.0629 0.2636 0.4231
Schistosoma mansoni cathepsin F (C01 family) 0.0629 0.2636 0.2636
Brugia malayi hypothetical protein 0.021 0.0839 0.0839
Brugia malayi Papain family cysteine protease containing protein 0.0629 0.2636 0.2636
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0455 0.189 0.189
Brugia malayi calpain family protein 1 0.0053 0.0168 0.0168
Plasmodium vivax vivapain-3 0.0259 0.1051 0.3941
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0629 0.2636 0.7169
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0171 0.0672 0.0672
Giardia lamblia Cathepsin B precursor 0.0207 0.0826 0.2181
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0207 0.0826 0.0826
Brugia malayi Importin beta-1 subunit 0.003 0.0069 0.0069
Giardia lamblia Cathepsin B precursor 0.0207 0.0826 0.2181
Giardia lamblia Cathepsin L precursor 0.0207 0.0826 0.2181
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0057 0.0186 0.0167
Onchocerca volvulus 0.0629 0.2636 0.379
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0207 0.0826 0.2181
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0207 0.0826 0.2181
Loa Loa (eye worm) hypothetical protein 0.0039 0.0108 0.0108
Schistosoma mansoni smad1 5 8 and 0.0024 0.0042 0.0042
Entamoeba histolytica cysteine protease, putative 0.0207 0.0826 0.3043
Trypanosoma cruzi histone deacetylase, putative 0.0046 0.0136 0.0116
Echinococcus granulosus glycine receptor subunit alpha 1 0.0455 0.189 0.189
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0455 0.189 0.189
Onchocerca volvulus 0.0028 0.0061 0.0088
Schistosoma mansoni nAChR subunit 0.0455 0.189 0.189
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Loa Loa (eye worm) hypothetical protein 0.0537 0.2244 0.2244
Schistosoma mansoni lamin 0.0027 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0047 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Trypanosoma brucei histone deacetylase, putative 0.0046 0.0136 0.0178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0629 0.2636 0.7169
Plasmodium vivax vivapain-2 0.0629 0.2636 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Plasmodium vivax serine-repeat antigen (SERA) 0.0207 0.0826 0.3084
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.1325 0.1325
Loa Loa (eye worm) hypothetical protein 0.0245 0.099 0.099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Brugia malayi MH2 domain containing protein 0.0024 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0048 0.0145 0.0145
Entamoeba histolytica hypothetical protein 0.0245 0.099 0.3672
Echinococcus multilocularis calpain A 0.0056 0.0179 0.0179
Echinococcus granulosus calpain 5 0.002 0.0026 0.0026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0328 0.0328
Echinococcus multilocularis microtubule associated protein 2 0.0716 0.301 0.301
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0216 0.0216
Giardia lamblia Cathepsin L-like protease 0.0207 0.0826 0.2181
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0328 0.0328
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0455 0.189 0.189
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0629 0.2636 1
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0537 0.2244 0.2244
Echinococcus multilocularis histone deacetylase 7 0.0046 0.0136 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Schistosoma mansoni microtubule-associated protein tau 0.0716 0.301 0.301
Loa Loa (eye worm) fibroinase 0.0629 0.2636 0.2636
Echinococcus multilocularis caspase 2 0.0248 0.1005 0.1005
Loa Loa (eye worm) hypothetical protein 0.0822 0.3468 0.3468
Echinococcus granulosus cathepsin L 0.0207 0.0826 0.0826
Loa Loa (eye worm) hypothetical protein 0.0052 0.0164 0.0164
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0455 0.189 0.189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Trypanosoma cruzi histone deacetylase, putative 0.0046 0.0136 0.0116
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.021 0.0839 0.0839
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0054 0.0054
Brugia malayi CXXC zinc finger family protein 0.0028 0.0061 0.0061
Echinococcus granulosus calpain A 0.002 0.0026 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Schistosoma mansoni calpain (C02 family) 0.002 0.0026 0.0026
Echinococcus granulosus cathepsin L cysteine proteinase 0.0629 0.2636 0.2636
Entamoeba histolytica cysteine proteinase 1, putative 0.0259 0.1051 0.3905
Echinococcus multilocularis calpain family protein 1, d 0.0039 0.0108 0.0108
Brugia malayi Cathepsin L-like precursor 0.0629 0.2636 0.2636
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0868 0.3664 0.3651
Loa Loa (eye worm) hypothetical protein 0.0576 0.2412 0.2412
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0207 0.0826 0.2181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0207 0.0826 0.3084
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0035 0.0059
Schistosoma mansoni nAChR subunit 0.021 0.0839 0.0839
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0261 0.1057 0.1057
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0216 0.0216
Echinococcus granulosus histone deacetylase 6 0.0046 0.0136 0.0136
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0455 0.189 0.189
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0042 0.0042
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0455 0.189 0.189
Leishmania major cathepsin L-like protease 0.0629 0.2636 0.4231
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0455 0.189 0.189
Echinococcus granulosus histone deacetylase 0.0046 0.0136 0.0136
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0042 0.0042
Onchocerca volvulus Cathepsin L homolog 0.0207 0.0826 0.1188
Loa Loa (eye worm) hypothetical protein 0.0245 0.099 0.099
Loa Loa (eye worm) hypothetical protein 0.0248 0.1005 0.1005
Echinococcus granulosus intermediate filament protein 0.0027 0.0054 0.0054
Schistosoma mansoni P2X receptor subunit 0.0068 0.0233 0.0233
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0207 0.0826 0.3084
Brugia malayi MH1 domain containing protein 0.0024 0.0042 0.0042
Echinococcus multilocularis importin subunit beta 1 0.003 0.0069 0.0069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0207 0.0826 0.2181
Brugia malayi gamma-secretase subunit aph-1 0.0261 0.1057 0.1057
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0455 0.189 0.189
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0054 0.0054
Brugia malayi RNA, U transporter 1 0.0086 0.0308 0.0308
Toxoplasma gondii kringle domain-containing protein 0.0019 0.0019 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2345 1 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0259 0.1051 0.1033
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0455 0.189 0.189
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0629 0.2636 0.2636
Brugia malayi MH1 domain containing protein 0.0024 0.0042 0.0042
Schistosoma mansoni nAChR subunit 0.0455 0.189 0.189
Echinococcus granulosus Dipeptidyl peptidase 9 0.0057 0.0186 0.0186
Echinococcus granulosus glycine receptor subunit beta 0.0455 0.189 0.189
Echinococcus multilocularis gamma secretase subunit aph 1 0.0261 0.1057 0.1057
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0199 0.0199
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0629 0.2636 0.7169
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Onchocerca volvulus 0.021 0.0839 0.1206
Brugia malayi hypothetical protein 0.021 0.0839 0.0839
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0052 0.0164 0.0164
Schistosoma mansoni histone deacetylase hda2 0.0046 0.0136 0.0136
Schistosoma mansoni survival motor neuron protein 0.0048 0.0145 0.0145
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0455 0.189 0.189
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0026 0.0006
Loa Loa (eye worm) hypothetical protein 0.0207 0.0826 0.0826
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0455 0.189 0.189
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0035 0.0015
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0035 0.0035
Plasmodium falciparum histone deacetylase 2 0.0046 0.0136 0.0444
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0207 0.0826 0.0826
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0455 0.189 0.189
Entamoeba histolytica cysteine protease, putative 0.0207 0.0826 0.3043
Onchocerca volvulus 0.021 0.0839 0.1206
Trypanosoma brucei C-8 sterol isomerase, putative 0.146 0.6204 1
Brugia malayi hypothetical protein 0.0044 0.0128 0.0128
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0207 0.0826 0.0826
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0537 0.2244 0.2244
Trypanosoma cruzi Aph-1 protein, putative 0.0102 0.0375 0.0356
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0035 0.0035
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0207 0.0826 0.2181
Onchocerca volvulus 0.0207 0.0826 0.1188
Loa Loa (eye worm) hypothetical protein 0.0235 0.0948 0.0948
Echinococcus multilocularis geminin 0.084 0.3544 0.3544
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0057 0.0186 0.0269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.1635 0.6956 0.6956
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.021 0.0839 0.0839
Giardia lamblia Hypothetical protein 0.0207 0.0826 0.2181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0328 0.0328
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2345 1 1
Schistosoma mansoni nAChR subunit 0.0455 0.189 0.189
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0259 0.1051 0.1659
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0216 0.0216
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0207 0.0826 0.3084
Loa Loa (eye worm) cathepsin B 0.0868 0.3664 0.3664
Schistosoma mansoni neurotransmitter gated ion channel 0.0245 0.099 0.099
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Schistosoma mansoni hypothetical protein 0.0323 0.1325 0.1325
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2345 1 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0455 0.189 0.189
Brugia malayi cathepsin F-like cysteine proteinase 0.0207 0.0826 0.0826
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0207 0.0826 0.2181
Brugia malayi Papain family cysteine protease containing protein 0.0259 0.1051 0.1051
Loa Loa (eye worm) cysteine protease 0.0629 0.2636 0.2636
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0455 0.189 0.189
Loa Loa (eye worm) ACC-1 protein 0.0455 0.189 0.189
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2345 1 1
Brugia malayi Cathepsin L-like precursor 0.0629 0.2636 0.2636
Plasmodium vivax histone deacetylase, putative 0.0046 0.0136 0.0444
Schistosoma mansoni ran 0.0022 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Brugia malayi MH2 domain containing protein 0.035 0.144 0.144
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0026 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0207 0.0826 0.2181
Onchocerca volvulus 0.0629 0.2636 0.379
Plasmodium vivax importin-beta 2, putative 0.003 0.0069 0.019
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0035 0.0035
Echinococcus multilocularis glycine receptor subunit beta 0.0455 0.189 0.189
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0868 0.3664 0.5892
Echinococcus granulosus Smad4 0.0024 0.0042 0.0042
Echinococcus granulosus histone deacetylase 6 0.0046 0.0136 0.0136
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0171 0.0672 0.0672
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Trypanosoma cruzi histone deacetylase, putative 0.0046 0.0136 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0868 0.3664 1
Schistosoma mansoni neurotransmitter gated ion channel 0.021 0.0839 0.0839
Schistosoma mansoni inhibitor of apoptosis protein 0.0537 0.2244 0.2244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Schistosoma mansoni smad1 5 8 and 0.0024 0.0042 0.0042
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0035 0.0015
Onchocerca volvulus Deterin homolog 0.0537 0.2244 0.3226
Brugia malayi cathepsin F-like cysteine proteinase 0.0052 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0207 0.0826 0.0826
Leishmania major cathepsin L-like protease 0.0819 0.3453 0.5552
Plasmodium falciparum histone deacetylase, putative 0.0046 0.0136 0.0444
Echinococcus granulosus histone deacetylase 7 0.0046 0.0136 0.0136
Leishmania major importin beta-1 subunit, putative 0.0025 0.0045 0.0041
Loa Loa (eye worm) hypothetical protein 0.0207 0.0826 0.0826
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0026 0.0006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0054 0.0054
Echinococcus multilocularis p2X purinoceptor 4 0.0068 0.0233 0.0233
Brugia malayi fibroinase precursor 0.0207 0.0826 0.0826
Echinococcus granulosus lamin 0.0027 0.0054 0.0054
Schistosoma mansoni cpg binding protein 0.003 0.0068 0.0068
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0455 0.189 0.189
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.1635 0.6956 0.6956
Brugia malayi cathepsin L precursor 0.0207 0.0826 0.0826
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0629 0.2636 0.7169
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0629 0.2636 1
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0207 0.0826 0.0826
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.021 0.0839 0.0839
Brugia malayi MH2 domain containing protein 0.0024 0.0042 0.0042
Loa Loa (eye worm) ctsf protein 0.0629 0.2636 0.2636
Trichomonas vaginalis conserved hypothetical protein 0.0207 0.0826 0.2181
Trypanosoma cruzi cysteine peptidase, putative 0.0259 0.1051 0.1033
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0026 0.0026
Onchocerca volvulus 0.0629 0.2636 0.379
Loa Loa (eye worm) calpain 0.002 0.0026 0.0026
Brugia malayi RNA binding protein 0.0065 0.0216 0.0216
Loa Loa (eye worm) Smad1 0.0024 0.0042 0.0042
Onchocerca volvulus 0.0248 0.1005 0.1445
Schistosoma mansoni histone deacetylase 4 5 0.0046 0.0136 0.0136
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0207 0.0826 0.3084
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0042 0.0042
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0259 0.1051 0.1051
Plasmodium falciparum serine repeat antigen 8 0.0207 0.0826 0.3084
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0001 0.0001
Onchocerca volvulus 0.0629 0.2636 0.379
Entamoeba histolytica cysteine proteinase, putative 0.0259 0.1051 0.3905
Brugia malayi Papain family cysteine protease containing protein 0.0207 0.0826 0.0826
Echinococcus granulosus cathepsin l cysteine peptidase 0.0629 0.2636 0.2636
Entamoeba histolytica cysteine protease, putative 0.0207 0.0826 0.3043
Echinococcus multilocularis tissue type plasminogen activator 0.0019 0.0019 0.0019
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0207 0.0826 0.3084
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.021 0.0839 0.0839
Toxoplasma gondii cathepsin B 0.0868 0.3664 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0207 0.0826 0.2181
Echinococcus granulosus calpain A 0.0056 0.0179 0.0179
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0629 0.2636 0.2636
Trypanosoma brucei cysteine peptidase C (CPC) 0.0868 0.3664 0.5888
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0164 0.0164
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0207 0.0826 0.0826
Giardia lamblia Cathepsin L precursor 0.0207 0.0826 0.2181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Loa Loa (eye worm) hypothetical protein 0.0207 0.0826 0.0826
Brugia malayi Cation transporter family protein 0.0455 0.189 0.189
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.021 0.0839 0.0839
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0057 0.0186 0.0259
Echinococcus granulosus cathepsin b 0.2345 1 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0171 0.0672 0.0966
Leishmania major cathepsin L-like protease 0.0629 0.2636 0.4231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0576 0.2412 0.6551
Entamoeba histolytica cysteine protease, putative 0.0207 0.0826 0.3043
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0455 0.189 0.189
Leishmania major GTP-binding protein, putative 0.0022 0.0035 0.0025
Giardia lamblia Cathepsin L precursor 0.0207 0.0826 0.2181
Brugia malayi Cell death protein 3 precursor 0.0248 0.1005 0.1005
Onchocerca volvulus Cathepsin F homolog 0.0629 0.2636 0.379
Loa Loa (eye worm) GABA receptor subunit 0.0245 0.099 0.099
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.021 0.0839 0.0839
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0207 0.0826 0.0826
Echinococcus granulosus geminin 0.084 0.3544 0.3544
Loa Loa (eye worm) hypothetical protein 0.0746 0.3141 0.3141
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0057 0.0186 0.0186
Brugia malayi Cation transporter family protein 0.0455 0.189 0.189
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0026 0.0006
Echinococcus multilocularis musashi 0.0027 0.0054 0.0054
Plasmodium falciparum serine repeat antigen 4 0.0207 0.0826 0.3084
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0207 0.0826 0.2181
Entamoeba histolytica cysteine proteinase, putative 0.0629 0.2636 1
Leishmania major histone deacetylase, putative 0.0046 0.0136 0.0188
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0207 0.0826 0.2181
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0245 0.099 0.099
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0207 0.0826 0.3084
Plasmodium falciparum serine repeat antigen 9 0.0207 0.0826 0.3084
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Echinococcus multilocularis cathepsin b 0.2345 1 1
Loa Loa (eye worm) calpain family protein 1 0.0039 0.0108 0.0108
Toxoplasma gondii histone deacetylase HDAC1 0.0046 0.0136 0.037
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0537 0.2244 0.2244
Loa Loa (eye worm) hypothetical protein 0.0245 0.099 0.099
Schistosoma mansoni caspase-7 (C14 family) 0.0248 0.1005 0.1005
Brugia malayi ERG2 and Sigma1 receptor like protein 0.146 0.6204 0.6204
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0455 0.189 0.189
Echinococcus multilocularis cysteine protease 0.0629 0.2636 0.2636
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0019
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0245 0.099 0.099
Leishmania major cathepsin L-like protease 0.0819 0.3453 0.5552
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0042 0.0042
Schistosoma mansoni nAChR subunit 0.0455 0.189 0.189
Echinococcus granulosus smad 0.0024 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0044 0.0128 0.0128
Echinococcus granulosus importin subunit beta 1 0.003 0.0069 0.0069
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0245 0.099 0.099
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0045 0.0027
Loa Loa (eye worm) ACC-1 protein 0.0455 0.189 0.189
Plasmodium falciparum serine repeat antigen 5 0.0207 0.0826 0.3084
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.1635 0.6956 0.6956
Echinococcus multilocularis glycine receptor subunit beta 0.0455 0.189 0.189
Plasmodium falciparum cysteine proteinase falcipain 3 0.0629 0.2636 1
Echinococcus multilocularis cathepsin L 0.0207 0.0826 0.0826
Trichomonas vaginalis conserved hypothetical protein 0.0207 0.0826 0.2181
Brugia malayi Kringle domain containing protein 0.0019 0.0019 0.0019
Loa Loa (eye worm) acetylcholine receptor protein 0.021 0.0839 0.0839
Echinococcus granulosus cathepsin L 0.0259 0.1051 0.1051
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0455 0.189 0.189
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Loa Loa (eye worm) hypothetical protein 0.0822 0.3468 0.3468
Loa Loa (eye worm) histone deacetylase 0.0046 0.0136 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0207 0.0826 0.2181
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0216 0.0216
Onchocerca volvulus 0.0822 0.3468 0.4986
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Echinococcus multilocularis calpain 0.002 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0245 0.099 0.099
Onchocerca volvulus 0.0576 0.2412 0.3468
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0179 0.0179
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0629 0.2636 0.2636
Giardia lamblia Encystation-specific protease 0.0207 0.0826 0.2181
Schistosoma mansoni cathepsin B (C01 family) 0.0207 0.0826 0.0826
Leishmania major cathepsin L-like protease 0.0629 0.2636 0.4231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0576 0.2412 0.6551
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0207 0.0826 0.2181
Brugia malayi TAR-binding protein 0.0065 0.0216 0.0216
Schistosoma mansoni cpg binding protein 0.003 0.0068 0.0068
Onchocerca volvulus Cathepsin L homolog 0.0629 0.2636 0.379
Schistosoma mansoni nAChR subunit 0.0455 0.189 0.189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0207 0.0826 0.3084
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0207 0.0826 0.3043
Echinococcus multilocularis nAChR subunit 0.0245 0.099 0.099
Brugia malayi Protein kinase domain containing protein 0.0019 0.0019 0.0019
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0057 0.0186 0.0186
Brugia malayi Cathepsin L-like precursor 0.0629 0.2636 0.2636
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0057 0.0186 0.0167
Trypanosoma cruzi calpain cysteine peptidase, putative 0.002 0.0026 0.0006
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Brugia malayi cathepsin L-like precursor 0.0576 0.2412 0.2412
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0026 0.0026
Trypanosoma cruzi major cysteine proteinase, putative 0.0207 0.0826 0.0809
Echinococcus granulosus caspase 2 0.0248 0.1005 0.1005
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0035 0.0015
Loa Loa (eye worm) hypothetical protein 0.0245 0.099 0.099
Brugia malayi excitatory GABA receptor EXP-1A 0.0455 0.189 0.189
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0207 0.0826 0.3084
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Echinococcus granulosus tar DNA binding protein 0.0065 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0207 0.0826 0.0826
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0455 0.189 0.189
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Echinococcus granulosus cathepsin L cysteine protease 0.0259 0.1051 0.1051
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Echinococcus granulosus cysteine protease 0.0259 0.1051 0.1051
Echinococcus multilocularis cathepsin L 0.0259 0.1051 0.1051
Plasmodium falciparum importin beta, putative 0.003 0.0069 0.019
Loa Loa (eye worm) hypothetical protein 0.0576 0.2412 0.2412
Brugia malayi hypothetical protein 0.021 0.0839 0.0839
Brugia malayi hypothetical protein 0.0235 0.0948 0.0948
Trypanosoma cruzi Aph-1 protein, putative 0.0102 0.0375 0.0356
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0629 0.2636 0.7169
Onchocerca volvulus 0.0245 0.099 0.1423
Trypanosoma cruzi C-8 sterol isomerase, putative 0.146 0.6204 0.6197
Onchocerca volvulus 0.0822 0.3468 0.4986
Echinococcus multilocularis cpg binding protein 0.003 0.0068 0.0068
Echinococcus multilocularis histone deacetylase 0.0046 0.0136 0.0136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0207 0.0826 0.2181
Loa Loa (eye worm) hypothetical protein 0.146 0.6204 0.6204
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0455 0.189 0.189
Brugia malayi Histone deacetylase family protein 0.0046 0.0136 0.0136
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0767 0.3229 0.3216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0259 0.1051 0.28
Trypanosoma cruzi major cysteine proteinase, putative 0.0397 0.1644 0.1627
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0207 0.0826 0.2181
Echinococcus multilocularis cathepsin b 0.2345 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0045 0.0027
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0455 0.189 0.189
Schistosoma mansoni hypothetical protein 0.0248 0.1005 0.1005
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0455 0.189 0.189
Brugia malayi Cation transporter family protein 0.0822 0.3468 0.3468
Loa Loa (eye worm) hypothetical protein 0.003 0.0069 0.0069
Plasmodium vivax histone deacetylase 2, putative 0.0046 0.0136 0.0444
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0026 0.0006
Plasmodium falciparum cysteine proteinase falcipain 1 0.0259 0.1051 0.3941
Echinococcus granulosus p2X purinoceptor 4 0.0068 0.0233 0.0233
Trypanosoma cruzi cysteine peptidase, putative 0.0819 0.3453 0.3441
Schistosoma mansoni cathepsin s 0.0052 0.0164 0.0164
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0328 0.0328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Giardia lamblia Hypothetical protein 0.0207 0.0826 0.2181
Plasmodium vivax vivapain-2 0.0629 0.2636 1
Echinococcus granulosus inhibitor of apoptosis protein 0.0537 0.2244 0.2244
Echinococcus granulosus glycine receptor subunit beta 0.0455 0.189 0.189
Echinococcus multilocularis apoptotic protease activating factor 1 0.0248 0.1005 0.1005
Brugia malayi cathepsin L-like cysteine proteinase 0.0207 0.0826 0.0826
Echinococcus granulosus tissue type plasminogen activator 0.0019 0.0019 0.0019
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.1635 0.6956 0.6956
Onchocerca volvulus 0.0019 0.0019 0.0028
Echinococcus granulosus glycine receptor subunit alpha 1 0.0455 0.189 0.189
Echinococcus granulosus microtubule associated protein 2 0.0716 0.301 0.301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Plasmodium vivax serine-repeat antigen (SERA) 0.0207 0.0826 0.3084
Plasmodium vivax unspecified product 0.0207 0.0826 0.3084
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0259 0.1051 0.1051
Trypanosoma brucei histone deacetylase 4 0.0046 0.0136 0.0178
Loa Loa (eye worm) hypothetical protein 0.0613 0.2568 0.2568
Schistosoma mansoni cathepsin F (C01 family) 0.0629 0.2636 0.2636
Echinococcus granulosus glycine receptor subunit alpha 1 0.0455 0.189 0.189
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.021 0.0839 0.0839
Loa Loa (eye worm) hypothetical protein 0.0052 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0052 0.0164 0.0164
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0537 0.2244 0.2244
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0026 0.0006
Schistosoma mansoni importin beta-1 0.003 0.0069 0.0069
Loa Loa (eye worm) prolyl oligopeptidase 0.0171 0.0672 0.0672
Brugia malayi cathepsin Z-like cysteine proteinase 0.0207 0.0826 0.0826
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0207 0.0826 0.2181
Echinococcus granulosus lamin dm0 0.0027 0.0054 0.0054
Giardia lamblia Cysteine protease 0.0207 0.0826 0.2181
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0455 0.189 0.189
Schistosoma mansoni hypothetical protein 0.0019 0.0019 0.0019
Echinococcus granulosus dnaJ subfamily B 0.0406 0.168 0.168
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.021 0.0839 0.0839
Onchocerca volvulus 0.0033 0.0082 0.0118
Echinococcus multilocularis lamin 0.0027 0.0054 0.0054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0328 0.0328
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0026 0.0006
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0207 0.0826 0.2181
Loa Loa (eye worm) histone deacetylase 7A 0.0046 0.0136 0.0136
Trypanosoma brucei histone deacetylase 3 0.0046 0.0136 0.0178
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Echinococcus granulosus snurportin 1 0.0323 0.1325 0.1325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Schistosoma mansoni smad1 5 8 and 0.0024 0.0042 0.0042
Schistosoma mansoni gamma-secretase subunit aph-1 0.0261 0.1057 0.1057
Loa Loa (eye worm) RNA binding protein 0.0065 0.0216 0.0216
Leishmania major cathepsin L-like protease 0.0629 0.2636 0.4231
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0455 0.189 0.189
Echinococcus multilocularis p2X purinoceptor 4 0.0068 0.0233 0.0233
Brugia malayi hypothetical protein 0.0248 0.1005 0.1005
Brugia malayi Cathepsin L-like precursor 0.0576 0.2412 0.2412
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.021 0.0839 0.0839
Onchocerca volvulus 0.0629 0.2636 0.379
Echinococcus granulosus p2X purinoceptor 4 0.0068 0.0233 0.0233
Giardia lamblia Cathepsin L-like protease 0.0207 0.0826 0.2181
Onchocerca volvulus Putative nachr subunit 0.1635 0.6956 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0245 0.099 0.099
Loa Loa (eye worm) hypothetical protein 0.0033 0.0082 0.0082
Brugia malayi Cathepsin L-like precursor 0.0629 0.2636 0.2636
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0035 0.0095
Schistosoma mansoni ran 0.0022 0.0035 0.0035
Echinococcus multilocularis histone deacetylase 6 0.0046 0.0136 0.0136
Loa Loa (eye worm) TK/ROR protein kinase 0.0019 0.0019 0.0019
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0053 0.0168 0.0168
Echinococcus multilocularis nAChR subunit 0.0455 0.189 0.189
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0328 0.0328
Giardia lamblia Cathepsin B precursor 0.0868 0.3664 1
Onchocerca volvulus 0.0245 0.099 0.1423
Schistosoma mansoni histone deacetylase 4 5 0.0046 0.0136 0.0136
Echinococcus multilocularis lamin dm0 0.0027 0.0054 0.0054
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0216 0.0216
Onchocerca volvulus 0.0455 0.189 0.2717
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0455 0.189 0.189
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0207 0.0826 0.0826
Echinococcus multilocularis histone deacetylase 6 0.0046 0.0136 0.0136
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Leishmania major C-8 sterol isomerase-like protein 0.146 0.6204 1
Brugia malayi prolyl oligopeptidase family protein 0.0057 0.0186 0.0186
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0171 0.0672 0.0672
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0455 0.189 0.189
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0868 0.3664 0.3664
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0629 0.2636 0.7169
Entamoeba histolytica cysteine proteinase 2 0.0259 0.1051 0.3905
Echinococcus multilocularis histone deacetylase 6 0.0046 0.0136 0.0136
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.0948 0.0948
Trypanosoma cruzi cruzipain precursor, putative 0.0052 0.0164 0.0144
Plasmodium falciparum serine repeat antigen 6 0.0207 0.0826 0.3084
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0822 0.3468 0.3468
Loa Loa (eye worm) hypothetical protein 0.0248 0.1005 0.1005
Loa Loa (eye worm) hypothetical protein 0.2345 1 1
Toxoplasma gondii cathepsin CPC1 0.0207 0.0826 0.2256
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0026 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Schistosoma mansoni hypothetical protein 0.084 0.3544 0.3544
Entamoeba histolytica cysteine protease, putative 0.0629 0.2636 1
Echinococcus granulosus gamma secretase subunit aph 1 0.0261 0.1057 0.1057
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0207 0.0826 0.3043
Schistosoma mansoni acetylcholine receptor-related 0.021 0.0839 0.0839
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0056 0.0179 0.0179
Plasmodium vivax vivapain-1 0.0259 0.1051 0.3941
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0207 0.0826 0.2181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0259 0.1051 0.1659
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0259 0.1051 0.1051
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0061 0.0061
Trypanosoma cruzi cysteine proteinase, putative 0.0259 0.1051 0.1033
Loa Loa (eye worm) hypothetical protein 0.0026 0.0052 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0819 0.3453 0.5548
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0045 0.0027
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0455 0.189 0.189
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0069 0.007
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0171 0.0466
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0056 0.0179 0.0179
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0045 0.0025
Echinococcus multilocularis hypothetical protein 0.002 0.0026 0.0026
Echinococcus multilocularis snurportin 1 0.0323 0.1325 0.1325
Onchocerca volvulus 0.0048 0.0145 0.0209
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Echinococcus multilocularis Smad4 0.0024 0.0042 0.0042
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0216 0.0216
Entamoeba histolytica cysteine proteinase, putative 0.0576 0.2412 0.9138
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0057 0.0186 0.0259
Brugia malayi Cathepsin L-like cysteine proteinase 0.0576 0.2412 0.2412
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0629 0.2636 0.2636
Toxoplasma gondii cathepsin CPC2 0.0207 0.0826 0.2256
Leishmania major cathepsin L-like protease 0.0819 0.3453 0.5552
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0455 0.189 0.189
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.1635 0.6956 0.6956
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0069 0.0189
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0455 0.189 0.189
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0026 0.001
Schistosoma mansoni lamin 0.0027 0.0054 0.0054
Plasmodium falciparum serine repeat antigen 3 0.0207 0.0826 0.3084
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0216 0.0216
Brugia malayi hypothetical protein 0.021 0.0839 0.0839
Echinococcus granulosus histone deacetylase 6 0.0046 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.021 0.0839 0.0839
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0026 0.0006
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0245 0.099 0.099
Onchocerca volvulus 0.0629 0.2636 0.379
Entamoeba histolytica cysteine proteinase, putative 0.0629 0.2636 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0629 0.2636 0.7169
Schistosoma mansoni P2X receptor subunit 0.0068 0.0233 0.0233
Echinococcus multilocularis cathepsin L cysteine protease 0.0629 0.2636 0.2636
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.1635 0.6956 0.6956
Echinococcus granulosus cathepsin l1 0.0576 0.2412 0.2412
Entamoeba histolytica cysteine protease, putative 0.0207 0.0826 0.3043
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0207 0.0826 0.0826
Echinococcus granulosus calpain 0.002 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0053 0.0168 0.0168
Schistosoma mansoni cpg binding protein 0.0028 0.0061 0.0061
Entamoeba histolytica cysteine proteinase, putative 0.0259 0.1051 0.3905
Onchocerca volvulus 0.0455 0.189 0.2717
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0822 0.3468 0.3468
Brugia malayi Cytochrome P450 family protein 0.0022 0.0036 0.0036
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0207 0.0826 0.3084
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0207 0.0826 0.2181
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0069 0.007
Schistosoma mansoni Smad4 0.0024 0.0042 0.0042
Entamoeba histolytica cysteine proteinase, putative 0.0259 0.1051 0.3905
Brugia malayi Cathepsin L-like precursor 0.0629 0.2636 0.2636
Loa Loa (eye worm) hypothetical protein 0.0207 0.0826 0.0826
Echinococcus granulosus cathepsin b 0.2345 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0136 0.0136
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0455 0.189 0.189
Onchocerca volvulus 0.0629 0.2636 0.379
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0328 0.0328
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0036 0.0036
Echinococcus granulosus calpain 7 C02 family 0.002 0.0026 0.0026
Loa Loa (eye worm) calpain family protein 1 0.0053 0.0168 0.0168
Entamoeba histolytica cysteine proteinase, putative 0.0259 0.1051 0.3905
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0057 0.0186 0.0507
Entamoeba histolytica cysteine protease, putative 0.0259 0.1051 0.3905
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0207 0.0826 0.3084
Trypanosoma brucei Aph-1 protein, putative 0.0102 0.0375 0.0565
Onchocerca volvulus 0.0822 0.3468 0.4986
Brugia malayi Smad1 0.0024 0.0042 0.0042
Echinococcus granulosus p2X purinoceptor 4 0.0068 0.0233 0.0233
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0207 0.0826 0.0826
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0629 0.2636 0.7169
Schistosoma mansoni intermediate filament proteins 0.0027 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0455 0.189 0.189
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0629 0.2636 0.7169
Trypanosoma cruzi cysteine proteinase, putative 0.0259 0.1051 0.1033
Schistosoma mansoni nAChR subunit 0.021 0.0839 0.0839
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0328 0.0328
Trypanosoma cruzi cysteine peptidase, putative 0.0629 0.2636 0.2622
Brugia malayi Histone deacetylase family protein 0.0046 0.0136 0.0136
Onchocerca volvulus 0.0537 0.2244 0.3226
Brugia malayi Papain family cysteine protease containing protein 0.0207 0.0826 0.0826
Onchocerca volvulus 0.0455 0.189 0.2717
Entamoeba histolytica cysteine protease, putative 0.0207 0.0826 0.3043
Loa Loa (eye worm) transcription factor SMAD2 0.035 0.144 0.144
Plasmodium vivax unspecified product 0.0052 0.0164 0.0551
Giardia lamblia Cathepsin L precursor 0.0207 0.0826 0.2181
Onchocerca volvulus Cathepsin L homolog 0.0629 0.2636 0.379
Echinococcus granulosus apoptotic protease activating factor 1 0.0248 0.1005 0.1005
Echinococcus multilocularis p2X purinoceptor 4 0.0068 0.0233 0.0233
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0207 0.0826 0.2181
Plasmodium falciparum serine repeat antigen 2 0.0207 0.0826 0.3084
Giardia lamblia Cysteine protease 0.0207 0.0826 0.2181
Loa Loa (eye worm) hypothetical protein 0.0576 0.2412 0.2412
Giardia lamblia Cathepsin B precursor 0.0207 0.0826 0.2181
Giardia lamblia Cathepsin L precursor 0.0207 0.0826 0.2181
Onchocerca volvulus Cell death protein 3 homolog 0.0248 0.1005 0.1445
Schistosoma mansoni P2X receptor subunit 0.0068 0.0233 0.0233
Brugia malayi intermediate filament protein 0.0027 0.0054 0.0054
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0207 0.0826 0.0826
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0207 0.0826 0.2181
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0207 0.0826 0.3084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0629 0.2636 0.7169
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0455 0.189 0.189
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Giardia lamblia Cathepsin B precursor 0.0207 0.0826 0.2181
Loa Loa (eye worm) hypothetical protein 0.0455 0.189 0.189
Echinococcus granulosus nAChR subunit 0.0455 0.189 0.189
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.021 0.0839 0.0839
Loa Loa (eye worm) hypothetical protein 0.0245 0.099 0.099
Echinococcus granulosus nAChR subunit 0.0245 0.099 0.099
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0164 0.0144
Brugia malayi Cathepsin L-like precursor 0.0576 0.2412 0.2412
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0001 0.0001
Schistosoma mansoni Mername-AA248 (C02 family) 0.002 0.0026 0.0026
Trypanosoma cruzi cysteine peptidase, putative 0.0819 0.3453 0.3441
Loa Loa (eye worm) MH2 domain-containing protein 0.035 0.144 0.144
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0042 0.0042
Schistosoma mansoni neurotransmitter gated ion channel 0.021 0.0839 0.0839
Plasmodium vivax unspecified product 0.0259 0.1051 0.3941
Brugia malayi calpain family protein 1 0.0053 0.0168 0.0168
Echinococcus multilocularis calpain 7 (C02 family) 0.002 0.0026 0.0026
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.021 0.0839 0.0839

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 42 uM Cytotoxicity against human MT2 cells by MTT assay ChEMBL. 22269110

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.