Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.039 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0132 | 0.2484 | 0.1247 |
Echinococcus granulosus | bromodomain containing 2 | 0.0211 | 0.4799 | 0.4327 |
Entamoeba histolytica | bromodomain-containing protein | 0.0095 | 0.1412 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0211 | 0.4799 | 0.425 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.2681 | 0.2681 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.039 | 1 | 1 |
Schistosoma mansoni | RNA binding protein | 0.0139 | 0.2681 | 0.0916 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0139 | 0.2681 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.2681 | 0.2681 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.039 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.2681 | 0.2681 |
Leishmania major | hypothetical protein, conserved | 0.0139 | 0.2681 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0139 | 0.2681 | 0.5 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0095 | 0.1412 | 0.1412 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.039 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.039 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0211 | 0.4799 | 0.425 |
Onchocerca volvulus | 0.0139 | 0.2681 | 0.1477 | |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.039 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.039 | 1 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0132 | 0.2484 | 0.1247 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0139 | 0.2681 | 0.5 |
Schistosoma mansoni | bromodomain-containing protein 3 brd3 | 0.0211 | 0.4799 | 0.3545 |
Loa Loa (eye worm) | brahma associated protein | 0.039 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0139 | 0.2681 | 0.1908 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0132 | 0.2484 | 0.1247 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0139 | 0.2681 | 0.0916 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0139 | 0.2681 | 0.2016 |
Loa Loa (eye worm) | CBP-B | 0.0083 | 0.1058 | 0.1058 |
Onchocerca volvulus | 0.0139 | 0.2681 | 0.1477 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0139 | 0.2681 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0116 | 0.2027 | 0.0716 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.039 | 1 | 1 |
Toxoplasma gondii | ran binding protein | 0.0139 | 0.2681 | 0.1477 |
Entamoeba histolytica | bromodomain-containing protein | 0.0095 | 0.1412 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0139 | 0.2681 | 0.5 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.039 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.039 | 1 | 0.5 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.039 | 1 | 0.5 |
Onchocerca volvulus | 0.039 | 1 | 1 | |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0132 | 0.2484 | 0.1247 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0139 | 0.2681 | 0.2016 |
Schistosoma mansoni | hypothetical protein | 0.039 | 1 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0139 | 0.2681 | 0.5 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.039 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0139 | 0.2681 | 0.1908 |
Onchocerca volvulus | 0.0139 | 0.2681 | 0.1477 | |
Echinococcus multilocularis | bromodomain containing 2 | 0.0211 | 0.4799 | 0.42 |
Echinococcus multilocularis | Bromodomain containing protein | 0.0095 | 0.1412 | 0.0423 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0139 | 0.2681 | 0.1908 |
Chlamydia trachomatis | SWIB complex protein | 0.039 | 1 | 0.5 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0139 | 0.2681 | 0.1838 |
Echinococcus granulosus | CREB binding protein | 0.0113 | 0.1943 | 0.1211 |
Onchocerca volvulus | 0.0139 | 0.2681 | 0.1477 | |
Schistosoma mansoni | brg-1 associated factor | 0.039 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.039 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0139 | 0.2681 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.039 | 1 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0139 | 0.2681 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0139 | 0.2681 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0139 | 0.2681 | 0.0916 |
Giardia lamblia | Kinase, putative | 0.0095 | 0.1412 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0139 | 0.2681 | 0.0916 |
Schistosoma mansoni | fusion | 0.0139 | 0.2681 | 0.0916 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0139 | 0.2681 | 0.2016 |
Leishmania major | hypothetical protein, conserved | 0.0139 | 0.2681 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0139 | 0.2681 | 0.5 |
Brugia malayi | TAZ zinc finger family protein | 0.0113 | 0.1943 | 0.1092 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0139 | 0.2681 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0211 | 0.4799 | 0.3944 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0139 | 0.2681 | 0.1477 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0139 | 0.2681 | 0.5 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.039 | 1 | 1 |
Toxoplasma gondii | Zn-finger in Ran binding protein and others domain-containing protein | 0.0139 | 0.2681 | 0.1477 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0139 | 0.2681 | 0.5 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0139 | 0.2681 | 0.5 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0139 | 0.2681 | 0.1838 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0139 | 0.2681 | 0.5 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0139 | 0.2681 | 0.5 |
Brugia malayi | YY1-associated factor 2 | 0.0139 | 0.2681 | 0.1908 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0211 | 0.4799 | 0.3944 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.4799 | 0.4799 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0139 | 0.2681 | 0.1908 |
Schistosoma mansoni | hypothetical protein | 0.039 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.039 | 1 | 1 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0139 | 0.2681 | 0.2016 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0139 | 0.2681 | 0.1838 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.2681 | 0.2681 |
Brugia malayi | brahma associated protein 60 kDa | 0.039 | 1 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.039 | 1 | 0.5 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.0132 | 0.2484 | 0.1247 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0139 | 0.2681 | 0.1838 |
Leishmania major | hypothetical protein, conserved | 0.0139 | 0.2681 | 0.5 |
Entamoeba histolytica | bromodomain-containing protein | 0.0095 | 0.1412 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.2681 | 0.2681 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 2.11 uM | Growth inhibition of human ZR-75-1 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 22364746 |
GI50 (functional) | = 2.3 uM | Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 22364746 |
GI50 (functional) | = 2.5 uM | Growth inhibition of human KB cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 22364746 |
GI50 (functional) | = 2.51 uM | Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 22364746 |
GI50 (functional) | = 2.8 uM | Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 22364746 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.