Detailed information for compound 1624642

Basic information

Technical information
  • TDR Targets ID: 1624642
  • Name: 3-chloro-6-methoxy-N-(pyridin-4-ylmethylidene amino)-1-benzothiophene-2-carboxamide
  • MW: 345.803 | Formula: C16H12ClN3O2S
  • H donors: 1 H acceptors: 2 LogP: 3.71 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)sc(c2Cl)C(=O)N/N=C/c1ccncc1
  • InChi: 1S/C16H12ClN3O2S/c1-22-11-2-3-12-13(8-11)23-15(14(12)17)16(21)20-19-9-10-4-6-18-7-5-10/h2-9H,1H3,(H,20,21)/b19-9+
  • InChiKey: SOVQDOMOSMBTOR-DJKKODMXSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-chloro-6-methoxy-N-(4-pyridylmethyleneamino)benzothiophene-2-carboxamide
  • 3-chloro-6-methoxy-N-(4-pyridylmethyleneamino)-2-benzothiophenecarboxamide
  • BAS 00483383
  • ZINC00318063

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens protein phosphatase 1, catalytic subunit, alpha isozyme Starlite/ChEMBL No references
Homo sapiens regulator of G-protein signaling 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis Serine threonine specific protein phosphatase bis(5 nucleosyl) tetraphosphatase Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus granulosus protein phosphatase 1 catalytic subunit Get druggable targets OG5_126821 All targets in OG5_126821
Schistosoma japonicum ko:K06269 protein phosphatase 1, catalytic subunit, putative Get druggable targets OG5_126821 All targets in OG5_126821
Candida albicans potential calcineurin-like phosphoesterase similar to S. cerevisiae GLC7 (YER133W) protein phosphatase involved in glycogen accu Get druggable targets OG5_126821 All targets in OG5_126821
Giardia lamblia Ser/Thr protein phosphatase PP1-alpha 2 catalytic subunit Get druggable targets OG5_126821 All targets in OG5_126821
Leishmania donovani serine/threonine protein phosphatase catalytic subunit, putative Get druggable targets OG5_126821 All targets in OG5_126821
Leishmania major serine/threonine protein phosphatase catalytic subunit, putative Get druggable targets OG5_126821 All targets in OG5_126821
Theileria parva serine/threonine protein phosphatase, putative Get druggable targets OG5_126821 All targets in OG5_126821
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126821 All targets in OG5_126821
Brugia malayi Serine/threonine protein phosphatase PP1-beta catalytic subunit Get druggable targets OG5_126821 All targets in OG5_126821
Schistosoma japonicum ko:K06269 protein phosphatase 1, catalytic subunit, putative Get druggable targets OG5_126821 All targets in OG5_126821
Cryptosporidium parvum serine/threonine protein phosphatase, putative Get druggable targets OG5_126821 All targets in OG5_126821
Trichomonas vaginalis serine/threonine protein phosphatase, putative Get druggable targets OG5_126821 All targets in OG5_126821
Trichomonas vaginalis bsu-protein phosphatase, putative Get druggable targets OG5_126821 All targets in OG5_126821
Leishmania mexicana serine/threonine protein phosphatase catalytic subunit, putative Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus multilocularis expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Trichomonas vaginalis protein phosphatase, caeel, putative Get druggable targets OG5_126821 All targets in OG5_126821
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126821 All targets in OG5_126821
Babesia bovis Ser/Thr protein phosphatase family protein Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus granulosus expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Toxoplasma gondii serine/threonine phosophatase PP1 Get druggable targets OG5_126821 All targets in OG5_126821
Plasmodium vivax serine/threonine protein phosphatase PP1, putative Get druggable targets OG5_126821 All targets in OG5_126821
Loa Loa (eye worm) serine/threonine-protein phosphatase PP1-beta Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus granulosus protein phosphatase 1, catalytic subunit, beta isozyme Get druggable targets OG5_126821 All targets in OG5_126821
Trypanosoma cruzi serine/threonine protein phosphatase catalytic subunit, putative Get druggable targets OG5_126821 All targets in OG5_126821
Plasmodium falciparum serine/threonine protein phosphatase PP1 Get druggable targets OG5_126821 All targets in OG5_126821
Trypanosoma congolense protein phosphatase 1, putative Get druggable targets OG5_126821 All targets in OG5_126821
Trichomonas vaginalis bsu-protein phosphatase, putative Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus multilocularis serine:threonine protein phosphatase PP1 isozyme Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus granulosus protein phosphatase 1 catalytic subunit Get druggable targets OG5_126821 All targets in OG5_126821
Leishmania infantum serine/threonine protein phosphatase catalytic subunit, putative Get druggable targets OG5_126821 All targets in OG5_126821
Schistosoma mansoni protein phosphatase type 1 Get druggable targets OG5_126821 All targets in OG5_126821
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-beta catalytic subunit Get druggable targets OG5_126821 All targets in OG5_126821
Neospora caninum hypothetical protein Get druggable targets OG5_126821 All targets in OG5_126821
Leishmania braziliensis serine/threonine protein phosphatase catalytic subunit, putative Get druggable targets OG5_126821 All targets in OG5_126821
Schistosoma mansoni protein phosphatase-1 Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus multilocularis protein phosphatase 1 catalytic subunit Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma Get druggable targets OG5_126821 All targets in OG5_126821
Trichomonas vaginalis protein phosphatase 2A, caeel, putative Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus multilocularis protein phosphatase 1 catalytic subunit Get druggable targets OG5_126821 All targets in OG5_126821
Giardia lamblia Phosphatase Get druggable targets OG5_126821 All targets in OG5_126821
Trypanosoma brucei protein phosphatase 1, putative Get druggable targets OG5_126821 All targets in OG5_126821
Trypanosoma brucei gambiense serine/threonine protein phosphatase catalytic subunit, putative,serine/threonine protein phosphatase PP1-gamma Get druggable targets OG5_126821 All targets in OG5_126821
Trichomonas vaginalis protein phosphatase-1, putative Get druggable targets OG5_126821 All targets in OG5_126821
Schistosoma mansoni protein phosphatase type 1 Get druggable targets OG5_126821 All targets in OG5_126821
Entamoeba histolytica serine/threonine protein phosphatase PP1-2, putative Get druggable targets OG5_126821 All targets in OG5_126821
Entamoeba histolytica serine/threonine protein phosphatase PP1-2, putative Get druggable targets OG5_126821 All targets in OG5_126821
Plasmodium yoelii serine/threonine protein phosphatase alpha-3 isoform Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus multilocularis serine:threonine protein phosphatase PP1 beta Get druggable targets OG5_126821 All targets in OG5_126821
Candida albicans potential calcineurin-like phosphoesterase similar to S. cerevisiae GLC7 (YER133W) protein phosphatase involved in glycogen accu Get druggable targets OG5_126821 All targets in OG5_126821
Schistosoma mansoni protein phosphatase-1 Get druggable targets OG5_126821 All targets in OG5_126821
Plasmodium knowlesi serine/threonine protein phosphatase PP1, putative Get druggable targets OG5_126821 All targets in OG5_126821
Brugia malayi Serine/threonine protein phosphatase F56C9.1 in chromosomeIII Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus multilocularis Serine threonine specific protein phosphatase bis(5 nucleosyl) tetraphosphatase Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma Get druggable targets OG5_126821 All targets in OG5_126821
Trichomonas vaginalis bsu-protein phosphatase, putative Get druggable targets OG5_126821 All targets in OG5_126821
Schistosoma japonicum ko:K06269 protein phosphatase 1, catalytic subunit, putative Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus granulosus serine:threonine protein phosphatase PP1 beta Get druggable targets OG5_126821 All targets in OG5_126821
Trichomonas vaginalis serine/threonine protein phosphatase, putative Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma Get druggable targets OG5_126821 All targets in OG5_126821
Plasmodium berghei serine/threonine protein phosphatase PP1 Get druggable targets OG5_126821 All targets in OG5_126821
Echinococcus granulosus serine:threonine protein phosphatase Get druggable targets OG5_126821 All targets in OG5_126821
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum protein phosphatase containing kelch-like domains protein phosphatase 1, catalytic subunit, alpha isozyme 341 aa 331 aa 41.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0353 0.0258
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0055 0.1051 0.1051
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0055 0.1051 0.1051
Leishmania major eukaryotic translation initiation factor-like 0.0458 1 1
Brugia malayi PXA domain containing protein 0.0023 0.0353 0.0353
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0055 0.1051 0.1051
Leishmania major eukaryotic translation initiation factor-like protein 0.0458 1 1
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0353 0.0353
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0353 0.0258
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0353 0.0258
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.0353 0.0258
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0353 0.0353
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0353 0.0258
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0055 0.1051 0.1051
Loa Loa (eye worm) hypothetical protein 0.0023 0.0353 0.0353
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.0353 0.0353
Trichomonas vaginalis protein phosphatase, caeel, putative 0.0012 0.0097 0.0097
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0055 0.1051 0.1051
Plasmodium vivax translation initiation factor 4E, putative 0.0055 0.1051 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0055 0.1051 0.1051
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0353 0.0353
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0458 1 1
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0012 0.0097 0.0097
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.0353 0.0353
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0458 1 1
Onchocerca volvulus 0.0182 0.3886 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0353 0.0353
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0055 0.1051 0.0963
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0055 0.1051 0.1051
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0353 0.0353
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0458 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0353 0.0353
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0353 0.0353
Giardia lamblia Hypothetical protein 0.0055 0.1051 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0353 0.0353
Schistosoma mansoni protein phosphatase-1 0.0012 0.0097 0.0097
Leishmania major hypothetical protein, conserved 0.0055 0.1051 0.1051
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0353 0.0353
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0353 0.0258
Entamoeba histolytica hypothetical protein 0.0055 0.1051 0.1051
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0055 0.1051 0.1051
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0353 0.0258
Loa Loa (eye worm) hypothetical protein 0.0182 0.3886 0.3886
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0458 1 1
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0012 0.0097 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0353 0.0353
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0055 0.1051 0.1051
Plasmodium falciparum eukaryotic translation initiation factor 4E 0.0055 0.1051 1
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0353 0.0353
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0055 0.1051 0.1051
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0055 0.1051 0.1051
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.1051 0.1051
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0353 0.0258
Trypanosoma cruzi serine/threonine protein phosphatase catalytic subunit, putative 0.0012 0.0097 0.0097
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.0353 0.0258
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0055 0.1051 0.1051
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0458 1 1
Trypanosoma brucei Eukaryotic translation initiation factor 4E type 5 0.0055 0.1051 0.1051
Entamoeba histolytica hypothetical protein 0.0023 0.0353 0.0353
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0055 0.1051 0.1051
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0458 1 1
Loa Loa (eye worm) RGS-3 protein 0.0023 0.0353 0.0353
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0353 0.0353
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0055 0.1051 0.1051
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0458 1 1
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.0353 0.0353
Loa Loa (eye worm) hypothetical protein 0.0023 0.0353 0.0353
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0353 0.0258
Leishmania major hypothetical protein, conserved 0.0055 0.1051 0.1051
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.0353 0.0353
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.0353 0.0353
Schistosoma mansoni protein phosphatase-1 0.0012 0.0097 0.0097
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0353 0.0353
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.0353 0.0258
Trypanosoma brucei Eukaryotic translation initiation factor 4E-2 0.0055 0.1051 0.1051
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0353 0.0353
Entamoeba histolytica hypothetical protein 0.0023 0.0353 0.0353
Echinococcus multilocularis expressed protein 0.0451 0.9834 0.9832
Entamoeba histolytica translation initiation factor 4e, putative 0.0055 0.1051 0.1051
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0055 0.1051 0.1051
Leishmania major eukaryotic translation initiation factor, putative 0.0055 0.1051 0.1051
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.0353 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0353 0.0353
Brugia malayi hypothetical protein 0.0023 0.0353 0.0353
Loa Loa (eye worm) hypothetical protein 0.0023 0.0353 0.0353
Brugia malayi Serine/threonine protein phosphatase F56C9.1 in chromosomeIII 0.0012 0.0097 0.0097
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0353 0.0353
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0055 0.1051 0.1051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.0097
Leishmania major serine/threonine protein phosphatase catalytic subunit, putative 0.0012 0.0097 0.0097
Echinococcus granulosus expressed protein 0.0451 0.9834 0.9832
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0458 1 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0458 1 1
Giardia lamblia Hypothetical protein 0.0055 0.1051 1
Trypanosoma brucei protein phosphatase 1, putative 0.0012 0.0097 0.0097
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0353 0.0353
Trichomonas vaginalis bsu-protein phosphatase, putative 0.0012 0.0097 0.0097
Giardia lamblia hypothetical protein 0.0055 0.1051 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0353 0.0353
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0055 0.1051 0.1051
Brugia malayi PXA domain containing protein 0.0023 0.0353 0.0353
Echinococcus granulosus eukaryotic translation initiation factor 4E type 0.0055 0.1051 0.0963
Trichomonas vaginalis serine/threonine protein phosphatase, putative 0.0012 0.0097 0.0097
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0458 1 1
Entamoeba histolytica hypothetical protein 0.0055 0.1051 0.1051
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0055 0.1051 0.1051
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0353 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0353 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0353 0.0353
Entamoeba histolytica hypothetical protein 0.0023 0.0353 0.0353
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0055 0.1051 0.1051
Loa Loa (eye worm) hypothetical protein 0.0023 0.0353 0.0353
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-beta catalytic subunit 0.0012 0.0097 0.0097
Toxoplasma gondii hypothetical protein 0.0055 0.1051 0.0963
Brugia malayi Eukaryotic translation initiation factor 4E type 3, putative 0.0055 0.1051 0.1051
Leishmania major eukaryotic translation initiation factor 4e, putative 0.0055 0.1051 0.1051
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0055 0.1051 0.1051
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0353 0.0353
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0458 1 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0353 0.0258
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0055 0.1051 0.1051
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0055 0.1051 0.1051
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.0353 0.0258
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.0353 0.0353
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0353 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.1051 0.1051
Loa Loa (eye worm) eukaryotic translation initiation factor 4E-1 0.0055 0.1051 0.1051
Loa Loa (eye worm) eukaryotic translation initiation factor 4E type 3 0.0055 0.1051 0.1051
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0353 0.0353
Trichomonas vaginalis hypothetical protein 0.0055 0.1051 0.1051
Trichomonas vaginalis protein phosphatase-1, putative 0.0012 0.0097 0.0097
Schistosoma mansoni protein phosphatase type 1 0.0012 0.0097 0.0097
Loa Loa (eye worm) translation initiation factor 4E 0.0458 1 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0458 1 1
Plasmodium vivax hypothetical protein, conserved 0.0055 0.1051 1
Brugia malayi Serine/threonine protein phosphatase PP1-beta catalytic subunit 0.0012 0.0097 0.0097
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0353 0.0258
Trypanosoma brucei Eukaryotic translation initiation factor 4E-4 0.0055 0.1051 0.1051
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0458 1 1
Giardia lamblia Translation elongation factor 0.0055 0.1051 1
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0055 0.1051 0.1051
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0353 0.0353
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0353 0.0353
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0353 0.0258
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0353 0.0258
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-3 0.0055 0.1051 0.1051
Schistosoma mansoni protein phosphatase type 1 0.0012 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0023 0.0353 0.0353
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0055 0.1051 0.1051
Trypanosoma brucei Eukaryotic translation initiation factor 4E-3 0.0055 0.1051 0.1051
Brugia malayi hypothetical protein 0.0182 0.3886 0.3886
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0353 0.0353
Brugia malayi eukaryotic translation initiation factor 4E-1 0.0055 0.1051 0.1051
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.0353 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.1051 0.1051
Brugia malayi hypothetical protein 0.0023 0.0353 0.0353
Plasmodium falciparum eukaryotic translation initiation factor 4E, putative 0.0055 0.1051 1
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0458 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.481 um PUBCHEM_BIOASSAY: Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Protein Phosphatase 1 (PP1). (Class of assay: confirmatory) [Related pubchem assays: 2034 (Summary (PP5 inhibitors)), 1987 (Primary screen (PP5 inhibitors)), 2235 (Screening assay (PP1 inhibitors in singlate))] ChEMBL. No reference
IC50 (binding) > 67.047 um PUBCHEM_BIOASSAY: Counterscreen for inhibitors of PP1: fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Protein Phosphatase 5 (PP5). (Class of assay: confirmatory) [Related pubchem assays: 2034 (Summary (PP5 inhibitors)), 1987 (PP5 inhibitors in singlate), 2235 (PP1 inhibitors in singlate)] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.