Detailed information for compound 1624645

Basic information

Technical information
  • TDR Targets ID: 1624645
  • Name: [2-oxo-1-phenyl-2-[(5-phenyl-1,3,4-oxadiazol- 2-yl)amino]ethyl] diethylaminomethanedithioat e
  • MW: 426.555 | Formula: C21H22N4O2S2
  • H donors: 1 H acceptors: 3 LogP: 4.42 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=S)SC(c1ccccc1)C(=O)Nc1nnc(o1)c1ccccc1)CC
  • InChi: 1S/C21H22N4O2S2/c1-3-25(4-2)21(28)29-17(15-11-7-5-8-12-15)18(26)22-20-24-23-19(27-20)16-13-9-6-10-14-16/h5-14,17H,3-4H2,1-2H3,(H,22,24,26)
  • InChiKey: CDPQDKIBQOUTTN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • diethylaminomethanedithioic acid [2-oxo-1-phenyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)amino]ethyl] ester
  • diethylaminomethanedithioic acid [2-keto-1-phenyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)amino]ethyl] ester
  • NCI60_038721
  • NSC709973

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) eukaryotic translation initiation factor 4E-1 0.0259 0.1165 0.1165
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.008 0.8871
Echinococcus granulosus endoplasmin 0.0026 0.009 0.009
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0166 0.0166
Leishmania major heat shock protein, putative 0.0013 0.0031 0.0031
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0132 0.0132
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.003 0.5848
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0166 0.0166
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0002 0.0002
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.003 0.003
Onchocerca volvulus 0.0007 0.0002 0.0014
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0121 0.0121
Plasmodium falciparum thioredoxin reductase 0.0038 0.0146 0.1251
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0146 0.3495
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0259 0.1165 0.1165
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.2172 1 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0052 0.576
Echinococcus granulosus nibrin 0.001 0.0015 0.0015
Brugia malayi beta-NAC-like protein 0.0035 0.0132 0.0132
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0007 0.0002 0.0177
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0121 0.1037
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.0417 1
Leishmania major hypothetical protein, conserved 0.0259 0.1165 0.1165
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0011 0.0011
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.008 0.1914
Schistosoma mansoni cpg binding protein 0.0029 0.0103 0.0103
Echinococcus multilocularis heat shock protein 90 0.0033 0.0121 0.0121
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0259 0.1165 0.1165
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0259 0.1165 0.1165
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.2172 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0372 0.8922
Brugia malayi heat shock protein 90 0.0033 0.0121 0.0121
Plasmodium falciparum thioredoxin reductase 0.0013 0.003 0.026
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0002 0.0002
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0259 0.1165 0.1165
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0015
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0024 0.008 0.008
Leishmania major heat shock protein 83-1 0.0033 0.0121 0.0121
Leishmania major heat shock protein 83-1 0.0033 0.0121 0.0121
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0015 0.0015
Schistosoma mansoni cpg binding protein 0.0031 0.0111 0.0111
Mycobacterium ulcerans heat shock protein 90 0.0026 0.009 1
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0259 0.1165 0.1165
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0015 0.1674
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0002 0.0002
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0014 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.8871
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0436 0.0436
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0002 0.0002
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.009 0.009
Toxoplasma gondii Hsp90 domain-containing protein 0.0013 0.0031 0.0031
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0166 0.0166
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.003 0.003
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0259 0.1165 0.1165
Loa Loa (eye worm) glutathione reductase 0.0038 0.0146 0.0146
Schistosoma mansoni hypothetical protein 0.0041 0.0159 0.0159
Plasmodium vivax hypothetical protein, conserved 0.0259 0.1165 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0002 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0183 0.0183
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0024 0.008 0.008
Mycobacterium ulcerans acetyl-CoA synthetase 0.0007 0.0002 0.0177
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0015 0.0015
Leishmania major heat shock protein 83-1 0.0033 0.0121 0.0121
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.009 0.009
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0002 0.0002
Trichomonas vaginalis hypothetical protein 0.0259 0.1165 0.1165
Loa Loa (eye worm) eukaryotic translation initiation factor 4E type 3 0.0259 0.1165 0.1165
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0372 0.8922
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.009 0.009
Brugia malayi AMP-binding enzyme family protein 0.0024 0.008 0.008
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0015 0.0015
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0002 0.0177
Echinococcus multilocularis heat shock protein 0.0033 0.0121 0.0121
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0052 0.0445
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0121 0.0121
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.008 0.008
Echinococcus granulosus eukaryotic translation initiation factor 4E type 0.0259 0.1165 0.1165
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0002 0.0002
Brugia malayi Hsp90 protein 0.0013 0.0031 0.0031
Leishmania major eukaryotic translation initiation factor-like 0.2172 1 1
Trypanosoma cruzi heat shock protein, putative 0.0013 0.0031 0.0031
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0132 0.0132
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0015 0.0015
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0002 0.0002
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0002 0.0002
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.003 0.3368
Trichomonas vaginalis conserved hypothetical protein 0.0259 0.1165 0.1165
Schistosoma mansoni hypothetical protein 0.0011 0.0022 0.0022
Leishmania major heat shock protein 83-1 0.0033 0.0121 0.0121
Brugia malayi Endoplasmin precursor 0.0033 0.0121 0.0121
Schistosoma mansoni heat shock protein 0.0033 0.0121 0.0121
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.003 0.026
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0148 0.0148
Onchocerca volvulus 0.0024 0.008 0.0685
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0015 0.0015
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0002 0.0177
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0002 0.0038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0183 0.0183
Echinococcus granulosus replication factor c subunit 1 0.001 0.0015 0.0015
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.0417 1
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0121 0.0121
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.003 0.003
Plasmodium vivax endoplasmin, putative 0.0033 0.0121 0.1037
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0007 0.0002 0.0038
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.003 0.003
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0015 0.0015
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0002 0.0002
Giardia lamblia Grp94/Hsp90 0.0026 0.009 0.0772
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.008 0.8871
Plasmodium falciparum glutathione reductase 0.0013 0.003 0.026
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0052
Trypanosoma brucei heat shock protein, putative 0.0033 0.0121 0.0121
Onchocerca volvulus 0.0007 0.0002 0.0014
Echinococcus granulosus heat shock protein 90 0.0033 0.0121 0.0121
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0002 0.0038
Treponema pallidum NADH oxidase 0.0013 0.003 0.3368
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0087 0.0745
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0087 0.0087
Leishmania major heat shock protein 83-1 0.0033 0.0121 0.0121
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.2172 1 1
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.003 0.003
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0031 0.0268
Leishmania major trypanothione reductase 0.0038 0.0146 0.0146
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0002 0.0038
Brugia malayi hypothetical protein 0.0016 0.0045 0.0045
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.008 0.8871
Trypanosoma brucei Eukaryotic translation initiation factor 4E-3 0.0259 0.1165 0.1165
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0087 0.0087
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0087 0.0087
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0002 0.0038
Echinococcus multilocularis endoplasmin 0.0026 0.009 0.009
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0022 0.0022
Echinococcus multilocularis nibrin 0.001 0.0015 0.0015
Schistosoma mansoni cpg binding protein 0.0031 0.0111 0.0111
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0146 0.0146
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0259 0.1165 0.1165
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.003 0.3368
Brugia malayi hypothetical protein 0.001 0.0015 0.0015
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.2172 1 1
Schistosoma mansoni topbp1 0.001 0.0015 0.0015
Leishmania major heat shock protein 83-1 0.0033 0.0121 0.0121
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0002 0.0038
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0166 0.0166
Brugia malayi Thioredoxin reductase 0.0038 0.0146 0.0146
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0121 0.0121
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0259 0.1165 0.1165
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0259 0.1165 0.1165
Trypanosoma brucei heat shock protein, putative 0.0033 0.0121 0.0121
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0015 0.1674
Trichomonas vaginalis heat shock protein, putative 0.0026 0.009 0.009
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0259 0.1165 0.1165
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.003 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0183 0.0183
Trypanosoma brucei heat shock protein, putative 0.0033 0.0121 0.0121
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0015
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.008 0.1914
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.8871
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0052 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0121 0.0121
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.0626 0.0626
Schistosoma mansoni endoplasmin 0.0033 0.0121 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0132 0.0132
Schistosoma mansoni topbp1 0.001 0.0015 0.0015
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0007 0.0002 0.0177
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0259 0.1165 0.1165
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0121 0.0121
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0121 0.0121
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0007 0.0002 0.0038
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0052
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0002 0.0038
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0132 0.0132
Trypanosoma brucei heat shock protein, putative 0.0033 0.0121 0.0121
Plasmodium falciparum endoplasmin, putative 0.002 0.0062 0.0534
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0052
Echinococcus multilocularis cpg binding protein 0.0031 0.0111 0.0111
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0002 0.0177
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.003 0.003
Entamoeba histolytica hypothetical protein 0.0259 0.1165 0.1165
Loa Loa (eye worm) translation initiation factor 4E 0.2172 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.003 0.003
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0132 0.0132
Echinococcus granulosus cpg binding protein 0.0031 0.0111 0.0111
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0259 0.1165 0.1165
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0014 0.0014
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0002 0.0038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.008 0.1914
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0015 0.0015
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0015 0.0129
Entamoeba histolytica hypothetical protein 0.0259 0.1165 0.1165
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0259 0.1165 0.1165
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0015 0.0015
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0121 0.0121
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0372 0.8922
Plasmodium falciparum eukaryotic translation initiation factor 4E, putative 0.0259 0.1165 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0087 0.0745
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0015
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.2172 1 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.003 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0002 0.0177
Loa Loa (eye worm) hypothetical protein 0.0025 0.0087 0.0087
Onchocerca volvulus 0.0029 0.0103 0.0886
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.8871
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.0002 0.0002
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0002 0.0002
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0223 0.0223
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.003 0.003
Plasmodium vivax heat shock protein, putative 0.0013 0.0031 0.0268
Loa Loa (eye worm) hypothetical protein 0.0024 0.008 0.008
Leishmania major eukaryotic translation initiation factor, putative 0.0259 0.1165 0.1165
Trypanosoma brucei Eukaryotic translation initiation factor 4E-2 0.0259 0.1165 0.1165
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.008 0.8871
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0259 0.1165 0.1165
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0002 0.0177
Loa Loa (eye worm) oxidoreductase 0.0007 0.0002 0.0002
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0015
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0002 0.0002
Leishmania major eukaryotic translation initiation factor 4e, putative 0.0259 0.1165 0.1165
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0015 0.0015
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0103 0.0103
Schistosoma mansoni heat shock protein 0.0013 0.0031 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0132 0.0132
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0259 0.1165 0.1165
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0002 0.0002
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0007 0.0002 0.0177
Leishmania major basic transcription factor 3a, putative 0.0035 0.0132 0.0132
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0121 0.0121
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.2172 1 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0002 0.0002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.008 0.1914
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.003 0.003
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.009 0.009
Toxoplasma gondii thioredoxin reductase 0.0038 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0002
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0059 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0015 0.0015
Treponema pallidum DNA ligase (lig) 0.001 0.0015 0.1674
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.2172 1 1
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-3 0.0259 0.1165 0.1165
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0132 0.1136
Trypanosoma brucei heat shock protein, putative 0.0033 0.0121 0.0121
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.2172 1 1
Plasmodium vivax heat shock protein 90, putative 0.0013 0.0031 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0259 0.1165 0.1165
Trichomonas vaginalis heat shock protein, putative 0.0026 0.009 0.009
Schistosoma mansoni endoplasmin 0.0033 0.0121 0.0121
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.0372 0.8922
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.003 0.003
Giardia lamblia Hypothetical protein 0.0259 0.1165 1
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0429 0.0429
Schistosoma mansoni DNA ligase IV 0.001 0.0015 0.0015
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0429 0.0429
Leishmania major heat shock protein 83-1 0.0033 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0414 0.1878 0.1878
Toxoplasma gondii hypothetical protein 0.0259 0.1165 0.1165
Plasmodium falciparum eukaryotic translation initiation factor 4E 0.0259 0.1165 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0022 0.0022
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0011 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0002 0.0002
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.0417 1
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0146 0.0146
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0132 0.0132
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0002 0.0038
Echinococcus multilocularis transcription factor btf3 0.0035 0.0132 0.0132
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0121 0.0121
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.003 0.026
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.009 1
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0015 0.0015
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0259 0.1165 0.1165
Leishmania major heat shock protein 83-1 0.0033 0.0121 0.0121
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0146 0.1251
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0183 0.0183
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.009 0.2157
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.009 0.0772
Trypanosoma brucei Eukaryotic translation initiation factor 4E-4 0.0259 0.1165 0.1165
Schistosoma mansoni hypothetical protein 0.0041 0.0159 0.0159
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0015 0.0015
Leishmania major heat shock protein 83-1 0.0033 0.0121 0.0121
Brugia malayi hypothetical protein 0.001 0.0015 0.0015
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.008 0.008
Trypanosoma brucei heat shock protein, putative 0.0033 0.0121 0.0121
Trichomonas vaginalis heat shock protein, putative 0.002 0.0062 0.0062
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.008 0.008
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0002 0.0038
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0166
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.2172 1 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0002 0.0002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.008 0.008
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.0002 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0047 0.1134
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0429 0.0429
Echinococcus multilocularis protein dispatched 1 0.0049 0.0194 0.0194
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.003 0.003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0047 0.1134
Mycobacterium tuberculosis Probable reductase 0.0087 0.0372 0.8922
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0015 0.0015
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0007 0.0002 0.0177
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0002 0.0002
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.01 0.0429 0.0429
Echinococcus granulosus dnaJ subfamily B 0.0414 0.1878 0.1878
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0011 0.0011
Plasmodium falciparum heat shock protein 90 0.0033 0.0121 0.1037
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0259 0.1165 0.1165
Giardia lamblia hypothetical protein 0.0259 0.1165 1
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.2172 1 1
Schistosoma mansoni transcription factor btf3 0.0035 0.0132 0.0132
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0047 0.1134
Brugia malayi eukaryotic translation initiation factor 4E-1 0.0259 0.1165 0.1165
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0259 0.1165 0.1165
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0183 0.0183
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0015 0.0015
Brugia malayi CXXC zinc finger family protein 0.0029 0.0103 0.0103
Plasmodium vivax glutathione reductase, putative 0.0038 0.0146 0.1251
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0132 0.1136
Toxoplasma gondii heat shock protein 75, putative 0.0013 0.0031 0.0031
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.003 0.026
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0002 0.0177
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0002 0.0002
Treponema pallidum heat shock protein 90 0.0026 0.009 1
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.003 0.003
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.009 0.2157
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0002 0.0014
Entamoeba histolytica hypothetical protein 0.001 0.0015 0.0015
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0015 0.0015
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.003 0.3368
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.2172 1 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.003 0.026
Echinococcus granulosus heat shock protein 0.0033 0.0121 0.0121
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0002 0.0002
Schistosoma mansoni patched 1 0.0043 0.0166 0.0166
Brugia malayi hypothetical protein 0.0025 0.0087 0.0087
Trypanosoma brucei heat shock protein, putative 0.0033 0.0121 0.0121
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.003 0.003
Trypanosoma brucei Eukaryotic translation initiation factor 4E type 5 0.0259 0.1165 0.1165
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0183 0.0183
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0002 0.0002
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0015 0.0361
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0015 0.0015
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0007 0.0002 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0259 0.1165 0.1165
Entamoeba histolytica translation initiation factor 4e, putative 0.0259 0.1165 0.1165
Echinococcus multilocularis protein patched 0.0043 0.0166 0.0166
Brugia malayi DKFZp564C0469 protein 0.001 0.0015 0.0015
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.2172 1 1
Trypanosoma brucei heat shock protein, putative 0.0033 0.0121 0.0121
Leishmania major eukaryotic translation initiation factor-like protein 0.2172 1 1
Brugia malayi glutathione reductase 0.0038 0.0146 0.0146
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.003 0.026
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0166 0.0166
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.001 0.001
Echinococcus granulosus expressed conserved protein 0.0094 0.0401 0.0401
Onchocerca volvulus Putative eukaryotic translation initiation factor 4e 0.0259 0.1165 1
Schistosoma mansoni heat shock protein 0.0033 0.0121 0.0121
Plasmodium falciparum glutathione reductase 0.0038 0.0146 0.1251
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0002 0.0177
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0002 0.0177
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0015 0.0129
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0183 0.0183
Chlamydia trachomatis DNA ligase 0.001 0.0015 0.2907
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0087 0.0745
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0148 0.0148
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0259 0.1165 0.1165
Loa Loa (eye worm) heat shock protein 75 0.0013 0.0031 0.0031
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.003 0.003
Trichomonas vaginalis heat shock protein, putative 0.0026 0.009 0.009
Leishmania major hypothetical protein, conserved 0.0259 0.1165 0.1165
Brugia malayi AMP-binding enzyme family protein 0.0024 0.008 0.008
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0007 0.0002 0.0177
Plasmodium vivax translation initiation factor 4E, putative 0.0259 0.1165 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0007 0.0002 0.0177
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0052 0.0445
Leishmania major heat shock protein 83-1 0.0033 0.0121 0.0121
Echinococcus multilocularis expressed conserved protein 0.0094 0.0401 0.0401
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.0031 0.0031
Brugia malayi topoisomerase 0.001 0.0015 0.0015
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0015 0.0015
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0013 0.0031 0.0031
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0002 0.0002
Leishmania major heat shock protein 83-1 0.0033 0.0121 0.0121
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0052 0.1243
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0052
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0259 0.1165 0.1165
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0002 0.0002
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0002 0.0014
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.0031 0.0031
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.003 0.003
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0121 0.0121
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.2172 1 1
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0015 0.0015
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0052 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0372 0.8922
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0002 0.0002
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0259 0.1165 0.1165
Echinococcus granulosus heat shock protein 90 0.0026 0.009 0.009
Giardia lamblia Translation elongation factor 0.0259 0.1165 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0007 0.0002 0.0177
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.1878 0.1878
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0047 0.1134
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.003 0.3368
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0015
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.003 0.0727
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0015 0.0015
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.2172 1 1
Onchocerca volvulus 0.001 0.0015 0.0129
Schistosoma mansoni hypothetical protein 0.0041 0.0159 0.0159
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0031 0.0268
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0002 0.0002
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.003 0.003
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0002 0.0002
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0002 0.0002
Leishmania major heat shock protein 83-1 0.0033 0.0121 0.0121
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.003 0.003
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0007 0.0002 0.0177
Giardia lamblia Hypothetical protein 0.0259 0.1165 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.008 0.8871
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.003 0.3368
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0183 0.0183
Brugia malayi Eukaryotic translation initiation factor 4E type 3, putative 0.0259 0.1165 0.1165
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.0417 1
Schistosoma mansoni hypothetical protein 0.0041 0.0159 0.0159
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0121 0.0121
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.0626 0.0626
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0259 0.1165 0.1165
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0121 0.0121
Leishmania major hypothetical protein, conserved 0.0025 0.0087 0.0087
Echinococcus granulosus transcription factor btf3 0.0035 0.0132 0.0132
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0013 0.0031 0.0268
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0002 0.0038
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0253 0.0253
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.003 0.003
Loa Loa (eye worm) endoplasmin 0.0033 0.0121 0.0121
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0087 0.0087
Echinococcus multilocularis heat shock protein 90 0.0026 0.009 0.009
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.003 0.003
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.003 0.003
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0259 0.1165 0.1165
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0002 0.0002
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0372 0.8922
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0015 0.0015
Trichomonas vaginalis endoplasmin, putative 0.002 0.0062 0.0062
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0259 0.1165 0.1165
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0429 0.0429
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0002 0.0038
Trypanosoma brucei heat shock protein 84, putative 0.0013 0.0031 0.0031
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.082 0.3754 0.3754
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0259 0.1165 0.1165
Onchocerca volvulus 0.0007 0.0002 0.0014
Brugia malayi CHE-14 protein 0.0043 0.0166 0.0166
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0132 0.0132
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0183 0.0183
Leishmania major heat shock protein 83-1 0.0033 0.0121 0.0121
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0121 0.1037
Leishmania major heat shock protein 83-1 0.0033 0.0121 0.0121
Onchocerca volvulus 0.0007 0.0002 0.0014
Trichomonas vaginalis heat shock protein, putative 0.0013 0.0031 0.0031
Leishmania major heat shock protein 83-1 0.0033 0.0121 0.0121
Leishmania major heat shock protein 83-1 0.0033 0.0121 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0015 0.0015
Trypanosoma brucei trypanothione reductase 0.0038 0.0146 0.0146
Giardia lamblia Replication factor C, subunit 1 0.001 0.0015 0.0129
Leishmania major heat shock protein 83-1 0.0033 0.0121 0.0121
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.003 0.003
Brugia malayi AMP-binding enzyme family protein 0.0024 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0052
Entamoeba histolytica hypothetical protein 0.0035 0.0132 0.0132

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.995 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.987 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.837 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.812 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.781 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.76 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.748 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.69 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.589 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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