Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcitonin receptor-like | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | calcitonin receptor-like | 461 aa | 434 aa | 28.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | YY1-associated factor 2 | 0.0476 | 0.3254 | 0.3254 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.3254 | 0.3254 |
Schistosoma mansoni | brg-1 associated factor | 0.1339 | 1 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0476 | 0.3254 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0476 | 0.3254 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.1339 | 1 | 0.5 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.1339 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1339 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0476 | 0.3254 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1339 | 1 | 0.5 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0476 | 0.3254 | 0.5 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0476 | 0.3254 | 0.1455 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0476 | 0.3254 | 0.1455 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0476 | 0.3254 | 0.1455 |
Chlamydia trachomatis | SWIB complex protein | 0.1339 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0476 | 0.3254 | 0.5 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.1339 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1339 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0476 | 0.3254 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1339 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.3254 | 0.3254 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.1339 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0476 | 0.3254 | 0.3254 |
Leishmania major | hypothetical protein, conserved | 0.0476 | 0.3254 | 0.5 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0476 | 0.3254 | 0.5 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.1339 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0476 | 0.3254 | 0.5 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.1339 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0476 | 0.3254 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0476 | 0.3254 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1339 | 1 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.1339 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0476 | 0.3254 | 0.5 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0476 | 0.3254 | 0.5 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0476 | 0.3254 | 0.1455 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0476 | 0.3254 | 0.1455 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.1339 | 1 | 1 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0476 | 0.3254 | 0.1455 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0476 | 0.3254 | 0.3254 |
Onchocerca volvulus | 0.1339 | 1 | 1 | |
Leishmania major | hypothetical protein, conserved | 0.0476 | 0.3254 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.1339 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0476 | 0.3254 | 0.3254 |
Schistosoma mansoni | hypothetical protein | 0.1339 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1339 | 1 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.1339 | 1 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0476 | 0.3254 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.3254 | 0.3254 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.3254 | 0.3254 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0476 | 0.3254 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.3254 | 0.3254 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0476 | 0.3254 | 0.1455 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0476 | 0.3254 | 0.3254 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0476 | 0.3254 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0476 | 0.3254 | 0.5 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0476 | 0.3254 | 0.1455 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.1339 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1339 | 1 | 1 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0476 | 0.3254 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1339 | 1 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.1339 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 80 nM | Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting | ChEMBL. | 22429471 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.