Detailed information for compound 1627574

Basic information

Technical information
  • TDR Targets ID: 1627574
  • Name: 3,5-Dibromo-2',3',5',7',8',9'-hexahydro-4H,6' H-spiro[cyclohexa-2,5-diene-1,10'-pyrrolo[4,3 ,2-de][1,7]phenanthroline]-4,6'-dione trifluo roacetate
  • MW: 577.146 | Formula: C20H14Br2F3N3O4
  • H donors: 3 H acceptors: 4 LogP: 4.2 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.O=C1C(=CC2(C=C1Br)CCNC1=C2C2=NCCc3c2c(C1=O)[nH]c3)Br
  • InChi: 1S/C18H13Br2N3O2.C2HF3O2/c19-9-5-18(6-10(20)16(9)24)2-4-22-15-12(18)13-11-8(1-3-21-13)7-23-14(11)17(15)25;3-2(4,5)1(6)7/h5-7,22-23H,1-4H2;(H,6,7)
  • InChiKey: BSRPLWPQKFQQOL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • AIDS-012673
  • AIDS012673
  • Discorhabdin C trifluoroacetate
  • Discorhabdin C . TFA
  • NSC626162

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) 0.0511 0.2483 0.2848
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0027 0.0006
Onchocerca volvulus 0.0188 0.0848 0.0823
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0188 0.0848 0.0848
Toxoplasma gondii PAN domain-containing protein 0.0402 0.1932 0.193
Schistosoma mansoni hypothetical protein 0.0516 0.2513 0.2513
Giardia lamblia High cysteine protein 0.0169 0.0752 1
Schistosoma mansoni hypothetical protein 0.0044 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0516 0.2513 0.2513
Mycobacterium tuberculosis Probable reductase 0.0117 0.049 0.0537
Mycobacterium ulcerans UDP-N-acetylmuramate--L-alanine ligase 0.1 0.4965 0.5727
Loa Loa (eye worm) DOMON domain-containing protein 0.1338 0.6672 0.6672
Brugia malayi Lectin C-type domain containing protein 0.0188 0.0848 0.0828
Mycobacterium tuberculosis Possible ligase 0.0169 0.0755 0.0844
Plasmodium vivax glutathione reductase, putative 0.0051 0.0157 0.0014
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.049 0.0537
Toxoplasma gondii microneme protein MIC4 0.0402 0.1932 0.193
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0244 0.1131 0.1123
Onchocerca volvulus 0.0169 0.0752 0.0726
Mycobacterium ulcerans folylpolyglutamate synthase protein FolC 0.0511 0.2483 0.2848
Brugia malayi CUB domain containing protein 0.0431 0.2082 0.2065
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0244 0.1131 0.1123
Onchocerca volvulus 0.0402 0.1932 0.191
Mycobacterium tuberculosis Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF 0.1728 0.8648 1
Brugia malayi EGF-like domain containing protein 0.0169 0.0752 0.0732
Schistosoma mansoni hypothetical protein 0.0271 0.1271 0.1271
Toxoplasma gondii microneme protein MIC17C 0.0402 0.1932 0.193
Schistosoma mansoni notch 0.0169 0.0752 0.0752
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0244 0.1131 0.1123
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0244 0.1131 0.1112
Entamoeba histolytica hypothetical protein 0.0039 0.0095 0.1765
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0025 0.0021 0.0019
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0244 0.1131 0.1112
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0244 0.1131 0.1123
Loa Loa (eye worm) bone morphogenetic protein 1b 0.063 0.3088 0.3088
Loa Loa (eye worm) hypothetical protein 0.0244 0.1131 0.1131
Chlamydia trachomatis UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminoligase 0.1728 0.8648 1
Brugia malayi Delta serrate ligand family protein 0.0169 0.0752 0.0732
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0143 0.0141
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0244 0.1131 0.1123
Schistosoma mansoni hypothetical protein 0.0169 0.0752 0.0752
Onchocerca volvulus 0.0402 0.1932 0.191
Schistosoma mansoni notch 0.0169 0.0752 0.0752
Loa Loa (eye worm) hypothetical protein 0.0026 0.0027 0.0027
Onchocerca volvulus 0.0516 0.2513 0.2492
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0143 0.0135
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.022 0.0212
Onchocerca volvulus 0.0516 0.2513 0.2492
Loa Loa (eye worm) hypothetical protein 0.0107 0.0438 0.0438
Onchocerca volvulus 0.0402 0.1932 0.191
Brugia malayi Calcium binding EGF domain containing protein 0.0442 0.2137 0.2121
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.022 0.0212
Schistosoma mansoni DNA polymerase eta 0.003 0.0047 0.0047
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.0556 0.0614
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0157 0.0154
Echinococcus multilocularis neural cadherin 0.0169 0.0752 0.0744
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0442 0.2137 0.2137
Loa Loa (eye worm) hypothetical protein 0.0402 0.1932 0.1932
Leishmania major folylpolyglutamate synthetase 0.0169 0.0755 0.0752
Onchocerca volvulus Arrow homolog 0.0686 0.3371 0.3353
Loa Loa (eye worm) hypothetical protein 0.0244 0.1131 0.1131
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0516 0.2513 0.2513
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0027 0.0006
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.0556 0.0614
Trypanosoma brucei trypanothione reductase 0.0051 0.0157 0.1644
Echinococcus granulosus Mastin 0.0516 0.2513 0.2506
Echinococcus granulosus neural cadherin 0.0169 0.0752 0.0744
Echinococcus granulosus dna polymerase eta 0.003 0.0047 0.0039
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0686 0.3371 0.3357
Echinococcus granulosus basement membrane specific heparan sulfate 0.0244 0.1131 0.1123
Onchocerca volvulus 0.0402 0.1932 0.191
Brugia malayi PAN domain containing protein 0.0402 0.1932 0.1915
Loa Loa (eye worm) hypothetical protein 0.0244 0.1131 0.1131
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0143 0.0141
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0076 0.0068
Plasmodium falciparum thioredoxin reductase 0.0051 0.0157 0.0046
Toxoplasma gondii microneme protein MIC17A 0.0402 0.1932 0.193
Brugia malayi Calcium binding EGF domain containing protein 0.0169 0.0752 0.0732
Brugia malayi Calcium binding EGF domain containing protein 0.0169 0.0752 0.0732
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0039 0.0094 0.0086
Toxoplasma gondii PAN domain-containing protein 0.0402 0.1932 0.193
Loa Loa (eye worm) glutathione reductase 0.0051 0.0157 0.0157
Loa Loa (eye worm) PAN domain-containing protein 0.0402 0.1932 0.1932
Brugia malayi CUB domain containing protein 0.0188 0.0848 0.0828
Echinococcus multilocularis neurogenic locus notch protein 4 0.0169 0.0752 0.0744
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0143 0.1477
Loa Loa (eye worm) hypothetical protein 0.0188 0.0848 0.0848
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0516 0.2513 0.2513
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0244 0.1131 0.1112
Toxoplasma gondii PAN domain-containing protein 0.0402 0.1932 0.193
Echinococcus granulosus protein jagged 1 0.0169 0.0752 0.0744
Loa Loa (eye worm) hypothetical protein 0.0442 0.2137 0.2137
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0244 0.1131 0.1131
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.0706 0.0698
Echinococcus multilocularis Mastin 0.0516 0.2513 0.2506
Loa Loa (eye worm) Notch2 0.0169 0.0752 0.0752
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.0556 0.0614
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0157 0.0149
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0516 0.2513 0.2513
Echinococcus granulosus delta-like protein 1 0.0169 0.0752 0.0744
Brugia malayi PAN domain containing protein 0.0402 0.1932 0.1915
Echinococcus multilocularis zinc finger protein 0.0024 0.002 0.0011
Echinococcus granulosus ubiquitin specific protease 41 0.0025 0.0021 0.0013
Brugia malayi EGF-like domain containing protein 0.0169 0.0752 0.0732
Loa Loa (eye worm) hypothetical protein 0.0188 0.0848 0.0848
Loa Loa (eye worm) hypothetical protein 0.0044 0.012 0.012
Onchocerca volvulus 0.0516 0.2513 0.2492
Loa Loa (eye worm) hypothetical protein 0.0431 0.2082 0.2082
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0095 0.0086
Trypanosoma cruzi folylpolyglutamate synthetase 0.0169 0.0755 0.0752
Loa Loa (eye worm) hypothetical protein 0.0244 0.1131 0.1131
Loa Loa (eye worm) hypothetical protein 0.0047 0.0135 0.0135
Echinococcus granulosus slit 2 protein 0.0169 0.0752 0.0744
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0076 0.0068
Loa Loa (eye worm) acetyltransferase 0.016 0.0706 0.0706
Toxoplasma gondii histone lysine methyltransferase SET1 0.0042 0.0111 0.0108
Brugia malayi EGF-like domain containing protein 0.0169 0.0752 0.0732
Brugia malayi hypothetical protein 0.0516 0.2513 0.2497
Loa Loa (eye worm) hypothetical protein 0.0169 0.0752 0.0752
Brugia malayi jmjC domain containing protein 0.0042 0.011 0.0089
Mycobacterium ulcerans UDP-N-acetylmuramyl tripeptide synthase 0.0169 0.0755 0.0844
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0244 0.1131 0.1106
Loa Loa (eye worm) hypothetical protein 0.0169 0.0752 0.0752
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.049 0.0537
Loa Loa (eye worm) CUB domain-containing protein 0.0188 0.0848 0.0848
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0188 0.0848 0.0848
Onchocerca volvulus 0.1338 0.6672 0.6663
Echinococcus granulosus protein jagged 2 0.0169 0.0752 0.0744
Schistosoma mansoni cpg binding protein 0.0022 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0356 0.1703 0.1703
Brugia malayi Calcium binding EGF domain containing protein 0.0244 0.1131 0.1112
Brugia malayi Trypsin family protein 0.0516 0.2513 0.2497
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0244 0.1131 0.1123
Brugia malayi CUB domain containing protein 0.0188 0.0848 0.0828
Onchocerca volvulus 0.0244 0.1131 0.1106
Brugia malayi Niemann-Pick C1 protein precursor 0.0107 0.0438 0.0418
Onchocerca volvulus 0.0169 0.0752 0.0726
Loa Loa (eye worm) hypothetical protein 0.0169 0.0752 0.0752
Onchocerca volvulus 0.0244 0.1131 0.1106
Schistosoma mansoni cercarial elastase (S01 family) 0.0516 0.2513 0.2513
Echinococcus granulosus neurogenic locus notch protein 0.0169 0.0752 0.0744
Schistosoma mansoni hypothetical protein 0.0169 0.0752 0.0752
Loa Loa (eye worm) FolC protein 0.0169 0.0755 0.0755
Brugia malayi ImpB/MucB/SamB family protein 0.003 0.0047 0.0026
Onchocerca volvulus 0.1338 0.6672 0.6663
Echinococcus multilocularis protein jagged 1 0.0169 0.0752 0.0744
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.049 0.0537
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.011 0.011
Schistosoma mansoni cercarial elastase (S01 family) 0.0516 0.2513 0.2513
Plasmodium falciparum dihydrofolate synthase/folylpolyglutamate synthase 0.0169 0.0755 0.065
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0188 0.0848 0.0828
Toxoplasma gondii thioredoxin reductase 0.0051 0.0157 0.0154
Brugia malayi Cadherin domain containing protein 0.0169 0.0752 0.0732
Echinococcus granulosus protein jagged 1 0.0169 0.0752 0.0744
Loa Loa (eye worm) hypothetical protein 0.0402 0.1932 0.1932
Plasmodium vivax cysteine repeat modular protein 1, putative 0.1995 1 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.0752 0.0752
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0025 0.0021 0.0019
Onchocerca volvulus 0.0402 0.1932 0.191
Loa Loa (eye worm) hypothetical protein 0.063 0.3088 0.3088
Brugia malayi EGF-like domain containing protein 0.0169 0.0752 0.0732
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0117 0.049 0.0537
Loa Loa (eye worm) hypothetical protein 0.0169 0.0752 0.0752
Echinococcus multilocularis protein patched 0.0046 0.0129 0.0121
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0244 0.1131 0.1112
Chlamydia trachomatis bifunctional UDP-N-acetylmuramate-alanine ligase/D-alanine-D-alanine ligase 0.1 0.4965 0.4025
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0157 0.015
Loa Loa (eye worm) hypothetical protein 0.0169 0.0752 0.0752
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.011 0.0101
Loa Loa (eye worm) hypothetical protein 0.0188 0.0848 0.0848
Brugia malayi Trypsin-like protease protein 5 0.0516 0.2513 0.2497
Entamoeba histolytica hypothetical protein 0.0039 0.0095 0.1765
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0129 0.0121
Echinococcus multilocularis protein dispatched 1 0.0052 0.0162 0.0154
Loa Loa (eye worm) hypothetical protein 0.0516 0.2513 0.2513
Loa Loa (eye worm) hypothetical protein 0.0188 0.0848 0.0848
Schistosoma mansoni hypothetical protein 0.0516 0.2513 0.2513
Schistosoma mansoni zinc finger protein 0.0024 0.002 0.002
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0188 0.0848 0.0828
Echinococcus multilocularis cubilin 0.0188 0.0848 0.084
Loa Loa (eye worm) hypothetical protein 0.0244 0.1131 0.1131
Echinococcus granulosus neurogenic locus protein delta 0.0169 0.0752 0.0744
Onchocerca volvulus 0.0402 0.1932 0.191
Treponema pallidum UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (murE) 0.1 0.4965 0.4025
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0244 0.1131 0.1112
Loa Loa (eye worm) hypothetical protein 0.0244 0.1131 0.1131
Schistosoma mansoni bromodomain containing protein 0.0067 0.0238 0.0238
Echinococcus multilocularis neurogenic locus protein delta 0.0169 0.0752 0.0744
Loa Loa (eye worm) hypothetical protein 0.0046 0.0129 0.0129
Echinococcus granulosus Niemann Pick C1 protein 0.0107 0.0438 0.043
Onchocerca volvulus 0.0244 0.1131 0.1106
Loa Loa (eye worm) hypothetical protein 0.003 0.0047 0.0047
Echinococcus granulosus notch 0.0169 0.0752 0.0744
Brugia malayi Cadherin domain containing protein 0.0169 0.0752 0.0732
Echinococcus granulosus dnaJ subfamily B 0.0271 0.1271 0.1264
Brugia malayi CHE-14 protein 0.0046 0.0129 0.0108
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0188 0.0848 0.0828
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0015 0.0015
Echinococcus multilocularis tissue type plasminogen activator 0.1995 1 1
Loa Loa (eye worm) trypsin family protein 0.0516 0.2513 0.2513
Echinococcus multilocularis Niemann Pick C1 protein 0.0107 0.0438 0.043
Mycobacterium ulcerans UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 0.0511 0.2483 0.2848
Echinococcus multilocularis CUB 0.0188 0.0848 0.084
Onchocerca volvulus 0.0188 0.0848 0.0823
Echinococcus multilocularis neurogenic locus protein delta 0.0169 0.0752 0.0744
Onchocerca volvulus Neurogenic locus notch homolog 0.0169 0.0752 0.0726
Schistosoma mansoni hypothetical protein 0.0044 0.0121 0.0121
Echinococcus granulosus neurogenic locus notch protein 0.0169 0.0752 0.0744
Schistosoma mansoni notch 0.0169 0.0752 0.0752
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0107 0.0438 1
Echinococcus multilocularis fibrillin 1 0.0442 0.2137 0.2131
Loa Loa (eye worm) hypothetical protein 0.0025 0.0021 0.0021
Echinococcus granulosus transmembrane protease serine 3 0.0516 0.2513 0.2506
Brugia malayi Nematode astacin protease protein 30 0.0188 0.0848 0.0828
Loa Loa (eye worm) hypothetical protein 0.0169 0.0752 0.0752
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0244 0.1131 0.1112
Schistosoma mansoni cercarial elastase (S01 family) 0.0516 0.2513 0.2513
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0244 0.1131 0.1106
Echinococcus multilocularis protein jagged 2 0.0169 0.0752 0.0744
Loa Loa (eye worm) hypothetical protein 0.0516 0.2513 0.2513
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0027 0.0025
Mycobacterium ulcerans hypothetical protein 0.0516 0.2513 0.2883
Schistosoma mansoni hypothetical protein 0.0044 0.0121 0.0121
Brugia malayi CUB domain containing protein 0.0188 0.0848 0.0828
Loa Loa (eye worm) hypothetical protein 0.007 0.025 0.025
Echinococcus multilocularis neurogenic locus notch protein 0.0169 0.0752 0.0744
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0129 0.0121
Schistosoma mansoni hypothetical protein 0.0188 0.0848 0.0848
Onchocerca volvulus 0.1338 0.6672 0.6663
Onchocerca volvulus 0.0402 0.1932 0.191
Schistosoma mansoni hypothetical protein 0.0188 0.0848 0.0848
Echinococcus multilocularis fat cadherin tumor suppressor 0.0169 0.0752 0.0744
Loa Loa (eye worm) hypothetical protein 0.0402 0.1932 0.1932
Schistosoma mansoni notch 0.0169 0.0752 0.0752
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0516 0.2513 0.2513
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.0447 0.0447
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.0706 0.0706
Schistosoma mansoni cercarial elastase (S01 family) 0.0516 0.2513 0.2513
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0402 0.1932 0.193
Loa Loa (eye worm) PAN domain-containing protein 0.0402 0.1932 0.1932
Echinococcus multilocularis ubiquitin specific protease 41 0.0025 0.0021 0.0013
Schistosoma mansoni folylpolyglutamate synthase 0.0169 0.0755 0.0755
Onchocerca volvulus 0.0244 0.1131 0.1106
Loa Loa (eye worm) hypothetical protein 0.0402 0.1932 0.1932
Loa Loa (eye worm) hypothetical protein 0.0038 0.0089 0.0089
Echinococcus multilocularis slit 2 protein 0.0169 0.0752 0.0744
Loa Loa (eye worm) hypothetical protein 0.0244 0.1131 0.1131
Toxoplasma gondii calcium binding egf domain-containing protein 0.0442 0.2137 0.2135
Echinococcus multilocularis neurogenic locus notch protein 0.0169 0.0752 0.0744
Echinococcus multilocularis folylpolyglutamate synthase, mitochondrial 0.0169 0.0755 0.0747
Loa Loa (eye worm) PAN domain-containing protein 0.0402 0.1932 0.1932
Onchocerca volvulus 0.1506 0.7527 0.752
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0169 0.0752 0.0752
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylmuramate-alanine ligase 0.1 0.4965 0.5333
Brugia malayi Kelch motif family protein 0.0188 0.0848 0.0828
Schistosoma mansoni cercarial elastase (S01 family) 0.0516 0.2513 0.2513
Brugia malayi basement membrane proteoglycan precursor 0.0244 0.1131 0.1112
Schistosoma mansoni hypothetical protein 0.0169 0.0752 0.0752
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0516 0.2513 0.2513
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0188 0.0848 0.0846
Trypanosoma brucei folylpolyglutamate synthase, putative 0.0169 0.0755 0.8875
Echinococcus granulosus Tolloid protein 1 0.063 0.3088 0.3083
Loa Loa (eye worm) PAN domain-containing protein 0.0402 0.1932 0.1932
Toxoplasma gondii PAN domain-containing protein 0.0402 0.1932 0.193
Echinococcus granulosus expressed conserved protein 0.01 0.0406 0.0398
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0015 0.0007
Loa Loa (eye worm) hypothetical protein 0.0402 0.1932 0.1932
Echinococcus multilocularis notch 0.0169 0.0752 0.0744
Echinococcus granulosus basement membrane specific heparan sulfate 0.0244 0.1131 0.1123
Echinococcus multilocularis protein jagged 1 0.0169 0.0752 0.0744
Schistosoma mansoni hypothetical protein 0.0188 0.0848 0.0848
Echinococcus multilocularis enteropeptidase 0.0516 0.2513 0.2506
Echinococcus granulosus folylpolyglutamate synthase mitochondrial 0.0169 0.0755 0.0747
Loa Loa (eye worm) CUB domain-containing protein 0.0188 0.0848 0.0848
Onchocerca volvulus 0.1995 1 1
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.0188 0.0848 0.084
Brugia malayi Fibulin-1 precursor 0.0442 0.2137 0.2121
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0244 0.1131 0.1131
Mycobacterium leprae ProbableUDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF 0.1728 0.8648 1
Schistosoma mansoni patched 1 0.0046 0.0129 0.0129
Echinococcus granulosus cubilin 0.0188 0.0848 0.084
Onchocerca volvulus 0.0516 0.2513 0.2492
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0516 0.2513 0.2513
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0188 0.0848 0.0848
Brugia malayi Trypsin family protein 0.0516 0.2513 0.2497
Brugia malayi EGF-like domain containing protein 0.0169 0.0752 0.0732
Onchocerca volvulus 0.1338 0.6672 0.6663
Echinococcus multilocularis folylpolyglutamate synthase, mitochondrial 0.0169 0.0755 0.0747
Toxoplasma gondii PAN domain-containing protein 0.0402 0.1932 0.193
Schistosoma mansoni hypothetical protein 0.0169 0.0752 0.0752
Brugia malayi PAN domain containing protein 0.0402 0.1932 0.1915
Brugia malayi astacin protease protein 30 0.0188 0.0848 0.0828
Loa Loa (eye worm) hypothetical protein 0.0169 0.0752 0.0752
Brugia malayi GCC2 and GCC3 family protein 0.0169 0.0752 0.0732
Brugia malayi FolC bifunctional protein 0.0169 0.0755 0.0735
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.049 0.0537
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0188 0.0848 0.0848
Echinococcus multilocularis dna polymerase eta 0.003 0.0047 0.0039
Brugia malayi Bromodomain containing protein 0.0079 0.0297 0.0276
Toxoplasma gondii hypothetical protein 0.0402 0.1932 0.193
Echinococcus multilocularis Niemann Pick C1 protein 0.0153 0.0671 0.0663
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0095 0.0095
Schistosoma mansoni septate junction protein 0.0169 0.0752 0.0752
Trichomonas vaginalis dihydrofolate synthase/folylpolyglutamate synthase, putative 0.0169 0.0755 0.8875
Echinococcus multilocularis laminin 0.0442 0.2137 0.2131
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylmuramyl pentapeptide synthase 0.1728 0.8648 1
Echinococcus multilocularis fibropellin Ia 0.0169 0.0752 0.0744
Toxoplasma gondii kringle domain-containing protein 0.1995 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0516 0.2513 0.2513
Schistosoma mansoni egf-like domain protein 0.0442 0.2137 0.2137
Echinococcus granulosus laminin 0.0442 0.2137 0.2131
Onchocerca volvulus Putative cubilin 0.0356 0.1703 0.168
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0112 0.2173
Loa Loa (eye worm) hypothetical protein 0.0516 0.2513 0.2513
Schistosoma mansoni notch 0.0169 0.0752 0.0752
Loa Loa (eye worm) hypothetical protein 0.1506 0.7527 0.7527
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0025 0.0021 0.0013
Toxoplasma gondii bifunctional protein FolC subfamily protein 0.0169 0.0755 0.0752
Entamoeba histolytica hypothetical protein 0.0039 0.0095 0.1765
Toxoplasma gondii PAN/Apple domain-containing protein 0.0402 0.1932 0.193
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0025 0.0021 0.0021
Brugia malayi PAN domain containing protein 0.0402 0.1932 0.1915
Onchocerca volvulus 0.0402 0.1932 0.191
Schistosoma mansoni hypothetical protein 0.0188 0.0848 0.0848
Mycobacterium leprae PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) 0.0511 0.2483 0.2848
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0244 0.1131 0.1112
Echinococcus granulosus low density lipoprotein receptor ldl 0.0244 0.1131 0.1123
Schistosoma mansoni cercarial elastase (S01 family) 0.0516 0.2513 0.2513
Schistosoma mansoni laminin gamma-3 chain 0.0169 0.0752 0.0752
Echinococcus multilocularis expressed conserved protein 0.01 0.0406 0.0398
Loa Loa (eye worm) hypothetical protein 0.0026 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.1995 1 1
Loa Loa (eye worm) hypothetical protein 0.0686 0.3371 0.3371
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0027 0.0006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.004 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0169 0.0752 0.0752
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.049 0.0537
Schistosoma mansoni cell polarity protein 0.0169 0.0752 0.0752
Loa Loa (eye worm) hypothetical protein 0.0188 0.0848 0.0848
Onchocerca volvulus Slit protein homolog 0.0169 0.0752 0.0726
Entamoeba histolytica hypothetical protein 0.0039 0.0095 0.1765
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.0556 0.0614
Treponema pallidum UDP-N-acetylmuramate--L-alanine ligase 0.1 0.4965 0.4025
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0244 0.1131 0.1131
Trypanosoma cruzi DNA polymerase eta, putative 0.003 0.0047 0.0045
Toxoplasma gondii PAN domain-containing protein 0.0402 0.1932 0.193
Echinococcus granulosus zinc finger protein 0.0024 0.002 0.0011
Brugia malayi glutathione reductase 0.0051 0.0157 0.0136
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0188 0.0848 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.0752 0.0752
Loa Loa (eye worm) hypothetical protein 0.0402 0.1932 0.1932
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0027 0.0025
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0442 0.2137 0.2137
Loa Loa (eye worm) hypothetical protein 0.0169 0.0752 0.0752
Brugia malayi PAN domain containing protein 0.0402 0.1932 0.1915
Loa Loa (eye worm) hypothetical protein 0.0244 0.1131 0.1131
Loa Loa (eye worm) hypothetical protein 0.0244 0.1131 0.1131
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0027 0.0025
Loa Loa (eye worm) hypothetical protein 0.0169 0.0752 0.0752
Schistosoma mansoni cercarial elastase (S01 family) 0.0516 0.2513 0.2513
Schistosoma mansoni hypothetical protein 0.1995 1 1
Leishmania major DNA polymerase eta, putative 0.003 0.0047 0.0045
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0025 0.0021 0.0013
Toxoplasma gondii subtilisin SUB12 0.0402 0.1932 0.193
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0516 0.2513 0.2506
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0143 0.1477
Onchocerca volvulus 0.0188 0.0848 0.0823
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0244 0.1131 0.1123
Brugia malayi enteropeptidase precursor 0.0244 0.1131 0.1112
Leishmania major hypothetical protein, conserved 0.1995 1 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0182 0.0182
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0112 0.1242
Onchocerca volvulus 0.0188 0.0848 0.0823
Brugia malayi Kringle domain containing protein 0.1995 1 1
Brugia malayi PAN domain containing protein 0.0402 0.1932 0.1915
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0704 0.3464 0.3464
Schistosoma mansoni hypothetical protein 0.0044 0.0121 0.0121
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0027 0.0148
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0881 0.4358 0.4353
Onchocerca volvulus 0.0169 0.0752 0.0726
Echinococcus granulosus protein jagged 2 0.0169 0.0752 0.0744
Echinococcus granulosus neurogenic locus notch protein 4 0.0169 0.0752 0.0744
Loa Loa (eye worm) hypothetical protein 0.0188 0.0848 0.0848
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0188 0.0848 0.0848
Echinococcus granulosus low density lipoprotein receptor protein 0.0244 0.1131 0.1123
Mycobacterium leprae possible ligase 0.0169 0.0755 0.0844
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.0706 0.0686
Brugia malayi Nematode astacin protease protein 30 0.0188 0.0848 0.0828
Plasmodium vivax dihydrofolate synthase/folylpolyglutamate synthase, putative 0.0169 0.0755 0.0621
Plasmodium falciparum cysteine repeat modular protein 1 0.1995 1 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.0752 0.0752
Brugia malayi Trypsin family protein 0.0516 0.2513 0.2497
Loa Loa (eye worm) hypothetical protein 0.0516 0.2513 0.2513
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0025 0.0021 0.0019
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0129 0.0121
Loa Loa (eye worm) hypothetical protein 0.0169 0.0752 0.0752
Onchocerca volvulus 0.0402 0.1932 0.191
Onchocerca volvulus 0.0516 0.2513 0.2492
Echinococcus granulosus folylpolyglutamate synthase, mitochondrial 0.0169 0.0755 0.0747
Schistosoma mansoni hypothetical protein 0.1338 0.6672 0.6672
Echinococcus granulosus low density lipoprotein receptor ldl 0.0244 0.1131 0.1123
Brugia malayi PHD-finger family protein 0.003 0.0046 0.0025
Echinococcus granulosus histone acetyltransferase KAT2B 0.0153 0.0672 0.0664
Toxoplasma gondii microneme protein, putative 0.0402 0.1932 0.193
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0244 0.1131 0.1131
Schistosoma mansoni hypothetical protein 0.0244 0.1131 0.1131
Schistosoma mansoni hypothetical protein 0.0169 0.0752 0.0752
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0025 0.0021 0.0021
Echinococcus granulosus tissue type plasminogen activator 0.1995 1 1
Treponema pallidum UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (murF) 0.1728 0.8648 1
Brugia malayi EGF-like domain containing protein 0.0169 0.0752 0.0732
Trypanosoma cruzi hypothetical protein, conserved 0.1995 1 1
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0686 0.3371 0.3371
Loa Loa (eye worm) hypothetical protein 0.0169 0.0752 0.0752
Mycobacterium ulcerans UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF 0.1728 0.8648 1
Brugia malayi EGF-like domain containing protein 0.0169 0.0752 0.0732
Loa Loa (eye worm) hypothetical protein 0.1338 0.6672 0.6672
Echinococcus granulosus neuropilin nrp and tolloid tll 0.0188 0.0848 0.084
Brugia malayi Thioredoxin reductase 0.0051 0.0157 0.0136
Brugia malayi hypothetical protein 0.0188 0.0848 0.0828
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0157 0.0149
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0244 0.1131 0.1131
Loa Loa (eye worm) DPY-31 protein 0.0188 0.0848 0.0848
Schistosoma mansoni notch 0.0169 0.0752 0.0752
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0169 0.0752 0.0752
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0244 0.1131 0.1123
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0015 0.0007
Onchocerca volvulus Putative folylpolyglutamate synthase 0.0169 0.0755 0.0729
Loa Loa (eye worm) hypothetical protein 0.0244 0.1131 0.1131
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0402 0.1932 0.1932
Brugia malayi Calcium binding EGF domain containing protein 0.0356 0.1703 0.1685
Loa Loa (eye worm) TK/ROR protein kinase 0.1995 1 1
Trypanosoma cruzi folylpolyglutamate synthase, putative 0.0169 0.0755 0.0752
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0188 0.0848 0.0846
Echinococcus multilocularis transmembrane protease serine 3 0.0516 0.2513 0.2506
Echinococcus granulosus cubilin 0.0188 0.0848 0.084
Brugia malayi hypothetical protein 0.0039 0.0095 0.0074
Loa Loa (eye worm) hypothetical protein 0.0169 0.0752 0.0752
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0244 0.1131 0.1123
Brugia malayi PAN domain containing protein 0.0402 0.1932 0.1915
Echinococcus granulosus glycoprotein Antigen 5 0.0516 0.2513 0.2506
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0025 0.0021 0.0013
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0039 0.0094 0.0086
Mycobacterium ulcerans UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase 0.1 0.4965 0.5727
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.063 0.3088 0.3088
Brugia malayi notch-like transmembrane receptor 0.0169 0.0752 0.0732
Onchocerca volvulus 0.0244 0.1131 0.1106
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0095 0.0086
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0094 0.0086
Schistosoma mansoni hypothetical protein 0.0188 0.0848 0.0848
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0948 0.4698 0.4698
Schistosoma mansoni hypothetical protein 0.0169 0.0752 0.0752
Schistosoma mansoni cpg binding protein 0.0022 0.0008 0.0008
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0244 0.1131 0.1131
Schistosoma mansoni cercarial elastase (S01 family) 0.0516 0.2513 0.2513
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0005 0.0005
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0025 0.0021 0.0013
Onchocerca volvulus 0.0402 0.1932 0.191
Onchocerca volvulus 0.0169 0.0752 0.0726
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0169 0.0752 0.0732
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0516 0.2513 0.2506
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0157 0.0014
Echinococcus granulosus Niemann Pick C1 protein 0.0153 0.0671 0.0663
Schistosoma mansoni slit 0.0169 0.0752 0.0752
Loa Loa (eye worm) hypothetical protein 0.0516 0.2513 0.2513
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.011 0.011
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0169 0.0752 0.0726
Loa Loa (eye worm) hypothetical protein 0.0169 0.0752 0.0752
Brugia malayi jmjC domain containing protein 0.0039 0.0094 0.0074
Brugia malayi Trypsin family protein 0.0516 0.2513 0.2497
Brugia malayi Bromodomain containing protein 0.0042 0.0108 0.0087
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0027 0.0148
Echinococcus multilocularis cubilin 0.0188 0.0848 0.084
Loa Loa (eye worm) hypothetical protein 0.0244 0.1131 0.1131
Echinococcus multilocularis dnaJ subfamily B 0.0271 0.1271 0.1264
Brugia malayi PAN domain containing protein 0.0402 0.1932 0.1915
Brugia malayi CUB domain containing protein 0.0188 0.0848 0.0828
Schistosoma mansoni cercarial elastase (S01 family) 0.0516 0.2513 0.2513
Onchocerca volvulus 0.0516 0.2513 0.2492
Loa Loa (eye worm) hypothetical protein 0.0516 0.2513 0.2513
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0129 0.1309
Schistosoma mansoni cercarial elastase (S01 family) 0.0516 0.2513 0.2513
Trichomonas vaginalis conserved hypothetical protein 0.0188 0.0848 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0027 0.0027
Loa Loa (eye worm) notch protein 0.0169 0.0752 0.0752
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0516 0.2513 0.2506
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0244 0.1131 0.1131
Echinococcus multilocularis Tolloid protein 1 0.063 0.3088 0.3083
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0244 0.1131 0.1112
Schistosoma mansoni hypothetical protein 0.0039 0.0095 0.0095
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylmuramyl tripeptide synthase 0.0511 0.2483 0.2189
Schistosoma mansoni hypothetical protein 0.0169 0.0752 0.0752
Toxoplasma gondii microneme protein MIC17B 0.0402 0.1932 0.193
Schistosoma mansoni hypothetical protein 0.0244 0.1131 0.1131
Schistosoma mansoni jumonji domain containing protein 0.0039 0.0094 0.0094
Toxoplasma gondii calcium binding egf domain-containing protein 0.0442 0.2137 0.2135
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0027 0.0148
Brugia malayi PAN domain containing protein 0.0402 0.1932 0.1915
Trypanosoma brucei DNA polymerase eta, putative 0.003 0.0047 0.0317
Onchocerca volvulus 0.0244 0.1131 0.1106
Leishmania major trypanothione reductase 0.0051 0.0157 0.0154
Echinococcus granulosus CUB 0.0188 0.0848 0.084
Echinococcus multilocularis glycoprotein Antigen 5 0.0516 0.2513 0.2506
Plasmodium falciparum glutathione reductase 0.0051 0.0157 0.0046
Loa Loa (eye worm) hypothetical protein 0.0169 0.0752 0.0752
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0516 0.2513 0.2506
Onchocerca volvulus 0.0402 0.1932 0.191
Loa Loa (eye worm) PAN domain-containing protein 0.0402 0.1932 0.1932
Loa Loa (eye worm) hypothetical protein 0.0169 0.0752 0.0752
Loa Loa (eye worm) hypothetical protein 0.0188 0.0848 0.0848
Echinococcus multilocularis low density lipoprotein receptor protein 0.0244 0.1131 0.1123
Brugia malayi PAN domain containing protein 0.0402 0.1932 0.1915
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0516 0.2513 0.2497
Brugia malayi Muscle positioning protein 4 0.1506 0.7527 0.7522
Loa Loa (eye worm) hypothetical protein 0.0874 0.4322 0.4322
Echinococcus granulosus enteropeptidase 0.0516 0.2513 0.2506
Toxoplasma gondii hypothetical protein 0.0402 0.1932 0.193
Toxoplasma gondii EGF family domain-containing protein 0.0169 0.0752 0.0749
Brugia malayi SEA domain containing protein 0.1338 0.6672 0.6665
Echinococcus granulosus fibropellin Ia 0.0169 0.0752 0.0744

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -7.89 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.837 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the P388 Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.088 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -7.017 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.991 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.923 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.898 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.837 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.609 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.511 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.091 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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