Detailed information for compound 1630319

Basic information

Technical information
  • TDR Targets ID: 1630319
  • Name: 1-[2-(cyclopentanecarbonylamino)-3-(3H-imidaz ol-4-yl)propanoyl]pyrrolidine-2-carboxamide
  • MW: 347.412 | Formula: C17H25N5O3
  • H donors: 3 H acceptors: 4 LogP: 0.24 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCCC1)NC(C(=O)N1CCCC1C(=O)N)Cc1c[nH]cn1
  • InChi: 1S/C17H25N5O3/c18-15(23)14-6-3-7-22(14)17(25)13(8-12-9-19-10-20-12)21-16(24)11-4-1-2-5-11/h9-11,13-14H,1-8H2,(H2,18,23)(H,19,20)(H,21,24)
  • InChiKey: UKQOBAWZNJCNOH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-[(cyclopentyl-oxomethyl)amino]-3-(3H-imidazol-4-yl)-1-oxopropyl]-2-pyrrolidinecarboxamide
  • 1-[2-(cyclopentylcarbonylamino)-3-(3H-imidazol-4-yl)propanoyl]pyrrolidine-2-carboxamide
  • NCI60_024034
  • 1-(2-((Cyclopentylcarbonyl)amino)-3-(1H-imidazol-4-yl)propanoyl)-2-pyrrolidinecarboxamide
  • AIDS-145047
  • AIDS145047
  • NSC668907

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0004 0.0004
Plasmodium falciparum cysteine proteinase falcipain 2b 0.189 0.4897 1
Loa Loa (eye worm) hypothetical protein 0.0435 0.1107 0.1107
Loa Loa (eye worm) fibroinase 0.189 0.4897 0.4897
Onchocerca volvulus Cathepsin F homolog 0.189 0.4897 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0435 0.1107 0.1107
Brugia malayi Papain family cysteine protease containing protein 0.1025 0.2644 0.2644
Entamoeba histolytica cysteine proteinase, putative 0.13 0.3361 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.189 0.4897 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.189 0.4897 1
Plasmodium vivax vivapain-2 0.189 0.4897 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0435 0.1107 0.1107
Plasmodium falciparum cysteine proteinase falcipain 3 0.189 0.4897 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0435 0.1107 0.1107
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0435 0.1107 0.1107
Onchocerca volvulus 0.189 0.4897 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0435 0.1107 0.2144
Plasmodium vivax unspecified product 0.1025 0.2644 0.5329
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0004 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0435 0.1107 0.2144
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0018 0.0018
Trypanosoma cruzi cruzipain precursor, putative 0.059 0.1511 0.1448
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0435 0.1107 0.2144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.189 0.4897 1
Entamoeba histolytica cysteine protease, putative 0.1025 0.2644 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.189 0.4897 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.189 0.4897 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0004 0.0003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0004 0.0003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0018 0.0018
Schistosoma mansoni cathepsin F (C01 family) 0.13 0.3361 0.3358
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0004 0.0003
Loa Loa (eye worm) cysteine protease 0.189 0.4897 0.4897
Loa Loa (eye worm) ctsf protein 0.189 0.4897 0.4897
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0004 0.0003
Brugia malayi beta-lactamase 0.0038 0.0073 0.0073
Entamoeba histolytica cysteine protease, putative 0.1025 0.2644 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.189 0.4897 1
Echinococcus multilocularis cathepsin b 0.385 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0004 0.0003
Trypanosoma cruzi cysteine protease, putative 0.1025 0.2644 0.2589
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0004 0.0004
Brugia malayi Papain family cysteine protease containing protein 0.0435 0.1107 0.1107
Toxoplasma gondii preprocathepsin c precursor, putative 0.0435 0.1107 0.2144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.189 0.4897 1
Loa Loa (eye worm) hypothetical protein 0.0435 0.1107 0.1107
Loa Loa (eye worm) hypothetical protein 0.13 0.3361 0.336
Entamoeba histolytica cysteine proteinase, putative 0.189 0.4897 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1025 0.2644 0.5329
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0435 0.1107 0.2144
Echinococcus multilocularis cathepsin L 0.1025 0.2644 0.2643
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1025 0.2644 0.5329
Brugia malayi Papain family cysteine protease containing protein 0.1025 0.2644 0.2644
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0435 0.1107 0.2144
Onchocerca volvulus 0.189 0.4897 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0073 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.189 0.4897 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0073 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1025 0.2644 0.5329
Schistosoma mansoni hypothetical protein 0.0017 0.0018 0.0014
Onchocerca volvulus 0.0038 0.0073 0.0142
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0018 0.0018
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0149 0.0145
Brugia malayi Cathepsin L-like precursor 0.189 0.4897 0.4897
Trypanosoma cruzi cysteine peptidase, putative 0.189 0.4897 0.4859
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0004 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0004 0.0004
Mycobacterium leprae Probable lipase LipE 0.0038 0.0073 0.5
Entamoeba histolytica cysteine proteinase, putative 0.1025 0.2644 0.4054
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0435 0.1107 0.2144
Onchocerca volvulus 0.189 0.4897 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.189 0.4897 1
Trypanosoma cruzi cysteine peptidase, putative 0.059 0.1511 0.1448
Brugia malayi cathepsin L-like cysteine proteinase 0.0435 0.1107 0.1107
Trypanosoma cruzi cruzipain precursor, putative 0.189 0.4897 0.4859
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0004 0.0003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0004 0.0003
Brugia malayi steroid hormone receptor 0.0011 0.0004 0.0004
Entamoeba histolytica cysteine proteinase, putative 0.1025 0.2644 0.4054
Echinococcus granulosus cathepsin l1 0.189 0.4897 0.4897
Loa Loa (eye worm) hypothetical protein 0.059 0.1511 0.1511
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0073 0.0073
Echinococcus multilocularis cysteine protease 0.189 0.4897 0.4897
Echinococcus multilocularis cathepsin L cysteine protease 0.189 0.4897 0.4897
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0435 0.1107 0.2144
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.08 0.0732
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0004 0.0003
Entamoeba histolytica cysteine protease, putative 0.1025 0.2644 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.189 0.4897 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0435 0.1107 0.1107
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1491 0.3858 0.7846
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.189 0.4897 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.189 0.4897 0.4897
Schistosoma mansoni cpg binding protein 0.0032 0.0057 0.0053
Brugia malayi Papain family cysteine protease containing protein 0.0435 0.1107 0.1107
Schistosoma mansoni cpg binding protein 0.0033 0.0062 0.0058
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0435 0.1107 0.2144
Plasmodium falciparum cysteine proteinase falcipain 1 0.1025 0.2644 0.4054
Plasmodium vivax vivapain-2 0.189 0.4897 1
Leishmania major cysteine peptidase A (CPA) 0.189 0.4897 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0111 0.0111
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0317 0.08 0.0732
Echinococcus granulosus cathepsin b 0.385 1 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0435 0.1107 0.1104
Brugia malayi cathepsin Z-like cysteine proteinase 0.0435 0.1107 0.1107
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0435 0.1107 0.1104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.189 0.4897 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0004 0.0003
Brugia malayi Cathepsin L-like cysteine proteinase 0.13 0.3361 0.3361
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0004 0.0004
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0435 0.1107 0.1104
Entamoeba histolytica cysteine protease, putative 0.1025 0.2644 0.4054
Plasmodium vivax unspecified product 0.0435 0.1107 0.2144
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0068
Schistosoma mansoni cpg binding protein 0.0033 0.0062 0.0058
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0003
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0435 0.1107 0.2144
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0004 0.0004
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0435 0.1107 0.2144
Echinococcus multilocularis cathepsin b 0.385 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0435 0.1107 0.2144
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0004 0.0003
Plasmodium vivax unspecified product 0.059 0.1511 0.2981
Echinococcus granulosus cathepsin L 0.1025 0.2644 0.2643
Brugia malayi nuclear hormone receptor 0.0011 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.189 0.4897 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.189 0.4897 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0435 0.1107 0.1104
Plasmodium vivax serine-repeat antigen (SERA) 0.0435 0.1107 0.2144
Schistosoma mansoni hypothetical protein 0.0036 0.0068 0.0064
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0073 0.0073
Leishmania major cathepsin L-like protease 0.189 0.4897 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0073 0.0073
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0091 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0004 0.0003
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1491 0.3858 0.3855
Loa Loa (eye worm) hypothetical protein 0.059 0.1511 0.1511
Loa Loa (eye worm) hypothetical protein 0.189 0.4897 0.4897
Brugia malayi CXXC zinc finger family protein 0.0032 0.0057 0.0057
Brugia malayi Cathepsin L-like precursor 0.189 0.4897 0.4897
Leishmania major cathepsin L-like protease 0.189 0.4897 1
Trypanosoma cruzi cysteine peptidase, putative 0.189 0.4897 0.4859
Brugia malayi beta-lactamase family protein 0.0038 0.0073 0.0073
Schistosoma mansoni cathepsin F (C01 family) 0.189 0.4897 0.4895
Toxoplasma gondii cathepsin CPC2 0.0435 0.1107 0.2144
Entamoeba histolytica cysteine protease, putative 0.1025 0.2644 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.13 0.3361 0.6815
Trypanosoma cruzi cysteine peptidase, putative 0.189 0.4897 0.4859
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.189 0.4897 1
Entamoeba histolytica cysteine protease, putative 0.1025 0.2644 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.189 0.4897 1
Giardia lamblia Cathepsin B precursor 0.1491 0.3858 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0073 0.0073
Trypanosoma cruzi cysteine peptidase, putative 0.1025 0.2644 0.2589
Toxoplasma gondii cathepsin B 0.1491 0.3858 0.7846
Echinococcus multilocularis geminin 0.0186 0.0459 0.0459
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0435 0.1107 0.2144
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.189 0.4897 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0111 0.0111
Brugia malayi cathepsin L precursor 0.0435 0.1107 0.1107
Loa Loa (eye worm) hypothetical protein 0.13 0.3361 0.336
Onchocerca volvulus 0.189 0.4897 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.189 0.4897 1
Trichomonas vaginalis conserved hypothetical protein 0.0435 0.1107 0.2144
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1025 0.2644 0.2641
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.189 0.4897 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0435 0.1107 0.2144
Trypanosoma brucei cysteine peptidase C (CPC) 0.1491 0.3858 0.7846
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.059 0.1511 0.1511
Leishmania major cathepsin L-like protease 0.189 0.4897 1
Entamoeba histolytica cysteine proteinase 1, putative 0.1025 0.2644 0.4054
Schistosoma mansoni hypothetical protein 0.0017 0.0018 0.0014
Leishmania major cathepsin L-like protease 0.189 0.4897 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.189 0.4897 1
Plasmodium vivax vivapain-3 0.1025 0.2644 0.5329
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0435 0.1107 0.1104
Echinococcus multilocularis GPCR, family 2 0.0017 0.0018 0.0018
Mycobacterium ulcerans hypothetical protein 0.0167 0.041 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0435 0.1107 0.2144
Brugia malayi nuclear receptor NHR-88 0.0011 0.0004 0.0004
Trypanosoma cruzi major cysteine proteinase, putative 0.0435 0.1107 0.1042
Onchocerca volvulus 0.0435 0.1107 0.2256
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.189 0.4897 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.189 0.4897 1
Brugia malayi beta-lactamase family protein 0.0038 0.0073 0.0073
Entamoeba histolytica cysteine protease, putative 0.1025 0.2644 0.4054
Entamoeba histolytica cysteine protease, putative 0.1025 0.2644 0.4054
Brugia malayi cathepsin F-like cysteine proteinase 0.059 0.1511 0.1511
Schistosoma mansoni hypothetical protein 0.0017 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0003
Brugia malayi cathepsin L-like precursor 0.13 0.3361 0.3361
Onchocerca volvulus Cathepsin L homolog 0.189 0.4897 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.189 0.4897 1
Schistosoma mansoni hypothetical protein 0.0017 0.0018 0.0014
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0435 0.1107 0.2144
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0435 0.1107 0.2144
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0435 0.1107 0.2144
Loa Loa (eye worm) hypothetical protein 0.0435 0.1107 0.1107
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0004 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0004 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0004 0.0003
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0435 0.1107 0.2144
Schistosoma mansoni cathepsin s 0.059 0.1511 0.1508
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0004 0.0003
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0435 0.1107 0.2144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1025 0.2644 0.5329
Echinococcus granulosus cathepsin L 0.0435 0.1107 0.1107
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.0366 0.0294
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0003
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0091 0.0018
Brugia malayi fibroinase precursor 0.0435 0.1107 0.1107
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0435 0.1107 0.1107
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.0366 0.0606
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.189 0.4897 1
Echinococcus granulosus geminin 0.0186 0.0459 0.0459
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0435 0.1107 0.1104
Loa Loa (eye worm) hypothetical protein 0.059 0.1511 0.1511
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.041 0.6343
Brugia malayi Cathepsin L-like precursor 0.13 0.3361 0.3361
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.189 0.4897 0.4897
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.385 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0435 0.1107 0.2144
Onchocerca volvulus 0.0032 0.0057 0.0109
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0004 0.0004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0004 0.0004
Echinococcus granulosus cathepsin L cysteine proteinase 0.189 0.4897 0.4897
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0038 0.0073 0.0073
Echinococcus multilocularis cathepsin L cysteine protease 0.189 0.4897 0.4897
Onchocerca volvulus 0.189 0.4897 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0004 0.0004
Entamoeba histolytica cysteine protease, putative 0.189 0.4897 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0435 0.1107 0.1104
Trypanosoma cruzi cysteine proteinase, putative 0.1025 0.2644 0.2589
Brugia malayi Cathepsin L-like precursor 0.189 0.4897 0.4897
Loa Loa (eye worm) beta-lactamase 0.0038 0.0073 0.0073
Onchocerca volvulus 0.0038 0.0073 0.0142
Toxoplasma gondii hypothetical protein 0.0051 0.0108 0.0072
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0073 0.007
Schistosoma mansoni hypothetical protein 0.0186 0.0459 0.0455
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.189 0.4897 1
Echinococcus multilocularis cpg binding protein 0.0033 0.0062 0.0061
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0003
Schistosoma mansoni hypothetical protein 0.0186 0.0459 0.0455
Loa Loa (eye worm) hypothetical protein 0.0435 0.1107 0.1107
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.385 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0435 0.1107 0.2144
Echinococcus granulosus cathepsin b 0.385 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0435 0.1107 0.2144
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0004 0.0003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0111 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.189 0.4897 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.189 0.4897 0.4897
Entamoeba histolytica cysteine protease, putative 0.1025 0.2644 0.4054
Onchocerca volvulus 0.0038 0.0073 0.0142
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0068 0.0068
Brugia malayi Cathepsin L-like precursor 0.189 0.4897 0.4897
Schistosoma mansoni cathepsin B (C01 family) 0.0435 0.1107 0.1104
Echinococcus granulosus cathepsin l cysteine peptidase 0.189 0.4897 0.4897
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.189 0.4897 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.0366 0.0606
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0004 0.0003
Schistosoma mansoni cathepsin C 0.0435 0.1107 0.1104
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0004 0.0003
Onchocerca volvulus Cathepsin L homolog 0.189 0.4897 1
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0073 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0073 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0004 0.0004
Schistosoma mansoni cathepsin F (C01 family) 0.189 0.4897 0.4895
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.189 0.4897 1
Loa Loa (eye worm) hypothetical protein 0.385 1 1
Loa Loa (eye worm) cathepsin B 0.1491 0.3858 0.3858
Plasmodium vivax vivapain-1 0.1025 0.2644 0.5329
Leishmania major cathepsin L-like protease 0.189 0.4897 1
Entamoeba histolytica cysteine protease, putative 0.1025 0.2644 0.4054
Brugia malayi Cathepsin L-like precursor 0.189 0.4897 0.4897
Toxoplasma gondii cathepsin CPL 0.189 0.4897 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0073 0.0073
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1025 0.2644 0.2641
Entamoeba histolytica cysteine proteinase, putative 0.189 0.4897 1
Schistosoma mansoni cathepsin S (C01 family) 0.0435 0.1107 0.1104
Loa Loa (eye worm) hypothetical protein 0.13 0.3361 0.336
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0091 0.0018
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.013 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0435 0.1107 0.2144
Onchocerca volvulus 0.189 0.4897 1
Echinococcus multilocularis cysteine protease 0.189 0.4897 0.4897
Giardia lamblia Cathepsin B precursor 0.1491 0.3858 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0057 0.0057
Leishmania major cathepsin L-like protease 0.189 0.4897 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.385 1 1
Loa Loa (eye worm) hypothetical protein 0.0435 0.1107 0.1107
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.189 0.4897 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0435 0.1107 0.2144
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.385 1 1
Entamoeba histolytica cysteine proteinase, putative 0.1025 0.2644 0.4054
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0116 0.0043
Leishmania major cathepsin L-like protease 0.189 0.4897 1
Entamoeba histolytica cysteine protease, putative 0.1025 0.2644 0.4054
Plasmodium vivax serine-repeat antigen (SERA) 0.0435 0.1107 0.2144
Entamoeba histolytica cysteine proteinase, putative 0.1025 0.2644 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.189 0.4897 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0435 0.1107 0.1042
Leishmania major cathepsin L-like protease 0.189 0.4897 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0435 0.1107 0.2144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.189 0.4897 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.189 0.4897 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.189 0.4897 1
Trypanosoma cruzi cysteine proteinase, putative 0.1025 0.2644 0.2589
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.0604 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0435 0.1107 0.1107
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0004 0.0003
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0004 0.0003
Entamoeba histolytica cysteine proteinase 2 0.1025 0.2644 0.4054
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0435 0.1107 0.1104
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.13 0.3361 0.3312
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0004 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1491 0.3858 0.7846
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.189 0.4897 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0435 0.1107 0.2144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.189 0.4897 1
Toxoplasma gondii cathepsin CPC1 0.0435 0.1107 0.2144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.189 0.4897 1
Brugia malayi Cathepsin L-like precursor 0.059 0.1511 0.1511
Brugia malayi Cathepsin L-like precursor 0.189 0.4897 0.4897
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0004 0.0004
Echinococcus granulosus cathepsin L cysteine protease 0.1025 0.2644 0.2643
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0018 0.0018
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0004 0.0003
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0004 0.0003
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.385 1 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0091 0.0037
Brugia malayi Cathepsin L-like precursor 0.13 0.3361 0.3361
Echinococcus granulosus cysteine protease 0.1025 0.2644 0.2643
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0004 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0435 0.1107 0.2144
Onchocerca volvulus Cathepsin L homolog 0.0435 0.1107 0.2256
Onchocerca volvulus 0.189 0.4897 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0004 0.0003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0018 0.0018
Brugia malayi ecdysteroid receptor 0.0011 0.0004 0.0004
Echinococcus multilocularis cathepsin l cysteine peptidase 0.189 0.4897 0.4897
Entamoeba histolytica cysteine protease, putative 0.1025 0.2644 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.189 0.4897 0.4897
Leishmania major mitochondrial DNA polymerase beta 0.0317 0.08 0.1507
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0435 0.1107 0.2144
Echinococcus granulosus cathepsin l1 0.13 0.3361 0.336
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0073 0.007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.189 0.4897 1
Entamoeba histolytica cysteine protease, putative 0.1025 0.2644 0.4054
Echinococcus multilocularis cathepsin L 0.0435 0.1107 0.1107
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1491 0.3858 0.3812
Loa Loa (eye worm) papain family cysteine protease containing protein 0.059 0.1511 0.1511
Brugia malayi Papain family cysteine protease containing protein 0.0435 0.1107 0.1107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.13 0.3361 0.6815
Loa Loa (eye worm) hypothetical protein 0.0052 0.0111 0.0111
Onchocerca volvulus 0.13 0.3361 0.686
Echinococcus granulosus cpg binding protein 0.0033 0.0062 0.0061
Echinococcus granulosus GPCR family 2 0.0017 0.0018 0.0018
Trypanosoma cruzi cysteine peptidase, putative 0.189 0.4897 0.4859
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0073 0.0073
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1025 0.2644 0.2641
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.1025 0.2644 0.2589
Giardia lamblia Cathepsin B precursor 0.1491 0.3858 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0435 0.1107 0.1104
Loa Loa (eye worm) hypothetical protein 0.0017 0.0018 0.0018
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0317 0.08 0.1507

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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