TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 437.439 | Formula: C24H21F2N3O3
H donors: 2 H acceptors: 3 LogP: 3.26 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)Nc1cccc(c1)c1ccnc2c1CC(O2)(C)C(=O)NCc1ccc(c(c1)F)F
InChi: 1S/C24H21F2N3O3/c1-14(30)29-17-5-3-4-16(11-17)18-8-9-27-22-19(18)12-24(2,32-22)23(31)28-13-15-6-7-20(25)21(26)10-15/h3-11H,12-13H2,1-2H3,(H,28,31)(H,29,30)
InChiKey: UKXAVQMJCILMON-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references
Homo sapiens	isocitrate dehydrogenase 1 (NADP+), soluble	Starlite/ChEMBL	No references
Homo sapiens	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Theileria parva	isocitrate dehydrogenase (NADP+), putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania donovani	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	Isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	hypothetical protein	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium berghei	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania braziliensis	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Babesia bovis	isocitrate dehydrogenase, NADP-dependent family protein	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania mexicana	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	C terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania infantum	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium knowlesi	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	N terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	Isocitrate dehydrogenase-like protein, related	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Cathepsin L homolog	0.0485	0.1095	0.219
Plasmodium falciparum	cysteine proteinase falcipain 3	0.2112	0.4916	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0485	0.1095	0.1095
Brugia malayi	cathepsin F-like cysteine proteinase	0.0485	0.1095	0.1095
Giardia lamblia	Cathepsin B precursor	0.0485	0.1095	0.2841
Echinococcus multilocularis	cysteine protease	0.2112	0.4916	0.4916
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0485	0.1095	0.2228
Trypanosoma cruzi	major cysteine proteinase, putative	0.0485	0.1095	0.1095
Brugia malayi	hypothetical protein	0.0182	0.0384	0.0384
Toxoplasma gondii	cathepsin CPC1	0.0485	0.1095	0.2228
Giardia lamblia	Cathepsin L precursor	0.0485	0.1095	0.2841
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.002	0.0003	0.0003
Plasmodium falciparum	serine repeat antigen 4	0.0485	0.1095	0.2228
Trypanosoma cruzi	cysteine peptidase, putative	0.2112	0.4916	0.4916
Entamoeba histolytica	cysteine protease, putative	0.1145	0.2644	0.5376
Echinococcus multilocularis	cathepsin L	0.0485	0.1095	0.1095
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2112	0.4916	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2112	0.4916	1
Loa Loa (eye worm)	hypothetical protein	0.4277	1	1
Toxoplasma gondii	cathepsin B	0.1658	0.3849	0.783
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0097	0.0097
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0029	0.0024	0.0024
Entamoeba histolytica	protein kinase, putative	0.003	0.0026	0.0049
Entamoeba histolytica	cysteine proteinase, putative	0.2112	0.4916	1
Brugia malayi	cathepsin L precursor	0.0485	0.1095	0.1095
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0029	0.0024	0.0024
Plasmodium falciparum	serine repeat antigen 7	0.0485	0.1095	0.2228
Plasmodium vivax	vivapain-2	0.2112	0.4916	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2112	0.4916	1
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0029	0.0024	0.0024
Plasmodium falciparum	serine repeat antigen 2	0.0485	0.1095	0.2228
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2112	0.4916	1
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0029	0.0024	0.0024
Brugia malayi	Cathepsin L-like precursor	0.1453	0.3367	0.3367
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0029	0.0024	0.0024
Schistosoma mansoni	hypothetical protein	0.0041	0.0052	0.0052
Entamoeba histolytica	cysteine proteinase, putative	0.1145	0.2644	0.5376
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2112	0.4916	1
Entamoeba histolytica	protein kinase, putative	0.0032	0.0031	0.0058
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.002	0.0003	0.0005
Giardia lamblia	Cathepsin L precursor	0.0485	0.1095	0.2841
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0029	0.0024	0.0024
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0485	0.1095	0.1095
Loa Loa (eye worm)	hypothetical protein	0.0485	0.1095	0.1095
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0031	0.0031
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2112	0.4916	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Trypanosoma cruzi	cruzipain precursor, putative	0.066	0.1504	0.1504
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Echinococcus multilocularis	nervana 2	0.002	0.0002	0.0002
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0485	0.1095	0.2228
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Echinococcus multilocularis		0.0029	0.0024	0.0024
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0029	0.0024	0.0024
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0019	0.0000073171	0.0000073171
Brugia malayi	Papain family cysteine protease containing protein	0.0485	0.1095	0.1095
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1453	0.3367	0.3367
Brugia malayi	Cathepsin L-like precursor	0.066	0.1504	0.1504
Plasmodium falciparum	serine repeat antigen 1	0.0485	0.1095	0.2228
Loa Loa (eye worm)	cysteine protease	0.2112	0.4916	0.4916
Schistosoma mansoni	cathepsin B (C01 family)	0.0485	0.1095	0.1095
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0029	0.0024	0.0024
Entamoeba histolytica	cysteine protease, putative	0.1145	0.2644	0.5376
Loa Loa (eye worm)	hypothetical protein	0.006	0.0097	0.0097
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0000073171	0.0000073171
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0029	0.0024	0.0024
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0029	0.0024	0.0024
Plasmodium vivax	unspecified product	0.066	0.1504	0.306
Giardia lamblia	Cathepsin L precursor	0.0485	0.1095	0.2841
Schistosoma mansoni	protein tyrosine phosphatase	0.0029	0.0024	0.0024
Onchocerca volvulus	Cathepsin L homolog	0.2112	0.4916	1
Giardia lamblia	Cysteine protease	0.0485	0.1095	0.2841
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0485	0.1095	0.1095
Entamoeba histolytica	cysteine protease, putative	0.1145	0.2644	0.5376
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2112	0.4916	1
Entamoeba histolytica	cysteine protease, putative	0.0485	0.1095	0.2224
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0024	0.0024
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0027	0.0054
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.0031	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0485	0.1095	0.1095
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0029	0.0024	0.0024
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Brugia malayi	cathepsin F-like cysteine proteinase	0.066	0.1504	0.1504
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.1658	0.3849	0.783
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0485	0.1095	0.2841
Brugia malayi	isocitrate dehydrogenase	0.0019	0.0000073171	0.0000073171
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Plasmodium falciparum	serine repeat antigen 6	0.0485	0.1095	0.2228
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1453	0.3367	0.6834
Echinococcus multilocularis	Glutaredoxin protein 5	0.002	0.0002	0.0002
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0485	0.1095	0.1095
Giardia lamblia	Cathepsin L-like protease	0.0485	0.1095	0.2841
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0029	0.0024	0.0024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1145	0.2644	0.5356
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0000073171	0.0000073171
Entamoeba histolytica	cysteine protease, putative	0.1145	0.2644	0.5376
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0029	0.0024	0.0024
Brugia malayi	hypothetical protein	0.0029	0.0024	0.0024
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0029	0.0024	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0052	0.0052
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0019	0.0000073171	0.0000073171
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1453	0.3367	0.3367
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2112	0.4916	1
Giardia lamblia	Cathepsin L precursor	0.0485	0.1095	0.2841
Brugia malayi	Papain family cysteine protease containing protein	0.0485	0.1095	0.1095
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0029	0.0024	0.0024
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0485	0.1095	0.219
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.4277	1	1
Schistosoma mansoni	hypothetical protein	0.017	0.0354	0.0354
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.2112	0.4916	0.4916
Echinococcus granulosus	cathepsin L cysteine proteinase	0.2112	0.4916	0.4916
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.002	0.0003	0.0005
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0029	0.0024	0.0024
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0485	0.1095	0.2228
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0485	0.1095	0.2228
Loa Loa (eye worm)	hypothetical protein	0.1453	0.3367	0.3367
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0019	0.0000073171	0.0000073171
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0022	0.0007	0.0007
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2112	0.4916	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0485	0.1095	0.2224
Leishmania major	cathepsin L-like protease	0.2112	0.4916	1
Plasmodium vivax	vivapain-3	0.1145	0.2644	0.5379
Entamoeba histolytica	cysteine protease, putative	0.1145	0.2644	0.5376
Trichomonas vaginalis	conserved hypothetical protein	0.0485	0.1095	0.219
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2112	0.4916	1
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.0031	0.0014
Onchocerca volvulus		0.1453	0.3367	0.6834
Giardia lamblia	Cathepsin B precursor	0.1658	0.3849	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.0007	0.001
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0024	0.0024
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0029	0.0024	0.0024
Plasmodium falciparum	cysteine proteinase falcipain 1	0.1145	0.2644	0.5379
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2112	0.4916	0.4916
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2112	0.4916	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2112	0.4916	1
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0029	0.0024	0.0024
Entamoeba histolytica	cysteine protease, putative	0.1145	0.2644	0.5376
Plasmodium vivax	unspecified product	0.1145	0.2644	0.5379
Brugia malayi	Protein-tyrosine phosphatase 1	0.0029	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.1156	0.267	0.267
Entamoeba histolytica	hypothetical protein	0.0485	0.1095	0.2224
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1145	0.2644	0.5379
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0485	0.1095	0.219
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1453	0.3367	0.6834
Entamoeba histolytica	cysteine proteinase, putative	0.2112	0.4916	1
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0032	0.0031	0.0031
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0029	0.0024	0.0024
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0029	0.0024	0.0024
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0052	0.0052
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Trypanosoma cruzi	cysteine proteinase, putative	0.1145	0.2644	0.2644
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0485	0.1095	0.1095
Onchocerca volvulus		0.2112	0.4916	1
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0029	0.0024	0.0024
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0029	0.0024	0.0024
Schistosoma mansoni	pcd6 interacting protein-related	0.0029	0.0024	0.0024
Trypanosoma cruzi	cysteine peptidase, putative	0.066	0.1504	0.1504
Plasmodium falciparum	serine repeat antigen 5	0.0485	0.1095	0.2228
Trypanosoma cruzi	major cysteine proteinase, putative	0.0485	0.1095	0.1095
Brugia malayi	Cathepsin L-like precursor	0.2112	0.4916	0.4916
Brugia malayi	Cathepsin L-like precursor	0.2112	0.4916	0.4916
Echinococcus granulosus	cysteine protease	0.1145	0.2644	0.2644
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0024	0.0024
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Leishmania major	cysteine peptidase A (CPA)	0.2112	0.4916	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0029	0.0024	0.0024
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0485	0.1095	0.219
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2112	0.4916	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0485	0.1095	0.1095
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2112	0.4916	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0027	0.0054
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.0031	0.0014
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2112	0.4916	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0485	0.1095	0.219
Entamoeba histolytica	cysteine proteinase 1, putative	0.1145	0.2644	0.5376
Giardia lamblia	Cathepsin L precursor	0.0485	0.1095	0.2841
Giardia lamblia	Hypothetical protein	0.0485	0.1095	0.2841
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.002	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Plasmodium vivax	vivapain-2	0.2112	0.4916	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.2112	0.4916	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0029	0.0024	0.0024
Brugia malayi	Cathepsin L-like precursor	0.1453	0.3367	0.3367
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.0031	0.0014
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0029	0.0024	0.0024
Toxoplasma gondii	AGC kinase	0.003	0.0026	0.0054
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0029	0.0024	0.0024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2112	0.4916	1
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.002	0.0002	0.0002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0485	0.1095	0.219
Entamoeba histolytica	cysteine protease, putative	0.0485	0.1095	0.2224
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.0007	0.001
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0029	0.0024	0.0024
Trypanosoma cruzi	cysteine protease, putative	0.1145	0.2644	0.2644
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0027	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Echinococcus granulosus	cathepsin b	0.4277	1	1
Entamoeba histolytica	cysteine protease, putative	0.1145	0.2644	0.5376
Plasmodium falciparum	serine repeat antigen 3	0.0485	0.1095	0.2228
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2112	0.4916	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0029	0.0024	0.0024
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Onchocerca volvulus		0.2112	0.4916	1
Loa Loa (eye worm)	hypothetical protein	0.066	0.1504	0.1504
Giardia lamblia	Cathepsin B precursor	0.1658	0.3849	1
Trypanosoma cruzi	cysteine proteinase, putative	0.1145	0.2644	0.2644
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2112	0.4916	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0485	0.1095	0.2228
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0019	0.0000073171	0.5
Giardia lamblia	Cathepsin B precursor	0.0485	0.1095	0.2841
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.0236	0.0236
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0029	0.0024	0.0024
Onchocerca volvulus		0.2112	0.4916	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1145	0.2644	0.2644
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1156	0.267	0.267
Entamoeba histolytica	cysteine protease, putative	0.0485	0.1095	0.2224
Trypanosoma cruzi	cysteine peptidase, putative	0.2112	0.4916	0.4916
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2112	0.4916	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.2112	0.4916	0.4916
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0027	0.0054
Loa Loa (eye worm)	hypothetical protein	0.066	0.1504	0.1504
Brugia malayi	Protein-tyrosine phosphatase	0.0029	0.0024	0.0024
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2112	0.4916	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0485	0.1095	0.219
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0485	0.1095	0.2228
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0485	0.1095	0.2228
Echinococcus granulosus	cathepsin b	0.4277	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Echinococcus multilocularis	cathepsin L cysteine protease	0.2112	0.4916	0.4916
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2112	0.4916	1
Giardia lamblia	Cysteine protease	0.0485	0.1095	0.2841
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.0236	0.0236
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0029	0.0024	0.0024
Giardia lamblia	Cathepsin B precursor	0.0485	0.1095	0.2841
Brugia malayi	hypothetical protein	0.0029	0.0024	0.0024
Entamoeba histolytica	protein kinase, putative	0.0032	0.0031	0.0058
Echinococcus multilocularis	geminin	0.017	0.0354	0.0354
Giardia lamblia	Cathepsin L precursor	0.0485	0.1095	0.2841
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0485	0.1095	0.1095
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Leishmania major	cathepsin L-like protease	0.2112	0.4916	1
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0485	0.1095	0.2228
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0485	0.1095	0.2228
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0485	0.1095	0.2228
Giardia lamblia	Cathepsin B precursor	0.0485	0.1095	0.2841
Loa Loa (eye worm)	ctsf protein	0.2112	0.4916	0.4916
Echinococcus multilocularis	nervana 2	0.002	0.0002	0.0002
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1145	0.2644	0.2644
Echinococcus multilocularis	hypothetical protein	0.0029	0.0024	0.0024
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0027	0.0054
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0029	0.0024	0.0024
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0029	0.0024	0.0024
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0485	0.1095	0.1095
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.002	0.0003	0.0003
Echinococcus granulosus	cathepsin L cysteine protease	0.1145	0.2644	0.2644
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0024	0.0024
Schistosoma mansoni	serine/threonine-protein kinase	0.0022	0.0007	0.0007
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2112	0.4916	1
Brugia malayi	Cathepsin L-like precursor	0.2112	0.4916	0.4916
Loa Loa (eye worm)	hypothetical protein	0.003	0.0027	0.0027
Schistosoma mansoni	cathepsin F (C01 family)	0.2112	0.4916	0.4916
Trypanosoma cruzi	Protein kinase B	0.0022	0.0007	0.0007
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0485	0.1095	0.1095
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4277	1	1
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.002	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0485	0.1095	0.1095
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0485	0.1095	0.1095
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0029	0.0024	0.0024
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4277	1	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Schistosoma mansoni	cathepsin S (C01 family)	0.0485	0.1095	0.1095
Trypanosoma cruzi	cysteine peptidase, putative	0.2112	0.4916	0.4916
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0027	0.0027
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Leishmania major	cathepsin L-like protease	0.2112	0.4916	1
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0029	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0024	0.0024
Trypanosoma cruzi	cruzipain precursor, putative	0.2112	0.4916	0.4916
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0485	0.1095	0.2841
Plasmodium falciparum	serine repeat antigen 9	0.0485	0.1095	0.2228
Entamoeba histolytica	cysteine protease, putative	0.1145	0.2644	0.5376
Loa Loa (eye worm)	hypothetical protein	0.066	0.1504	0.1504
Onchocerca volvulus		0.2112	0.4916	1
Entamoeba histolytica	cysteine protease, putative	0.0485	0.1095	0.2224
Loa Loa (eye worm)	hypothetical protein	0.0485	0.1095	0.1095
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0485	0.1095	0.1095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0485	0.1095	0.219
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0024	0.0024
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0029	0.0024	0.0024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0485	0.1095	0.219
Brugia malayi	fibroinase precursor	0.0485	0.1095	0.1095
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0485	0.1095	0.219
Plasmodium vivax	serine-repeat antigen (SERA)	0.0485	0.1095	0.2228
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0029	0.0024	0.0024
Onchocerca volvulus		0.0485	0.1095	0.219
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1156	0.267	0.267
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0485	0.1095	0.219
Entamoeba histolytica	cysteine proteinase, putative	0.1145	0.2644	0.5376
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0029	0.0024	0.0024
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0029	0.0024	0.0024
Echinococcus granulosus	geminin	0.017	0.0354	0.0354
Brugia malayi	hypothetical protein	0.003	0.0027	0.0027
Onchocerca volvulus		0.2112	0.4916	1
Echinococcus multilocularis	isocitrate dehydrogenase	0.0019	0.0000073171	0.0000073171
Echinococcus multilocularis	cathepsin b	0.4277	1	1
Giardia lamblia	Hypothetical protein	0.0485	0.1095	0.2841
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0485	0.1095	0.1095
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Entamoeba histolytica	cysteine protease, putative	0.2112	0.4916	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0029	0.0024	0.0024
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0029	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.2112	0.4916	0.4916
Brugia malayi	hypothetical protein	0.0029	0.0024	0.0024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0485	0.1095	0.219
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0029	0.0024	0.0024
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Echinococcus granulosus	serine threonine protein kinase nrc	0.002	0.0003	0.0003
Brugia malayi	Papain family cysteine protease containing protein	0.2112	0.4916	0.4916
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2112	0.4916	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1145	0.2644	0.2644
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0485	0.1095	0.219
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0029	0.0024	0.0024
Brugia malayi	hypothetical protein	0.002	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.1453	0.3367	0.3367
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4277	1	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.066	0.1504	0.1504
Entamoeba histolytica	cysteine protease, putative	0.1145	0.2644	0.5376
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0029	0.0024	0.0024
Leishmania major	cathepsin L-like protease	0.2112	0.4916	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Schistosoma mansoni	protein tyrosine phosphatase	0.0029	0.0024	0.0024
Brugia malayi	MH2 domain containing protein	0.012	0.0236	0.0236
Giardia lamblia	Cathepsin B precursor	0.1658	0.3849	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0485	0.1095	0.2228
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2112	0.4916	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1453	0.3367	0.3367
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0029	0.0024	0.0024
Onchocerca volvulus		0.0182	0.0384	0.0735
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0485	0.1095	0.2228
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0029	0.0024	0.0024
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0029	0.0024	0.0024
Schistosoma mansoni	cathepsin F (C01 family)	0.2112	0.4916	0.4916
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2112	0.4916	0.4916
Echinococcus granulosus	cathepsin L	0.1145	0.2644	0.2644
Brugia malayi	Papain family cysteine protease containing protein	0.1145	0.2644	0.2644
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0029	0.0024	0.0024
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2112	0.4916	1
Echinococcus multilocularis	cathepsin L	0.1145	0.2644	0.2644
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Schistosoma mansoni	protein tyrosine phosphatase	0.0029	0.0024	0.0024
Loa Loa (eye worm)	cathepsin B	0.1658	0.3849	0.3849
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0029	0.0024	0.0024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2112	0.4916	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0485	0.1095	0.219
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0485	0.1095	0.2224
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0485	0.1095	0.219
Onchocerca volvulus	Cathepsin F homolog	0.2112	0.4916	1
Schistosoma mansoni	cathepsin C	0.0485	0.1095	0.1095
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.4277	1	1
Entamoeba histolytica	cysteine protease, putative	0.1145	0.2644	0.5376
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0485	0.1095	0.219
Echinococcus granulosus	cathepsin l1	0.2112	0.4916	0.4916
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1145	0.2644	0.2644
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Giardia lamblia	Encystation-specific protease	0.0485	0.1095	0.2841
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0485	0.1095	0.1095
Echinococcus granulosus	nervana 2	0.002	0.0002	0.0002
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0485	0.1095	0.2841
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2112	0.4916	1
Brugia malayi	hypothetical protein	0.0029	0.0024	0.0024
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0029	0.0024	0.0044
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.2112	0.4916	0.4916
Plasmodium vivax	unspecified product	0.0485	0.1095	0.2228
Leishmania major	cathepsin L-like protease	0.2112	0.4916	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2112	0.4916	1
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.0031	0.0014
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0024	0.0024
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0485	0.1095	0.1095
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0485	0.1095	0.2228
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0032	0.0031	0.0063
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0029	0.0024	0.0024
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0485	0.1095	0.1095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2112	0.4916	1
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0029	0.0024	0.0024
Entamoeba histolytica	cysteine protease, putative	0.1145	0.2644	0.5376
Brugia malayi	Cathepsin L-like precursor	0.2112	0.4916	0.4916
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2112	0.4916	1
Leishmania major	tyrosine specific protein phosphatase, putative	0.0029	0.0024	0.0049
Entamoeba histolytica	cysteine proteinase, putative	0.1145	0.2644	0.5376
Brugia malayi	hypothetical protein	0.0029	0.0024	0.0024
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0485	0.1095	0.2228
Entamoeba histolytica	cysteine protease, putative	0.0485	0.1095	0.2224
Echinococcus multilocularis	cysteine protease	0.2112	0.4916	0.4916
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0485	0.1095	0.1095
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.1145	0.2644	0.2644
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Echinococcus granulosus	nervana 2	0.002	0.0002	0.0002
Brugia malayi	cathepsin L-like precursor	0.1453	0.3367	0.3367
Toxoplasma gondii	cathepsin CPL	0.2112	0.4916	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0024	0.0024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2112	0.4916	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0024	0.0024
Entamoeba histolytica	cysteine proteinase, putative	0.1145	0.2644	0.5376
Loa Loa (eye worm)	fibroinase	0.2112	0.4916	0.4916
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0029	0.0024	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0029	0.0024	0.0024
Entamoeba histolytica	cysteine protease, putative	0.1145	0.2644	0.5376
Entamoeba histolytica	cysteine protease, putative	0.0485	0.1095	0.2224
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0029	0.0024	0.0024
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0029	0.0024	0.0024
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0485	0.1095	0.219
Onchocerca volvulus	Cathepsin L homolog	0.2112	0.4916	1
Giardia lamblia	Protein tyrosine phosphatase	0.0029	0.0024	0.0056
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1145	0.2644	0.5379
Echinococcus granulosus	cathepsin L	0.0485	0.1095	0.1095
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.0031	0.0014
Schistosoma mansoni	serine/threonine-protein kinase	0.0022	0.0007	0.0007
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0029	0.0024	0.0049
Brugia malayi	Cathepsin L-like precursor	0.2112	0.4916	0.4916
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1156	0.267	0.267
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2112	0.4916	1
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0029	0.0024	0.0044
Giardia lamblia	Cysteine protease	0.0485	0.1095	0.2841
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0000073171	0.0000073171
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2112	0.4916	1
Echinococcus granulosus	serine/threonine protein kinase	0.0022	0.0007	0.0007
Giardia lamblia	Cysteine protease	0.0485	0.1095	0.2841
Echinococcus granulosus	cathepsin l1	0.1453	0.3367	0.3367
Brugia malayi	Cathepsin L-like precursor	0.2112	0.4916	0.4916
Schistosoma mansoni	hypothetical protein	0.017	0.0354	0.0354
Echinococcus multilocularis	cathepsin L cysteine protease	0.2112	0.4916	0.4916
Leishmania major	cathepsin L-like protease	0.2112	0.4916	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0024	0.0024
Brugia malayi	Papain family cysteine protease containing protein	0.0485	0.1095	0.1095
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.1658	0.3849	0.7819
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2112	0.4916	1
Brugia malayi	Papain family cysteine protease containing protein	0.1145	0.2644	0.2644
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0029	0.0024	0.0024
Leishmania major	cathepsin L-like protease	0.2112	0.4916	1
Trypanosoma cruzi	cysteine peptidase, putative	0.2112	0.4916	0.4916
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2112	0.4916	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.066	0.1504	0.1504
Entamoeba histolytica	cysteine proteinase, putative	0.1453	0.3367	0.6848
Brugia malayi	p70 ribosomal S6 kinase beta	0.003	0.0026	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2112	0.4916	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0485	0.1095	0.2228
Brugia malayi	Protein-tyrosine phosphatase	0.0029	0.0024	0.0024
Toxoplasma gondii	cathepsin CPC2	0.0485	0.1095	0.2228
Trypanosoma brucei	cysteine peptidase C (CPC)	0.1658	0.3849	0.783
Brugia malayi	Isocitrate dehydrogenase	0.0019	0.0000073171	0.0000073171
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0029	0.0024	0.0024
Onchocerca volvulus		0.2112	0.4916	1
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0019	0.0000073171	0.0000073171
Trichomonas vaginalis	AGC family protein kinase	0.0032	0.0031	0.0014
Entamoeba histolytica	cysteine proteinase 2	0.1145	0.2644	0.5376
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1658	0.3849	0.3849
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.2112	0.4916	1
Plasmodium vivax	vivapain-1	0.1145	0.2644	0.5379
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.003	0.0026	0.0026
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0485	0.1095	0.1095
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0029	0.0024	0.0024
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0029	0.0024	0.0024
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1658	0.3849	0.3849
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0029	0.0024	0.0024
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0029	0.0024	0.0024
Giardia lamblia	Cathepsin B precursor	0.0485	0.1095	0.2841
Schistosoma mansoni	cathepsin s	0.066	0.1504	0.1504
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0029	0.0024	0.0024
Entamoeba histolytica	cysteine protease, putative	0.1145	0.2644	0.5376
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0384	0.0384
Trichomonas vaginalis	conserved hypothetical protein	0.0485	0.1095	0.219
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1145	0.2644	0.5356
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0029	0.0024	0.0024
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0029	0.0024	0.0024
Echinococcus multilocularis	cathepsin b	0.4277	1	1
Giardia lamblia	Cathepsin L-like protease	0.0485	0.1095	0.2841
Plasmodium falciparum	serine repeat antigen 8	0.0485	0.1095	0.2228
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1156	0.267	0.267
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0029	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0024	0.0024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0485	0.1095	0.219
Leishmania major	hypothetical protein, conserved	0.003	0.0027	0.0054
Loa Loa (eye worm)	hypothetical protein	0.1453	0.3367	0.3367
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0029	0.0024	0.0024
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0029	0.0024	0.0024
Echinococcus granulosus	Glutaredoxin protein 5	0.002	0.0002	0.0002
Onchocerca volvulus		0.2112	0.4916	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0485	0.1095	0.1095
Leishmania major	cathepsin L-like protease	0.2112	0.4916	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0485	0.1095	0.2841
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0029	0.0024	0.0024
Echinococcus multilocularis	rac serine:threonine kinase	0.0022	0.0007	0.0007

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.5119 uM	PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.2643 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.9811 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1986846

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1630328