TDR Targets

Basic information

Technical information

TDR Targets ID: 1630334
Name: 4-[4-(4-methoxyphenyl)-5-[(3-phenyl-1,2,4-oxa diazol-5-yl)methylsulfanyl]-1,2,4-triazol-3-y l]pyridine
MW: 442.493 | Formula: C23H18N6O2S
H donors: 0 H acceptors: 5 LogP: 3.9 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)n1c(SCc2onc(n2)c2ccccc2)nnc1c1ccncc1
InChi: 1S/C23H18N6O2S/c1-30-19-9-7-18(8-10-19)29-22(17-11-13-24-14-12-17)26-27-23(29)32-15-20-25-21(28-31-20)16-5-3-2-4-6-16/h2-14H,15H2,1H3
InChiKey: OPXUZDOALWXAIC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[4-(4-methoxyphenyl)-5-[(3-phenyl-1,2,4-oxadiazol-5-yl)methylthio]-1,2,4-triazol-3-yl]pyridine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	wingless-type MMTV integration site family, member 3A	Starlite/ChEMBL	References
Homo sapiens	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	Starlite/ChEMBL	References
Homo sapiens	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	tnks protein	Get druggable targets OG5_131205	All targets in OG5_131205
Theileria parva	hypothetical protein	Get druggable targets OG5_131205	All targets in OG5_131205
Schistosoma japonicum	Tankyrase-1, putative	Get druggable targets OG5_131205	All targets in OG5_131205
Schistosoma mansoni	tankyrase	Get druggable targets OG5_131205	All targets in OG5_131205
Brugia malayi	Tnks protein	Get druggable targets OG5_131205	All targets in OG5_131205
Echinococcus multilocularis	tankyrase	Get druggable targets OG5_131205	All targets in OG5_131205
Echinococcus granulosus	tankyrase	Get druggable targets OG5_131205	All targets in OG5_131205
Onchocerca volvulus	Tankyrase homolog	Get druggable targets OG5_131205	All targets in OG5_131205
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131205	All targets in OG5_131205
Schistosoma japonicum	ko:K00774 NAD ADP-ribosyltransferase [EC2.4.2.30], putative	Get druggable targets OG5_131205	All targets in OG5_131205

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Wnt-2 protein precursor	wingless-type MMTV integration site family, member 3A	352 aa	355 aa	39.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	WNT	0.0016	0.0035	0.0035
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.0024	0.0054	0.0054
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0451	0.1114	0.1114
Entamoeba histolytica	cysteine protease, putative	0.1061	0.2628	0.5421
Loa Loa (eye worm)	tnks protein	0.0154	0.0377	0.0377
Echinococcus multilocularis	liprin beta 1	0.0015	0.0031	0.0031
Echinococcus multilocularis	protein Wnt 1	0.0016	0.0035	0.0035
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0003	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.1346	0.3334	0.3334
Brugia malayi	wnt family protein	0.0016	0.0035	0.0035
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0451	0.1114	0.2298
Leishmania major	cathepsin L-like protease	0.1955	0.4848	1
Schistosoma mansoni	lar interacting protein (lip)-related protein	0.0015	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.061	0.1508	0.1508
Schistosoma mansoni	hypothetical protein	0.0015	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.4031	1	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0451	0.1114	0.2248
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0054	0.0112
Giardia lamblia	Cathepsin B precursor	0.0451	0.1114	0.2884
Plasmodium vivax	serine-repeat antigen (SERA)	0.0451	0.1114	0.2248
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0003	0.0001	0.0001
Leishmania major	cathepsin L-like protease	0.1955	0.4848	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1061	0.2628	0.5421
Echinococcus granulosus	Protein Wnt-04	0.0016	0.0035	0.0035
Brugia malayi	wnt family protein	0.0016	0.0035	0.0035
Onchocerca volvulus	Cathepsin L homolog	0.0451	0.1114	0.2298
Onchocerca volvulus		0.1955	0.4848	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0451	0.1114	0.2884
Brugia malayi	Tnks protein	0.0168	0.041	0.041
Brugia malayi	fibroinase precursor	0.0451	0.1114	0.1114
Echinococcus multilocularis	cathepsin L cysteine protease	0.1955	0.4848	0.4848
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0451	0.1114	0.2298
Trypanosoma cruzi	major cysteine proteinase, putative	0.0451	0.1114	0.1114
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1558	0.3862	0.3862
Brugia malayi	Patatin-like phospholipase family protein	0.0003	0.0001	0.0001
Brugia malayi	Cathepsin L-like precursor	0.1955	0.4848	0.4848
Trichomonas vaginalis	unc-44 ankyrins, putative	0.0003	0.0001	0.0001
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0451	0.1114	0.1114
Echinococcus granulosus	sterile alpha and tir motif containing protein	0.0015	0.0031	0.0031
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0003	0.0001	0.0001
Brugia malayi	Cathepsin L-like precursor	0.1955	0.4848	0.4848
Schistosoma mansoni	cathepsin F (C01 family)	0.1955	0.4848	0.4848
Brugia malayi	wnt family protein	0.0016	0.0035	0.0035
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1955	0.4848	1
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0451	0.1114	0.2248
Entamoeba histolytica	cysteine protease, putative	0.1061	0.2628	0.5421
Onchocerca volvulus	Tankyrase homolog	0.0152	0.0371	0.0765
Trypanosoma brucei	poly(adp-ribose) polymerase	0.0024	0.0054	0.0112
Giardia lamblia	Cathepsin L precursor	0.0451	0.1114	0.2884
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0451	0.1114	0.1114
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0451	0.1114	0.2248
Plasmodium falciparum	serine repeat antigen 8	0.0451	0.1114	0.2248
Entamoeba histolytica	cysteine protease, putative	0.0451	0.1114	0.2298
Plasmodium vivax	unspecified product	0.0451	0.1114	0.2248
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0003	0.0001	0.0001
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.4031	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.1955	0.4848	0.4848
Trichomonas vaginalis	ankyrin, putative	0.0003	0.0001	0.0001
Leishmania major	cathepsin L-like protease	0.1955	0.4848	1
Loa Loa (eye worm)	Wnt2 protein	0.0016	0.0035	0.0035
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0451	0.1114	0.2248
Entamoeba histolytica	hypothetical protein	0.0451	0.1114	0.2298
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0003	0.0002	0.0005
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1558	0.3862	0.3862
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1955	0.4848	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1955	0.4848	0.4848
Giardia lamblia	Cysteine protease	0.0451	0.1114	0.2884
Brugia malayi	cathepsin L-like precursor	0.1346	0.3334	0.3334
Plasmodium falciparum	serine repeat antigen 1	0.0451	0.1114	0.2248
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.1558	0.3862	0.7967
Giardia lamblia	Cathepsin L-like protease	0.0451	0.1114	0.2884
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.061	0.1508	0.1508
Echinococcus multilocularis	cysteine protease	0.1955	0.4848	0.4848
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1955	0.4848	1
Schistosoma mansoni	wnt related	0.0016	0.0035	0.0035
Entamoeba histolytica	cysteine protease, putative	0.1061	0.2628	0.5421
Brugia malayi	cathepsin L-like cysteine proteinase	0.0451	0.1114	0.1114
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0001	0.0001
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0451	0.1114	0.2298
Brugia malayi	WGR domain containing protein	0.0024	0.0054	0.0054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1955	0.4848	1
Plasmodium vivax	vivapain-1	0.1061	0.2628	0.5391
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1955	0.4848	1
Entamoeba histolytica	hypothetical protein	0.0024	0.0054	0.0112
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1061	0.2628	0.2628
Leishmania major	cathepsin L-like protease	0.1955	0.4848	1
Schistosoma mansoni	cathepsin s	0.061	0.1508	0.1508
Echinococcus granulosus	Protein Wnt-11b	0.0016	0.0035	0.0035
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.1558	0.3862	0.7967
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1061	0.2628	0.5421
Schistosoma mansoni	cathepsin B (C01 family)	0.0451	0.1114	0.1114
Entamoeba histolytica	cysteine proteinase, putative	0.1346	0.3334	0.6878
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1955	0.4848	0.4848
Echinococcus granulosus	tankyrase	0.0169	0.0414	0.0414
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1955	0.4848	1
Brugia malayi	Uncoordinated protein 44	0.0002	0.0000061497	0.0000061497
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0024	0.0054	0.0054
Onchocerca volvulus	Cathepsin L homolog	0.1955	0.4848	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1955	0.4848	0.4848
Leishmania major	cathepsin L-like protease	0.1955	0.4848	1
Echinococcus granulosus	26S proteasome non ATPase regulatory subunit 10	0.0002	0.0000061497	0.0000061497
Echinococcus multilocularis	cathepsin L	0.1061	0.2628	0.2628
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0031	0.0065
Trypanosoma cruzi	cysteine peptidase, putative	0.1955	0.4848	0.4848
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1955	0.4848	0.4848
Entamoeba histolytica	cysteine protease, putative	0.1061	0.2628	0.5421
Brugia malayi	Papain family cysteine protease containing protein	0.0451	0.1114	0.1114
Onchocerca volvulus		0.0015	0.0031	0.0065
Trypanosoma brucei	cysteine peptidase C (CPC)	0.1558	0.3862	0.7967
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0003	0.0001	0.0001
Brugia malayi	WGR domain containing protein	0.0024	0.0054	0.0054
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1955	0.4848	1
Loa Loa (eye worm)	toll and interleukin 1 receptor domain-containing protein isoform f	0.0015	0.0031	0.0031
Brugia malayi	Cathepsin L-like precursor	0.1955	0.4848	0.4848
Entamoeba histolytica	cysteine proteinase 2	0.1061	0.2628	0.5421
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0451	0.1114	0.2248
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1955	0.4848	1
Trypanosoma cruzi	cysteine proteinase, putative	0.1061	0.2628	0.2628
Loa Loa (eye worm)	hypothetical protein	0.0451	0.1114	0.1114
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0054	0.0112
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1955	0.4848	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1955	0.4848	1
Trichomonas vaginalis	ankyrin, putative	0.0003	0.0001	0.0001
Echinococcus granulosus	cathepsin l1	0.1346	0.3334	0.3334
Onchocerca volvulus		0.0015	0.0031	0.0065
Entamoeba histolytica	hypothetical protein	0.0024	0.0054	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0054	0.0054
Brugia malayi	coiled-coil like protein 1	0.0015	0.0031	0.0031
Trypanosoma cruzi	major cysteine proteinase, putative	0.0451	0.1114	0.1114
Entamoeba histolytica	cysteine protease, putative	0.1061	0.2628	0.5421
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0035	0.0035
Echinococcus granulosus	Protein Wnt-111	0.0016	0.0035	0.0035
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1955	0.4848	0.4848
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.4031	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0451	0.1114	0.1114
Onchocerca volvulus		0.1955	0.4848	1
Giardia lamblia	Cysteine protease	0.0451	0.1114	0.2884
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1955	0.4848	1
Echinococcus multilocularis	protein Wnt 2	0.0016	0.0035	0.0035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1346	0.3334	0.6878
Onchocerca volvulus	Cathepsin L homolog	0.1955	0.4848	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1955	0.4848	1
Brugia malayi	Liprin-alpha 2	0.0015	0.0031	0.0031
Entamoeba histolytica	cysteine proteinase, putative	0.1955	0.4848	1
Entamoeba histolytica	cysteine proteinase, putative	0.1061	0.2628	0.5421
Echinococcus multilocularis	SAM domain containing protein	0.0015	0.0031	0.0031
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0451	0.1114	0.2884
Brugia malayi	Cathepsin L-like precursor	0.1955	0.4848	0.4848
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0054	0.0112
Entamoeba histolytica	cysteine proteinase, putative	0.1061	0.2628	0.5421
Brugia malayi	Papain family cysteine protease containing protein	0.1955	0.4848	0.4848
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0451	0.1114	0.2298
Echinococcus multilocularis	sterile alpha and tir motif containing protein	0.0015	0.0031	0.0031
Giardia lamblia	Cathepsin L precursor	0.0451	0.1114	0.2884
Giardia lamblia	Cathepsin L precursor	0.0451	0.1114	0.2884
Brugia malayi	Papain family cysteine protease containing protein	0.0451	0.1114	0.1114
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1955	0.4848	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0031	0.0065
Loa Loa (eye worm)	hypothetical protein	0.061	0.1508	0.1508
Giardia lamblia	Cathepsin B precursor	0.0451	0.1114	0.2884
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0024	0.0054	0.0054
Brugia malayi	cathepsin F-like cysteine proteinase	0.0451	0.1114	0.1114
Trypanosoma cruzi	cruzipain precursor, putative	0.1955	0.4848	0.4848
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.061	0.1508	0.1508
Schistosoma mansoni	cathepsin C	0.0451	0.1114	0.1114
Entamoeba histolytica	cysteine proteinase, putative	0.1061	0.2628	0.5421
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1955	0.4848	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0451	0.1114	0.2298
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1955	0.4848	1
Echinococcus granulosus	protein Wnt 1	0.0016	0.0035	0.0035
Echinococcus granulosus	liprin alpha 2	0.0015	0.0031	0.0031
Schistosoma mansoni	hypothetical protein	0.0015	0.0031	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0031	0.0065
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0003	0.0001	0.0001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1955	0.4848	1
Entamoeba histolytica	cysteine protease, putative	0.0451	0.1114	0.2298
Plasmodium vivax	unspecified product	0.1061	0.2628	0.5391
Entamoeba histolytica	cysteine protease, putative	0.1955	0.4848	1
Loa Loa (eye worm)	hypothetical protein	0.061	0.1508	0.1508
Brugia malayi	hypothetical protein	0.0015	0.0031	0.0031
Trichomonas vaginalis	protein phosphatase 1 regulatory subunit 12C, putative	0.0003	0.0001	0.0001
Schistosoma mansoni	wnt related	0.0016	0.0035	0.0035
Brugia malayi	Wnt-4 protein precursor	0.0016	0.0035	0.0035
Plasmodium falciparum	cysteine proteinase falcipain 1	0.1061	0.2628	0.5391
Echinococcus granulosus	cathepsin l1	0.1955	0.4848	0.4848
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0451	0.1114	0.2248
Schistosoma mansoni	cathepsin S (C01 family)	0.0451	0.1114	0.1114
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0451	0.1114	0.2884
Loa Loa (eye worm)	hypothetical protein	0.1346	0.3334	0.3334
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1955	0.4848	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1955	0.4848	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0451	0.1114	0.2248
Entamoeba histolytica	cysteine protease, putative	0.1061	0.2628	0.5421
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0003	0.0001	0.0001
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1955	0.4848	0.4848
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1061	0.2628	0.5421
Leishmania major	huntingtin interacting protein (HIP), putative	0.0003	0.0001	0.0001
Echinococcus multilocularis	26S proteasome non ATPase regulatory subunit 10	0.0002	0.0000061497	0.0000061497
Entamoeba histolytica	cysteine protease, putative	0.1061	0.2628	0.5421
Giardia lamblia	Cathepsin L precursor	0.0451	0.1114	0.2884
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1061	0.2628	0.2628
Entamoeba histolytica	hypothetical protein	0.0024	0.0054	0.0112
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.0024	0.0054	0.0112
Giardia lamblia	Cathepsin L precursor	0.0451	0.1114	0.2884
Brugia malayi	Neurabin protein 1	0.0015	0.0031	0.0031
Entamoeba histolytica	hypothetical protein	0.0024	0.0054	0.0112
Entamoeba histolytica	cysteine protease, putative	0.0451	0.1114	0.2298
Plasmodium vivax	vivapain-3	0.1061	0.2628	0.5391
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1955	0.4848	1
Entamoeba histolytica	cysteine protease, putative	0.0451	0.1114	0.2298
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0024	0.0054	0.0054
Onchocerca volvulus		0.1955	0.4848	1
Plasmodium falciparum	serine repeat antigen 4	0.0451	0.1114	0.2248
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1955	0.4848	1
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0054	0.0112
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4031	1	1
Echinococcus granulosus	cathepsin L	0.1061	0.2628	0.2628
Loa Loa (eye worm)	hypothetical protein	0.0451	0.1114	0.1114
Loa Loa (eye worm)	ctsf protein	0.1955	0.4848	0.4848
Loa Loa (eye worm)	hypothetical protein	0.0451	0.1114	0.1114
Onchocerca volvulus		0.1955	0.4848	1
Giardia lamblia	Cathepsin B precursor	0.0451	0.1114	0.2884
Onchocerca volvulus		0.1955	0.4848	1
Entamoeba histolytica	cysteine protease, putative	0.1061	0.2628	0.5421
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0451	0.1114	0.2298
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.1061	0.2628	0.2628
Leishmania major	cathepsin L-like protease	0.1955	0.4848	1
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0451	0.1114	0.2298
Entamoeba histolytica	cysteine proteinase 1, putative	0.1061	0.2628	0.5421
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1955	0.4848	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1955	0.4848	1
Onchocerca volvulus	Cathepsin F homolog	0.1955	0.4848	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1346	0.3334	0.3334
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0024	0.0054	0.0054
Brugia malayi	cathepsin L precursor	0.0451	0.1114	0.1114
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1955	0.4848	1
Giardia lamblia	Cathepsin B precursor	0.1558	0.3862	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1061	0.2628	0.2628
Loa Loa (eye worm)	CWN-2 protein	0.0016	0.0035	0.0035
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0003	0.0002	0.0003
Echinococcus multilocularis	wnt family member wnt11 2	0.0016	0.0035	0.0035
Entamoeba histolytica	cysteine protease, putative	0.0451	0.1114	0.2298
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0451	0.1114	0.1114
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0003	0.0001	0.0001
Leishmania major	cathepsin L-like protease	0.1955	0.4848	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1061	0.2628	0.2628
Trichomonas vaginalis	unc-44 ankyrins, putative	0.0003	0.0001	0.0001
Loa Loa (eye worm)	Notch2	0.0002	0.0000061457	0.0000061457
Trichomonas vaginalis	conserved hypothetical protein	0.0451	0.1114	0.2298
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1955	0.4848	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0031	0.0031
Brugia malayi	Cathepsin L-like precursor	0.1955	0.4848	0.4848
Entamoeba histolytica	cysteine protease, putative	0.1061	0.2628	0.5421
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1955	0.4848	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0451	0.1114	0.1114
Trypanosoma cruzi	cysteine protease, putative	0.1061	0.2628	0.2628
Entamoeba histolytica	cysteine proteinase, putative	0.1955	0.4848	1
Giardia lamblia	Cathepsin B precursor	0.1558	0.3862	1
Plasmodium falciparum	serine repeat antigen 3	0.0451	0.1114	0.2248
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1955	0.4848	1
Toxoplasma gondii	cathepsin CPC2	0.0451	0.1114	0.2298
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0451	0.1114	0.2298
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1346	0.3334	0.3334
Brugia malayi	Papain family cysteine protease containing protein	0.0451	0.1114	0.1114
Trypanosoma cruzi	palmitoyl acyltransferase 1, putative	0.0003	0.0001	0.0001
Echinococcus multilocularis	cathepsin b	0.4031	1	1
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0024	0.0054	0.0054
Trypanosoma cruzi	cysteine peptidase, putative	0.1955	0.4848	0.4848
Schistosoma mansoni	ankyrin 23/unc44	0.0003	0.0001	0.0001
Schistosoma mansoni	sarm1	0.0015	0.0031	0.0031
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1955	0.4848	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0003	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0031	0.0031
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0451	0.1114	0.1114
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0003	0.0001	0.0001
Brugia malayi	Cathepsin L-like precursor	0.1346	0.3334	0.3334
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0451	0.1114	0.2248
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0451	0.1114	0.2298
Trypanosoma cruzi	cruzipain precursor, putative	0.061	0.1508	0.1508
Toxoplasma gondii	cathepsin B	0.1558	0.3862	0.7967
Entamoeba histolytica	cysteine protease, putative	0.1061	0.2628	0.5421
Schistosoma mansoni	hypothetical protein	0.0015	0.0031	0.0031
Echinococcus multilocularis	Ankyrin	0.0003	0.0001	0.0001
Trypanosoma cruzi	cysteine peptidase, putative	0.1955	0.4848	0.4848
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1346	0.3334	0.6878
Giardia lamblia	Kinase, NEK	0.0003	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0311	0.0311
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0054	0.0112
Plasmodium falciparum	serine repeat antigen 2	0.0451	0.1114	0.2248
Onchocerca volvulus		0.1346	0.3334	0.6878
Schistosoma mansoni	hypothetical protein	0.0015	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0031	0.0031
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.0024	0.0054	0.0054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0451	0.1114	0.1114
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0451	0.1114	0.2298
Entamoeba histolytica	cysteine protease, putative	0.1061	0.2628	0.5421
Giardia lamblia	Cathepsin B precursor	0.1558	0.3862	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0451	0.1114	0.1114
Echinococcus granulosus	cysteine protease	0.1061	0.2628	0.2628
Onchocerca volvulus		0.1955	0.4848	1
Brugia malayi	hypothetical protein	0.0015	0.0031	0.0031
Trypanosoma cruzi	cysteine peptidase, putative	0.061	0.1508	0.1508
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0451	0.1114	0.2298
Echinococcus granulosus	Ankyrin	0.0003	0.0001	0.0001
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0451	0.1114	0.1114
Leishmania major	cysteine peptidase A (CPA)	0.1955	0.4848	1
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0003	0.0001	0.0001
Trichomonas vaginalis	2-5A-dependent ribonuclease, putative	0.0003	0.0001	0.0001
Entamoeba histolytica	cysteine protease, putative	0.1061	0.2628	0.5421
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1955	0.4848	1
Schistosoma mansoni	wnt related	0.0016	0.0035	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0031	0.0065
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.0024	0.0054	0.0054
Brugia malayi	Papain family cysteine protease containing protein	0.1061	0.2628	0.2628
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0451	0.1114	0.2298
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.1346	0.3334	0.3334
Echinococcus multilocularis	cathepsin b	0.4031	1	1
Loa Loa (eye worm)	hypothetical protein	0.0451	0.1114	0.1114
Schistosoma mansoni	lip-related protein (liprin) alpha	0.0015	0.0031	0.0031
Echinococcus multilocularis	stromal interaction molecule 1	0.0015	0.0031	0.0031
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0451	0.1114	0.1114
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0451	0.1114	0.2298
Trypanosoma cruzi	cysteine proteinase, putative	0.1061	0.2628	0.2628
Giardia lamblia	Kinase, NEK	0.0003	0.0001	0.0002
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1955	0.4848	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1955	0.4848	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0451	0.1114	0.2884
Loa Loa (eye worm)	cysteine protease	0.1955	0.4848	0.4848
Echinococcus multilocularis	wingless type MMTV integration site family	0.0016	0.0035	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0054	0.0112
Brugia malayi	Wnt-2 protein precursor	0.0016	0.0035	0.0035
Echinococcus granulosus	stromal interaction molecule 1	0.0015	0.0031	0.0031
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0451	0.1114	0.2298
Entamoeba histolytica	cysteine protease, putative	0.1061	0.2628	0.5421
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0451	0.1114	0.2298
Plasmodium vivax	unspecified product	0.061	0.1508	0.3066
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0003	0.0001	0.0001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0451	0.1114	0.2298
Giardia lamblia	Cathepsin L-like protease	0.0451	0.1114	0.2884
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0003	0.0001	0.0001
Entamoeba histolytica	cysteine protease, putative	0.0451	0.1114	0.2298
Echinococcus multilocularis	liprin alpha 2	0.0015	0.0031	0.0031
Plasmodium falciparum	serine repeat antigen 5	0.0451	0.1114	0.2248
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1955	0.4848	1
Echinococcus granulosus	cathepsin b	0.4031	1	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0451	0.1114	0.2248
Brugia malayi	Cathepsin L-like precursor	0.1346	0.3334	0.3334
Brugia malayi	Cathepsin L-like precursor	0.061	0.1508	0.1508
Echinococcus multilocularis	cysteine protease	0.1955	0.4848	0.4848
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0451	0.1114	0.2298
Onchocerca volvulus		0.0451	0.1114	0.2298
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0451	0.1114	0.2248
Trichomonas vaginalis	ion channel nompc, putative	0.0003	0.0001	0.0001
Plasmodium falciparum	serine repeat antigen 6	0.0451	0.1114	0.2248
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0035	0.0035
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0003	0.0001	0.0001
Brugia malayi	sterile alpha and TIR motif containing protein 1 isoform a	0.0015	0.0031	0.0031
Entamoeba histolytica	zinc finger protein, putative	0.0024	0.0054	0.0112
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0024	0.0054	0.0054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1955	0.4848	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1955	0.4848	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0451	0.1114	0.2248
Echinococcus granulosus	poly adp ribose polymerase 2	0.0024	0.0054	0.0054
Plasmodium falciparum	serine repeat antigen 7	0.0451	0.1114	0.2248
Giardia lamblia	Encystation-specific protease	0.0451	0.1114	0.2884
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0451	0.1114	0.1114
Brugia malayi	Cathepsin L-like precursor	0.1955	0.4848	0.4848
Trypanosoma cruzi	palmitoyl acyltransferase 1, putative	0.0003	0.0001	0.0001
Echinococcus multilocularis	WNT	0.0016	0.0035	0.0035
Schistosoma mansoni	cathepsin F (C01 family)	0.1346	0.3334	0.3334
Loa Loa (eye worm)	hypothetical protein	0.0451	0.1114	0.1114
Brugia malayi	cathepsin F-like cysteine proteinase	0.061	0.1508	0.1508
Entamoeba histolytica	cysteine proteinase, putative	0.1061	0.2628	0.5421
Brugia malayi	Papain family cysteine protease containing protein	0.1061	0.2628	0.2628
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0054	0.0112
Giardia lamblia	Cathepsin B precursor	0.0451	0.1114	0.2884
Trichomonas vaginalis	multiple ankyrin repeats single kh domain protein, putative	0.0003	0.0001	0.0001
Toxoplasma gondii	cathepsin CPC1	0.0451	0.1114	0.2298
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0451	0.1114	0.2298
Giardia lamblia	Cathepsin L precursor	0.0451	0.1114	0.2884
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1955	0.4848	1
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0024	0.0054	0.0112
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0451	0.1114	0.2248
Echinococcus granulosus	SAM domain containing protein	0.0015	0.0031	0.0031
Echinococcus granulosus	protein Wnt 2	0.0016	0.0035	0.0035
Brugia malayi	wnt family protein	0.0016	0.0035	0.0035
Schistosoma mansoni	tankyrase	0.0169	0.0414	0.0414
Echinococcus granulosus	cathepsin L cysteine protease	0.1061	0.2628	0.2628
Leishmania major	cathepsin L-like protease	0.1955	0.4848	1
Loa Loa (eye worm)	fibroinase	0.1955	0.4848	0.4848
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0451	0.1114	0.2298
Echinococcus multilocularis	tankyrase	0.0169	0.0414	0.0414
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1955	0.4848	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0003	0.0002	0.0003
Trypanosoma brucei	palmitoyl acyltransferase 1, putative	0.0003	0.0001	0.0001
Giardia lamblia	Cysteine protease	0.0451	0.1114	0.2884
Echinococcus granulosus	Sterile alpha motif SAM	0.0015	0.0031	0.0031
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1955	0.4848	1
Plasmodium vivax	vivapain-2	0.1955	0.4848	1
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0451	0.1114	0.2248
Echinococcus granulosus	cathepsin L	0.0451	0.1114	0.1114
Echinococcus granulosus	liprin beta 1	0.0015	0.0031	0.0031
Trypanosoma cruzi	cysteine peptidase, putative	0.1955	0.4848	0.4848
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4031	1	1
Loa Loa (eye worm)	cathepsin B	0.1558	0.3862	0.3862
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0054	0.0112
Onchocerca volvulus		0.1955	0.4848	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1955	0.4848	0.4848
Schistosoma mansoni	wnt related	0.0016	0.0035	0.0035
Giardia lamblia	Hypothetical protein	0.0451	0.1114	0.2884
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0451	0.1114	0.2298
Loa Loa (eye worm)	hypothetical protein	0.1955	0.4848	0.4848
Loa Loa (eye worm)	wnt-4 protein	0.0016	0.0035	0.0035
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1955	0.4848	1
Toxoplasma gondii	cathepsin CPL	0.1955	0.4848	1
Loa Loa (eye worm)	hypothetical protein	0.0451	0.1114	0.1114
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0035	0.0035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1955	0.4848	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0015	0.0031	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0031	0.0031
Echinococcus multilocularis	cathepsin L	0.0451	0.1114	0.1114
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0451	0.1114	0.1114
Plasmodium vivax	vivapain-2	0.1955	0.4848	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1061	0.2628	0.5421
Giardia lamblia	Hypothetical protein	0.0451	0.1114	0.2884
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0451	0.1114	0.1114
Echinococcus granulosus	cathepsin b	0.4031	1	1
Giardia lamblia	Cysteine protease	0.0451	0.1114	0.2884
Trichomonas vaginalis	c2h2 zinc finger protein, putative	0.0015	0.0031	0.0065
Schistosoma mansoni	wnt-5	0.0016	0.0035	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.0054	0.0112
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0451	0.1114	0.2248
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0451	0.1114	0.1114
Echinococcus granulosus	Protein Wnt-5	0.0016	0.0035	0.0035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1955	0.4848	1
Plasmodium falciparum	serine repeat antigen 9	0.0451	0.1114	0.2248
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4031	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0035	0.0035
Giardia lamblia	Cathepsin B precursor	0.0451	0.1114	0.2884
Trichomonas vaginalis	conserved hypothetical protein	0.0451	0.1114	0.2298

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.272 uM	Inhibition of GST-tagged TNKS2P catalytic domain autoPARsylation measuring nicotinamide concentration after 2 hrs by LC-MS analysis	ChEMBL.	22260203
IC50 (binding)	= 1.01 uM	Inhibition of GST-tagged TNKS1P catalytic domain autoPARsylation measuring nicotinamide concentration after 2 hrs by LC-MS analysis	ChEMBL.	22260203
IC50 (binding)	= 1.06 uM	Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assay	ChEMBL.	22260203

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2016634

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1630334