TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 426.494 | Formula: C23H18N6OS
H donors: 0 H acceptors: 5 LogP: 4.3 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)n1c(SCc2onc(n2)c2ccccc2)nnc1c1ccncc1
InChi: 1S/C23H18N6OS/c1-16-7-9-19(10-8-16)29-22(18-11-13-24-14-12-18)26-27-23(29)31-15-20-25-21(28-30-20)17-5-3-2-4-6-17/h2-14H,15H2,1H3
InChiKey: CXBQBYIAXNRWLH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Theileria parva	hypothetical protein	Get druggable targets OG5_131205	All targets in OG5_131205
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131205	All targets in OG5_131205
Schistosoma mansoni	tankyrase	Get druggable targets OG5_131205	All targets in OG5_131205
Brugia malayi	Tnks protein	Get druggable targets OG5_131205	All targets in OG5_131205
Schistosoma japonicum	ko:K00774 NAD ADP-ribosyltransferase [EC2.4.2.30], putative	Get druggable targets OG5_131205	All targets in OG5_131205
Echinococcus granulosus	tankyrase	Get druggable targets OG5_131205	All targets in OG5_131205
Echinococcus multilocularis	tankyrase	Get druggable targets OG5_131205	All targets in OG5_131205
Onchocerca volvulus	Tankyrase homolog	Get druggable targets OG5_131205	All targets in OG5_131205
Schistosoma japonicum	Tankyrase-1, putative	Get druggable targets OG5_131205	All targets in OG5_131205
Loa Loa (eye worm)	tnks protein	Get druggable targets OG5_131205	All targets in OG5_131205

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Liprin-alpha 2	0.0008	0.0015	0.0015
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0497	0.1141	0.2265
Giardia lamblia	Cathepsin B precursor	0.0497	0.1141	0.2939
Brugia malayi	Cathepsin L-like precursor	0.0677	0.1555	0.1555
Echinococcus granulosus	cathepsin b	0.4345	1	1
Giardia lamblia	Cysteine protease	0.0497	0.1141	0.2939
Echinococcus granulosus	liprin alpha 2	0.0008	0.0015	0.0015
Onchocerca volvulus		0.1489	0.3426	0.6864
Echinococcus granulosus	Sterile alpha motif SAM	0.0008	0.0015	0.0015
Plasmodium falciparum	serine repeat antigen 1	0.0497	0.1141	0.2265
Loa Loa (eye worm)	fibroinase	0.2166	0.4984	0.4984
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0015	0.0015
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.0013	0.0027	0.0026
Plasmodium vivax	unspecified product	0.0497	0.1141	0.2265
Entamoeba histolytica	cysteine proteinase 2	0.1173	0.2699	0.539
Onchocerca volvulus	Tankyrase homolog	0.0081	0.0183	0.0338
Loa Loa (eye worm)	tnks protein	0.0082	0.0186	0.0186
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0497	0.1141	0.1141
Plasmodium vivax	serine-repeat antigen (SERA)	0.0497	0.1141	0.2265
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2166	0.4984	0.4984
Entamoeba histolytica	cysteine protease, putative	0.0497	0.1141	0.2247
Onchocerca volvulus	Cathepsin L homolog	0.2166	0.4984	1
Giardia lamblia	Cathepsin L precursor	0.0497	0.1141	0.2939
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0497	0.1141	0.1141
Entamoeba histolytica	cysteine protease, putative	0.1173	0.2699	0.539
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0015	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0015	0.0031
Echinococcus multilocularis	cathepsin L cysteine protease	0.2166	0.4984	0.4984
Brugia malayi	Cathepsin L-like precursor	0.2166	0.4984	0.4984
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2166	0.4984	1
Echinococcus multilocularis	sterile alpha and tir motif containing protein	0.0008	0.0015	0.0015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2166	0.4984	1
Brugia malayi	Papain family cysteine protease containing protein	0.0497	0.1141	0.1141
Giardia lamblia	Cathepsin B precursor	0.1687	0.3881	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0497	0.1141	0.1141
Giardia lamblia	Cysteine protease	0.0497	0.1141	0.2939
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.4345	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.2166	0.4984	1
Plasmodium falciparum	serine repeat antigen 2	0.0497	0.1141	0.2265
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0497	0.1141	0.1141
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0497	0.1141	0.1141
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0154	0.0154
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.0013	0.0027	0.0026
Plasmodium falciparum	serine repeat antigen 5	0.0497	0.1141	0.2265
Brugia malayi	Papain family cysteine protease containing protein	0.2166	0.4984	0.4984
Loa Loa (eye worm)	hypothetical protein	0.0497	0.1141	0.1141
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0677	0.1555	0.1555
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0497	0.1141	0.1141
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2166	0.4984	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.2166	0.4984	0.4984
Loa Loa (eye worm)	hypothetical protein	0.0497	0.1141	0.1141
Brugia malayi	Cathepsin L-like precursor	0.1489	0.3426	0.3426
Entamoeba histolytica	hypothetical protein	0.0497	0.1141	0.2247
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1489	0.3426	0.3408
Giardia lamblia	Hypothetical protein	0.0497	0.1141	0.2939
Schistosoma mansoni	hypothetical protein	0.0008	0.0015	0.0015
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2166	0.4984	1
Onchocerca volvulus	Cathepsin F homolog	0.2166	0.4984	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1173	0.2699	0.539
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0027	0.0053
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0497	0.1141	0.2265
Brugia malayi	WGR domain containing protein	0.0013	0.0027	0.0027
Onchocerca volvulus		0.2166	0.4984	1
Trypanosoma cruzi	cysteine proteinase, putative	0.1173	0.2699	0.2679
Echinococcus granulosus	cathepsin L	0.1173	0.2699	0.2699
Echinococcus granulosus	SAM domain containing protein	0.0008	0.0015	0.0015
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0497	0.1141	0.2289
Schistosoma mansoni	cathepsin s	0.0677	0.1555	0.1555
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0497	0.1141	0.2265
Toxoplasma gondii	cathepsin B	0.1687	0.3881	0.778
Onchocerca volvulus		0.2166	0.4984	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2166	0.4984	1
Leishmania major	cathepsin L-like protease	0.2166	0.4984	1
Echinococcus multilocularis	cysteine protease	0.2166	0.4984	0.4984
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.0013	0.0027	0.0026
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.2166	0.4984	1
Entamoeba histolytica	cysteine protease, putative	0.1173	0.2699	0.539
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0497	0.1141	0.2265
Entamoeba histolytica	cysteine proteinase, putative	0.1489	0.3426	0.6857
Schistosoma mansoni	tankyrase	0.009	0.0205	0.0205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2166	0.4984	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0015	0.0015
Trypanosoma brucei	cysteine peptidase C (CPC)	0.1687	0.3881	0.7775
Loa Loa (eye worm)	hypothetical protein	0.0677	0.1555	0.1555
Loa Loa (eye worm)	ctsf protein	0.2166	0.4984	0.4984
Plasmodium vivax	serine-repeat antigen (SERA)	0.0497	0.1141	0.2265
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1687	0.3881	0.3881
Echinococcus multilocularis	cathepsin L	0.1173	0.2699	0.2699
Entamoeba histolytica	cysteine protease, putative	0.1173	0.2699	0.539
Echinococcus multilocularis	cysteine protease	0.2166	0.4984	0.4984
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2166	0.4984	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2166	0.4984	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.2166	0.4984	0.4984
Onchocerca volvulus		0.2166	0.4984	1
Schistosoma mansoni	hypothetical protein	0.0008	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.1489	0.3426	0.3426
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0027	0.0053
Plasmodium falciparum	cysteine proteinase falcipain 1	0.1173	0.2699	0.5401
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0497	0.1141	0.1141
Brugia malayi	sterile alpha and TIR motif containing protein 1 isoform a	0.0008	0.0015	0.0015
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1173	0.2699	0.539
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0497	0.1141	0.2265
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2166	0.4984	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0015	0.0031
Trypanosoma cruzi	cysteine peptidase, putative	0.2166	0.4984	0.497
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2166	0.4984	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0497	0.1141	0.2289
Trichomonas vaginalis	ankyrin, putative	0.0001	0.0000030426	0.0000061052
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2166	0.4984	1
Echinococcus multilocularis	cathepsin b	0.4345	1	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0497	0.1141	0.2247
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1173	0.2699	0.2699
Brugia malayi	coiled-coil like protein 1	0.0008	0.0015	0.0015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0497	0.1141	0.2289
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0013	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2166	0.4984	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1489	0.3426	0.3426
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2166	0.4984	1
Schistosoma mansoni	cathepsin F (C01 family)	0.2166	0.4984	0.4984
Leishmania major	cathepsin L-like protease	0.2166	0.4984	1
Trypanosoma cruzi	cysteine protease, putative	0.1173	0.2699	0.2679
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2166	0.4984	1
Onchocerca volvulus		0.0008	0.0015	0.0000000039983
Trypanosoma cruzi	cysteine peptidase, putative	0.2166	0.4984	0.497
Plasmodium falciparum	serine repeat antigen 7	0.0497	0.1141	0.2265
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0027	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.0497	0.1141	0.2289
Brugia malayi	cathepsin F-like cysteine proteinase	0.0677	0.1555	0.1555
Plasmodium falciparum	serine repeat antigen 3	0.0497	0.1141	0.2265
Onchocerca volvulus		0.2166	0.4984	1
Brugia malayi	Cathepsin L-like precursor	0.2166	0.4984	0.4984
Entamoeba histolytica	cysteine protease, putative	0.1173	0.2699	0.539
Loa Loa (eye worm)	hypothetical protein	0.0497	0.1141	0.1141
Plasmodium falciparum	serine repeat antigen 6	0.0497	0.1141	0.2265
Brugia malayi	cathepsin L precursor	0.0497	0.1141	0.1141
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0015	0.0015
Brugia malayi	cathepsin L-like cysteine proteinase	0.0497	0.1141	0.1141
Entamoeba histolytica	cysteine protease, putative	0.1173	0.2699	0.539
Giardia lamblia	Cathepsin B precursor	0.0497	0.1141	0.2939
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2166	0.4984	1
Trichomonas vaginalis	conserved hypothetical protein	0.0497	0.1141	0.2289
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2166	0.4984	1
Brugia malayi	Papain family cysteine protease containing protein	0.0497	0.1141	0.1141
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.2166	0.4984	0.4984
Entamoeba histolytica	cysteine proteinase, putative	0.2166	0.4984	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0497	0.1141	0.2289
Entamoeba histolytica	cysteine protease, putative	0.0497	0.1141	0.2247
Schistosoma mansoni	hypothetical protein	0.0008	0.0015	0.0015
Entamoeba histolytica	cysteine proteinase 1, putative	0.1173	0.2699	0.539
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0015	0.0015
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2166	0.4984	1
Plasmodium falciparum	serine repeat antigen 8	0.0497	0.1141	0.2265
Schistosoma mansoni	cathepsin F (C01 family)	0.2166	0.4984	0.4984
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1173	0.2699	0.5415
Trypanosoma cruzi	cruzipain precursor, putative	0.0677	0.1555	0.1532
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0497	0.1141	0.2289
Entamoeba histolytica	cysteine protease, putative	0.1173	0.2699	0.539
Schistosoma mansoni	sarm1	0.0008	0.0015	0.0015
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1173	0.2699	0.2699
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0497	0.1141	0.2289
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2166	0.4984	1
Plasmodium vivax	vivapain-3	0.1173	0.2699	0.5401
Entamoeba histolytica	cysteine proteinase, putative	0.1173	0.2699	0.539
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1489	0.3426	0.6874
Plasmodium vivax	vivapain-2	0.2166	0.4984	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0497	0.1141	0.2289
Trypanosoma cruzi	cysteine peptidase, putative	0.2166	0.4984	0.497
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2166	0.4984	1
Giardia lamblia	Encystation-specific protease	0.0497	0.1141	0.2939
Leishmania major	cathepsin L-like protease	0.2166	0.4984	1
Schistosoma mansoni	hypothetical protein	0.0008	0.0015	0.0015
Echinococcus multilocularis	liprin beta 1	0.0008	0.0015	0.0015
Brugia malayi	WGR domain containing protein	0.0013	0.0027	0.0027
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1173	0.2699	0.2699
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0497	0.1141	0.1141
Echinococcus multilocularis	cathepsin L cysteine protease	0.2166	0.4984	0.4984
Schistosoma mansoni	cathepsin B (C01 family)	0.0497	0.1141	0.1141
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0027	0.0053
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0497	0.1141	0.2939
Plasmodium falciparum	serine repeat antigen 9	0.0497	0.1141	0.2265
Entamoeba histolytica	cysteine protease, putative	0.1173	0.2699	0.539
Entamoeba histolytica	cysteine protease, putative	0.1173	0.2699	0.539
Onchocerca volvulus		0.2166	0.4984	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0497	0.1141	0.2265
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0497	0.1141	0.2289
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2166	0.4984	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0497	0.1141	0.2289
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2166	0.4984	0.4984
Onchocerca volvulus	Cathepsin L homolog	0.0497	0.1141	0.2265
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2166	0.4984	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4345	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.1173	0.2699	0.539
Entamoeba histolytica	cysteine protease, putative	0.0497	0.1141	0.2247
Entamoeba histolytica	cysteine protease, putative	0.0497	0.1141	0.2247
Onchocerca volvulus		0.0497	0.1141	0.2265
Loa Loa (eye worm)	hypothetical protein	0.1489	0.3426	0.3426
Echinococcus multilocularis	liprin alpha 2	0.0008	0.0015	0.0015
Entamoeba histolytica	cysteine protease, putative	0.2166	0.4984	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.1687	0.3881	0.7787
Entamoeba histolytica	cysteine protease, putative	0.1173	0.2699	0.539
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.1173	0.2699	0.2679
Leishmania major	cathepsin L-like protease	0.2166	0.4984	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2166	0.4984	1
Leishmania major	cathepsin L-like protease	0.2166	0.4984	1
Plasmodium vivax	vivapain-2	0.2166	0.4984	1
Plasmodium vivax	vivapain-1	0.1173	0.2699	0.5401
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2166	0.4984	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0497	0.1141	0.2939
Echinococcus granulosus	cathepsin L cysteine protease	0.1173	0.2699	0.2699
Toxoplasma gondii	cathepsin CPC2	0.0497	0.1141	0.2265
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2166	0.4984	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1173	0.2699	0.2679
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2166	0.4984	1
Loa Loa (eye worm)	hypothetical protein	0.4345	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0027	0.0053
Trypanosoma cruzi	cruzipain precursor, putative	0.2166	0.4984	0.497
Brugia malayi	cathepsin F-like cysteine proteinase	0.0497	0.1141	0.1141
Giardia lamblia	Cathepsin L precursor	0.0497	0.1141	0.2939
Brugia malayi	cathepsin L-like precursor	0.1489	0.3426	0.3426
Brugia malayi	Cathepsin L-like precursor	0.2166	0.4984	0.4984
Giardia lamblia	Cathepsin B precursor	0.1687	0.3881	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0497	0.1141	0.1141
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2166	0.4984	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0497	0.1141	0.1141
Entamoeba histolytica	cysteine protease, putative	0.1173	0.2699	0.539
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0497	0.1141	0.2289
Loa Loa (eye worm)	hypothetical protein	0.0677	0.1555	0.1555
Loa Loa (eye worm)	hypothetical protein	0.0497	0.1141	0.1141
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1687	0.3881	0.3864
Echinococcus granulosus	cathepsin l1	0.1489	0.3426	0.3426
Leishmania major	cathepsin L-like protease	0.2166	0.4984	1
Giardia lamblia	Cysteine protease	0.0497	0.1141	0.2939
Echinococcus granulosus	cysteine protease	0.1173	0.2699	0.2699
Giardia lamblia	Cathepsin B precursor	0.1687	0.3881	1
Schistosoma mansoni	cathepsin C	0.0497	0.1141	0.1141
Entamoeba histolytica	cysteine proteinase, putative	0.1173	0.2699	0.539
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0013	0.0027	0.0027
Echinococcus granulosus	cathepsin L	0.0497	0.1141	0.1141
Giardia lamblia	Cathepsin L precursor	0.0497	0.1141	0.2939
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0497	0.1141	0.1141
Loa Loa (eye worm)	hypothetical protein	0.1489	0.3426	0.3426
Loa Loa (eye worm)	cysteine protease	0.2166	0.4984	0.4984
Brugia malayi	Papain family cysteine protease containing protein	0.1173	0.2699	0.2699
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0027	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0027	0.0026
Echinococcus granulosus	liprin beta 1	0.0008	0.0015	0.0015
Entamoeba histolytica	cysteine protease, putative	0.1173	0.2699	0.539
Entamoeba histolytica	cysteine proteinase, putative	0.2166	0.4984	1
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0013	0.0027	0.0026
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0497	0.1141	0.1141
Giardia lamblia	Cathepsin B precursor	0.0497	0.1141	0.2939
Onchocerca volvulus		0.2166	0.4984	1
Loa Loa (eye worm)	hypothetical protein	0.2166	0.4984	0.4984
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0677	0.1555	0.1555
Plasmodium falciparum	cysteine proteinase falcipain 3	0.2166	0.4984	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2166	0.4984	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0497	0.1141	0.2289
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0027	0.0053
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0001	0.0000030426	0.0000061052
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0015	0.0015
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0497	0.1141	0.2265
Loa Loa (eye worm)	hypothetical protein	0.0497	0.1141	0.1141
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1173	0.2699	0.5415
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2166	0.4984	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0497	0.1141	0.2265
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4345	1	1
Plasmodium vivax	unspecified product	0.1173	0.2699	0.5401
Echinococcus multilocularis	stromal interaction molecule 1	0.0008	0.0015	0.0015
Echinococcus multilocularis	cathepsin L	0.0497	0.1141	0.1141
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1489	0.3426	0.6874
Giardia lamblia	Cathepsin L-like protease	0.0497	0.1141	0.2939
Giardia lamblia	Cathepsin B precursor	0.0497	0.1141	0.2939
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0497	0.1141	0.2289
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0497	0.1141	0.2289
Loa Loa (eye worm)	hypothetical protein	0.0677	0.1555	0.1555
Entamoeba histolytica	cysteine protease, putative	0.1173	0.2699	0.539
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0497	0.1141	0.2265
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0497	0.1141	0.2289
Schistosoma mansoni	lip-related protein (liprin) alpha	0.0008	0.0015	0.0015
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0027	0.0053
Echinococcus granulosus	stromal interaction molecule 1	0.0008	0.0015	0.0015
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0497	0.1141	0.2247
Plasmodium vivax	unspecified product	0.0677	0.1555	0.3099
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0497	0.1141	0.2939
Trypanosoma cruzi	cysteine peptidase, putative	0.2166	0.4984	0.497
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0497	0.1141	0.2265
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0497	0.1141	0.2265
Onchocerca volvulus		0.2166	0.4984	1
Echinococcus multilocularis	cathepsin b	0.4345	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0497	0.1141	0.1141
Schistosoma mansoni	cathepsin F (C01 family)	0.1489	0.3426	0.3426
Brugia malayi	Cathepsin L-like precursor	0.1489	0.3426	0.3426
Brugia malayi	hypothetical protein	0.0008	0.0015	0.0015
Schistosoma mansoni	cathepsin S (C01 family)	0.0497	0.1141	0.1141
Entamoeba histolytica	cysteine proteinase, putative	0.1173	0.2699	0.539
Trypanosoma cruzi	cysteine peptidase, putative	0.0677	0.1555	0.1532
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0013	0.0027	0.0027
Brugia malayi	Papain family cysteine protease containing protein	0.1173	0.2699	0.2699
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2166	0.4984	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0497	0.1141	0.1141
Trypanosoma cruzi	major cysteine proteinase, putative	0.0497	0.1141	0.1117
Brugia malayi	Neurabin protein 1	0.0008	0.0015	0.0015
Entamoeba histolytica	cysteine protease, putative	0.0497	0.1141	0.2247
Plasmodium falciparum	serine repeat antigen 4	0.0497	0.1141	0.2265
Onchocerca volvulus	Cathepsin L homolog	0.2166	0.4984	1
Leishmania major	cathepsin L-like protease	0.2166	0.4984	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0001	0.0000030426	0.0000061052
Trichomonas vaginalis	c2h2 zinc finger protein, putative	0.0008	0.0015	0.0031
Trypanosoma cruzi	major cysteine proteinase, putative	0.0497	0.1141	0.1117
Giardia lamblia	Cathepsin L precursor	0.0497	0.1141	0.2939
Echinococcus granulosus	poly adp ribose polymerase 2	0.0013	0.0027	0.0027
Toxoplasma gondii	cathepsin CPL	0.2166	0.4984	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0497	0.1141	0.2289
Loa Loa (eye worm)	hypothetical protein	0.0497	0.1141	0.1141
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0497	0.1141	0.1141
Brugia malayi	Tnks protein	0.0089	0.0202	0.0202
Brugia malayi	Cathepsin L-like precursor	0.2166	0.4984	0.4984
Entamoeba histolytica	cysteine protease, putative	0.0497	0.1141	0.2247
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2166	0.4984	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2166	0.4984	1
Echinococcus granulosus	tankyrase	0.009	0.0204	0.0204
Entamoeba histolytica	cysteine protease, putative	0.1173	0.2699	0.539
Brugia malayi	Cathepsin L-like precursor	0.2166	0.4984	0.4984
Loa Loa (eye worm)	toll and interleukin 1 receptor domain-containing protein isoform f	0.0008	0.0015	0.0015
Echinococcus multilocularis	tankyrase	0.009	0.0204	0.0204
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4345	1	1
Loa Loa (eye worm)	cathepsin B	0.1687	0.3881	0.3881
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0027	0.0053
Leishmania major	cysteine peptidase A (CPA)	0.2166	0.4984	1
Brugia malayi	Cathepsin L-like precursor	0.2166	0.4984	0.4984
Echinococcus granulosus	cathepsin l1	0.2166	0.4984	0.4984
Leishmania major	cathepsin L-like protease	0.2166	0.4984	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0497	0.1141	0.2265
Giardia lamblia	Cathepsin L precursor	0.0497	0.1141	0.2939
Giardia lamblia	Cathepsin B precursor	0.0497	0.1141	0.2939
Toxoplasma gondii	cathepsin CPC1	0.0497	0.1141	0.2265
Giardia lamblia	Cathepsin L precursor	0.0497	0.1141	0.2939
Trypanosoma cruzi	cysteine proteinase, putative	0.1173	0.2699	0.2679
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2166	0.4984	1
Giardia lamblia	Cysteine protease	0.0497	0.1141	0.2939
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0497	0.1141	0.1141
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2166	0.4984	1
Echinococcus granulosus	sterile alpha and tir motif containing protein	0.0008	0.0015	0.0015
Echinococcus granulosus	cathepsin L cysteine proteinase	0.2166	0.4984	0.4984
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0497	0.1141	0.2939
Giardia lamblia	Hypothetical protein	0.0497	0.1141	0.2939
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2166	0.4984	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2166	0.4984	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0015	0.0031
Echinococcus granulosus	cathepsin b	0.4345	1	1
Echinococcus multilocularis	SAM domain containing protein	0.0008	0.0015	0.0015
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0497	0.1141	0.2289
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0497	0.1141	0.2289
Giardia lamblia	Cathepsin L-like protease	0.0497	0.1141	0.2939
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0013	0.0027	0.0023
Brugia malayi	hypothetical protein	0.0008	0.0015	0.0015
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0497	0.1141	0.2265
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0497	0.1141	0.2265
Schistosoma mansoni	lar interacting protein (lip)-related protein	0.0008	0.0015	0.0015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2166	0.4984	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.4345	1	1
Brugia malayi	fibroinase precursor	0.0497	0.1141	0.1141

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.88 uM	Inhibition of GST-tagged TNKS2P catalytic domain autoPARsylation measuring nicotinamide concentration after 2 hrs by LC-MS analysis	ChEMBL.	22260203

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2016635

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1630335