Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hyaluronidase | 1.1425 | 1 | 1 |
Echinococcus granulosus | bifunctional protein NCOAT | 1.1425 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | bifunctional protein NCOAT | 1.1425 | 1 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 1.1425 | 1 | 0.5 |
Schistosoma mansoni | Hyaluronidase | 1.1425 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4854 | 0.4239 | 0.4239 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.