Detailed information for compound 1632150

Basic information

Technical information
  • TDR Targets ID: 1632150
  • Name: 2-dimethylamino-4-methylsulfanylbutanoic acid
  • MW: 177.264 | Formula: C7H15NO2S
  • H donors: 1 H acceptors: 2 LogP: -1.38 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSCCC(C(=O)O)N(C)C
  • InChi: 1S/C7H15NO2S/c1-8(2)6(7(9)10)4-5-11-3/h6H,4-5H2,1-3H3,(H,9,10)
  • InChiKey: FLEXUHXAXRFRAU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-dimethylamino-4-methylsulfanyl-butanoic acid
  • 2-dimethylamino-4-(methylthio)butanoic acid
  • 2-dimethylamino-4-(methylthio)butyric acid
  • NCI60_004055
  • NSC45514
  • N,N,S-trimethylhomocysteine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.047 0.1143 0.1133
Entamoeba histolytica cysteine proteinase, putative 0.2009 0.4985 1
Giardia lamblia Cathepsin L-like protease 0.047 0.1143 0.2916
Loa Loa (eye worm) papain family cysteine protease containing protein 0.047 0.1143 0.1143
Brugia malayi fibroinase precursor 0.047 0.1143 0.1139
Plasmodium falciparum serine repeat antigen 5 0.047 0.1143 0.2269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0018
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0018 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.047 0.1143 0.2288
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.047 0.1143 0.1133
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.047 0.1143 0.2269
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0016 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0037 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0037 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.047 0.1143 0.1143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Plasmodium falciparum serine repeat antigen 9 0.047 0.1143 0.2269
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0058 0.0111
Brugia malayi Cathepsin L-like precursor 0.2009 0.4985 0.4982
Trypanosoma cruzi cysteine peptidase, putative 0.2498 0.6205 0.6201
Trypanosoma cruzi cysteine protease, putative 0.1104 0.2725 0.2716
Schistosoma mansoni cathepsin B (C01 family) 0.047 0.1143 0.1133
Brugia malayi Pre-SET motif family protein 0.0236 0.0558 0.0553
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0058 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2009 0.4985 1
Schistosoma mansoni DNA helicase recq1 0.002 0.0018 0.0007
Schistosoma mansoni cathepsin S (C01 family) 0.047 0.1143 0.1133
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0016 0.0004
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4018 1 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0058 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1865 0.4624 0.4618
Brugia malayi RNA recognition motif domain containing protein 0.0333 0.08 0.0796
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0018 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.047 0.1143 0.1133
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0058 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0096 0.0187
Schistosoma mansoni sodium-dependent amino acid transporter 0.0047 0.0086 0.0074
Loa Loa (eye worm) hypothetical protein 0.047 0.1143 0.1143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1376 0.3403 0.6825
Entamoeba histolytica hypothetical protein 0.0109 0.0241 0.0453
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0045 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0045 0.0084
Brugia malayi RNA binding protein 0.0333 0.08 0.0796
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0086 0.0086
Echinococcus multilocularis serotonin receptor 0.0306 0.0732 0.0731
Plasmodium falciparum cysteine proteinase falcipain 2a 0.2009 0.4985 1
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0018 0.0013
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0053 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.047 0.1143 0.2288
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0016 0.0011
Echinococcus multilocularis lamin dm0 0.0027 0.0036 0.0035
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0012 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Loa Loa (eye worm) hypothetical protein 0.0306 0.0732 0.0732
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0121
Trypanosoma cruzi major cysteine proteinase, putative 0.047 0.1143 0.1133
Giardia lamblia Cathepsin L precursor 0.047 0.1143 0.2916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0121
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0058 0.0111
Echinococcus granulosus sodium and chloride dependent glycine 0.0047 0.0086 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0701 0.1719 0.3444
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0086 0.0141
Loa Loa (eye worm) phosphatidylinositol 3 0.0051 0.0096 0.0096
Brugia malayi cathepsin F-like cysteine proteinase 0.047 0.1143 0.1139
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0053 0.0052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.0357 0.0353
Echinococcus multilocularis bloom syndrome protein 0.002 0.0018 0.0017
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0086 0.0081
Onchocerca volvulus 0.2009 0.4985 1
Echinococcus multilocularis cathepsin L 0.047 0.1143 0.1142
Brugia malayi hypothetical protein 0.0738 0.1811 0.1807
Giardia lamblia Cathepsin L precursor 0.047 0.1143 0.2916
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0016 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0012 0.0017
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0551 0.1345 0.3438
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0038 0.0069
Brugia malayi Cathepsin L-like precursor 0.1376 0.3403 0.34
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Echinococcus multilocularis GPCR, family 2 0.0049 0.0092 0.0091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0053 0.0042
Brugia malayi TAR-binding protein 0.0333 0.08 0.0796
Onchocerca volvulus 0.0036 0.0058 0.0045
Loa Loa (eye worm) hypothetical protein 0.0047 0.0086 0.0086
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0086 0.0074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.047 0.1143 0.2288
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0041 0.007 0.0095
Plasmodium falciparum serine repeat antigen 4 0.047 0.1143 0.2269
Loa Loa (eye worm) hypothetical protein 0.2009 0.4985 0.4985
Schistosoma mansoni hypothetical protein 0.0049 0.0092 0.008
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0701 0.1719 0.1719
Echinococcus granulosus bloom syndrome protein 0.002 0.0018 0.0017
Trypanosoma cruzi cruzipain precursor, putative 0.0634 0.1551 0.1541
Onchocerca volvulus 0.0275 0.0657 0.1254
Echinococcus granulosus biogenic amine 5HT receptor 0.0306 0.0732 0.0731
Brugia malayi hypothetical protein 0.0109 0.0241 0.0236
Plasmodium falciparum serine repeat antigen 3 0.047 0.1143 0.2269
Brugia malayi Papain family cysteine protease containing protein 0.1104 0.2725 0.2721
Plasmodium vivax vivapain-2 0.2009 0.4985 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0018 0.0013
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.047 0.1143 0.1133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0096 0.0187
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0265 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0051 0.0097
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0058 0.0813
Giardia lamblia Cathepsin B precursor 0.1568 0.3882 1
Giardia lamblia Cathepsin B precursor 0.0701 0.1719 0.4405
Entamoeba histolytica cysteine protease, putative 0.047 0.1143 0.2269
Loa Loa (eye worm) hypothetical protein 0.1376 0.3403 0.3403
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.047 0.1143 0.2288
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0051 0.0096 0.0095
Entamoeba histolytica cysteine proteinase, putative 0.1104 0.2725 0.5452
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0016 0.0007
Plasmodium vivax SET domain protein, putative 0.0034 0.0053 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1104 0.2725 0.5463
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0058 0.0057
Entamoeba histolytica papain family cysteine protease domain containing protein 0.047 0.1143 0.2269
Entamoeba histolytica hypothetical protein 0.047 0.1143 0.2269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0121
Brugia malayi Cathepsin L-like cysteine proteinase 0.1376 0.3403 0.34
Entamoeba histolytica recQ family helicase, putative 0.002 0.0018 0.0005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0092 0.0091
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0047 0.0086 0.0074
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0092 0.0092
Mycobacterium ulcerans hypothetical protein 0.0036 0.0058 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0053 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0333 0.08 0.079
Loa Loa (eye worm) hypothetical protein 0.047 0.1143 0.1143
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0086 0.0081
Echinococcus granulosus cathepsin l1 0.2009 0.4985 0.4984
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.047 0.1143 0.2288
Loa Loa (eye worm) hypothetical protein 0.0047 0.0086 0.0086
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0086 0.0074
Echinococcus multilocularis cathepsin b 0.4018 1 1
Schistosoma mansoni tar DNA-binding protein 0.0333 0.08 0.079
Onchocerca volvulus 0.2009 0.4985 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.047 0.1143 0.2288
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0012 0.001
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0018 0.0005
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.047 0.1143 0.2916
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0018 0.0017
Schistosoma mansoni cathepsin F (C01 family) 0.1376 0.3403 0.3396
Onchocerca volvulus 0.0034 0.0053 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0054 0.0103
Trypanosoma cruzi target of rapamycin kinase 3 0.0041 0.007 0.0059
Loa Loa (eye worm) hypothetical protein 0.047 0.1143 0.1143
Entamoeba histolytica cysteine proteinase, putative 0.1104 0.2725 0.5452
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0035
Brugia malayi Papain family cysteine protease containing protein 0.2009 0.4985 0.4982
Mycobacterium ulcerans lipase LipD 0.0036 0.0058 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0684 0.1676 0.1666
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2009 0.4985 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0551 0.1345 0.2675
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Echinococcus multilocularis lamin 0.0027 0.0036 0.0035
Brugia malayi beta-lactamase family protein 0.0036 0.0058 0.0053
Schistosoma mansoni hypothetical protein 0.0106 0.0234 0.0223
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0234 0.023
Echinococcus multilocularis serotonin transporter 0.0275 0.0657 0.0655
Loa Loa (eye worm) hypothetical protein 0.1376 0.3403 0.3403
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1568 0.3882 0.6249
Trypanosoma cruzi cysteine proteinase, putative 0.1104 0.2725 0.2716
Onchocerca volvulus 0.2009 0.4985 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.005 0.0049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2009 0.4985 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0121
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0018 0.0005
Brugia malayi beta-lactamase family protein 0.0036 0.0058 0.0053
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0634 0.1551 0.1551
Echinococcus granulosus serotonin transporter 0.0275 0.0657 0.0655
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0086 0.0074
Trypanosoma cruzi cysteine peptidase, putative 0.1104 0.2725 0.2716
Plasmodium vivax amine transporter, putative 0.0047 0.0086 0.0141
Plasmodium vivax unspecified product 0.1104 0.2725 0.5452
Mycobacterium ulcerans beta-lactamase 0.0036 0.0058 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0018 0.0007
Entamoeba histolytica cysteine proteinase 1, putative 0.1104 0.2725 0.5452
Echinococcus multilocularis musashi 0.0027 0.0036 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1376 0.3403 0.6825
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0603 0.1474 0.2952
Brugia malayi Cathepsin L-like precursor 0.2009 0.4985 0.4982
Plasmodium falciparum amino acid transporter, putative 0.0047 0.0086 0.0141
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0058 0.0813
Schistosoma mansoni sodium/chloride dependent transporter 0.0275 0.0657 0.0646
Brugia malayi Papain family cysteine protease containing protein 0.1104 0.2725 0.2721
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.0036
Giardia lamblia Hypothetical protein 0.047 0.1143 0.2916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0038 0.0069
Onchocerca volvulus 0.2009 0.4985 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.007 0.0134
Loa Loa (eye worm) TAR-binding protein 0.0333 0.08 0.08
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0092 0.0091
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0047 0.0086 0.0074
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0051 0.0096 0.0136
Brugia malayi cathepsin Z-like cysteine proteinase 0.0701 0.1719 0.1715
Entamoeba histolytica cysteine protease, putative 0.047 0.1143 0.2269
Entamoeba histolytica cysteine protease, putative 0.047 0.1143 0.2269
Plasmodium falciparum cysteine proteinase falcipain 2b 0.2009 0.4985 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0086 0.0141
Echinococcus granulosus intermediate filament protein 0.0027 0.0036 0.0035
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1104 0.2725 0.2716
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0092 0.0091
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0051 0.0096 0.0162
Schistosoma mansoni cathepsin s 0.0634 0.1551 0.1541
Leishmania major cathepsin L-like protease 0.2498 0.6205 1
Loa Loa (eye worm) RNA binding protein 0.0333 0.08 0.08
Leishmania major cathepsin L-like protease 0.2009 0.4985 0.8029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Loa Loa (eye worm) hypothetical protein 0.0275 0.0657 0.0657
Loa Loa (eye worm) hypothetical protein 0.0634 0.1551 0.1551
Echinococcus multilocularis serotonin receptor 0.0306 0.0732 0.0731
Toxoplasma gondii cathepsin CPC1 0.0684 0.1676 0.3341
Trichomonas vaginalis esterase, putative 0.0036 0.0058 0.0111
Leishmania major cathepsin L-like protease 0.2498 0.6205 1
Echinococcus granulosus cysteine protease 0.1104 0.2725 0.2724
Giardia lamblia Encystation-specific protease 0.0551 0.1345 0.3438
Brugia malayi cathepsin F-like cysteine proteinase 0.0634 0.1551 0.1547
Loa Loa (eye worm) hypothetical protein 0.0036 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2009 0.4985 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.2009 0.4985 0.4984
Brugia malayi hypothetical protein 0.0047 0.0086 0.0081
Echinococcus multilocularis tar DNA binding protein 0.0333 0.08 0.0799
Onchocerca volvulus 0.1376 0.3403 0.6804
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0051 0.0096 0.0085
Loa Loa (eye worm) serotonin transporter b 0.0275 0.0657 0.0657
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0036 0.0036
Brugia malayi beta-lactamase 0.0036 0.0058 0.0053
Brugia malayi Papain family cysteine protease containing protein 0.047 0.1143 0.1139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0012 0.0017
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0275 0.0657 0.0646
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0086 0.0086
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0086 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0684 0.1676 0.3341
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0058 0.0047
Onchocerca volvulus 0.0047 0.0086 0.0101
Schistosoma mansoni hypothetical protein 0.0109 0.0241 0.0229
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4018 1 1
Trichomonas vaginalis set domain proteins, putative 0.0268 0.0639 0.1277
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1104 0.2725 0.2716
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.007 0.0134
Loa Loa (eye worm) fibroinase 0.2009 0.4985 0.4985
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0047 0.0086 0.0084
Echinococcus multilocularis cysteine protease 0.2009 0.4985 0.4984
Plasmodium vivax vivapain-1 0.1104 0.2725 0.5452
Brugia malayi cahepsin L-like non-peptiedase homolog 0.047 0.1143 0.1139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0012 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1568 0.3882 0.7787
Echinococcus multilocularis survival motor neuron protein 1 0.0738 0.1811 0.181
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0018 0.0013
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0051 0.0096 0.0162
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0018 0.0017
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0012 0.0012
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.047 0.1143 0.1133
Schistosoma mansoni cathepsin F (C01 family) 0.2009 0.4985 0.4979
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0044 0.0082
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0053 0.0052
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0018 0.0005
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0058 0.0813
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.047 0.1143 0.2269
Echinococcus granulosus tar DNA binding protein 0.0333 0.08 0.0799
Echinococcus multilocularis sodium and chloride dependent glycine 0.0047 0.0086 0.0084
Echinococcus multilocularis cathepsin L cysteine protease 0.2009 0.4985 0.4984
Entamoeba histolytica cysteine proteinase, putative 0.1104 0.2725 0.5452
Toxoplasma gondii preprocathepsin c precursor, putative 0.0684 0.1676 0.3341
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Trypanosoma cruzi cysteine peptidase, putative 0.2009 0.4985 0.4979
Onchocerca volvulus 0.0268 0.0639 0.1219
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0016 0.0007
Brugia malayi cathepsin Z-like cysteine proteinase 0.0701 0.1719 0.1715
Leishmania major cathepsin L-like protease 0.2498 0.6205 1
Toxoplasma gondii hypothetical protein 0.0047 0.0086 0.0141
Plasmodium falciparum serine repeat antigen 2 0.047 0.1143 0.2269
Giardia lamblia Cathepsin L precursor 0.047 0.1143 0.2916
Echinococcus multilocularis cathepsin b 0.4018 1 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0086 0.0084
Plasmodium falciparum cysteine proteinase falcipain 3 0.2009 0.4985 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.047 0.1143 0.2288
Schistosoma mansoni tar DNA-binding protein 0.0333 0.08 0.079
Schistosoma mansoni cathepsin F (C01 family) 0.2009 0.4985 0.4979
Plasmodium vivax serine-repeat antigen (SERA), putative 0.047 0.1143 0.2269
Loa Loa (eye worm) hypothetical protein 0.0275 0.0657 0.0657
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0051 0.0096 0.0136
Plasmodium falciparum serine repeat antigen 7 0.047 0.1143 0.2269
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0058 0.0813
Loa Loa (eye worm) hypothetical protein 0.0047 0.0086 0.0086
Echinococcus granulosus lamin 0.0027 0.0036 0.0035
Onchocerca volvulus Cathepsin L homolog 0.2009 0.4985 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.047 0.1143 0.2288
Entamoeba histolytica papain family cysteine protease domain containing protein 0.047 0.1143 0.2269
Brugia malayi Papain family cysteine protease containing protein 0.047 0.1143 0.1139
Giardia lamblia Cysteine protease 0.047 0.1143 0.2916
Echinococcus granulosus cathepsin L 0.047 0.1143 0.1142
Giardia lamblia Cathepsin L precursor 0.047 0.1143 0.2916
Giardia lamblia Cathepsin B precursor 0.047 0.1143 0.2916
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0265 0.0265
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.0357 0.0353
Onchocerca volvulus Cathepsin F homolog 0.2009 0.4985 1
Leishmania major hypothetical protein, conserved 0.0036 0.0058 0.0075
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0058 0.0047
Giardia lamblia Cathepsin L precursor 0.047 0.1143 0.2916
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Onchocerca volvulus 0.0047 0.0086 0.0101
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0047 0.0086 0.0084
Toxoplasma gondii cathepsin CPL 0.2009 0.4985 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.0558 0.0558
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.2009 0.4985 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0036 0.0024
Loa Loa (eye worm) hypothetical protein 0.0036 0.0058 0.0058
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.015 0.0345 0.034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.4018 1 1
Brugia malayi Pre-SET motif family protein 0.0034 0.0053 0.0049
Schistosoma mansoni hypothetical protein 0.015 0.0345 0.0333
Brugia malayi Cathepsin L-like precursor 0.0634 0.1551 0.1547
Mycobacterium leprae Probable lipase LipE 0.0036 0.0058 0.5
Giardia lamblia Cysteine protease 0.047 0.1143 0.2916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0038 0.0069
Brugia malayi MH2 domain containing protein 0.0118 0.0265 0.026
Schistosoma mansoni cathepsin C 0.047 0.1143 0.1133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0275 0.0657 0.0652
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0047 0.0086 0.0141
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.0063 0.0096
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.4018 1 1
Plasmodium vivax unspecified product 0.0634 0.1551 0.3089
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0016 0.0025
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0041 0.007 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.2009 0.4985 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0051 0.0096 0.0136
Mycobacterium tuberculosis Conserved protein 0.0036 0.0058 0.0813
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Plasmodium falciparum serine repeat antigen 6 0.047 0.1143 0.2269
Plasmodium falciparum transporter, putative 0.0047 0.0086 0.0141
Loa Loa (eye worm) hypothetical protein 0.047 0.1143 0.1143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1104 0.2725 0.438
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0701 0.1719 0.3444
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0684 0.1676 0.4293
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0029 0.0028
Echinococcus granulosus microtubule associated protein 2 0.0685 0.1679 0.1678
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0551 0.1345 0.3438
Giardia lamblia Hypothetical protein 0.047 0.1143 0.2916
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0036 0.0036
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.2009 0.4985 0.4985
Entamoeba histolytica hypothetical protein 0.0109 0.0241 0.0453
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0051 0.0096 0.0136
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0018 0.0017
Onchocerca volvulus 0.015 0.0345 0.0624
Brugia malayi cathepsin L precursor 0.047 0.1143 0.1139
Schistosoma mansoni ap endonuclease 0.0019 0.0016 0.0004
Onchocerca volvulus 0.0047 0.0086 0.0101
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0634 0.1551 0.1547
Giardia lamblia Cathepsin B precursor 0.047 0.1143 0.2916
Echinococcus granulosus lamin dm0 0.0027 0.0036 0.0035
Loa Loa (eye worm) papain family cysteine protease containing protein 0.047 0.1143 0.1143
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0051 0.0096 0.0095
Plasmodium vivax serine-repeat antigen (SERA) 0.047 0.1143 0.2269
Loa Loa (eye worm) hypothetical protein 0.0738 0.1811 0.1811
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.047 0.1143 0.2288
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0047 0.0086 0.0084
Schistosoma mansoni tar DNA-binding protein 0.0333 0.08 0.079
Loa Loa (eye worm) norepinephrine transporter 0.0275 0.0657 0.0657
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.007 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0045 0.0084
Entamoeba histolytica cysteine protease, putative 0.047 0.1143 0.2269
Giardia lamblia Cysteine protease 0.047 0.1143 0.2916
Toxoplasma gondii hypothetical protein 0.0047 0.0086 0.0141
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0053 0.0042
Onchocerca volvulus 0.2009 0.4985 1
Echinococcus granulosus cathepsin b 0.4018 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.0357 0.0357
Mycobacterium tuberculosis Conserved protein 0.0036 0.0058 0.0813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0077 0.0149
Loa Loa (eye worm) RecQ helicase 0.002 0.0018 0.0018
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0047 0.0086 0.0086
Onchocerca volvulus 0.2009 0.4985 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0058 0.0058
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0058 0.0075
Echinococcus granulosus cathepsin L cysteine proteinase 0.2009 0.4985 0.4984
Trypanosoma cruzi cysteine peptidase, putative 0.2498 0.6205 0.6201
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0018 0.0017
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.047 0.1143 0.2269
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0047 0.0086 0.0081
Loa Loa (eye worm) hypothetical protein 0.4018 1 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.0022 0.0016
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0051 0.0096 0.0085
Echinococcus multilocularis cathepsin L 0.1104 0.2725 0.2724
Toxoplasma gondii cathepsin CPC2 0.0551 0.1345 0.2675
Loa Loa (eye worm) hypothetical protein 0.0036 0.0058 0.0058
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0058 0.0111
Entamoeba histolytica cysteine proteinase, putative 0.1376 0.3403 0.6817
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1104 0.2725 0.5463
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0701 0.1719 0.3444
Schistosoma mansoni sodium/chloride dependent transporter 0.0047 0.0086 0.0074
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0051 0.0096 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0047 0.0086 0.0081
Trypanosoma brucei cysteine peptidase C (CPC) 0.1568 0.3882 0.6249
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.047 0.1143 0.1133
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0333 0.08 0.08
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0036 0.0031
Giardia lamblia Cathepsin B precursor 0.047 0.1143 0.2916
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0092 0.0087
Toxoplasma gondii ABC1 family protein 0.0036 0.0058 0.0086
Leishmania major cathepsin L-like protease 0.2009 0.4985 0.8029
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0047 0.0086 0.0084
Brugia malayi cathepsin L-like precursor 0.1376 0.3403 0.34
Giardia lamblia Cathepsin L-like protease 0.047 0.1143 0.2916
Schistosoma mansoni hypothetical protein 0.0049 0.0092 0.008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2009 0.4985 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1104 0.2725 0.2716
Brugia malayi Cathepsin L-like precursor 0.2009 0.4985 0.4982
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Schistosoma mansoni ap endonuclease 0.0019 0.0016 0.0004
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0018 0.0018
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0047 0.0086 0.5
Entamoeba histolytica cysteine protease, putative 0.2009 0.4985 1
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0047 0.0086 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0044 0.0082
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1568 0.3882 0.3875
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0058 0.0047
Trypanosoma cruzi cysteine peptidase, putative 0.2498 0.6205 0.6201
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0551 0.1345 0.2675
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.047 0.1143 0.2269
Echinococcus multilocularis cysteine protease 0.2009 0.4985 0.4984
Giardia lamblia Cathepsin L precursor 0.047 0.1143 0.2916
Loa Loa (eye worm) hypothetical protein 0.0634 0.1551 0.1551
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.4018 1 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.1104 0.2725 0.2716
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0086 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.047 0.1143 0.2288
Plasmodium falciparum serine repeat antigen 1 0.047 0.1143 0.2269
Plasmodium vivax serine-repeat antigen (SERA) 0.047 0.1143 0.2269
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2009 0.4985 1
Plasmodium vivax vivapain-3 0.1104 0.2725 0.5452
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0058 0.0047
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0005 0.0005
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0684 0.1676 0.3341
Brugia malayi Cathepsin L-like precursor 0.2009 0.4985 0.4982
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0047 0.0086 0.0084
Onchocerca volvulus 0.0036 0.0058 0.0045
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0016 0.0025
Onchocerca volvulus Cathepsin L homolog 0.2009 0.4985 1
Plasmodium vivax vivapain-2 0.2009 0.4985 1
Giardia lamblia Cysteine protease 0.047 0.1143 0.2916
Leishmania major cathepsin L-like protease 0.2009 0.4985 0.8029
Loa Loa (eye worm) solute carrier family 6 member 4 0.0275 0.0657 0.0657
Loa Loa (eye worm) hypothetical protein 0.0306 0.0732 0.0732
Schistosoma mansoni lamin 0.0027 0.0036 0.0024
Loa Loa (eye worm) hypothetical protein 0.047 0.1143 0.1143
Plasmodium falciparum serine repeat antigen 8 0.047 0.1143 0.2269
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0092 0.0091
Loa Loa (eye worm) hypothetical protein 0.0106 0.0234 0.0234
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0241 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0012 0.0017
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0058 0.0111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1104 0.2725 0.438
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0684 0.1676 0.3341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.047 0.1143 0.2288
Schistosoma mansoni microtubule-associated protein tau 0.0685 0.1679 0.1669
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0241 0.024
Mycobacterium tuberculosis Conserved protein 0.0036 0.0058 0.0813
Entamoeba histolytica cysteine proteinase, putative 0.1104 0.2725 0.5452
Schistosoma mansoni survival motor neuron protein 0.015 0.0345 0.0333
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0058 0.0813
Brugia malayi Cathepsin L-like precursor 0.2009 0.4985 0.4982
Giardia lamblia Cathepsin B precursor 0.047 0.1143 0.2916
Echinococcus granulosus hypothetical protein 0.0845 0.2078 0.2077
Brugia malayi Cathepsin L-like precursor 0.1376 0.3403 0.34
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2498 0.6205 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2009 0.4985 1
Schistosoma mansoni hypothetical protein 0.0049 0.0092 0.008
Schistosoma mansoni DNA helicase recq5 0.002 0.0018 0.0007
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0058 0.0813
Echinococcus granulosus cathepsin L cysteine protease 0.1104 0.2725 0.2724
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0058 0.0058
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0058 0.0813
Loa Loa (eye worm) papain family cysteine protease containing protein 0.2009 0.4985 0.4985
Loa Loa (eye worm) hypothetical protein 0.0634 0.1551 0.1551
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0037 0.0069
Loa Loa (eye worm) hypothetical protein 0.0049 0.0092 0.0092
Echinococcus granulosus survival motor neuron protein 1 0.0738 0.1811 0.181
Loa Loa (eye worm) cysteine protease 0.2009 0.4985 0.4985
Loa Loa (eye worm) hypothetical protein 0.0036 0.0058 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0096 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0121
Trypanosoma cruzi cysteine peptidase, putative 0.0634 0.1551 0.1541
Loa Loa (eye worm) hypothetical protein 0.0036 0.0058 0.0058
Echinococcus granulosus GPCR family 2 0.0049 0.0092 0.0091
Brugia malayi cathepsin L-like cysteine proteinase 0.047 0.1143 0.1139
Trypanosoma cruzi cysteine proteinase, putative 0.1104 0.2725 0.2716
Loa Loa (eye worm) hypothetical protein 0.0275 0.0657 0.0657
Echinococcus granulosus cathepsin L 0.1104 0.2725 0.2724
Brugia malayi Cathepsin L-like precursor 0.2009 0.4985 0.4982
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2009 0.4985 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0018 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0121
Loa Loa (eye worm) hypothetical protein 0.0034 0.0053 0.0053
Trypanosoma cruzi cruzipain precursor, putative 0.2498 0.6205 0.6201
Onchocerca volvulus 0.047 0.1143 0.2237
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2009 0.4985 1
Schistosoma mansoni tar DNA-binding protein 0.0333 0.08 0.079
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0058 0.0111
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0018 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.047 0.1143 0.2288
Giardia lamblia Cathepsin B precursor 0.1568 0.3882 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.2009 0.4985 0.4984
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0241 0.0229
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0016 0.0016
Onchocerca volvulus 0.2009 0.4985 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.047 0.1143 0.1133
Loa Loa (eye worm) cathepsin B 0.1568 0.3882 0.3882
Entamoeba histolytica cysteine proteinase 2 0.1104 0.2725 0.5452
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0092 0.0087
Leishmania major cathepsin L-like protease 0.2009 0.4985 0.8029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0086 0.0141
Entamoeba histolytica cysteine proteinase, putative 0.2009 0.4985 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0016 0.5
Leishmania major cathepsin L-like protease 0.2009 0.4985 0.8029
Echinococcus multilocularis microtubule associated protein 2 0.0685 0.1679 0.1678
Echinococcus granulosus cathepsin l1 0.1376 0.3403 0.3402
Echinococcus multilocularis sodium and chloride dependent glycine 0.0047 0.0086 0.0084
Onchocerca volvulus Cathepsin L homolog 0.047 0.1143 0.2237
Giardia lamblia Cathepsin B precursor 0.1568 0.3882 1
Treponema pallidum sodium- and chloride- dependent transporter 0.0275 0.0657 1
Entamoeba histolytica cysteine protease, putative 0.047 0.1143 0.2269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2009 0.4985 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0018 0.0005
Echinococcus multilocularis cathepsin L cysteine protease 0.2009 0.4985 0.4984
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0053 0.0042
Brugia malayi intermediate filament protein 0.0027 0.0036 0.0031
Schistosoma mansoni biogenic amine (5HT) receptor 0.0306 0.0732 0.0721
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0018 0.003
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0047 0.0086 0.0074
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0053 0.0052
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.0357 0.0357
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0051 0.0096 0.0085
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.047 0.1143 0.2269
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0016 0.0014
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1568 0.3882 0.3875
Trypanosoma cruzi major cysteine proteinase, putative 0.0959 0.2364 0.2355
Echinococcus multilocularis cathepsin l cysteine peptidase 0.2009 0.4985 0.4984
Echinococcus granulosus sodium and chloride dependent glycine 0.0047 0.0086 0.0084
Loa Loa (eye worm) hypothetical protein 0.0047 0.0086 0.0086
Schistosoma mansoni lamin 0.0027 0.0036 0.0024
Toxoplasma gondii cathepsin B 0.1568 0.3882 0.7781
Loa Loa (eye worm) hypothetical protein 0.0047 0.0086 0.0086
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0058 0.0057
Loa Loa (eye worm) hypothetical protein 0.0047 0.0086 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0701 0.1719 0.3444
Plasmodium vivax serine-repeat antigen (SERA), putative 0.047 0.1143 0.2269
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0012 0.0007
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.047 0.1143 0.1133
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0684 0.1676 0.3341
Plasmodium falciparum cysteine proteinase falcipain 1 0.1104 0.2725 0.5452
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.047 0.1143 0.2288
Brugia malayi Papain family cysteine protease containing protein 0.047 0.1143 0.1139
Echinococcus multilocularis conserved hypothetical protein 0.0833 0.2049 0.2048
Schistosoma mansoni hypothetical protein 0.0049 0.0092 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.007 0.0134
Echinococcus granulosus cathepsin b 0.4018 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.007 0.0134
Giardia lamblia GTOR 0.0051 0.0096 0.0208
Entamoeba histolytica hypothetical protein 0.0109 0.0241 0.0453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0038 0.0069
Loa Loa (eye worm) hypothetical protein 0.1376 0.3403 0.3403
Entamoeba histolytica cysteine protease, putative 0.047 0.1143 0.2269
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.0539 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0058 0.0053
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0058 0.0086
Entamoeba histolytica hypothetical protein 0.0109 0.0241 0.0453
Entamoeba histolytica cysteine protease, putative 0.1104 0.2725 0.5452
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0018 0.003
Plasmodium vivax unspecified product 0.047 0.1143 0.2269
Leishmania major cysteine peptidase A (CPA) 0.2009 0.4985 0.8029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.047 0.1143 0.2288
Loa Loa (eye worm) hypothetical protein 0.0036 0.0058 0.0058
Loa Loa (eye worm) ctsf protein 0.2009 0.4985 0.4985
Onchocerca volvulus 0.0036 0.0058 0.0045
Schistosoma mansoni sodium/chloride dependent transporter 0.0047 0.0086 0.0074

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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