Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | UDP-glucose 4-epimerase, putative | 0.0654 | 0.3236 | 1 |
Echinococcus granulosus | MAM | 0.0228 | 0.0983 | 0.1552 |
Echinococcus multilocularis | Immunoglobulin | 0.0079 | 0.0194 | 0.0306 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0017 | 0.0027 |
Echinococcus granulosus | defective proboscis extension response | 0.0079 | 0.0194 | 0.0306 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0017 | 0.0053 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0054 | 0.0065 | 0.0102 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0017 | 0.0017 |
Trichomonas vaginalis | NAD dependent epimerase/dehydratase, putative | 0.0654 | 0.3236 | 1 |
Onchocerca volvulus | 0.0252 | 0.1111 | 1 | |
Brugia malayi | hypothetical protein | 0.0228 | 0.0983 | 0.0983 |
Schistosoma mansoni | nephrin | 0.0103 | 0.0322 | 0.0996 |
Leishmania major | udp-glc 4-epimerase, putative | 0.068 | 0.3377 | 1 |
Trichomonas vaginalis | NAD dependent epimerase/dehydratase, putative | 0.0654 | 0.3236 | 1 |
Trypanosoma brucei | UDP-galactose 4-epimerase | 0.068 | 0.3377 | 1 |
Echinococcus multilocularis | tyrosine protein kinase | 0.1239 | 0.6332 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0194 | 0.0194 |
Mycobacterium ulcerans | lipase LipD | 0.0042 | 0 | 0.5 |
Schistosoma mansoni | ephrin receptor | 0.0054 | 0.0065 | 0.02 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0109 | 0.0352 | 0.0352 |
Echinococcus granulosus | roundabout 2 | 0.0103 | 0.0322 | 0.0509 |
Echinococcus multilocularis | Immunoglobulin | 0.0079 | 0.0194 | 0.0306 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0079 | 0.0194 | 0.0306 |
Brugia malayi | hypothetical protein | 0.0161 | 0.0628 | 0.0628 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.1674 | 0.8633 | 0.8636 |
Onchocerca volvulus | 0.0228 | 0.0983 | 0.8843 | |
Echinococcus multilocularis | MAM | 0.0228 | 0.0983 | 0.1552 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0042 | 0 | 0.5 |
Echinococcus multilocularis | UDP glucose 4 epimerase | 0.0654 | 0.3236 | 0.511 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0017 | 0.0053 |
Giardia lamblia | UDP-glucose 4-epimerase | 0.068 | 0.3377 | 0.5 |
Schistosoma mansoni | UDP-glucose 4-epimerase | 0.0654 | 0.3236 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0194 | 0.0194 |
Schistosoma mansoni | hypothetical protein | 0.0228 | 0.0983 | 0.3037 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0148 | 0.0562 | 0.0563 |
Loa Loa (eye worm) | UDP galactose 4'-epimerase | 0.0654 | 0.3236 | 0.3237 |
Echinococcus granulosus | neuroglian | 0.0079 | 0.0194 | 0.0306 |
Brugia malayi | PAS domain containing protein | 0.0048 | 0.0031 | 0.0031 |
Echinococcus granulosus | twitchin | 0.0079 | 0.0194 | 0.0306 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0194 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0194 | 0.0194 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0049 | 0.0037 | 0.0037 |
Entamoeba histolytica | UDP-glucose 4-epimerase, putative | 0.0654 | 0.3236 | 0.5 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0048 | 0.0031 | 0.0096 |
Mycobacterium leprae | Probable lipase LipE | 0.0042 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0228 | 0.0983 | 0.3037 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0103 | 0.0322 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.0983 | 0.0983 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.0628 | 0.0628 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0017 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0322 | 0.0322 |
Mycobacterium ulcerans | beta-lactamase | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0194 | 0.0194 |
Brugia malayi | hypoxia-induced factor 1 | 0.0148 | 0.0562 | 0.0562 |
Brugia malayi | UDP galactose 4'-epimerase | 0.0654 | 0.3236 | 0.3236 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0017 | 0.0027 |
Trypanosoma cruzi | UDP-galactose 4-epimerase, putative | 0.0654 | 0.3236 | 1 |
Echinococcus granulosus | UDP glucose 4 epimerase | 0.0654 | 0.3236 | 0.511 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0194 | 0.0194 |
Loa Loa (eye worm) | TK protein kinase | 0.1239 | 0.6332 | 0.6334 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0017 | 0.0017 |
Schistosoma mansoni | cell adhesion molecule | 0.0103 | 0.0322 | 0.0996 |
Schistosoma mansoni | single-minded | 0.0048 | 0.0031 | 0.0096 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0238 | 0.1038 | 0.1039 |
Brugia malayi | follicle stimulating hormone receptor | 0.0238 | 0.1038 | 0.1038 |
Echinococcus multilocularis | roundabout 2 | 0.0103 | 0.0322 | 0.0509 |
Echinococcus multilocularis | neuroglian | 0.0079 | 0.0194 | 0.0306 |
Loa Loa (eye worm) | hypothetical protein | 0.1209 | 0.6173 | 0.6175 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.0983 | 0.0983 |
Schistosoma mansoni | vesicular amine transporter | 0.0079 | 0.0194 | 0.0598 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0268 | 0.1198 | 1 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0079 | 0.0194 | 0.0306 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.1931 | 0.9997 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0049 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0322 | 0.0322 |
Echinococcus granulosus | tyrosine protein kinase | 0.1239 | 0.6332 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.0983 | 0.0983 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0054 | 0.0065 | 0.0102 |
Brugia malayi | Protein kinase domain containing protein | 0.1239 | 0.6332 | 0.6332 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0103 | 0.0322 | 0.0322 |
Trypanosoma cruzi | UDP-galactose 4-epimerase | 0.0654 | 0.3236 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0017 | 0.0053 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0017 | 0.0027 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0042 | 0 | 0.5 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0079 | 0.0194 | 0.0598 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0079 | 0.0194 | 0.0598 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0109 | 0.0352 | 0.0352 |
Brugia malayi | hypothetical protein | 0.0103 | 0.0322 | 0.0322 |
Toxoplasma gondii | UDP-glucose 4-epimerase | 0.0654 | 0.3236 | 1 |
Echinococcus granulosus | Immunoglobulin | 0.0079 | 0.0194 | 0.0306 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.67 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.668 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.628 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.62 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.61 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.586 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.583 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.583 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.565 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.55 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.