TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 495.367 | Formula: C22H38BrCl2N3
H donors: 0 H acceptors: 0 LogP: 6.44 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: CN(CCCCN1CCCC1)CCCCN(CCc1ccc(c(c1)Cl)Cl)C.Br
InChi: 1S/C22H37Cl2N3.BrH/c1-25(13-5-6-15-27-16-7-8-17-27)12-3-4-14-26(2)18-11-20-9-10-21(23)22(24)19-20;/h9-10,19H,3-8,11-18H2,1-2H3;1H
InChiKey: SAJDFXCTCCWXLD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	MH2 domain containing protein	0.0009	0.0015	0.0015
Brugia malayi	SWIB/MDM2 domain containing protein	0.0993	1	1
Schistosoma mansoni	zinc finger protein	0.0018	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0104	0.0104
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0138	0.0102
Schistosoma mansoni	fusion	0.0353	0.3507	0.3507
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0353	0.3507	1
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0018	0.0104	0.0104
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0353	0.3507	1
Echinococcus multilocularis	SWI:SNF matrix associated	0.0993	1	1
Echinococcus multilocularis	roundabout 2	0.0011	0.0034	0.0034
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.0138	1
Echinococcus granulosus	zinc finger protein Ran binding	0.0353	0.3507	0.3507
Echinococcus multilocularis	smad	0.0009	0.0015	0.0015
Onchocerca volvulus		0.0353	0.3507	0.3507
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0104	0.0104
Echinococcus multilocularis	Lipid transport protein, N terminal	0.0093	0.0868	0.0868
Loa Loa (eye worm)	brahma associated protein	0.0993	1	1
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0993	1	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0138	0.0138
Schistosoma mansoni	hypothetical protein	0.0018	0.0104	0.0104
Schistosoma mansoni	hypothetical protein	0.0353	0.3507	0.3507
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0104	0.0104
Brugia malayi	brahma associated protein 60 kDa	0.0993	1	1
Schistosoma mansoni	hypothetical protein	0.0993	1	1
Echinococcus granulosus	neuroglian	0.0009	0.0011	0.0011
Echinococcus granulosus	ring finger protein 113a	0.0018	0.0104	0.0104
Leishmania major	hypothetical protein, conserved	0.0353	0.3507	1
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0018	0.0104	0.0104
Echinococcus multilocularis	RING finger protein 185	0.0018	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0104	0.0104
Echinococcus multilocularis	E3 ubiquitin protein ligase MYLIP	0.0018	0.0104	0.0104
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0.0138	1
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0353	0.3507	0.3507
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0138	0.0035
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0138	0.5
Onchocerca volvulus		0.0104	0.0978	0.0978
Loa Loa (eye worm)	transcription factor SMAD2	0.0136	0.13	0.13
Loa Loa (eye worm)	RiNg Finger protein family member	0.0018	0.0104	0.0104
Schistosoma mansoni	hypothetical protein	0.0018	0.0104	0.0104
Schistosoma mansoni	peter pan-related	0.0018	0.0104	0.0104
Brugia malayi	hypothetical protein	0.0018	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0104	0.0104
Schistosoma mansoni	brg-1 associated factor	0.0993	1	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0138	0.0138
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0015	0.0015
Loa Loa (eye worm)	MH2 domain-containing protein	0.0136	0.13	0.13
Chlamydia trachomatis	DNA topoisomerase I	0.0993	1	0.5
Toxoplasma gondii	ran binding protein	0.0353	0.3507	0.3438
Schistosoma mansoni	ap endonuclease	0.0021	0.0138	0.0138
Loa Loa (eye worm)	Smad1	0.0009	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0492	0.0492
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0993	1	1
Loa Loa (eye worm)	hypothetical protein	0.0353	0.3507	0.3507
Echinococcus granulosus	E3 ubiquitin protein ligase LRSAM1	0.0018	0.0104	0.0104
Onchocerca volvulus		0.0018	0.0104	0.0104
Schistosoma mansoni	hypothetical protein	0.0993	1	1
Trypanosoma cruzi	WLM domain containing protein, putative	0.0353	0.3507	1
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0993	1	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0034	0.0034
Echinococcus granulosus	E3 ubiquitin protein ligase RNF146	0.0018	0.0104	0.0104
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0114	0.1079	0.1079
Onchocerca volvulus	Protein neuralized homolog	0.0018	0.0104	0.0104
Schistosoma mansoni	peter pan-related	0.0018	0.0104	0.0104
Brugia malayi	hypothetical protein	0.0018	0.0104	0.0104
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0353	0.3507	0.3438
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0138	0.0102
Brugia malayi	hypothetical protein	0.0018	0.0104	0.0104
Echinococcus multilocularis	E3 ubiquitin protein ligase LRSAM1	0.0018	0.0104	0.0104
Echinococcus multilocularis	ring finger protein 113a	0.0018	0.0104	0.0104
Brugia malayi	hypothetical protein	0.0018	0.0104	0.0104
Trypanosoma cruzi	hypothetical protein, conserved	0.0353	0.3507	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.0138	0.5
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0015	0.0015
Schistosoma mansoni	serine/threonine protein kinase	0.0018	0.0104	0.0104
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0353	0.3507	0.3507
Onchocerca volvulus		0.0018	0.0104	0.0104
Trypanosoma cruzi	WLM domain containing protein, putative	0.0353	0.3507	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0138	0.0035
Brugia malayi	RING finger protein 20	0.0018	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0104	0.0104
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0138	0.0102
Schistosoma mansoni	RNA binding protein	0.0353	0.3507	0.3507
Echinococcus multilocularis	neuropeptide receptor	0.0408	0.4059	0.4059
Schistosoma mansoni	neuropeptide receptor	0.0408	0.4059	0.4059
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0138	0.0035
Echinococcus multilocularis	ring and YY1 binding protein	0.0353	0.3507	0.3507
Trypanosoma cruzi	hypothetical protein, conserved	0.0353	0.3507	1
Schistosoma mansoni	Smad4	0.0009	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0353	0.3507	0.3507
Onchocerca volvulus		0.0018	0.0104	0.0104
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0993	1	1
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0993	1	1
Echinococcus granulosus	microsomal triglyceride transfer protein large	0.0164	0.159	0.159
Echinococcus multilocularis	Smad4	0.0009	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0104	0.0104
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0353	0.3507	0.3438
Trypanosoma cruzi	hypothetical protein, conserved	0.0353	0.3507	1
Onchocerca volvulus	Apolipophorins homolog	0.0093	0.0868	0.0868
Schistosoma mansoni	smad	0.0009	0.0015	0.0015
Schistosoma mansoni	hypothetical protein	0.0164	0.159	0.159
Onchocerca volvulus		0.0018	0.0104	0.0104
Echinococcus granulosus	Lipid transport protein N terminal	0.0093	0.0868	0.0868
Echinococcus granulosus	Zinc finger RanBP2 type	0.0353	0.3507	0.3507
Echinococcus granulosus	neuropeptide receptor	0.0408	0.4059	0.4059
Loa Loa (eye worm)	RING finger protein 20	0.0018	0.0104	0.0104
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0993	1	1
Onchocerca volvulus	Putative RING finger protein 207	0.0018	0.0104	0.0104
Echinococcus multilocularis	zinc finger protein Ran binding	0.0353	0.3507	0.3507
Echinococcus granulosus	twitchin	0.0009	0.0011	0.0011
Brugia malayi	RING zinc finger protein	0.0018	0.0104	0.0104
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0138	0.0035
Echinococcus granulosus	ring and YY1 binding protein	0.0353	0.3507	0.3507
Brugia malayi	MH2 domain containing protein	0.0009	0.0015	0.0015
Brugia malayi	B-box zinc finger family protein	0.0018	0.0104	0.0104
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0015	0.0015
Echinococcus granulosus	smad	0.0009	0.0015	0.0015
Echinococcus multilocularis	E3 ubiquitin protein ligase Bre1	0.0018	0.0104	0.0104
Brugia malayi	hypothetical protein	0.0018	0.0104	0.0104
Schistosoma mansoni	nephrin	0.0009	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0353	0.3507	0.3507
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0015	0.0015
Brugia malayi	Neuralized family protein	0.0018	0.0104	0.0104
Brugia malayi	hypothetical protein	0.0018	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0104	0.0104
Brugia malayi	MH2 domain containing protein	0.0136	0.13	0.13
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0164	0.159	0.159
Trypanosoma brucei	hypothetical protein, conserved	0.0353	0.3507	1
Echinococcus multilocularis	microsomal triglyceride transfer protein large	0.0164	0.159	0.159
Schistosoma mansoni	cell adhesion molecule	0.0009	0.0016	0.0016
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0353	0.3507	1
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0015	0.0015
Echinococcus multilocularis	G protein coupled receptor 139	0.0408	0.4059	0.4059
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0015	0.0015
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0993	1	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0016	0.0016
Schistosoma mansoni	rnf5	0.0018	0.0104	0.0104
Schistosoma mansoni	TRABID protein (C64 family)	0.0353	0.3507	0.3507
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0138	0.0138
Echinococcus granulosus	RING finger protein 185	0.0018	0.0104	0.0104
Schistosoma mansoni	cellular tumor antigen P53	0.0056	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0353	0.3507	0.3507
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0138	0.0102
Brugia malayi	Hypothetical RING finger protein C16C10.7 in chromosome III	0.0018	0.0104	0.0104
Brugia malayi	Zinc finger protein 183 homolog	0.0018	0.0104	0.0104
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0353	0.3507	1
Echinococcus granulosus	ring finger protein 170	0.0018	0.0104	0.0104
Trichomonas vaginalis	conserved hypothetical protein	0.0993	1	1
Plasmodium vivax	hypothetical protein, conserved	0.0993	1	1
Echinococcus granulosus	SWI:SNF matrix associated	0.0993	1	1
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0353	0.3507	0.3507
Echinococcus granulosus	E3 ubiquitin protein ligase MYLIP	0.0018	0.0104	0.0104
Echinococcus multilocularis	SWI:SNF matrix associated	0.0993	1	1
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0353	0.3507	1
Echinococcus granulosus	tumor protein p63	0.0384	0.3823	0.3823
Schistosoma mansoni	ring finger protein 151	0.0018	0.0104	0.0104
Echinococcus multilocularis	ring finger protein 170	0.0018	0.0104	0.0104
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0138	0.5
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0868	0.0868
Toxoplasma gondii	exonuclease III APE	0.0021	0.0138	0.0035
Trypanosoma brucei	hypothetical protein, conserved	0.0353	0.3507	1
Echinococcus granulosus	E3 ubiquitin protein ligase Bre1	0.0018	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0104	0.0104
Schistosoma mansoni	ap endonuclease	0.0021	0.0138	0.0138
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0353	0.3507	0.3507
Echinococcus granulosus	RING finger and transmembrane domain containing protein	0.0018	0.0104	0.0104
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0353	0.3507	1
Echinococcus granulosus	cell growth regulator with ring finger domain	0.0018	0.0104	0.0104
Schistosoma mansoni	inhibitor of apoptosis 1 diap1	0.0018	0.0104	0.0104
Onchocerca volvulus		0.0993	1	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0015	0.0015
Echinococcus multilocularis	neuroglian	0.0009	0.0011	0.0011
Echinococcus multilocularis	SWI:SNF matrix associated	0.0993	1	1
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0015	0.0015
Brugia malayi	Zinc finger, C2H2 type family protein	0.0018	0.0104	0.0104
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0353	0.3507	1
Onchocerca volvulus		0.0353	0.3507	0.3507
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0034	0.0034
Leishmania major	hypothetical protein, conserved	0.0353	0.3507	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0107	0.1003	0.1003
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0353	0.3507	0.3507
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0353	0.3507	0.3507
Brugia malayi	YY1-associated factor 2	0.0353	0.3507	0.3507
Brugia malayi	MH1 domain containing protein	0.0009	0.0015	0.0015
Schistosoma mansoni	zinc finger protein	0.0353	0.3507	0.3507
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0021	0.0138	0.5
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0138	0.0138
Echinococcus multilocularis	RING finger and transmembrane domain containing protein	0.0018	0.0104	0.0104
Onchocerca volvulus		0.0353	0.3507	0.3507
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0114	0.1079	0.1079
Echinococcus multilocularis	tumor protein p63	0.0384	0.3823	0.3823
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0993	1	1
Onchocerca volvulus		0.0056	0.0492	0.0492
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0353	0.3507	0.3507
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0015	0.0015
Leishmania major	hypothetical protein, conserved	0.0353	0.3507	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0353	0.3507	0.3507
Schistosoma mansoni	mind bomb	0.0018	0.0104	0.0104
Onchocerca volvulus		0.0353	0.3507	0.3507
Echinococcus granulosus	Smad4	0.0009	0.0015	0.0015
Leishmania major	hypothetical protein, conserved	0.0353	0.3507	1
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0009	0.0016	0.0016
Brugia malayi	MH1 domain containing protein	0.0009	0.0015	0.0015
Echinococcus multilocularis		0.0018	0.0104	0.0104
Onchocerca volvulus		0.0018	0.0104	0.0104
Leishmania major	hypothetical protein, conserved	0.0353	0.3507	1
Chlamydia trachomatis	SWIB complex protein	0.0993	1	0.5
Schistosoma mansoni	hypothetical protein	0.0993	1	1
Schistosoma mansoni	hypothetical protein	0.0018	0.0104	0.0104
Onchocerca volvulus	RING finger protein 141 homolog	0.0018	0.0104	0.0104
Onchocerca volvulus		0.0018	0.0104	0.0104
Echinococcus granulosus	roundabout 2	0.0011	0.0034	0.0034
Brugia malayi	Smad1	0.0009	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0353	0.3507	0.3507

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-6.293	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-6.045	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.994	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.901	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.9	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.828	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.767	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.718	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.718	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.704	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.564	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2004580

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1632522