Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0363 | 0.3359 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.102 | 1 | 0.5 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0363 | 0.3359 | 1 |
Onchocerca volvulus | 0.102 | 1 | 1 | |
Loa Loa (eye worm) | brahma associated protein | 0.102 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.3359 | 0.3359 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.102 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.3359 | 0.3359 |
Toxoplasma gondii | ran binding protein | 0.0363 | 0.3359 | 0.3359 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.3359 | 0.3359 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.3359 | 0.3359 |
Toxoplasma gondii | Zn-finger in Ran binding protein and others domain-containing protein | 0.0363 | 0.3359 | 0.3359 |
Plasmodium falciparum | zinc finger Ran-binding domain-containing protein 2, putative | 0.0363 | 0.3359 | 0.3359 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.102 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0363 | 0.3359 | 0.3359 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0363 | 0.3359 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.102 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0363 | 0.3359 | 1 |
Schistosoma mansoni | hypothetical protein | 0.102 | 1 | 1 |
Schistosoma mansoni | brg-1 associated factor | 0.102 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.102 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.102 | 1 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0363 | 0.3359 | 1 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.102 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.102 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0363 | 0.3359 | 0.3359 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0363 | 0.3359 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0363 | 0.3359 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0363 | 0.3359 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0363 | 0.3359 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0363 | 0.3359 | 0.3359 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.102 | 1 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0363 | 0.3359 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0363 | 0.3359 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.102 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.102 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0363 | 0.3359 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0363 | 0.3359 | 0.3359 |
Schistosoma mansoni | hypothetical protein | 0.102 | 1 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.0363 | 0.3359 | 0.3359 |
Plasmodium vivax | hypothetical protein, conserved | 0.102 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0363 | 0.3359 | 1 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0363 | 0.3359 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0363 | 0.3359 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0363 | 0.3359 | 1 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.102 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.102 | 1 | 0.5 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.102 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.102 | 1 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.102 | 1 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0363 | 0.3359 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0363 | 0.3359 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.3359 | 0.3359 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.102 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0363 | 0.3359 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.102 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 53 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | > 47.1 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.5623 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.