Detailed information for compound 1632535

Basic information

Technical information
  • TDR Targets ID: 1632535
  • Name: 1-[2-chloro-1-(4-methoxyphenyl)-2-phenylethen yl]-4-methoxybenzene
  • MW: 350.838 | Formula: C22H19ClO2
  • H donors: 0 H acceptors: 0 LogP: 6.44 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=C(c1ccccc1)Cl)c1ccc(cc1)OC
  • InChi: 1S/C22H19ClO2/c1-24-19-12-8-16(9-13-19)21(17-10-14-20(25-2)15-11-17)22(23)18-6-4-3-5-7-18/h3-15H,1-2H3
  • InChiKey: SXHPIOYGNGNXRF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-chloro-1-(4-methoxyphenyl)-2-phenyl-vinyl]-4-methoxy-benzene
  • 1-[2-chloro-1-(4-methoxyphenyl)-2-phenylvinyl]-4-methoxybenzene
  • 1-[2-chloro-1-(4-methoxyphenyl)-2-phenyl-ethenyl]-4-methoxy-benzene
  • AIDS146754
  • NSC674613
  • NCI60_026458
  • 1-(2-Chloro-1-(4-methoxyphenyl)-2-phenylvinyl)-4-methoxybenzene
  • AIDS-146754

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0729 0.872 0.872
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0187 0.0622
Plasmodium vivax vivapain-2 0.002 0.0062 0.0018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0062 0.0069
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0062 0.0069
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0165 0.0165
Echinococcus multilocularis musashi 0.0033 0.0213 0.0213
Brugia malayi Death domain containing protein 0.0017 0.0027 0.0031
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0346 0.0346
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0165 0.0165
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.0001 0.0001
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0062 0.0062
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0675 0.2259
Schistosoma mansoni hypothetical protein 0.0019 0.0048 0.0048
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0259 0.2982 0.2982
Entamoeba histolytica hypothetical protein 0.0043 0.0346 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0062 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0756 0.2418
Echinococcus granulosus GPCR family 2 0.0019 0.0048 0.0048
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0165 0.0165
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0683 0.0783
Onchocerca volvulus 0.002 0.0062 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0165 0.019
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0062 0.0018
Leishmania major cysteine peptidase A (CPA) 0.002 0.0062 0.0203
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0165 0.019
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0213 0.0244
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.0001 0.0001
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0259 0.2982 0.2982
Schistosoma mansoni hypothetical protein 0.0017 0.0027 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.049 0.049
Onchocerca volvulus 0.0033 0.0213 0.0243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0062 0.0069
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0213 0.0244
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0165 0.019
Schistosoma mansoni hypothetical protein 0.0019 0.0048 0.0048
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0046 0.0046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0165 0.019
Brugia malayi SWIB/MDM2 domain containing protein 0.0729 0.872 1
Brugia malayi ecdysteroid receptor 0.0029 0.0165 0.019
Echinococcus multilocularis geminin 0.0205 0.2316 0.2316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0062 0.0069
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0062 0.0062
Brugia malayi brahma associated protein 60 kDa 0.0729 0.872 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0165 0.019
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0165 0.019
Loa Loa (eye worm) hypothetical protein 0.0535 0.6352 0.7285
Onchocerca volvulus Cathepsin F homolog 0.002 0.0062 0.0069
Schistosoma mansoni lamin 0.0033 0.0213 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0165 0.019
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0259 0.2982 0.2982
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0007 0.0007
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0046 0.0151
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0187 0.0162
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0165 0.0165
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0683 0.0683
Schistosoma mansoni lozenge 0.0067 0.0635 0.0635
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0165 0.0165
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0756 0.2533
Echinococcus multilocularis zinc finger protein Ran binding 0.0259 0.2982 0.2982
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0033
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0046 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0165 0.019
Loa Loa (eye worm) hypothetical protein 0.0029 0.0165 0.019
Brugia malayi YY1-associated factor 2 0.0259 0.2982 0.342
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0062 0.0069
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0213 0.0244
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0165 0.0165
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3305 0.3305
Brugia malayi jmjC domain containing protein 0.0019 0.0046 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0165 0.019
Echinococcus granulosus cathepsin l1 0.002 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0259 0.2982 0.342
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0062 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0756 0.2418
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0165 0.019
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0165 0.0165
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0048 0.0055
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0259 0.2982 1
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0165 0.019
Loa Loa (eye worm) hypothetical protein 0.0029 0.0165 0.019
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0346 0.0346
Leishmania major hypothetical protein, conserved 0.0259 0.2982 1
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0729 0.872 1
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Echinococcus granulosus Zinc finger RanBP2 type 0.0259 0.2982 0.2982
Brugia malayi PAS domain containing protein 0.0059 0.0533 0.0611
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0046 0.0046
Loa Loa (eye worm) ctsf protein 0.002 0.0062 0.0071
Loa Loa (eye worm) hypothetical protein 0.0033 0.0213 0.0244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0062 0.0069
Schistosoma mansoni TRABID protein (C64 family) 0.0259 0.2982 0.2982
Loa Loa (eye worm) hypothetical protein 0.0197 0.2224 0.255
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0729 0.872 0.872
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0187 0.0162
Loa Loa (eye worm) hypothetical protein 0.0259 0.2982 0.342
Onchocerca volvulus 0.002 0.0062 0.0069
Leishmania major cathepsin L-like protease 0.0077 0.0756 0.2533
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0062 0.0069
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0165 0.019
Entamoeba histolytica hypothetical protein 0.0043 0.0346 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0259 0.2982 0.342
Brugia malayi steroid hormone receptor 0.0029 0.0165 0.019
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0551 0.0631
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0346 0.0397
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0551 0.0631
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0062 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0756 0.2418
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0259 0.2982 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0683 0.0683
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.049 0.0562
Schistosoma mansoni netrin receptor unc5 0.0017 0.0027 0.0027
Echinococcus multilocularis SWI:SNF matrix associated 0.0729 0.872 0.872
Schistosoma mansoni brg-1 associated factor 0.0729 0.872 0.872
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0187 0.0162
Schistosoma mansoni hypothetical protein 0.0019 0.0048 0.0048
Schistosoma mansoni zinc finger protein 0.0259 0.2982 0.2982
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0259 0.2982 1
Onchocerca volvulus 0.0259 0.2982 0.3419
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0027 0.0031
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0259 0.2982 0.3385
Echinococcus multilocularis thyroid hormone receptor alpha 0.0029 0.0165 0.0165
Brugia malayi Cathepsin L-like precursor 0.002 0.0062 0.0071
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.664 0.664
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0165 0.0165
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0046 0.0046
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.049 0.049
Loa Loa (eye worm) hypothetical protein 0.003 0.0187 0.0214
Brugia malayi Uncoordinated protein 44 0.0017 0.0027 0.0031
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0346 0.5
Chlamydia trachomatis SWIB complex protein 0.0729 0.872 1
Schistosoma mansoni fusion 0.0259 0.2982 0.2982
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.049 0.049
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0729 0.872 1
Echinococcus granulosus geminin 0.0205 0.2316 0.2316
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0062 0.0069
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0165 0.0165
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0259 0.2982 0.3385
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0346 0.0346
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0062 0.0018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.049 0.049
Onchocerca volvulus 0.0033 0.0213 0.0243
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Loa Loa (eye worm) hypothetical protein 0.0286 0.3305 0.379
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.006 0.0551 0.0631
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0053
Onchocerca volvulus 0.002 0.0062 0.0069
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0165 0.0165
Leishmania major cathepsin L-like protease 0.002 0.0062 0.0203
Loa Loa (eye worm) hypothetical protein 0.0029 0.0165 0.019
Echinococcus granulosus death domain containing protein 0.0017 0.0027 0.0027
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0048 0.0055
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0027 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.049 0.049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0062 0.0069
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0029 0.0165 0.019
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3305 0.3305
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0165 0.019
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0165 0.0165
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0165 0.0165
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0165 0.0165
Brugia malayi hypothetical protein 0.0197 0.2224 0.255
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0259 0.2982 1
Brugia malayi jmjC domain containing protein 0.0019 0.0046 0.0053
Schistosoma mansoni hypothetical protein 0.0729 0.872 0.872
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0062 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0259 0.2982 1
Brugia malayi intermediate filament protein 0.0033 0.0213 0.0244
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0259 0.2982 0.342
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0027 0.0027
Brugia malayi hypothetical protein 0.0535 0.6352 0.7285
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0259 0.2982 1
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.664 0.664
Schistosoma mansoni coup transcription factor 0.0029 0.0165 0.0165
Brugia malayi hypoxia-induced factor 1 0.0182 0.2037 0.2336
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0165 0.0165
Leishmania major cathepsin L-like protease 0.002 0.0062 0.0203
Toxoplasma gondii cathepsin CPL 0.002 0.0062 0.0018
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.0001 0.0002
Onchocerca volvulus 0.0058 0.0527 0.0603
Schistosoma mansoni hypothetical protein 0.0041 0.0318 0.0318
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0062 0.0062
Echinococcus granulosus zinc finger protein Ran binding 0.0259 0.2982 0.2982
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0018 0.0029 0.0029
Schistosoma mansoni lamin 0.0033 0.0213 0.0213
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0187 0.0622
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.049 0.0562
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0165 0.0165
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0046 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0165 0.019
Leishmania major hypothetical protein, conserved 0.0259 0.2982 1
Leishmania major hypothetical protein, conserved 0.0019 0.0046 0.0151
Loa Loa (eye worm) hypothetical protein 0.0259 0.2982 0.342
Echinococcus granulosus SWI:SNF matrix associated 0.0729 0.872 0.872
Brugia malayi Cathepsin L-like precursor 0.002 0.0062 0.0071
Schistosoma mansoni hypothetical protein 0.0058 0.0527 0.0527
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0165 0.019
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0062 0.0062
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0062 0.0071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0062 0.0069
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0062 0.0071
Brugia malayi hypothetical protein 0.0043 0.0346 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0062 0.0069
Leishmania major hypothetical protein, conserved 0.0259 0.2982 1
Leishmania major cathepsin L-like protease 0.0077 0.0756 0.2533
Echinococcus multilocularis lamin 0.0033 0.0213 0.0213
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0259 0.2982 0.342
Echinococcus granulosus single minded 2 0.0043 0.0346 0.0346
Onchocerca volvulus 0.0535 0.6352 0.7285
Echinococcus granulosus phd:f box containing protein 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0029 0.0165 0.019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0756 0.2418
Echinococcus multilocularis Protein lozenge 0.0067 0.0635 0.0635
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0346 0.0346
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0259 0.2982 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0165 0.019
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0089 0.0902 0.0902
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.049 0.049
Onchocerca volvulus 0.0043 0.0346 0.0396
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0165 0.0165
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0046 0.0046
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0046 0.0046
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0165 0.0188
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0027 0.0027
Leishmania major hypothetical protein, conserved 0.0259 0.2982 1
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0165 0.0165
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0002
Loa Loa (eye worm) cysteine protease 0.002 0.0062 0.0071
Brugia malayi jmjC domain containing protein 0.0071 0.0683 0.0783
Loa Loa (eye worm) hypothetical protein 0.0259 0.2982 0.342
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0048 0.0055
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0046 0.0053
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0165 0.019
Echinococcus multilocularis SWI:SNF matrix associated 0.0729 0.872 0.872
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0046 0.0053
Loa Loa (eye worm) hypothetical protein 0.0029 0.0165 0.019
Schistosoma mansoni hypothetical protein 0.0729 0.872 0.872
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0165 0.019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0062 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0062 0.0069
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0683 0.0683
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0259 0.2982 0.3419
Onchocerca volvulus 0.002 0.0062 0.0069
Onchocerca volvulus 0.0259 0.2982 0.3419
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0165 0.0165
Entamoeba histolytica hypothetical protein 0.0043 0.0346 1
Brugia malayi Protein kinase domain containing protein 0.0017 0.0027 0.0031
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0756 0.2533
Loa Loa (eye worm) hypothetical protein 0.0218 0.2479 0.2843
Trypanosoma cruzi WLM domain containing protein, putative 0.0259 0.2982 1
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0729 0.872 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0062 0.0071
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0683 0.0683
Schistosoma mansoni intermediate filament proteins 0.0033 0.0213 0.0213
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0165 0.0165
Echinococcus multilocularis Ankyrin 0.0018 0.0029 0.0029
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0046 0.0053
Leishmania major cathepsin L-like protease 0.0077 0.0756 0.2533
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0555 0.1857
Mycobacterium leprae Possible regulatory protein 0.0015 0.0001 0.5
Echinococcus granulosus ring and YY1 binding protein 0.0259 0.2982 0.2982
Leishmania major hypothetical protein, conserved 0.0259 0.2982 1
Chlamydia trachomatis DNA topoisomerase I 0.0729 0.872 1
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0027 0.0029
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0756 0.2533
Echinococcus granulosus lamin 0.0033 0.0213 0.0213
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0165 0.0165
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0259 0.2982 0.2982
Brugia malayi Cathepsin L-like precursor 0.002 0.0062 0.0071
Echinococcus multilocularis GPCR, family 2 0.0019 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0043 0.0346 0.0346
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0756 0.2418
Echinococcus multilocularis SWI:SNF matrix associated 0.0729 0.872 0.872
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0046 0.0046
Echinococcus granulosus Ankyrin 0.0018 0.0029 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0756 0.2418
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0527 0.0604
Plasmodium vivax vivapain-2 0.002 0.0062 0.0018
Leishmania major cathepsin L-like protease 0.002 0.0062 0.0203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0165 0.019
Brugia malayi jmjC domain containing protein 0.0071 0.0683 0.0783
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0062 0.0069
Schistosoma mansoni hypothetical protein 0.0019 0.0048 0.0048
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0165 0.019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0062 0.0069
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0165 0.0188
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0729 0.872 1
Trypanosoma cruzi hypothetical protein, conserved 0.0259 0.2982 1
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0027 0.0027
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0165 0.0165
Schistosoma mansoni hypothetical protein 0.0205 0.2316 0.2316
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0048 0.0048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0062 0.0069
Echinococcus multilocularis cysteine protease 0.002 0.0062 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0756 0.2418
Brugia malayi brahma associated protein 60 kDa 0.0729 0.872 1
Echinococcus multilocularis cysteine protease 0.002 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0729 0.872 0.872
Onchocerca volvulus 0.0729 0.872 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0059 0.0533 0.0533
Brugia malayi hypothetical protein 0.003 0.0187 0.0214
Schistosoma mansoni RNA binding protein 0.0259 0.2982 0.2982
Trypanosoma cruzi WLM domain containing protein, putative 0.0259 0.2982 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0071
Entamoeba histolytica hypothetical protein 0.0043 0.0346 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0031
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0165 0.0165
Echinococcus granulosus lamin dm0 0.0033 0.0213 0.0213
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0046 0.0046
Onchocerca volvulus 0.002 0.0062 0.0069
Trypanosoma brucei hypothetical protein, conserved 0.0259 0.2982 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0089 0.0902 0.0902
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0165 0.0165
Plasmodium vivax hypothetical protein, conserved 0.0729 0.872 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0756 0.2418
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0165 0.019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0756 0.2418
Loa Loa (eye worm) hypothetical protein 0.0029 0.0165 0.019
Loa Loa (eye worm) runx1 0.0067 0.0635 0.0728
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0683 0.0683
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0259 0.2982 1
Brugia malayi jmjC domain containing protein 0.0019 0.0046 0.0053
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0046 0.0046
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0551 0.0631
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0187 0.0479
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0165 0.019
Onchocerca volvulus Cathepsin L homolog 0.002 0.0062 0.0069
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0007 0.0007
Echinococcus multilocularis lamin dm0 0.0033 0.0213 0.0213
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.049 0.049
Onchocerca volvulus 0.002 0.0062 0.0069
Brugia malayi nuclear hormone receptor 0.0029 0.0165 0.019
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0062 0.0071
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0165 0.0165
Leishmania major cathepsin L-like protease 0.002 0.0062 0.0203
Loa Loa (eye worm) brahma associated protein 0.0729 0.872 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0318 0.0364
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0756 0.2533
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0187 0.0162
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0756 0.2418
Schistosoma mansoni survival motor neuron protein 0.0058 0.0527 0.0527
Toxoplasma gondii ran binding protein 0.0259 0.2982 0.3385
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0165 0.019
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0062 0.0203
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0165 0.0165
Brugia malayi Cathepsin L-like precursor 0.002 0.0062 0.0071
Brugia malayi nuclear receptor NHR-88 0.0029 0.0165 0.019
Onchocerca volvulus 0.0259 0.2982 0.3419
Brugia malayi Cytochrome P450 family protein 0.0027 0.0149 0.017
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0046 0.0046
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.664 0.664
Leishmania major protein kinase, putative 0.002 0.0059 0.0193
Loa Loa (eye worm) hypothetical protein 0.0535 0.6352 0.7285
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.2479 0.2842
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0062 0.0062
Schistosoma mansoni single-minded 0.0059 0.0533 0.0533
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0165 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0165 0.019
Loa Loa (eye worm) hypoxia-induced factor 1 0.0182 0.2037 0.2336
Loa Loa (eye worm) hypothetical protein 0.0259 0.2982 0.342
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0149 0.017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0062 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0165 0.019
Brugia malayi hypothetical protein 0.0286 0.3305 0.379
Trypanosoma cruzi hypothetical protein, conserved 0.0259 0.2982 1
Trypanosoma brucei hypothetical protein, conserved 0.0259 0.2982 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0683 0.0683
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0756 0.2418
Echinococcus multilocularis ring and YY1 binding protein 0.0259 0.2982 0.2982
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0046 0.0046
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0046 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0729 0.872 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0062 0.0062
Brugia malayi Cathepsin L-like precursor 0.002 0.0062 0.0071
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0027 0.0031
Leishmania major cathepsin L-like protease 0.002 0.0062 0.0203
Brugia malayi hypothetical protein 0.002 0.0055 0.0063
Loa Loa (eye worm) hypothetical protein 0.0032 0.0206 0.0236
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0028 0.0032
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0683 0.0683
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0062 0.0069
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0205 0.2316 0.2316
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0729 0.872 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0318 0.0364
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0048 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0062 0.0069
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0729 0.872 1
Loa Loa (eye worm) fibroinase 0.002 0.0062 0.0071
Echinococcus granulosus neuropeptide s receptor 0.0558 0.664 0.664
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0165 0.0188
Onchocerca volvulus 0.0259 0.2982 0.3419
Onchocerca volvulus 0.002 0.0062 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0062 0.0069
Onchocerca volvulus 0.0029 0.0165 0.0188
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0046 0.0151
Brugia malayi N-terminal motif family protein 0.0218 0.2479 0.2843
Brugia malayi jmjC domain containing protein 0.0019 0.0046 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0062 0.0069
Echinococcus granulosus intermediate filament protein 0.0033 0.0213 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0062 0.0069
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.0001 0.0001
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0028 0.0032
Leishmania major hypothetical protein, conserved 0.003 0.0187 0.0622
Onchocerca volvulus Cathepsin L homolog 0.002 0.0062 0.0069
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0259 0.2982 0.342

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.238 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.101 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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