Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 | Starlite/ChEMBL | References |
Homo sapiens | germ cell associated 2 (haspin) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dual specificity | 0.0064 | 0.7243 | 0.7302 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0064 | 0.7243 | 1 |
Echinococcus granulosus | dual specificity | 0.0064 | 0.7243 | 0.7302 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0082 | 0.9918 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0064 | 0.7243 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0064 | 0.7243 | 1 |
Brugia malayi | GSG2 | 0.0082 | 0.9918 | 1 |
Echinococcus granulosus | dual specificity | 0.0064 | 0.7243 | 0.7302 |
Loa Loa (eye worm) | haspin protein kinase | 0.0082 | 0.9918 | 0.9918 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0082 | 0.9918 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0082 | 0.9918 | 1 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0064 | 0.7243 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0064 | 0.7243 | 0.7243 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0064 | 0.7243 | 0.5 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0064 | 0.7243 | 0.7302 |
Plasmodium falciparum | MO15-related protein kinase | 0.0015 | 0 | 0.5 |
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.0015 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0064 | 0.7243 | 1 |
Echinococcus multilocularis | dual specificity | 0.0064 | 0.7243 | 0.7302 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0064 | 0.7243 | 0.7302 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0064 | 0.7243 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.9918 | 1 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0064 | 0.7243 | 1 |
Echinococcus multilocularis | dual specificity | 0.0064 | 0.7243 | 0.7302 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0082 | 0.9918 | 1 |
Loa Loa (eye worm) | haspin protein kinase | 0.0082 | 0.9918 | 0.9918 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0064 | 0.7243 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0064 | 0.7243 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0064 | 0.7243 | 1 |
Echinococcus multilocularis | dual specificity | 0.0064 | 0.7243 | 0.7302 |
Brugia malayi | hypothetical protein | 0.0082 | 0.9918 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0064 | 0.7243 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0064 | 0.7243 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0082 | 0.9918 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.6 uM | Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay | ChEMBL. | 22335895 |
IC50 (binding) | > 10 uM | Inhibition of human N-terminal GST-tagged DYRK2 expressed in baculovirus using DYRKtide-F as substrate assessed as inhibition of [33P] incorporation into substrate using [gamma33P]ATP after 10 mins by liquid scintillation counting | ChEMBL. | 22335895 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.