Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.3239 | 0.3239 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0311 | 0.3239 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0311 | 0.3239 | 0.3239 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0874 | 1 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0874 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0311 | 0.3239 | 0.5 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0874 | 1 | 0.5 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0874 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 0.3886 | 0.3886 |
Onchocerca volvulus | 0.0365 | 0.3886 | 0.0957 | |
Schistosoma mansoni | zinc finger protein | 0.0311 | 0.3239 | 0.3239 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0311 | 0.3239 | 0.5 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0311 | 0.3239 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0229 | 0.0229 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0874 | 1 | 1 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0311 | 0.3239 | 0.3239 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0311 | 0.3239 | 0.3239 |
Leishmania major | hypothetical protein, conserved | 0.0311 | 0.3239 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.3239 | 0.3239 |
Leishmania major | hypothetical protein, conserved | 0.0311 | 0.3239 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0311 | 0.3239 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0229 | 0.0229 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0311 | 0.3239 | 0.5 |
Brugia malayi | YY1-associated factor 2 | 0.0311 | 0.3239 | 0.3239 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0874 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0874 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0311 | 0.3239 | 0.5 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0311 | 0.3239 | 0.5 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0874 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.3239 | 0.3239 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0874 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.3239 | 0.3239 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0874 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0311 | 0.3239 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0311 | 0.3239 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0874 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0874 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0874 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0874 | 1 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0874 | 1 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0311 | 0.3239 | 0.3239 |
Schistosoma mansoni | hypothetical protein | 0.0874 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0311 | 0.3239 | 0.5 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0311 | 0.3239 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0229 | 0.0229 |
Chlamydia trachomatis | SWIB complex protein | 0.0874 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0365 | 0.3886 | 0.3886 |
Schistosoma mansoni | fusion | 0.0311 | 0.3239 | 0.3239 |
Loa Loa (eye worm) | brahma associated protein | 0.0874 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0874 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0311 | 0.3239 | 0.3239 |
Leishmania major | hypothetical protein, conserved | 0.0311 | 0.3239 | 0.5 |
Onchocerca volvulus | 0.0874 | 1 | 1 | |
Brugia malayi | brahma associated protein 60 kDa | 0.0874 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0229 | 0.0229 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.3239 | 0.3239 |
Leishmania major | hypothetical protein, conserved | 0.0311 | 0.3239 | 0.5 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0874 | 1 | 1 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0311 | 0.3239 | 0.5 |
Schistosoma mansoni | RNA binding protein | 0.0311 | 0.3239 | 0.3239 |
Schistosoma mansoni | brg-1 associated factor | 0.0874 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0311 | 0.3239 | 0.3239 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0311 | 0.3239 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0311 | 0.3239 | 0.5 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0874 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5168 uM | PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5168 uM | PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.0441 uM | PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.