Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0875 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0875 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0311 | 0.3264 | 1 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0311 | 0.3264 | 0.3264 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0311 | 0.3264 | 0.3264 |
Loa Loa (eye worm) | brahma associated protein | 0.0875 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0311 | 0.3264 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.0311 | 0.3264 | 0.3264 |
Onchocerca volvulus | 0.0311 | 0.3264 | 0.2732 | |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0875 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.3264 | 0.3264 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0727 | 0.8234 | 0.8234 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0311 | 0.3264 | 0.3264 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0157 | 0.1426 | 0.1426 |
Brugia malayi | brahma associated protein 60 kDa | 0.0875 | 1 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0875 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0875 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0875 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0875 | 1 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.0157 | 0.1426 | 0.1426 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0311 | 0.3264 | 1 |
Toxoplasma gondii | Zn-finger in Ran binding protein and others domain-containing protein | 0.0311 | 0.3264 | 0.3264 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0311 | 0.3264 | 0.3264 |
Schistosoma mansoni | zinc finger protein | 0.0311 | 0.3264 | 0.3264 |
Schistosoma mansoni | hypothetical protein | 0.0875 | 1 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0727 | 0.8234 | 0.8234 |
Leishmania major | hypothetical protein, conserved | 0.0311 | 0.3264 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0172 | 0.1596 | 0.1596 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0311 | 0.3264 | 0.3264 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0157 | 0.1426 | 0.1426 |
Leishmania major | hypothetical protein, conserved | 0.0311 | 0.3264 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0875 | 1 | 0.5 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0875 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1426 | 0.1426 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0311 | 0.3264 | 0.3264 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0311 | 0.3264 | 1 |
Schistosoma mansoni | RNA binding protein | 0.0311 | 0.3264 | 0.3264 |
Schistosoma mansoni | alpha-glucosidase | 0.0148 | 0.1311 | 0.1311 |
Leishmania major | hypothetical protein, conserved | 0.0311 | 0.3264 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0311 | 0.3264 | 1 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0311 | 0.3264 | 0.3264 |
Schistosoma mansoni | brg-1 associated factor | 0.0875 | 1 | 1 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0311 | 0.3264 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0311 | 0.3264 | 1 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0875 | 1 | 1 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0311 | 0.3264 | 0.3264 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1426 | 0.1426 |
Schistosoma mansoni | hypothetical protein | 0.0875 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0875 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0311 | 0.3264 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0311 | 0.3264 | 0.3264 |
Onchocerca volvulus | 0.0311 | 0.3264 | 0.2732 | |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0875 | 1 | 1 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0311 | 0.3264 | 0.2732 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0311 | 0.3264 | 0.3264 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0875 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0311 | 0.3264 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0157 | 0.1426 | 0.1426 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0875 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0172 | 0.1596 | 0.1596 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.3264 | 0.3264 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0311 | 0.3264 | 1 |
Onchocerca volvulus | 0.0311 | 0.3264 | 0.2732 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0875 | 1 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0172 | 0.1596 | 0.1596 |
Onchocerca volvulus | 0.0875 | 1 | 1 | |
Chlamydia trachomatis | SWIB complex protein | 0.0875 | 1 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0875 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0311 | 0.3264 | 0.3264 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0172 | 0.1596 | 0.1596 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.3264 | 0.3264 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0311 | 0.3264 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0855 | 0.9755 | 0.9755 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0727 | 0.8234 | 0.8234 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.3264 | 0.3264 |
Toxoplasma gondii | ran binding protein | 0.0311 | 0.3264 | 0.3264 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0311 | 0.3264 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0311 | 0.3264 | 0.3264 |
Leishmania major | hypothetical protein, conserved | 0.0311 | 0.3264 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0311 | 0.3264 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0311 | 0.3264 | 1 |
Schistosoma mansoni | fusion | 0.0311 | 0.3264 | 0.3264 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0875 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0148 | 0.1311 | 0.1311 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0311 | 0.3264 | 0.3264 |
Loa Loa (eye worm) | hypothetical protein | 0.0311 | 0.3264 | 0.3264 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0311 | 0.3264 | 1 |
Onchocerca volvulus | 0.0311 | 0.3264 | 0.2732 | |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0311 | 0.3264 | 0.3264 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0172 | 0.1596 | 0.1596 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -6.56 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.491 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.459 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.298 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.271 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.209 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.936 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.897 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.