Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0635 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0635 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0103 | 0.0579 | 0.0579 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0635 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0103 | 0.0579 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0579 | 0.0579 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0103 | 0.0579 | 1 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0635 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0635 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 39.22 uM | Cytotoxicity against human SGC7901 cells after 48 hrs by MTT assay | ChEMBL. | 22405648 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.