TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 373.511 | Formula: C24H23NOS
H donors: 0 H acceptors: 0 LogP: 5.46 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: c1ccc(cc1)CO/N=C/1\C[C@H](S[C@H](C1)c1ccccc1)c1ccccc1
InChi: 1S/C24H23NOS/c1-4-10-19(11-5-1)18-26-25-22-16-23(20-12-6-2-7-13-20)27-24(17-22)21-14-8-3-9-15-21/h1-15,23-24H,16-18H2/b25-22-/t23-,24+/m1/s1
InChiKey: OOCRJFRTLQORLS-UOFJDMSKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.0017	0.0049
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0994	1	1
Loa Loa (eye worm)	cysteine protease	0.002	0.0038	0.0038
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0166	0.0166
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Echinococcus multilocularis	pyruvate kinase	0.002	0.0033	0.0033
Trypanosoma brucei	pyruvate kinase 1, putative	0.0038	0.0222	0.0645
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0045	0.0296	0.6838
Onchocerca volvulus		0.002	0.0038	0.0021
Echinococcus multilocularis	tar DNA binding protein	0.0038	0.0222	0.0222
Giardia lamblia	Hypothetical protein	0.0018	0.0017	0.0766
Schistosoma mansoni	inhibitor of apoptosis 1 diap1	0.0018	0.0017	0.0017
Entamoeba histolytica	hypothetical protein	0.0025	0.0092	0.8841
Plasmodium falciparum	cysteine proteinase falcipain 3	0.002	0.0038	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Echinococcus multilocularis	E3 ubiquitin protein ligase Bre1	0.0018	0.0017	0.0017
Toxoplasma gondii	Bardet-Biedl syndrome 5, putative	0.0018	0.0017	0.0017
Leishmania major	hypothetical protein, conserved	0.0354	0.345	1
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0018	0.0017	0.0017
Leishmania major	hypothetical protein, conserved	0.0354	0.345	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.0384	0.0384
Schistosoma mansoni	pyruvate kinase	0.0038	0.0222	0.0222
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0994	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.0017	0.0049
Mycobacterium tuberculosis	Probable hydrolase	0.0046	0.0304	0.1069
Echinococcus multilocularis	SWI:SNF matrix associated	0.0994	1	1
Leishmania major	hypothetical protein	0.0018	0.0017	0.0049
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0045	0.0296	0.1042
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0103	0.0886	0.0886
Loa Loa (eye worm)	pyruvate kinase	0.0038	0.0222	0.0222
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Giardia lamblia	Hypothetical protein	0.0018	0.0017	0.0766
Schistosoma mansoni	hypothetical protein	0.0047	0.031	0.031
Trichomonas vaginalis	cell cycle control protein cwf24, putative	0.0018	0.0017	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0038	0.0038
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Onchocerca volvulus		0.0354	0.345	0.3438
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0994	1	1
Mycobacterium ulcerans	hypothetical protein	0.0046	0.0304	0.7016
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0045	0.0296	0.0858
Onchocerca volvulus		0.0047	0.031	0.0293
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0433	0.0433
Leishmania major	cathepsin L-like protease	0.0076	0.0614	0.1781
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0038	0.0038
Plasmodium falciparum	zinc finger protein, putative	0.0018	0.0017	0.0017
Plasmodium vivax	pyruvate kinase, putative	0.0038	0.0222	0.0222
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0038	0.0038
Mycobacterium ulcerans	esterase/lipase LipP	0.0046	0.0304	0.7016
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Trypanosoma cruzi	hypothetical protein, conserved	0.0046	0.0304	0.088
Leishmania major	hypothetical protein, conserved	0.0354	0.345	1
Schistosoma mansoni	zinc finger protein	0.0018	0.0017	0.0017
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0017
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger) containing protein, putative	0.0018	0.0017	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0017
Leishmania major	pyruvate kinase	0.0038	0.0222	0.0645
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0038	0.0038
Brugia malayi	hypothetical protein	0.0018	0.0017	0.0017
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.002	0.0038	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Leishmania major	hypothetical protein, conserved	0.0018	0.0017	0.0049
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0354	0.345	1
Loa Loa (eye worm)	RiNg Finger protein family member	0.0018	0.0017	0.0017
Brugia malayi	SWIB/MDM2 domain containing protein	0.0994	1	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0018	0.0017	0.0017
Giardia lamblia	Kinase	0.0018	0.0017	0.0766
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0614	0.1781
Brugia malayi	beta-lactamase	0.0046	0.0304	0.0304
Loa Loa (eye worm)	beta-lactamase	0.0046	0.0304	0.0304
Entamoeba histolytica	cysteine protease, putative	0.002	0.0038	0.3644
Leishmania major	hypothetical protein, conserved	0.0354	0.345	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0057	0.0414	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0105	0.0105
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.0017	0.0049
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Entamoeba histolytica	SPRY domain protein	0.0018	0.0017	0.1629
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.031	0.031
Mycobacterium leprae	conserved hypothetical protein	0.0046	0.0304	1
Schistosoma mansoni	brg-1 associated factor	0.0994	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Trypanosoma cruzi	cysteine peptidase, putative	0.0076	0.0614	0.1781
Leishmania major	hypothetical protein, conserved	0.0018	0.0017	0.0049
Plasmodium vivax	hypothetical protein, conserved	0.0046	0.0304	0.0304
Schistosoma mansoni	hypothetical protein	0.0199	0.1873	0.1873
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0354	0.345	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0614	0.1781
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0994	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0614	0.1781
Loa Loa (eye worm)	brahma associated protein	0.0994	1	1
Echinococcus granulosus	ring finger protein 170	0.0018	0.0017	0.0017
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0038	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Brugia malayi	Cathepsin L-like precursor	0.002	0.0038	0.0038
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Mycobacterium leprae	Probable lipase LipE	0.0046	0.0304	1
Toxoplasma gondii	hypothetical protein	0.0018	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0018	0.0017	0.0017
Loa Loa (eye worm)	RNA binding protein	0.0038	0.0222	0.0222
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Trichomonas vaginalis	ankyrin, putative	0.0018	0.0017	0.0017
Echinococcus multilocularis	cysteine protease	0.002	0.0038	0.0038
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0038	0.0038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0038	0.0038
Leishmania major	cysteine peptidase A (CPA)	0.002	0.0038	0.0111
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.0384	0.0384
Mycobacterium ulcerans	pyruvate kinase	0.0038	0.0222	0.5139
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0038	0.0038
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0433	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0016	0	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0038	0.3644
Echinococcus multilocularis	microtubule associated protein 2	0.0837	0.8393	0.8393
Loa Loa (eye worm)	hypothetical protein	0.0354	0.345	0.345
Echinococcus granulosus	ring and YY1 binding protein	0.0354	0.345	0.345
Loa Loa (eye worm)	transcription factor SMAD2	0.0216	0.2047	0.2047
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0166	0.0166
Leishmania major	hypothetical protein, conserved	0.0018	0.0017	0.0049
Brugia malayi	RNA recognition motif domain containing protein	0.0038	0.0222	0.0222
Schistosoma mansoni	serine/threonine protein kinase	0.0018	0.0017	0.0017
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0046	0.0304	0.1069
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0994	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0614	0.1781
Toxoplasma gondii	RING zinc finger protein	0.0018	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0033	0.0166	0.0166
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0038	0.0222	0.0222
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0103	0.0886	0.0886
Toxoplasma gondii	pyruvate kinase PyK1	0.0038	0.0222	0.0222
Echinococcus granulosus	pyruvate kinase	0.002	0.0033	0.0033
Echinococcus multilocularis	SWI:SNF matrix associated	0.0994	1	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0304	0.0304
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0038	0.0038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0038	0.0038
Echinococcus granulosus	E3 ubiquitin protein ligase MYLIP	0.0018	0.0017	0.0017
Entamoeba histolytica	hypothetical protein	0.0018	0.0017	0.1629
Brugia malayi	jmjC domain containing protein	0.0057	0.0414	0.0414
Mycobacterium tuberculosis	Probable esterase LipL	0.0046	0.0304	0.1069
Entamoeba histolytica	zinc finger domain containing protein	0.0018	0.0017	0.1629
Toxoplasma gondii	helicase, putative	0.0018	0.0017	0.0017
Trypanosoma cruzi	hypothetical protein, conserved	0.0354	0.345	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0433	0.0433
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0038	0.0038
Schistosoma mansoni	RNA binding protein	0.0354	0.345	0.345
Schistosoma mansoni	hypothetical protein	0.0033	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0228	0.2169	0.2169
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0045	0.0296	0.6838
Brugia malayi	RING finger protein 20	0.0018	0.0017	0.0017
Trypanosoma cruzi	hypothetical protein	0.0018	0.0017	0.0049
Echinococcus multilocularis	tumor protein p63	0.0632	0.6293	0.6293
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0166	0.0166
Giardia lamblia	Hypothetical protein	0.0018	0.0017	0.0766
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0057	0.0414	0.0414
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0994	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Brugia malayi	Cathepsin L-like precursor	0.002	0.0038	0.0038
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Trypanosoma cruzi	major cysteine proteinase, putative	0.006	0.0447	0.1296
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0018	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0994	1	1
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0994	1	1
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0354	0.345	0.345
Trypanosoma cruzi	hypothetical protein, conserved	0.0354	0.345	1
Trypanosoma brucei	hypothetical protein, conserved	0.0046	0.0304	0.088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0384	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0779	0.0779
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.0553	0.0553
Echinococcus multilocularis	pyruvate kinase	0.002	0.0033	0.0033
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0038	0.0222	0.0645
Trypanosoma brucei	predicted zinc finger protein	0.0018	0.0017	0.0049
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.002	0.0038	0.0038
Schistosoma mansoni	cellular tumor antigen P53	0.0092	0.0779	0.0779
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0054	0.0384	0.0384
Trichomonas vaginalis	pyruvate kinase, putative	0.0038	0.0222	0.0222
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0166	0.0166
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0103	0.0886	0.0886
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0018	0.0017	0.0017
Entamoeba histolytica	zinc finger domain containing protein	0.0018	0.0017	0.1629
Echinococcus granulosus	beta LACTamase domain containing family member	0.0046	0.0304	0.0304
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0614	0.1781
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Onchocerca volvulus		0.0046	0.0304	0.0287
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Trichomonas vaginalis	D-aminoacylase, putative	0.0046	0.0304	0.0304
Trypanosoma cruzi	cysteine peptidase, putative	0.0076	0.0614	0.1781
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.0017	0.0049
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0046	0.0304	0.0304
Schistosoma mansoni	rnf5	0.0018	0.0017	0.0017
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Schistosoma mansoni	tar DNA-binding protein	0.0038	0.0222	0.0222
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0354	0.345	1
Plasmodium vivax	DNA repair protein RAD5, putative	0.0018	0.0017	0.0017
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0354	0.345	0.345
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0038	0.0222	0.0222
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Onchocerca volvulus		0.002	0.0038	0.0021
Echinococcus granulosus	survival motor neuron protein 1	0.0228	0.2169	0.2169
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Echinococcus multilocularis	E3 ubiquitin protein ligase LRSAM1	0.0018	0.0017	0.0017
Schistosoma mansoni	zinc finger protein	0.0354	0.345	0.345
Entamoeba histolytica	zinc finger domain containing protein	0.0018	0.0017	0.1629
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0354	0.345	0.345
Trypanosoma cruzi	WLM domain containing protein, putative	0.0354	0.345	1
Schistosoma mansoni	ring finger protein 151	0.0018	0.0017	0.0017
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0046	0.0304	0.0304
Brugia malayi	TAR-binding protein	0.0038	0.0222	0.0222
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0046	0.0304	0.0304
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0614	0.1781
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Echinococcus multilocularis	ring finger protein 113a	0.0018	0.0017	0.0017
Echinococcus multilocularis	pyruvate kinase	0.003	0.014	0.014
Trichomonas vaginalis	D-aminoacylase, putative	0.0046	0.0304	0.0304
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0038	0.0021
Schistosoma mansoni	hypothetical protein	0.0025	0.0092	0.0092
Leishmania major	cathepsin L-like protease	0.002	0.0038	0.0111
Echinococcus granulosus	RING finger protein 185	0.0018	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0228	0.2169	0.2169
Loa Loa (eye worm)	hypothetical protein	0.0354	0.345	0.345
Brugia malayi	Cathepsin L-like precursor	0.002	0.0038	0.0038
Schistosoma mansoni	hypothetical protein	0.0018	0.0017	0.0017
Leishmania major	hypothetical protein, conserved	0.0018	0.0017	0.0049
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0038	0.0038
Loa Loa (eye worm)	RING finger protein 20	0.0018	0.0017	0.0017
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0433	0.1255
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Entamoeba histolytica	zinc finger domain containing protein	0.0018	0.0017	0.1629
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0045	0.0296	0.0296
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0354	0.345	1
Brugia malayi	Cathepsin L-like precursor	0.002	0.0038	0.0038
Entamoeba histolytica	zinc finger domain containing protein	0.0018	0.0017	0.1629
Toxoplasma gondii	hypothetical protein	0.0018	0.0017	0.0017
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0354	0.345	1
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0038	0.0222	0.0645
Trypanosoma cruzi	hypothetical protein, conserved	0.0354	0.345	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Trypanosoma brucei	pyruvate kinase 1	0.0038	0.0222	0.0645
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0018	0.0017	0.0017
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Leishmania major	hypothetical protein, conserved	0.0354	0.345	1
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0384	0.0384
Mycobacterium ulcerans	beta-lactamase	0.0046	0.0304	0.7016
Toxoplasma gondii	ran binding protein	0.0354	0.345	0.345
Echinococcus granulosus	E3 ubiquitin protein ligase LRSAM1	0.0018	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0033	0.0166	0.0166
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0038	0.0038
Plasmodium vivax	trophozoite exported protein 1, putative	0.0018	0.0017	0.0017
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0166	0.0166
Onchocerca volvulus		0.0092	0.0779	0.0763
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0046	0.0304	0.0304
Brugia malayi	brahma associated protein 60 kDa	0.0994	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0038	0.0038
Loa Loa (eye worm)	jmjC domain-containing protein	0.0057	0.0414	0.0414
Mycobacterium tuberculosis	Probable lipase LipE	0.0046	0.0304	0.1069
Echinococcus multilocularis		0.0018	0.0017	0.0017
Mycobacterium tuberculosis	Conserved protein	0.0046	0.0304	0.1069
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0038	0.0038
Giardia lamblia	Zinc finger domain	0.0018	0.0017	0.0766
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0038	0.0038
Brugia malayi	RNA binding protein	0.0038	0.0222	0.0222
Echinococcus granulosus	tar DNA binding protein	0.0038	0.0222	0.0222
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Leishmania major	hypothetical protein, conserved	0.0018	0.0017	0.0049
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0025	0.0092	0.0092
Plasmodium vivax	E3 ubiquitin-protein ligase RNF5, putative	0.0018	0.0017	0.0017
Leishmania major	hypothetical protein, unknown function	0.0018	0.0017	0.0049
Chlamydia trachomatis	SWIB complex protein	0.0994	1	1
Plasmodium vivax	hypothetical protein, conserved	0.0994	1	1
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.0017	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0166	0.0166
Trypanosoma cruzi	WLM domain containing protein, putative	0.0354	0.345	1
Onchocerca volvulus		0.002	0.0038	0.0021
Chlamydia trachomatis	DNA topoisomerase I	0.0994	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0038	0.0038
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Echinococcus multilocularis	SWI:SNF matrix associated	0.0994	1	1
Schistosoma mansoni	hypothetical protein	0.0994	1	1
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0045	0.0296	0.0296
Trichomonas vaginalis	D-aminoacylase, putative	0.0046	0.0304	0.0304
Brugia malayi	beta-lactamase family protein	0.0046	0.0304	0.0304
Plasmodium vivax	E3 ubiquitin-protein ligase, putative	0.0018	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0017
Giardia lamblia	Hypothetical protein	0.0018	0.0017	0.0766
Echinococcus granulosus	E3 ubiquitin protein ligase Bre1	0.0018	0.0017	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Echinococcus granulosus	tumor protein p63	0.0632	0.6293	0.6293
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0045	0.0296	0.0296
Onchocerca volvulus		0.0354	0.345	0.3438
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0433	0.0433
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Plasmodium vivax	vivapain-2	0.002	0.0038	0.0038
Onchocerca volvulus		0.002	0.0038	0.0021
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.0017	0.0049
Brugia malayi	MH2 domain containing protein	0.0216	0.2047	0.2047
Echinococcus multilocularis	zinc finger protein Ran binding	0.0354	0.345	0.345
Schistosoma mansoni	peter pan-related	0.0018	0.0017	0.0017
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Toxoplasma gondii	cathepsin CPL	0.002	0.0038	0.0038
Echinococcus granulosus	microtubule associated protein 2	0.0837	0.8393	0.8393
Leishmania major	pyruvate kinase	0.0038	0.0222	0.0645
Entamoeba histolytica	pyruvate kinase, putative	0.0027	0.0105	1
Trichomonas vaginalis	sex-determining protein fem-1, putative	0.0018	0.0017	0.0017
Leishmania major	hypothetical protein, conserved	0.0018	0.0017	0.0049
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0042	0.0265	0.0265
Onchocerca volvulus	Cathepsin F homolog	0.002	0.0038	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0354	0.345	0.345
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0038	0.3644
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0038	0.0021
Echinococcus granulosus	cell growth regulator with ring finger domain	0.0018	0.0017	0.0017
Brugia malayi	Zinc finger, C2H2 type family protein	0.0018	0.0017	0.0017
Giardia lamblia	Pyruvate kinase	0.002	0.0033	0.1479
Trypanosoma cruzi	hypothetical protein	0.0018	0.0017	0.0049
Giardia lamblia	Zinc finger domain	0.0018	0.0017	0.0766
Plasmodium vivax	RING zinc finger protein, putative	0.0018	0.0017	0.0017
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Echinococcus granulosus	cathepsin l1	0.002	0.0038	0.0038
Onchocerca volvulus		0.002	0.0038	0.0021
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0046	0.0304	0.1069
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0018	0.0017	0.0049
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Schistosoma mansoni	tar DNA-binding protein	0.0038	0.0222	0.0222
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Echinococcus multilocularis	geminin	0.0199	0.1873	0.1873
Schistosoma mansoni	hypothetical protein	0.007	0.0553	0.0553
Plasmodium vivax	vivapain-2	0.002	0.0038	0.0038
Giardia lamblia	Ser/Thr protein kinase	0.0018	0.0017	0.0766
Entamoeba histolytica	zinc finger domain containing protein	0.0018	0.0017	0.1629
Schistosoma mansoni	peter pan-related	0.0018	0.0017	0.0017
Brugia malayi	Cathepsin L-like precursor	0.002	0.0038	0.0038
Mycobacterium tuberculosis	Conserved protein	0.0046	0.0304	0.1069
Echinococcus granulosus	ring finger protein 113a	0.0018	0.0017	0.0017
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0354	0.345	0.345
Schistosoma mansoni	mind bomb	0.0018	0.0017	0.0017
Plasmodium falciparum	trophozoite exported protein 1	0.0018	0.0017	0.0017
Entamoeba histolytica	hypothetical protein	0.0025	0.0092	0.8841
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0886	0.0886
Giardia lamblia	Kinase, NEK	0.0018	0.0017	0.0766
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0018	0.0017	0.0017
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0614	0.1781
Trichomonas vaginalis	penicillin-binding protein, putative	0.0046	0.0304	0.0304
Echinococcus multilocularis	ring and YY1 binding protein	0.0354	0.345	0.345
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0304	0.0304
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0054	0.0384	0.0384
Brugia malayi	Cathepsin L-like precursor	0.002	0.0038	0.0038
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0057	0.0414	0.0414
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0166	0.0166
Entamoeba histolytica	hypothetical protein	0.0025	0.0092	0.8841
Trypanosoma brucei	DNA repair protein, putative	0.0018	0.0017	0.0049
Echinococcus granulosus	GPCR family 2	0.0033	0.0166	0.0166
Leishmania major	hypothetical protein, conserved	0.0018	0.0017	0.0049
Brugia malayi	beta-lactamase family protein	0.0046	0.0304	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0304	0.0304
Trypanosoma cruzi	cysteine peptidase, putative	0.002	0.0038	0.0111
Echinococcus granulosus	pyruvate kinase	0.002	0.0033	0.0033
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Trypanosoma brucei	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Trypanosoma cruzi	hypothetical protein, conserved	0.0046	0.0304	0.088
Giardia lamblia	E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B	0.0018	0.0017	0.0766
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0433	1
Onchocerca volvulus		0.0046	0.0304	0.0287
Brugia malayi	YY1-associated factor 2	0.0354	0.345	0.345
Plasmodium vivax	zinc finger protein, putative	0.0018	0.0017	0.0017
Schistosoma mansoni	tar DNA-binding protein	0.0038	0.0222	0.0222
Plasmodium falciparum	E3 ubiquitin-protein ligase RNF5, putative	0.0018	0.0017	0.0017
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0354	0.345	1
Leishmania major	cathepsin L-like protease	0.002	0.0038	0.0111
Giardia lamblia	Hypothetical protein	0.0018	0.0017	0.0766
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Brugia malayi	hypothetical protein	0.0018	0.0017	0.0017
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0018	0.0017	0.0017
Onchocerca volvulus		0.0046	0.0304	0.0287
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0354	0.345	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0038	0.0038
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0354	0.345	0.345
Leishmania major	cathepsin L-like protease	0.0076	0.0614	0.1781
Brugia malayi	jmjC domain containing protein	0.0057	0.0414	0.0414
Giardia lamblia	Hypothetical protein	0.0018	0.0017	0.0766
Leishmania major	hypothetical protein, conserved	0.0018	0.0017	0.0049
Toxoplasma gondii	hypothetical protein	0.0018	0.0017	0.0017
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0018	0.0017	0.0017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0038	0.0038
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0354	0.345	0.345
Brugia malayi	hypothetical protein	0.0018	0.0017	0.0017
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0057	0.0414	0.0414
Leishmania major	cathepsin L-like protease	0.0076	0.0614	0.1781
Leishmania major	DNA repair protein-like protein	0.0018	0.0017	0.0049
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Trypanosoma brucei	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Schistosoma mansoni	hypothetical protein	0.0354	0.345	0.345
Leishmania major	hypothetical protein, conserved	0.0018	0.0017	0.0049
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.0384	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0304	0.0304
Schistosoma mansoni	pyruvate kinase	0.002	0.0033	0.0033
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0038	0.0038
Trypanosoma brucei	ring finger containing protein	0.0018	0.0017	0.0049
Onchocerca volvulus		0.0994	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0018	0.0017	0.0017
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0045	0.0296	0.0296
Giardia lamblia	Pyruvate kinase	0.0038	0.0222	1
Loa Loa (eye worm)	hypothetical protein	0.0354	0.345	0.345
Toxoplasma gondii	ABC1 family protein	0.0046	0.0304	0.0304
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Schistosoma mansoni	tar DNA-binding protein	0.0038	0.0222	0.0222
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Schistosoma mansoni	survival motor neuron protein	0.0047	0.031	0.031
Leishmania major	cathepsin L-like protease	0.002	0.0038	0.0111
Echinococcus granulosus	pyruvate kinase	0.0038	0.0222	0.0222
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0433	0.1524
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0994	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.002	0.0038	0.0038
Mycobacterium tuberculosis	Probable lipase LipD	0.0046	0.0304	0.1069
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.007	0.0547	0.1585
Onchocerca volvulus	Pyruvate kinase homolog	0.0038	0.0222	0.0206
Loa Loa (eye worm)	ctsf protein	0.002	0.0038	0.0038
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0614	0.1781
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.0384	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0017
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0038	0.0222	0.0783
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0038	0.0038
Toxoplasma gondii	SWI2/SNF2-containing protein RAD5	0.0018	0.0017	0.0017
Plasmodium falciparum	E3 ubiquitin-protein ligase, putative	0.0018	0.0017	0.0017
Trichomonas vaginalis	ankyrin, putative	0.0018	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0018	0.0017	0.0017
Schistosoma mansoni	fusion	0.0354	0.345	0.345
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0994	1	1
Brugia malayi	hypothetical protein	0.0025	0.0092	0.0092
Onchocerca volvulus		0.0354	0.345	0.3438
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0018	0.0017	0.0049
Echinococcus granulosus	pyruvate kinase	0.002	0.0033	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0038	0.0222	0.0222
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0384	0.0384
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0354	0.345	0.3438
Entamoeba histolytica	zinc finger domain containing protein	0.0018	0.0017	0.1629
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0166	0.0166
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0614	0.1781
Toxoplasma gondii	hypothetical protein	0.0018	0.0017	0.0017
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0614	0.1781
Onchocerca volvulus		0.002	0.0038	0.0021
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0038	0.0038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0038	0.0038
Mycobacterium tuberculosis	Conserved protein	0.0046	0.0304	0.1069
Plasmodium falciparum	pyruvate kinase	0.0038	0.0222	0.0222
Schistosoma mansoni	jumonji domain containing protein	0.0057	0.0414	0.0414
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Echinococcus granulosus	cathepsin L cysteine proteinase	0.002	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0304	0.0304
Schistosoma mansoni	TRABID protein (C64 family)	0.0354	0.345	0.345
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0433	1
Giardia lamblia	Kinase, NEK	0.0018	0.0017	0.0766
Echinococcus granulosus	RING finger and transmembrane domain containing protein	0.0018	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0018	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0017
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Echinococcus granulosus	zinc finger protein Ran binding	0.0354	0.345	0.345
Schistosoma mansoni	microtubule-associated protein tau	0.0837	0.8393	0.8393
Schistosoma mansoni	transcription factor LCR-F1	0.0025	0.0092	0.0092
Echinococcus granulosus	lysine specific demethylase 5A	0.0057	0.0414	0.0414
Entamoeba histolytica	hypothetical protein	0.0025	0.0092	0.8841
Loa Loa (eye worm)	fibroinase	0.002	0.0038	0.0038
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0433	0.0433
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Loa Loa (eye worm)	pyruvate kinase	0.0038	0.0222	0.0222
Trypanosoma brucei	SNF2 family N-terminal domain/Ring finger domain containing protein, putative	0.0018	0.0017	0.0049
Echinococcus multilocularis	pyruvate kinase	0.002	0.0033	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Trypanosoma brucei	hypothetical protein, conserved	0.0354	0.345	1
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Echinococcus granulosus	geminin	0.0199	0.1873	0.1873
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.0017	0.0049
Onchocerca volvulus	Pyruvate kinase homolog	0.0038	0.0222	0.0206
Loa Loa (eye worm)	hypothetical protein	0.002	0.0038	0.0038
Trypanosoma brucei	hypothetical protein, conserved	0.0354	0.345	1
Mycobacterium ulcerans	lipase LipD	0.0046	0.0304	0.7016
Trichomonas vaginalis	ion channel nompc, putative	0.0018	0.0017	0.0017
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0018	0.0017	0.0017
Trichomonas vaginalis	hypothetical protein	0.0018	0.0017	0.0017
Giardia lamblia	Hypothetical protein	0.0018	0.0017	0.0766
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0076	0.0614	0.1781
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0354	0.345	0.345
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Onchocerca volvulus	Pyruvate kinase homolog	0.0038	0.0222	0.0206
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0038	0.0038
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0018	0.0017	0.0017
Brugia malayi	Zinc finger protein 183 homolog	0.0018	0.0017	0.0017
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Plasmodium falciparum	pyruvate kinase 2	0.002	0.0033	0.0033
Loa Loa (eye worm)	TAR-binding protein	0.0038	0.0222	0.0222
Echinococcus multilocularis	cysteine protease	0.002	0.0038	0.0038
Onchocerca volvulus		0.002	0.0038	0.0021
Trypanosoma cruzi	cysteine peptidase, putative	0.0076	0.0614	0.1781
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0025	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0017
Loa Loa (eye worm)	pyruvate kinase	0.0038	0.0222	0.0222
Echinococcus multilocularis	RING finger protein 185	0.0018	0.0017	0.0017
Entamoeba histolytica	hypothetical protein	0.0018	0.0017	0.1629
Echinococcus granulosus	E3 ubiquitin protein ligase RNF146	0.0018	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0994	1	1
Giardia lamblia	Ribonuclease	0.0018	0.0017	0.0766
Schistosoma mansoni	hypothetical protein	0.0199	0.1873	0.1873
Leishmania major	hypothetical protein, conserved	0.0046	0.0304	0.088
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0038	0.0038
Schistosoma mansoni	tar DNA-binding protein	0.0038	0.0222	0.0222
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Toxoplasma gondii	pyruvate kinase PyKII	0.002	0.0033	0.0033
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0038	0.0038
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Brugia malayi	RING zinc finger protein	0.0018	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0304	0.0304
Trichomonas vaginalis	penicillin-binding protein, putative	0.0046	0.0304	0.0304
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0354	0.345	0.345
Loa Loa (eye worm)	hypothetical protein	0.007	0.0553	0.0553
Trichomonas vaginalis	ankyrin, putative	0.0018	0.0017	0.0017
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Loa Loa (eye worm)	pyruvate kinase-PB	0.0027	0.0105	0.0105
Schistosoma mansoni	hypothetical protein	0.0033	0.0166	0.0166
Leishmania major	cathepsin L-like protease	0.002	0.0038	0.0111
Trichomonas vaginalis	pyruvate kinase, putative	0.0038	0.0222	0.0222
Echinococcus granulosus	Zinc finger RanBP2 type	0.0354	0.345	0.345
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0354	0.345	0.345
Echinococcus multilocularis	pyruvate kinase	0.0038	0.0222	0.0222
Leishmania major	hypothetical protein, conserved	0.0018	0.0017	0.0049
Echinococcus multilocularis	RING finger and transmembrane domain containing protein	0.0018	0.0017	0.0017
Echinococcus multilocularis	ring finger protein 170	0.0018	0.0017	0.0017
Echinococcus multilocularis	pyruvate kinase	0.0038	0.0222	0.0222
Trypanosoma cruzi	cruzipain precursor, putative	0.0076	0.0614	0.1781
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0038	0.0038
Schistosoma mansoni	hypothetical protein	0.0018	0.0017	0.0017
Leishmania major	hypothetical protein, conserved	0.0018	0.0017	0.0049
Plasmodium falciparum	RING zinc finger protein, putative	0.0018	0.0017	0.0017
Onchocerca volvulus		0.0354	0.345	0.3438
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0016	0	0.5
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0046	0.0304	0.1069
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0354	0.345	0.345
Brugia malayi	B-box zinc finger family protein	0.0018	0.0017	0.0017
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Leishmania major	hypothetical protein, conserved	0.0018	0.0017	0.0049
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0038	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0433	0.0433
Plasmodium vivax	pyruvate kinase 2, putative	0.002	0.0033	0.0033
Echinococcus granulosus	SWI:SNF matrix associated	0.0994	1	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0057	0.0414	0.0414
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0038	0.0038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0038	0.0038
Leishmania major	hypothetical protein, conserved	0.0018	0.0017	0.0049
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0017
Echinococcus multilocularis	survival motor neuron protein 1	0.0228	0.2169	0.2169
Echinococcus multilocularis	E3 ubiquitin protein ligase MYLIP	0.0018	0.0017	0.0017
Brugia malayi	Neuralized family protein	0.0018	0.0017	0.0017
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0038	0.0038
Giardia lamblia	Protein 21.1	0.0018	0.0017	0.0766
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0865	0.8677	0.8677
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0038	0.0038
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0038	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0017	0.0017
Echinococcus granulosus	pyruvate kinase	0.0038	0.0222	0.0222
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0018	0.0017	0.0049
Echinococcus granulosus	cathepsin l cysteine peptidase	0.002	0.0038	0.0038
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0294	0.284	1
Leishmania major	cathepsin L-like protease	0.002	0.0038	0.0111
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0018	0.0017	0.0017
Brugia malayi	Hypothetical RING finger protein C16C10.7 in chromosome III	0.0018	0.0017	0.0017
Schistosoma mansoni	pyruvate kinase	0.0038	0.0222	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0222	0.0222
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0018	0.0017	0.0017
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0046	0.0304	0.0304
Trichomonas vaginalis	esterase, putative	0.0046	0.0304	0.0304
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0046	0.0304	0.7016
Loa Loa (eye worm)	MH2 domain-containing protein	0.0216	0.2047	0.2047
Entamoeba histolytica	zinc finger domain containing protein	0.0018	0.0017	0.1629

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 200 ug ml-1	Antibacterial activity against Escherichia coli by twofold dilution method	ChEMBL.	19419867
MIC (functional)	> 200 ug ml-1	Antifungal activity against Candida albicans by twofold dilution method	ChEMBL.	19419867
MIC (functional)	> 200 ug ml-1	Antifungal activity against Cryptococcus neoformans by twofold dilution method	ChEMBL.	19419867

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2021456

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1637156