Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0011 | 0.0017 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.4309 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0011 | 1 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.4309 | 1 | 1 |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.4309 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2862 | 0.6598 | 0.6598 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.4309 | 1 | 1 |
Toxoplasma gondii | cathepsin CPC1 | 0.4309 | 1 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.4309 | 1 | 1 |
Echinococcus multilocularis | hormone sensitive lipase | 0.2862 | 0.6598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2862 | 0.6598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0011 | 0.0017 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2862 | 0.6598 | 0.6598 |
Echinococcus granulosus | hormone sensitive lipase | 0.2862 | 0.6598 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2862 | 0.6598 | 0.6598 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.4309 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0011 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.2674 | 0.6158 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.189 ug ml-1 | Growth inhibition of mouse P388 cells after 48 hrs by Z1 Beckman/Coulter particle counter analysis | ChEMBL. | 22324723 |
GI50 (functional) | = 2.7 ug ml-1 | Growth inhibition of human BxPC3 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 22324723 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.