Detailed information for compound 1638063

Basic information

Technical information
  • TDR Targets ID: 1638063
  • Name: 1-(2-methylphenyl)-3-(3-nitrophenyl)urea
  • MW: 271.271 | Formula: C14H13N3O3
  • H donors: 2 H acceptors: 3 LogP: 2.68 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1C)Nc1cccc(c1)[N+](=O)[O-]
  • InChi: 1S/C14H13N3O3/c1-10-5-2-3-8-13(10)16-14(18)15-11-6-4-7-12(9-11)17(19)20/h2-9H,1H3,(H2,15,16,18)
  • InChiKey: MSBVHIWAXMMCPU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni DEAD box ATP-dependent RNA helicase Get druggable targets OG5_126849 All targets in OG5_126849
Plasmodium yoelii DEAD box polypeptide, Y chromosome-related Get druggable targets OG5_126849 All targets in OG5_126849
Babesia bovis DEAD/DEAH box helicase Get druggable targets OG5_126849 All targets in OG5_126849
Echinococcus multilocularis ATP dependent RNA helicase DDX3X Get druggable targets OG5_126849 All targets in OG5_126849
Brugia malayi ATP-dependent RNA helicase An3 Get druggable targets OG5_126849 All targets in OG5_126849
Toxoplasma gondii DEAD (Asp-Glu-Ala-Asp) box polypeptide DDX3X Get druggable targets OG5_126849 All targets in OG5_126849
Leishmania infantum ATP-dependent RNA helicase, putative Get druggable targets OG5_126849 All targets in OG5_126849
Giardia lamblia ATP-dependent RNA helicase-like protein Get druggable targets OG5_126849 All targets in OG5_126849
Cryptosporidium parvum Dbp1p, eIF4a-1 family RNA SFII helicase (DEXDC+HELICc) Get druggable targets OG5_126849 All targets in OG5_126849
Loa Loa (eye worm) ATP-dependent RNA helicase An3 Get druggable targets OG5_126849 All targets in OG5_126849
Trypanosoma brucei ATP-dependent RNA helicase HEL67 Get druggable targets OG5_126849 All targets in OG5_126849
Echinococcus granulosus ATP dependent RNA helicase ded1 Get druggable targets OG5_126849 All targets in OG5_126849
Echinococcus multilocularis atp dependent rna helicase ddxx atp dependent rna helicase an Get druggable targets OG5_126849 All targets in OG5_126849
Trypanosoma congolense ATP-dependent RNA helicase HEL67 Get druggable targets OG5_126849 All targets in OG5_126849
Schistosoma japonicum ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative Get druggable targets OG5_126849 All targets in OG5_126849
Trypanosoma brucei gambiense ATP-dependent DEAD/H RNA helicase, putative Get druggable targets OG5_126849 All targets in OG5_126849
Echinococcus multilocularis ATP dependent RNA helicase DDX3X Get druggable targets OG5_126849 All targets in OG5_126849
Schistosoma japonicum Putative ATP-dependent RNA helicase Pl10, putative Get druggable targets OG5_126849 All targets in OG5_126849
Leishmania mexicana ATP-dependent RNA helicase, putative Get druggable targets OG5_126849 All targets in OG5_126849
Schistosoma mansoni DEAD box ATP-dependent RNA helicase Get druggable targets OG5_126849 All targets in OG5_126849
Giardia lamblia DEAD box RNA helicase Vasa Get druggable targets OG5_126849 All targets in OG5_126849
Theileria parva RNA helicase, putative Get druggable targets OG5_126849 All targets in OG5_126849
Echinococcus granulosus DEAD box ATP dependent RNA helicase Get druggable targets OG5_126849 All targets in OG5_126849
Plasmodium falciparum ATP-dependent RNA helicase DBP1, putative Get druggable targets OG5_126849 All targets in OG5_126849
Trypanosoma cruzi ATP-dependent RNA helicase HEL67 Get druggable targets OG5_126849 All targets in OG5_126849
Cryptosporidium hominis DEAD box polypeptide, Y chromosome-related Get druggable targets OG5_126849 All targets in OG5_126849
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126849 All targets in OG5_126849
Echinococcus granulosus atp dependent rna helicase ddxx Get druggable targets OG5_126849 All targets in OG5_126849
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126849 All targets in OG5_126849
Onchocerca volvulus Get druggable targets OG5_126849 All targets in OG5_126849
Plasmodium knowlesi ATP-dependent RNA helicase DBP1, putative Get druggable targets OG5_126849 All targets in OG5_126849
Trypanosoma cruzi ATP-dependent RNA helicase HEL67 Get druggable targets OG5_126849 All targets in OG5_126849
Plasmodium vivax DEAD/DEAH box helicase, putative Get druggable targets OG5_126849 All targets in OG5_126849
Leishmania braziliensis ATP-dependent RNA helicase, putative Get druggable targets OG5_126849 All targets in OG5_126849
Schistosoma japonicum Putative ATP-dependent RNA helicase Pl10, putative Get druggable targets OG5_126849 All targets in OG5_126849
Mycobacterium ulcerans ATP-dependent RNA helicase, RhlE1 Get druggable targets OG5_126849 All targets in OG5_126849
Entamoeba histolytica DEAD/DEAH box helicase, putative Get druggable targets OG5_126849 All targets in OG5_126849
Leishmania donovani ATP-dependent RNA helicase HEL67 Get druggable targets OG5_126849 All targets in OG5_126849
Candida albicans ATP-dependent RNA helicase of DEAD box family Get druggable targets OG5_126849 All targets in OG5_126849
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126849 All targets in OG5_126849
Plasmodium berghei ATP-dependent RNA helicase DBP1, putative Get druggable targets OG5_126849 All targets in OG5_126849
Neospora caninum VASA RNA helicase, related Get druggable targets OG5_126849 All targets in OG5_126849
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.3988 0.5
Brugia malayi PHD-finger family protein 0.001 0.0007 0.0007
Plasmodium vivax hypothetical protein, conserved 0.003 0.1145 0.287
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.1145 0.287
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.013 0.0261
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.1016 0.2549
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.1807 0.362
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.013 0.0327
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.2426 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.013 0.0261
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.001 0 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.15 0.15
Onchocerca volvulus 0.0185 1 1
Leishmania major hypothetical protein, conserved 0.001 0 0.5
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0106 0.55 0.55
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0369 0.0369
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0185 1 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.3988 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0007 1
Schistosoma mansoni coup transcription factor 0.0012 0.013 0.0327
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.013 0.013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.2345 0.2345
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.013 0.013
Brugia malayi steroid hormone receptor 0.0012 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0106 0.55 0.55
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.15 0.3762
Schistosoma mansoni hypothetical protein 0.0016 0.0369 0.0925
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.013 0.0261
Brugia malayi AF-10 protein 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.1145 0.1145
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.3955 0.5
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.1145 0.2294
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.2345 0.2345
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.1145 0.287
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.013 0.0261
Echinococcus multilocularis GPCR, family 2 0.0016 0.0369 0.0739
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.013 0.013
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0007 0.0017
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.013 0.0261
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.013 0.0261
Onchocerca volvulus 0.0185 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.013 0.013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0007 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.013 0.013
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.013 0.0261
Loa Loa (eye worm) hypothetical protein 0.0106 0.55 0.55
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0106 0.55 0.55
Brugia malayi nuclear receptor NHR-88 0.0012 0.013 0.013
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.013 0.0261
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.3988 1
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0012 0.013 0.013
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0369 0.0739
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.2945 0.2945
Loa Loa (eye worm) hypothetical protein 0.0079 0.3955 0.3955
Onchocerca volvulus 0.0079 0.3955 0.3875
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.3988 0.5
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0106 0.55 0.55
Schistosoma mansoni hypothetical protein 0.0016 0.0369 0.0925
Echinococcus granulosus peregrin 0.003 0.1145 0.2294
Brugia malayi jmjC domain containing protein 0.0097 0.4991 0.4991
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.1016 0.2549
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.013 0.013
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.15 0.3006
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.013 0.0261
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.013 0.0327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.013 0.013
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.1145 0.287
Loa Loa (eye worm) hypothetical protein 0.0035 0.143 0.143
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.013 0.013
Echinococcus multilocularis peregrin 0.003 0.1145 0.2294
Loa Loa (eye worm) hypothetical protein 0.0079 0.3955 0.3955
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.2345 0.2345
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0016 0.0369 0.0925
Onchocerca volvulus 0.0185 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0012 0.013 0.013
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0007 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.013 0.013
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.1145 0.2294
Echinococcus granulosus FTZ F1 alpha 0.0012 0.013 0.0261
Brugia malayi hypothetical protein 0.0079 0.3955 0.3955
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Brugia malayi Probable ClpP-like protease 0.008 0.3988 0.3988
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.3988 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0051 0.2352 0.2352
Schistosoma mansoni hypothetical protein 0.001 0.0007 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.013 0.013
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.013 0.0261
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.15 0.3006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.013 0.013
Onchocerca volvulus 0.0185 1 1
Loa Loa (eye worm) hypothetical protein 0.0185 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.013 0.0327
Brugia malayi ecdysteroid receptor 0.0012 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0106 0.55 0.55
Echinococcus granulosus jumonji domain containing protein 0.0041 0.1807 0.362
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0012 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0079 0.3955 0.3955
Onchocerca volvulus 0.0185 1 1
Schistosoma mansoni jumonji domain containing protein 0.0077 0.3853 0.966
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.4991 1
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.013 0.0261
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.013 0.0261
Brugia malayi PHD-finger family protein 0.003 0.1145 0.1145
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.013 0.0327
Loa Loa (eye worm) hypothetical protein 0.0012 0.013 0.013
Onchocerca volvulus 0.0185 1 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.55 0.55
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0007 0.0017
Onchocerca volvulus 0.0185 1 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.4991 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.013 0.013
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0369 0.0739
Schistosoma mansoni hypothetical protein 0.003 0.1145 0.287
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.013 0.0261
Onchocerca volvulus Alhambra homolog 0.003 0.1145 0.1028
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.3988 0.7992
Toxoplasma gondii hypothetical protein 0.0027 0.1016 0.2549
Brugia malayi hypothetical protein 0.0106 0.55 0.55
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0016 0.0369 0.0925
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.013 0.0327
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.3988 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.013 0.013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0369 0.0739
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.013 0.0261
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.3988 0.5
Brugia malayi jmjC domain containing protein 0.0036 0.15 0.15
Brugia malayi hypothetical protein 0.0106 0.55 0.55
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.013 0.013
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0185 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.013 0.013
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.001 0.0007 0.0017
Loa Loa (eye worm) PHD-finger family protein 0.003 0.1145 0.1145
Loa Loa (eye worm) hypothetical protein 0.0012 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.008 0.3988 0.3988
Brugia malayi LBP/BPI 0.0079 0.3955 0.3955
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.2426 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.013 0.0327
Plasmodium falciparum phd finger protein, putative 0.003 0.1145 0.287
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0185 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0079 0.3955 0.3955
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.3988 0.7992
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0369 0.0369
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.001 0 0.5
Brugia malayi Bromodomain containing protein 0.003 0.1145 0.1145
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.143 0.143
Loa Loa (eye worm) hypothetical protein 0.0106 0.55 0.55
Onchocerca volvulus 0.0106 0.55 0.544
Onchocerca volvulus 0.0106 0.55 0.544
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.013 0.013
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.013 0.0327
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.15 0.3762
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0035 0.143 0.3586
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.3988 1
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0106 0.55 0.55
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.013 0.0327
Giardia lamblia PHD finger protein 15 0.003 0.1145 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.013 0.013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.013 0.0261
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.2426 0.4862
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0106 0.55 0.55
Brugia malayi nuclear hormone receptor 0.0012 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0051 0.2345 0.2345
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.013 0.0261
Schistosoma mansoni thyroid hormone receptor 0.0012 0.013 0.0327
Echinococcus granulosus GPCR family 2 0.0016 0.0369 0.0739
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.013 0.0261
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.3988 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.013 0.0327
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.013 0.013
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.3988 0.5
Schistosoma mansoni thyroid hormone receptor 0.0012 0.013 0.0327
Plasmodium vivax hypothetical protein, conserved 0.001 0.0007 0.0017
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.3988 1
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.2426 0.4862
Loa Loa (eye worm) hypothetical protein 0.0012 0.013 0.013
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0369 0.0739
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0369 0.0369
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.3988 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.013 0.013
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.2426 0.4744
Schistosoma mansoni nuclear hormone receptor 0.0012 0.013 0.0327
Onchocerca volvulus 0.0185 1 1

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 100 uM Cytotoxicity against human PBMC cells assessed as cell viability after 72 hrs by MTS assay ChEMBL. 22300661
IC50 (binding) = 1 uM Inhibition of human recombinant DDX3 helicase activity expressed in Escherichia coli assessed as conversion of a 6-FAM-labeled double stranded RNA in to single stranded nucleic acid by laser scanning densitometric analysis ChEMBL. 22300661
IC50 (binding) = 20 uM Inhibition of human recombinant DDX3 ATPase activity expressed in Escherichia coli assessed as [gamma-32P] ATP hydrolysis after 5 mins by densitometric analysis ChEMBL. 22300661
IC50 (binding) > 500 uM Inhibition of human recombinant DDX1 helicase activity expressed in Escherichia coli assessed as conversion of a 6-FAM-labeled double stranded RNA in to single stranded nucleic acid by laser scanning densitometric analysis ChEMBL. 22300661

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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