Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0971 | 0.145 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0057 | 0.269 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.3467 | 0.5178 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.3511 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.00000060783 | 0.00000090764 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.5618 | 0.839 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.5618 | 0.839 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.6697 | 1 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0057 | 0.269 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.1449 | 0.8789 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.3511 | 0.3511 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.5618 | 0.839 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.00000060783 | 0.00000090764 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0881 | 0.1316 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1449 | 0.2164 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Leishmania major | leucyl-tRNA synthetase, putative | 0.0022 | 0.0298 | 0.1106 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0022 | 0.0298 | 0.0298 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.3511 | 0.3511 |
Toxoplasma gondii | tRNA ligases class I (M) protein | 0.0022 | 0.0298 | 0.1106 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.1449 | 0.4129 |
Onchocerca volvulus | 0.003 | 0.0881 | 0.5345 | |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0298 | 0.0444 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0971 | 0.0971 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.3511 | 0.3511 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0971 | 0.0971 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0682 | 0.1942 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0971 | 0.0971 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0057 | 0.269 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.5618 | 0.839 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.3511 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0971 | 0.145 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0971 | 0.0971 |
Schistosoma mansoni | transient receptor potential channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0057 | 0.269 | 0.269 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0057 | 0.269 | 0.269 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0022 | 0.0298 | 0.0298 |
Brugia malayi | Heterochromatin protein 1 | 0.0069 | 0.3511 | 0.5242 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0682 | 0.1942 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.3467 | 0.5178 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.1449 | 0.2164 |
Echinococcus multilocularis | geminin | 0.0164 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0057 | 0.269 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0971 | 0.0971 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0057 | 0.269 | 0.269 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0022 | 0.0298 | 0.0298 |
Brugia malayi | methionyl-tRNA synthetase | 0.0057 | 0.269 | 0.4017 |
Onchocerca volvulus | 0.0035 | 0.1213 | 0.7356 | |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0022 | 0.0298 | 0.0298 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0069 | 0.3511 | 0.5242 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0057 | 0.269 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0971 | 0.145 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0022 | 0.0298 | 0.0298 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.1449 | 0.4129 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0971 | 0.0971 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.00000060783 | 0.00000090764 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.6697 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0298 | 0.0444 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.3511 | 0.3511 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.3511 | 0.3511 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0022 | 0.0298 | 0.5 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0057 | 0.269 | 0.7663 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0971 | 0.0971 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.6697 | 1 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0057 | 0.269 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.3467 | 0.3467 |
Brugia malayi | olfactory channel protein osm-9 | 0.0017 | 0.00000060783 | 0.00000090764 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0022 | 0.0298 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0971 | 0.145 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0057 | 0.269 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0971 | 0.0971 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.1649 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Brugia malayi | protein ZK524.3 | 0.0022 | 0.0298 | 0.0444 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0022 | 0.0298 | 0.5 |
Loa Loa (eye worm) | tyrosyl-tRNA synthetase | 0.0035 | 0.1213 | 0.1811 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0298 | 0.0444 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0057 | 0.269 | 1 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0057 | 0.269 | 1 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0022 | 0.0298 | 0.5 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0057 | 0.269 | 1 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0022 | 0.0298 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0971 | 0.0971 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.3511 | 0.3511 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0057 | 0.269 | 0.4017 |
Brugia malayi | methionyl-tRNA synthetase | 0.0022 | 0.0298 | 0.0444 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.1649 | 0.4697 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0971 | 0.0971 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.1649 | 0.4697 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 1 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0057 | 0.269 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.