Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcitonin receptor-like | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | calcitonin receptor-like | 461 aa | 434 aa | 28.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Fatty acid elongase | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1314 | 1 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0041 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0041 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0074 | 0.0264 | 0.4945 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0041 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0109 | 0.0534 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0041 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0109 | 0.0534 | 1 |
Toxoplasma gondii | integral membrane protein, GNS1/SUR4 family protein, putative | 0.0041 | 0 | 0.5 |
Plasmodium falciparum | long chain fatty acid elongation enzyme, putative | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0534 | 0.0534 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1314 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0264 | 0.0264 |
Toxoplasma gondii | GNS1/SUR4 family protein | 0.0041 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.1314 | 1 | 0.5 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0109 | 0.0534 | 0.0534 |
Plasmodium vivax | GNS1/SUR4 domain containing protein | 0.0041 | 0 | 0.5 |
Leishmania major | fatty acid elongase, putative | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1314 | 1 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0041 | 0 | 0.5 |
Plasmodium falciparum | fatty acid elongation protein, GNS1/SUR4 family, putative | 0.0041 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 220 nM | Displacement of [125]CGRP from human CGRP receptor expressed in human SK-N-MC cell membrane after 2 hrs by scintillation counting | ChEMBL. | 22429471 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.