Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.1023 | 0.1023 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.1022 | 0.1155 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.1023 | 0.1056 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.1023 | 0.2091 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0204 | 0.8847 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1458 | 0.1648 |
Leishmania major | trypanothione reductase | 0.0037 | 0.1105 | 0.2257 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0093 | 0.3701 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0229 | 1 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.1023 | 0.2091 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0748 | 0.0846 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0119 | 0.4894 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1023 | 0.034 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.1023 | 0.9262 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.1023 | 0.1056 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.1023 | 0.1023 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0037 | 0.1127 | 0.1274 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0204 | 0.8847 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.1023 | 0.1157 |
Mycobacterium tuberculosis | Probable reductase | 0.0084 | 0.327 | 0.3374 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0204 | 0.8847 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.1105 | 0.1268 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0748 | 0.0846 |
Onchocerca volvulus | 0.0035 | 0.1023 | 0.0297 | |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0748 | 0.0846 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0748 | 0.0846 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.1023 | 0.1174 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1023 | 0.034 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.1023 | 0.2091 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.1105 | 0.044 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.1105 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0119 | 0.4894 | 0.5532 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0748 | 0.0846 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1023 | 0.034 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.1023 | 0.2091 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1022 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.1023 | 0.1056 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0119 | 0.4894 | 0.5049 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.1023 | 0.9262 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.1023 | 0.1056 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.1023 | 0.034 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0699 | 0.079 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.1023 | 0.1023 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.1105 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1458 | 0.1648 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.1022 | 0.1155 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1458 | 0.1648 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0084 | 0.327 | 0.3374 |
Brugia malayi | beta-lactamase | 0.0035 | 0.1023 | 0.1174 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.1023 | 0.1056 |
Treponema pallidum | NADH oxidase | 0.0013 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.1023 | 0.1023 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1022 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.1105 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.1023 | 0.1056 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0093 | 0.3701 | 0.3818 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0119 | 0.4894 | 1 |
Brugia malayi | glutathione reductase | 0.0037 | 0.1105 | 0.1268 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.1023 | 0.1157 |
Trypanosoma brucei | trypanothione reductase | 0.0037 | 0.1105 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1458 | 0.1648 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1022 | 0.1155 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0084 | 0.327 | 0.8393 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0084 | 0.327 | 0.3374 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.1105 | 0.044 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0748 | 0.1529 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.1023 | 0.2091 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0119 | 0.4894 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1023 | 0.034 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0204 | 0.8847 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.1023 | 0.1157 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0013 | 0 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0037 | 0.1105 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.1023 | 0.1056 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.9694 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0037 | 0.1127 | 0.1274 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.1023 | 0.2091 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1023 | 0.034 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.1458 | 0.1673 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.1023 | 0.9262 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0119 | 0.4894 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0084 | 0.327 | 0.3374 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1458 | 0.1648 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.1023 | 0.1174 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0748 | 0.6773 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.1023 | 0.9262 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0748 | 0.0846 |
Echinococcus granulosus | hormone sensitive lipase | 0.0204 | 0.8847 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0093 | 0.3701 | 0.3818 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.1022 | 0.1155 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1022 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0119 | 0.4894 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1458 | 0.1648 |
Brugia malayi | hypothetical protein | 0.0035 | 0.1022 | 0.1173 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1458 | 0.1648 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0119 | 0.4894 | 0.5532 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0093 | 0.3701 | 0.3818 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.1023 | 0.034 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0084 | 0.327 | 0.3374 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0119 | 0.4894 | 0.5532 |
Onchocerca volvulus | 0.0035 | 0.1023 | 0.0297 | |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.1023 | 0.1056 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1023 | 0.034 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.1023 | 0.0297 | |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.1023 | 0.2091 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0084 | 0.327 | 0.3374 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0037 | 0.1105 | 0.114 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.8847 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1022 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.1105 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.1023 | 0.1056 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0748 | 0.0846 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.1023 | 0.1157 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.1023 | 0.1056 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.8715 | 0.9837 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0119 | 0.4894 | 0.5532 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0013 | 0 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.8715 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.1023 | 0.1174 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.1105 | 0.2257 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.1023 | 0.1023 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0748 | 0.0859 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.1023 | 0.1023 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.1458 | 0.0877 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | <= 0.000463 umol/ml | Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by EUCAST broth dilution method | ChEMBL. | 21982337 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.