Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.013 uM | Inhibition of wild type Mycobacterium tuberculosis RNA polymerase after 10 mins using ribo green staining by rolling circle transcription assay | ChEMBL. | 21903392 |
logIC50 (binding) | = -1.8767 | Inhibition of wild type Mycobacterium tuberculosis RNA polymerase after 10 mins using ribo green staining by rolling circle transcription assay | ChEMBL. | 21903392 |
MIC90 (functional) | = 0.07 uM | Antimicrobial activity against replicating Mycobacterium tuberculosis after 8 days by micro plate alamar blue assay | ChEMBL. | 21903392 |
MIC90 (functional) | = 0.1 uM | Antimicrobial activity against Escherichia coli EC2880 mutant after 16 to 20 hrs | ChEMBL. | 21903392 |
MIC90 (functional) | = 0.5 uM | Antimicrobial activity against non-replicating Mycobacterium tuberculosis after 11 days by luminescence based low oxygen recovery assay | ChEMBL. | 21903392 |
MIC90 (functional) | = 12.5 uM | Antimicrobial activity against wild type Escherichia coli TG2 after 16 to 20 hrs | ChEMBL. | 21903392 |
MIC90 (functional) | = 25 uM | Antimicrobial activity against wild type Escherichia coli DH5[alpha] after 16 to 20 hrs | ChEMBL. | 21903392 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.