Detailed information for compound 1639775

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 521.95 | Formula: C12H8Br3N7O2
  • H donors: 1 H acceptors: 7 LogP: 2.95 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)Cn1nnc(n1)c1nnn(c1)Cc1cc(Br)c(c(c1)Br)Br
  • InChi: 1S/C12H8Br3N7O2/c13-7-1-6(2-8(14)11(7)15)3-21-4-9(16-19-21)12-17-20-22(18-12)5-10(23)24/h1-2,4H,3,5H2,(H,23,24)
  • InChiKey: CQTWZHICLDACPY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0028 0.0028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.098 0.098
Entamoeba histolytica hypothetical protein 0.0073 0.0775 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0133 0.172
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0133 0.385
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0133 0.385
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0133 0.385
Mycobacterium tuberculosis Probable acetyl-hydrolase/esterase LipR 0.0014 0.0083 0.2401
Loa Loa (eye worm) hypothetical protein 0.0019 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0028
Schistosoma mansoni dishevelled 0.0009 0.0014 0.0014
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0028 0.0028
Schistosoma mansoni ap endonuclease 0.0037 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0028
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0028 0.0028
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0174 0.198 1
Echinococcus multilocularis hormone sensitive lipase 0.0851 1 1
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0028 0.0143
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0133 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0028 0.0028
Trichomonas vaginalis Esterase, putative 0.0014 0.0083 0.2401
Brugia malayi DIX domain containing protein 0.0009 0.0014 0.0071
Schistosoma mansoni ap endonuclease 0.0037 0.0346 0.0346
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0028 0.0028
Toxoplasma gondii exonuclease III APE 0.0037 0.0346 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0028 0.0143
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0851 1 1
Brugia malayi nuclear hormone receptor 0.001 0.0028 0.0143
Schistosoma mansoni apoferritin-2 0.0009 0.0015 0.0015
Mycobacterium tuberculosis Probable lipase LipH 0.0014 0.0083 0.2401
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0028 0.0143
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0346 0.0346
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0028 0.0028
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0133 0.385
Brugia malayi ecdysteroid receptor 0.001 0.0028 0.0143
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0014
Schistosoma mansoni thyroid hormone receptor 0.001 0.0028 0.0028
Toxoplasma gondii hypothetical protein 0.0009 0.0014 0.0407
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0133 0.385
Onchocerca volvulus 0.0014 0.0083 0.042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.098 0.098
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0133 0.385
Brugia malayi hypothetical protein 0.0073 0.0775 0.3916
Schistosoma mansoni ferritin 0.0009 0.0015 0.0015
Mycobacterium tuberculosis Probable esterase LipM 0.0014 0.0083 0.2401
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0015 0.042
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0346 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0346 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.0028 0.0028
Echinococcus granulosus FTZ F1 alpha 0.001 0.0028 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0028 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0065 0.187
Onchocerca volvulus 0.001 0.0028 0.0143
Loa Loa (eye worm) hypothetical protein 0.0851 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0133 0.0674
Trypanosoma brucei unspecified product 0.0013 0.0065 0.187
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0028
Schistosoma mansoni dishevelled 0.0009 0.0014 0.0014
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0028 0.0143
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0133 0.385
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0346 1
Trypanosoma brucei unspecified product 0.0019 0.0133 0.385
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0028 0.0143
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0028 0.0028
Echinococcus multilocularis expressed protein 0.0009 0.0015 0.0015
Mycobacterium ulcerans lipase/esterase LipN 0.0014 0.0083 0.2068
Toxoplasma gondii alpha/beta hydrolase fold domain-containing protein 0.0014 0.0083 0.2401
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0028 0.0028
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0133 0.385
Mycobacterium ulcerans esterase LipC 0.0014 0.0083 0.2068
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0028 0.0143
Mycobacterium tuberculosis Possible esterase LipW 0.0014 0.0083 0.2401
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0028 0.0028
Echinococcus granulosus expressed protein 0.0009 0.0015 0.0015
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0028 0.0028
Leishmania major DNA polymerase kappa, putative 0.0019 0.0133 0.385
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0014
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0133 0.358
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0014 0.0071
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0015 0.042
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0346 1
Trypanosoma cruzi Isoprenylcysteine alpha-carbonyl methylesterase, putative 0.0014 0.0083 0.2401
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0028 0.0028
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.098 0.4948
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0028 0.0028
Schistosoma mansoni ferritin 0.0009 0.0015 0.0015
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0028 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0028 0.0143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.098 0.098
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0028 0.0028
Trichomonas vaginalis ferritin, putative 0.0009 0.0015 0.042
Mycobacterium tuberculosis Probable carboxylesterase LipQ 0.0014 0.0083 0.2401
Schistosoma mansoni ferritin light chain 0.0009 0.0015 0.0015
Mycobacterium tuberculosis Putative acetyl hydrolase MbtJ 0.0014 0.0083 0.2401
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0028
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0133 0.358
Mycobacterium ulcerans lipase LipU 0.0014 0.0083 0.2068
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0015 0.042
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0028 0.0143
Brugia malayi hypothetical protein 0.0009 0.0014 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0028 0.0028
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0346 0.0346
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0028 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0028 0.0143
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0073 0.0775 0.0775
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0014 0.0014
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0133 0.385
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0028 0.0143
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0346 0.175
Echinococcus multilocularis ferritin 0.0009 0.0015 0.0015
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0028 0.0143
Loa Loa (eye worm) hypothetical protein 0.0174 0.198 0.198
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0014 0.0014
Loa Loa (eye worm) ammd protein 0.0014 0.0083 0.0083
Toxoplasma gondii alpha/beta hydrolase fold domain-containing protein 0.0014 0.0083 0.2401
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0133 0.0133
Mycobacterium ulcerans acetyl hydrolase MbtJ 0.0014 0.0083 0.2068
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0014 0.0014
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0014 0.0071
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0133 0.385
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0028 0.0028
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0014 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0028 0.0143
Giardia lamblia DINP protein human, muc B family 0.0019 0.0133 0.385
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0028 0.0143
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0346 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0028 0.0028
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0014 0.0014
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0014 0.0014
Leishmania major DNA polymerase eta, putative 0.0019 0.0133 0.385
Trichomonas vaginalis Esterase, putative 0.0014 0.0083 0.2401
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0346 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0028 0.0028
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0133 0.385
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0775 0.0775
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0851 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0133 0.385
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0065 0.187
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0014 0.0014
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0346 1
Treponema pallidum N-acetylphosphinothricin-tripetide-deacetylase 0.0014 0.0083 0.2401
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0851 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0028 0.0028
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0346 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0028 0.0028
Echinococcus granulosus dna polymerase kappa 0.0019 0.0133 0.0133
Echinococcus granulosus ferritin 0.0009 0.0015 0.0015
Schistosoma mansoni ferritin 0.0009 0.0015 0.0015
Mycobacterium ulcerans hypothetical protein 0.0014 0.0083 0.2068
Brugia malayi steroid hormone receptor 0.001 0.0028 0.0143
Mycobacterium ulcerans esterase/lipase 0.0014 0.0083 0.2068
Mycobacterium tuberculosis Probable esterase LipC 0.0014 0.0083 0.2401
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0028 0.0028
Brugia malayi aryl-acylamidase 0.0014 0.0083 0.042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0028 0.0028
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0028 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0028 0.0143
Mycobacterium tuberculosis Probable non lipolytic carboxylesterase NlhH 0.0014 0.0083 0.2401
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.098 0.098
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0083 0.2401
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0346 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0028
Mycobacterium ulcerans lipase LipH 0.0014 0.0083 0.2068
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.001 0.0028 0.0028
Onchocerca volvulus 0.0009 0.0014 0.0071
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0014 0.0014
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0775 0.0775
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0346 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0133 0.385
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0133 0.385
Loa Loa (eye worm) hypothetical protein 0.0009 0.0014 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0028 0.0143
Leishmania major hypothetical protein, conserved 0.0014 0.0083 0.2401
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0014 0.0083 0.0083
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0133 0.0133
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0133 0.0133
Trypanosoma cruzi serine peptidase, Clan SC, Family S9D 0.0014 0.0083 0.2401
Mycobacterium ulcerans esterase LipW 0.0014 0.0083 0.2068
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0346 0.4469
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0028 0.0028
Echinococcus multilocularis dna polymerase eta 0.0019 0.0133 0.0133
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0346 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.098 0.098
Leishmania major ecotin, putative 0.0014 0.0083 0.2401
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0028 0.0028
Echinococcus multilocularis geminin 0.033 0.3819 0.3819
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0028 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0133 0.385
Entamoeba histolytica hypothetical protein 0.0073 0.0775 1
Schistosoma mansoni dep domain containing protein 0.0009 0.0014 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0133 0.385
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.098 0.098
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0028 0.0028
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0133 0.385
Schistosoma mansoni coup transcription factor 0.001 0.0028 0.0028
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0346 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0028 0.0028
Trypanosoma brucei Isoprenylcysteine alpha-carbonyl methylesterase, putative 0.0014 0.0083 0.2401
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0133 0.385
Entamoeba histolytica hypothetical protein 0.0073 0.0775 1
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0014 0.0014
Brugia malayi hypothetical protein 0.0009 0.0014 0.0071
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0346 1
Schistosoma mansoni hypothetical protein 0.033 0.3819 0.3819
Trypanosoma cruzi Isoprenylcysteine alpha-carbonyl methylesterase, putative 0.0014 0.0083 0.2401
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0028 0.0143
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0028 0.0028
Mycobacterium ulcerans membrane-bound esterase LipM 0.0014 0.0083 0.2068
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0133 0.385
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0133 0.385
Mycobacterium tuberculosis Probable esterase/lipase LipF 0.0014 0.0083 0.2401
Mycobacterium leprae Possible lipase LipU 0.0014 0.0083 1
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0014 0.0014
Schistosoma mansoni DNA polymerase eta 0.0019 0.0133 0.0133
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0133 0.0674
Mycobacterium ulcerans esterase LipO 0.0014 0.0083 0.2068
Brugia malayi N-terminal motif family protein 0.0174 0.198 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0028 0.0028
Trichomonas vaginalis Esterase, putative 0.0014 0.0083 0.2401
Echinococcus granulosus geminin 0.033 0.3819 0.3819
Brugia malayi nuclear receptor NHR-88 0.001 0.0028 0.0143
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0014 0.0071
Echinococcus granulosus dna polymerase eta 0.0019 0.0133 0.0133
Mycobacterium ulcerans carboxylesterase LipQ 0.0014 0.0083 0.2068
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0065 0.187
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0014 0.0014
Trypanosoma cruzi Alpha/beta hydrolase domain-containing protein 0.0014 0.0083 0.2401
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0014 0.0014
Schistosoma mansoni ferritin light chain 0.0009 0.0015 0.0015
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0133 0.385
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0133 0.385
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.098 0.098
Schistosoma mansoni ferritin 0.0009 0.0015 0.0015
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.098 0.098
Trypanosoma brucei unspecified product 0.0013 0.0065 0.187
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0028 0.0028
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0346 0.0346
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0133 0.0133
Loa Loa (eye worm) aryl-acylamidase 0.0014 0.0083 0.0083
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0775 0.0775
Entamoeba histolytica hypothetical protein 0.0073 0.0775 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0028 0.0028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0028 0.0028
Schistosoma mansoni apoferritin-2 0.0009 0.0015 0.0015
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0014 0.0014
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0014 0.0014
Mycobacterium ulcerans lipase LipU 0.0014 0.0083 0.2068
Schistosoma mansoni hypothetical protein 0.033 0.3819 0.3819
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0133 0.385
Mycobacterium tuberculosis Possible lipase LipU 0.0014 0.0083 0.2401
Mycobacterium ulcerans lipase LipI 0.0014 0.0083 0.2068
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0014 0.0014
Mycobacterium tuberculosis Probable esterase LipO 0.0014 0.0083 0.2401
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0014 0.0014
Mycobacterium tuberculosis Probable lipase/esterase LipN 0.0014 0.0083 0.2401
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0133 0.385

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 20000 nM Inhibition of rat SCD by rat microsomal assay ChEMBL. 21924609

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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