Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 13.78 nM | Inhibition of human DPP4 after 10 mins | ChEMBL. | 22475866 |
IC50 (binding) | > 25000 nM | Inhibition of DPP9 | ChEMBL. | 22475866 |
IC50 (binding) | > 25000 nM | Inhibition of DPP8 | ChEMBL. | 22475866 |
IC50 (binding) | > 300 uM | Inhibition of human ERG | ChEMBL. | 22475866 |
Papp (ADMET) | = 9.36 ucm/s | Apparent permeability from basolateral to apical side in human Caco2 cells at 10 uM after 60 mins by LC-MS/MS analysis | ChEMBL. | 22475866 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.