Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sigma non-opioid intracellular receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0104 | 0.07 | 0.07 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0104 | 0.07 | 0.07 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0802 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.064 | 0.7843 | 1 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0285 | 0.3113 | 0.3113 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0802 | 1 | 1 |
Onchocerca volvulus | 0.0802 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.3113 | 0.3113 |
Echinococcus multilocularis | geminin | 0.0379 | 0.4365 | 0.4365 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0802 | 1 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0802 | 1 | 1 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0802 | 1 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.0285 | 0.3113 | 0.3113 |
Schistosoma mansoni | hypothetical protein | 0.0802 | 1 | 1 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0285 | 0.3113 | 0.3113 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.3113 | 0.3113 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.3113 | 0.3113 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0285 | 0.3113 | 0.3113 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0104 | 0.07 | 0.07 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0285 | 0.3113 | 0.3113 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0802 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0379 | 0.4365 | 0.4365 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.064 | 0.7843 | 0.7843 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0802 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0802 | 1 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0802 | 1 | 1 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0285 | 0.3113 | 0.3113 |
Onchocerca volvulus | 0.0285 | 0.3113 | 0.3113 | |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.3671 | 0.3671 |
Loa Loa (eye worm) | brahma associated protein | 0.0802 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0285 | 0.3113 | 0.3113 |
Schistosoma mansoni | RNA binding protein | 0.0285 | 0.3113 | 0.3113 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0104 | 0.07 | 0.07 |
Chlamydia trachomatis | SWIB complex protein | 0.0802 | 1 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0285 | 0.3113 | 0.3113 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0285 | 0.3113 | 0.3113 |
Leishmania major | C-8 sterol isomerase-like protein | 0.064 | 0.7843 | 1 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0285 | 0.3113 | 0.3113 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0285 | 0.3113 | 0.3113 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0285 | 0.3113 | 0.3113 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.3113 | 0.3113 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0285 | 0.3113 | 0.3113 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0802 | 1 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0802 | 1 | 1 |
Onchocerca volvulus | 0.0285 | 0.3113 | 0.3113 | |
Schistosoma mansoni | brg-1 associated factor | 0.0802 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0104 | 0.07 | 0.07 |
Plasmodium vivax | hypothetical protein, conserved | 0.0802 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.064 | 0.7843 | 0.7843 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.064 | 0.7843 | 1 |
Onchocerca volvulus | 0.0285 | 0.3113 | 0.3113 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0104 | 0.07 | 0.07 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0802 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0285 | 0.3113 | 0.3113 |
Echinococcus granulosus | geminin | 0.0379 | 0.4365 | 0.4365 |
Schistosoma mansoni | fusion | 0.0285 | 0.3113 | 0.3113 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0802 | 1 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0802 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0379 | 0.4365 | 0.4365 |
Schistosoma mansoni | hypothetical protein | 0.0802 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0285 | 0.3113 | 0.3113 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0104 | 0.07 | 0.07 |
Onchocerca volvulus | 0.0285 | 0.3113 | 0.3113 | |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0802 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0802 | 1 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0104 | 0.07 | 0.07 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0285 | 0.3113 | 0.3113 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0104 | 0.07 | 0.07 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0285 | 0.3113 | 0.3113 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.3113 | 0.3113 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0802 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 3.67 uM | Growth inhibition of human HCT116 cells after 48 hrs by SRB assay | ChEMBL. | 22512908 |
IC50 (binding) | = 12.4 nM | Displacement of [3H](+)pentazocine from sigma-1 receptor expressed in human Jurkat cell membranes after 2 hrs by liquid scintillation spectroscopy | ChEMBL. | 22512908 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.