TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 482.527 | Formula: C29H26N2O5
H donors: 2 H acceptors: 2 LogP: 4.92 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)c(CCNC(=O)c1cc(=O)c3c(o1)cccc3OCc1ccc(cc1)C)c[nH]2
InChi: 1S/C29H26N2O5/c1-18-6-8-19(9-7-18)17-35-25-4-3-5-26-28(25)24(32)15-27(36-26)29(33)30-13-12-20-16-31-23-11-10-21(34-2)14-22(20)23/h3-11,14-16,31H,12-13,17H2,1-2H3,(H,30,33)
InChiKey: PBCHRNMPZHSGCE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	Get druggable targets OG5_126574	All targets in OG5_126574
Plasmodium vivax	ABC transporter G family member 2, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Candida albicans	similar to S. cerevisiae PDR5 (YOR153W)	Get druggable targets OG5_126574	All targets in OG5_126574
Candida albicans	potential ABC transporter similar to S. cerevisiae YOL075C	Get druggable targets OG5_126574	All targets in OG5_126574
Echinococcus multilocularis	ATP binding cassette sub family G	Get druggable targets OG5_126574	All targets in OG5_126574
Schistosoma japonicum	ATP-binding cassette sub-family G member 1, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Echinococcus multilocularis	ATP binding cassette sub family G	Get druggable targets OG5_126574	All targets in OG5_126574
Neospora caninum	hypothetical protein	Get druggable targets OG5_126574	All targets in OG5_126574
Mycobacterium tuberculosis	Probable conserved transmembrane ATP-binding protein ABC transporter	Get druggable targets OG5_126574	All targets in OG5_126574
Candida albicans	potential ABC transporter whose deletion does not affect fluconazole resistance	Get druggable targets OG5_126574	All targets in OG5_126574
Plasmodium knowlesi	ABC transporter G family member 2, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Candida albicans	similar to S. cerevisiae PDR5 (YOR153W)	Get druggable targets OG5_126574	All targets in OG5_126574
Trypanosoma brucei gambiense	ATP-binding cassette protein, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Candida albicans	potential ABC transporter whose deletion does not affect fluconazole resistance	Get druggable targets OG5_126574	All targets in OG5_126574
Toxoplasma gondii	ATP-binding cassette G family transporter ABCG84	Get druggable targets OG5_126574	All targets in OG5_126574
Candida albicans	identical to C terminus of nonallelic CaP19.919	Get druggable targets OG5_126574	All targets in OG5_126574
Candida albicans	multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC	Get druggable targets OG5_126574	All targets in OG5_126574
Cryptosporidium parvum	ABC transporter, AAA domain	Get druggable targets OG5_126574	All targets in OG5_126574
Schistosoma mansoni	ABC transporter	Get druggable targets OG5_126574	All targets in OG5_126574
Giardia lamblia	ABC transporter	Get druggable targets OG5_126574	All targets in OG5_126574
Schistosoma japonicum	ko:K05681 ATP-binding cassette, subfamily G (WHITE), member 2, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Leishmania major	ATP-binding cassette protein subfamily G, member 4, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Loa Loa (eye worm)	ABC transporter	Get druggable targets OG5_126574	All targets in OG5_126574
Leishmania braziliensis	ATP-binding cassette protein, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Trypanosoma brucei	ATP-binding cassette protein, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Candida albicans	potential ABC family transporter similar to S. cerevisiae YNR070W	Get druggable targets OG5_126574	All targets in OG5_126574
Echinococcus multilocularis	ATP binding cassette sub family G	Get druggable targets OG5_126574	All targets in OG5_126574
Trypanosoma cruzi	ATP-binding cassette protein, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Candida albicans	potential ABC family transporter similar to S. cerevisiae YNR070W	Get druggable targets OG5_126574	All targets in OG5_126574
Candida albicans	identical to C terminus of nonallelic CaP19.919	Get druggable targets OG5_126574	All targets in OG5_126574
Echinococcus granulosus	ATP binding cassette sub family G	Get druggable targets OG5_126574	All targets in OG5_126574
Trypanosoma brucei gambiense	ABC transporter, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	Get druggable targets OG5_126574	All targets in OG5_126574
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_126574	All targets in OG5_126574
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	Get druggable targets OG5_126574	All targets in OG5_126574
Leishmania major	ATP-binding cassette protein subfamily G, member 6, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Candida albicans	multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC	Get druggable targets OG5_126574	All targets in OG5_126574
Candida albicans	similar to N terminus of CaP19.6000 multidrug resistance transporter CDR1	Get druggable targets OG5_126574	All targets in OG5_126574
Candida albicans	similar to N terminus of CaP19.6000 multidrug resistance transporter CDR1	Get druggable targets OG5_126574	All targets in OG5_126574
Echinococcus granulosus	ATP binding cassette sub family G	Get druggable targets OG5_126574	All targets in OG5_126574
Trypanosoma cruzi	ABC transporter, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Leishmania braziliensis	ABC transporter, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Leishmania donovani	ATP-binding cassette protein subfamily G, member 4, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Schistosoma mansoni	ATP-binding cassette sub-family g2 (white protein) (abcg2)	Get druggable targets OG5_126574	All targets in OG5_126574
Candida albicans	N terminal 2/3 of Opaque-specific ABC transporter	Get druggable targets OG5_126574	All targets in OG5_126574
Plasmodium berghei	ABC transporter G family member 2, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Candida albicans	multidrug resistance ABC transporter similar to S. cerevisiae PDR5 (YOR153W)	Get druggable targets OG5_126574	All targets in OG5_126574
Entamoeba histolytica	ABC transporter, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Candida albicans	multidrug resistance ABC transporter similar to S. cerevisiae PDR5 (YOR153W)	Get druggable targets OG5_126574	All targets in OG5_126574
Cryptosporidium hominis	ABC transporter protein	Get druggable targets OG5_126574	All targets in OG5_126574
Leishmania mexicana	ABC transporter, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Brugia malayi	ABC transporter family protein	Get druggable targets OG5_126574	All targets in OG5_126574
Trypanosoma congolense	ATP-binding cassette protein, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Leishmania infantum	ATP-binding cassette protein subfamily G, member 4, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Trypanosoma congolense	ABC transporter, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Candida albicans	N terminal 2/3 of Opaque-specific ABC transporter	Get druggable targets OG5_126574	All targets in OG5_126574
Trypanosoma brucei	ABC transporter, putative	Get druggable targets OG5_126574	All targets in OG5_126574
Echinococcus granulosus	ATP binding cassette sub family G	Get druggable targets OG5_126574	All targets in OG5_126574
Plasmodium falciparum	ABC transporter G family member 2	Get druggable targets OG5_126574	All targets in OG5_126574
Candida albicans	potential ABC transporter similar to S. cerevisiae YOL075C	Get druggable targets OG5_126574	All targets in OG5_126574

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	ABC transporter, putative	ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)	611 aa	557 aa	28.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Zinc finger RanBP2 type	0.038	0.3496	0.3485
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0087	0.0202
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.038	0.3496	1
Schistosoma mansoni	inhibitor of apoptosis 1 diap1	0.0019	0.0087	0.0087
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.038	0.3496	0.3496
Echinococcus multilocularis	SWI:SNF matrix associated	0.1068	1	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Echinococcus granulosus	SWI:SNF matrix associated	0.1068	1	1
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Echinococcus multilocularis	RING finger protein 185	0.0019	0.0087	0.007
Brugia malayi	hypothetical protein	0.0019	0.0087	0.0087
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.1068	1	1
Echinococcus multilocularis	ring and YY1 binding protein	0.038	0.3496	0.3485
Giardia lamblia	Zinc finger domain	0.0019	0.0087	1
Echinococcus multilocularis	RING finger and transmembrane domain containing protein	0.0019	0.0087	0.007
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.038	0.3496	1
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0087	0.0202
Leishmania major	hypothetical protein, conserved	0.038	0.3496	1
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0012	0.0017	0.5
Entamoeba histolytica	zinc finger domain containing protein	0.0019	0.0087	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Echinococcus granulosus	RING finger and transmembrane domain containing protein	0.0019	0.0087	0.007
Echinococcus multilocularis	E3 ubiquitin protein ligase LRSAM1	0.0019	0.0087	0.007
Giardia lamblia	Hypothetical protein	0.0019	0.0087	1
Trypanosoma cruzi	WLM domain containing protein, putative	0.038	0.3496	1
Onchocerca volvulus		0.038	0.3496	0.3438
Giardia lamblia	Kinase	0.0019	0.0087	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0087	0.0202
Echinococcus granulosus	RING finger protein 185	0.0019	0.0087	0.007
Schistosoma mansoni	rnf5	0.0019	0.0087	0.0087
Brugia malayi	YY1-associated factor 2	0.038	0.3496	0.3496
Leishmania major	DNA repair protein-like protein	0.0019	0.0087	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0087	0.0087
Brugia malayi	Zinc finger protein 183 homolog	0.0019	0.0087	0.0087
Echinococcus granulosus	E3 ubiquitin protein ligase LRSAM1	0.0019	0.0087	0.007
Brugia malayi	hypothetical protein	0.0019	0.0087	0.0087
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.1068	1	1
Plasmodium vivax	DNA repair protein RAD5, putative	0.0019	0.0087	0.007
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger) containing protein, putative	0.0019	0.0087	0.0202
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0019	0.0087	0.0202
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Plasmodium falciparum	E3 ubiquitin-protein ligase RNF5, putative	0.0019	0.0087	0.007
Trypanosoma brucei	hypothetical protein, conserved	0.038	0.3496	1
Echinococcus multilocularis		0.0019	0.0087	0.007
Echinococcus multilocularis	E3 ubiquitin protein ligase MYLIP	0.0019	0.0087	0.007
Leishmania major	hypothetical protein, conserved	0.0019	0.0087	0.0202
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Echinococcus granulosus	E3 ubiquitin protein ligase MYLIP	0.0019	0.0087	0.007
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.1068	1	1
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0019	0.0087	0.007
Entamoeba histolytica	SPRY domain protein	0.0019	0.0087	1
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Brugia malayi	Zinc finger, C2H2 type family protein	0.0019	0.0087	0.0087
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0019	0.0087	0.007
Toxoplasma gondii	SWI2/SNF2-containing protein RAD5	0.0019	0.0087	0.007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0087	0.0087
Giardia lamblia	Hypothetical protein	0.0019	0.0087	1
Onchocerca volvulus		0.038	0.3496	0.3438
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Echinococcus multilocularis	E3 ubiquitin protein ligase Bre1	0.0019	0.0087	0.007
Brugia malayi	SWIB/MDM2 domain containing protein	0.1068	1	1
Onchocerca volvulus		0.038	0.3496	0.3438
Toxoplasma gondii	ran binding protein	0.038	0.3496	0.3485
Entamoeba histolytica	hypothetical protein	0.0019	0.0087	1
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Toxoplasma gondii	RING zinc finger protein	0.0019	0.0087	0.007
Giardia lamblia	Hypothetical protein	0.0019	0.0087	1
Onchocerca volvulus		0.1068	1	1
Leishmania major	hypothetical protein, conserved	0.0019	0.0087	0.0202
Echinococcus granulosus	E3 ubiquitin protein ligase Bre1	0.0019	0.0087	0.007
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Trypanosoma brucei	ring finger containing protein	0.0019	0.0087	0.0202
Entamoeba histolytica	hypothetical protein	0.0019	0.0087	1
Schistosoma mansoni	hypothetical protein	0.1068	1	1
Giardia lamblia	Ser/Thr protein kinase	0.0019	0.0087	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0087	0.0087
Leishmania major	hypothetical protein, conserved	0.038	0.3496	1
Brugia malayi	B-box zinc finger family protein	0.0019	0.0087	0.0087
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0019	0.0087	0.007
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Schistosoma mansoni	hypothetical protein	0.1068	1	1
Loa Loa (eye worm)	hypothetical protein	0.038	0.3496	0.3496
Schistosoma mansoni	RNA binding protein	0.038	0.3496	0.3496
Plasmodium falciparum	E3 ubiquitin-protein ligase, putative	0.0019	0.0087	0.007
Entamoeba histolytica	zinc finger domain containing protein	0.0019	0.0087	1
Leishmania major	hypothetical protein, conserved	0.0019	0.0087	0.0202
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0019	0.0087	0.0202
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Schistosoma mansoni	hypothetical protein	0.1068	1	1
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.038	0.3496	1
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Giardia lamblia	Kinase, NEK	0.0019	0.0087	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0087	0.0087
Leishmania major	hypothetical protein, conserved	0.0019	0.0087	0.0202
Onchocerca volvulus		0.038	0.3496	0.3438
Leishmania major	hypothetical protein, conserved	0.038	0.3496	1
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Schistosoma mansoni	ring finger protein 151	0.0019	0.0087	0.0087
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.1068	1	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.1068	1	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Trypanosoma cruzi	WLM domain containing protein, putative	0.038	0.3496	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0087	0.0087
Plasmodium vivax	zinc finger protein, putative	0.0019	0.0087	0.007
Trypanosoma brucei	hypothetical protein, conserved	0.038	0.3496	1
Schistosoma mansoni	zinc finger protein	0.0019	0.0087	0.0087
Schistosoma mansoni	hypothetical protein	0.0019	0.0087	0.0087
Toxoplasma gondii	hypothetical protein	0.0019	0.0087	0.007
Loa Loa (eye worm)	RING finger protein 20	0.0019	0.0087	0.0087
Plasmodium vivax	RING zinc finger protein, putative	0.0019	0.0087	0.007
Entamoeba histolytica	zinc finger domain containing protein	0.0019	0.0087	1
Trypanosoma brucei	SNF2 family N-terminal domain/Ring finger domain containing protein, putative	0.0019	0.0087	0.0202
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0087	0.0087
Plasmodium falciparum	RING zinc finger protein, putative	0.0019	0.0087	0.007
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Leishmania major	hypothetical protein, conserved	0.0019	0.0087	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0087	0.0087
Brugia malayi	Hypothetical RING finger protein C16C10.7 in chromosome III	0.0019	0.0087	0.0087
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.038	0.3496	0.3485
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.038	0.3496	1
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.038	0.3496	1
Giardia lamblia	Hypothetical protein	0.0019	0.0087	1
Trypanosoma brucei	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Trypanosoma cruzi	hypothetical protein	0.0019	0.0087	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0087	0.0087
Trichomonas vaginalis	conserved hypothetical protein	0.1068	1	1
Leishmania major	hypothetical protein, conserved	0.038	0.3496	1
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.038	0.3496	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Leishmania major	hypothetical protein, conserved	0.0019	0.0087	0.0202
Giardia lamblia	Zinc finger domain	0.0019	0.0087	1
Brugia malayi	RING finger protein 20	0.0019	0.0087	0.0087
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0087	0.0202
Loa Loa (eye worm)	hypothetical protein	0.038	0.3496	0.3496
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Toxoplasma gondii	hypothetical protein	0.0019	0.0087	0.007
Schistosoma mansoni	peter pan-related	0.0019	0.0087	0.0087
Entamoeba histolytica	zinc finger domain containing protein	0.0019	0.0087	1
Plasmodium vivax	trophozoite exported protein 1, putative	0.0019	0.0087	0.007
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.038	0.3496	0.3496
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.038	0.3496	1
Trypanosoma cruzi	hypothetical protein, conserved	0.038	0.3496	1
Trypanosoma cruzi	hypothetical protein	0.0019	0.0087	0.0202
Giardia lamblia	Ribonuclease	0.0019	0.0087	1
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.1068	1	1
Entamoeba histolytica	zinc finger domain containing protein	0.0019	0.0087	1
Echinococcus granulosus	ring finger protein 113a	0.0019	0.0087	0.007
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.038	0.3496	0.3485
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0012	0.0017	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0087	0.0202
Leishmania major	hypothetical protein, conserved	0.0019	0.0087	0.0202
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.038	0.3496	0.3496
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0087	0.0202
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Leishmania major	hypothetical protein, conserved	0.0019	0.0087	0.0202
Leishmania major	hypothetical protein, conserved	0.0019	0.0087	0.0202
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0019	0.0087	0.007
Trypanosoma cruzi	hypothetical protein, conserved	0.038	0.3496	1
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Loa Loa (eye worm)	brahma associated protein	0.1068	1	1
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Echinococcus multilocularis	zinc finger protein Ran binding	0.038	0.3496	0.3485
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Entamoeba histolytica	zinc finger domain containing protein	0.0019	0.0087	1
Schistosoma mansoni	brg-1 associated factor	0.1068	1	1
Loa Loa (eye worm)	RiNg Finger protein family member	0.0019	0.0087	0.0087
Echinococcus granulosus	zinc finger protein Ran binding	0.038	0.3496	0.3485
Chlamydia trachomatis	DNA topoisomerase I	0.1068	1	0.5
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Brugia malayi	Neuralized family protein	0.0019	0.0087	0.0087
Toxoplasma gondii	Bardet-Biedl syndrome 5, putative	0.0019	0.0087	0.007
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.038	0.3496	0.3496
Echinococcus granulosus	cell growth regulator with ring finger domain	0.0019	0.0087	0.007
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Leishmania major	hypothetical protein, conserved	0.038	0.3496	1
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Loa Loa (eye worm)	hypothetical protein	0.038	0.3496	0.3496
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.038	0.3496	0.3438
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Echinococcus multilocularis	SWI:SNF matrix associated	0.1068	1	1
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Echinococcus multilocularis	ring finger protein 113a	0.0019	0.0087	0.007
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Plasmodium falciparum	zinc finger protein, putative	0.0019	0.0087	0.007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0087	0.0087
Plasmodium falciparum	trophozoite exported protein 1	0.0019	0.0087	0.007
Toxoplasma gondii	hypothetical protein	0.0019	0.0087	0.007
Schistosoma mansoni	hypothetical protein	0.038	0.3496	0.3496
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Giardia lamblia	Hypothetical protein	0.0019	0.0087	1
Echinococcus granulosus	ring finger protein 170	0.0019	0.0087	0.007
Echinococcus granulosus	ring and YY1 binding protein	0.038	0.3496	0.3485
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Entamoeba histolytica	zinc finger domain containing protein	0.0019	0.0087	1
Chlamydia trachomatis	SWIB complex protein	0.1068	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.038	0.3496	0.3496
Brugia malayi	hypothetical protein	0.0019	0.0087	0.0087
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Schistosoma mansoni	TRABID protein (C64 family)	0.038	0.3496	0.3496
Brugia malayi	brahma associated protein 60 kDa	0.1068	1	1
Echinococcus multilocularis	SWI:SNF matrix associated	0.1068	1	1
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Trypanosoma brucei	predicted zinc finger protein	0.0019	0.0087	0.0202
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0087	0.0202
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0012	0.0017	0.5
Giardia lamblia	Hypothetical protein	0.0019	0.0087	1
Plasmodium vivax	E3 ubiquitin-protein ligase, putative	0.0019	0.0087	0.007
Leishmania major	hypothetical protein, conserved	0.0019	0.0087	0.0202
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Schistosoma mansoni	fusion	0.038	0.3496	0.3496
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Brugia malayi	hypothetical protein	0.0019	0.0087	0.0087
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.038	0.3496	0.3485
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0087	0.0087
Schistosoma mansoni	zinc finger protein	0.038	0.3496	0.3496
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Leishmania major	hypothetical protein, unknown function	0.0019	0.0087	0.0202
Leishmania major	hypothetical protein, conserved	0.0019	0.0087	0.0202
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.038	0.3496	0.3485
Trypanosoma brucei	DNA repair protein, putative	0.0019	0.0087	0.0202
Giardia lamblia	Protein 21.1	0.0019	0.0087	1
Schistosoma mansoni	mind bomb	0.0019	0.0087	0.0087
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.038	0.3496	0.3485
Schistosoma mansoni	hypothetical protein	0.0019	0.0087	0.0087
Brugia malayi	hypothetical protein	0.0019	0.0087	0.0087
Toxoplasma gondii	helicase, putative	0.0019	0.0087	0.007
Trypanosoma cruzi	hypothetical protein, conserved	0.038	0.3496	1
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Plasmodium vivax	hypothetical protein, conserved	0.1068	1	1
Schistosoma mansoni	peter pan-related	0.0019	0.0087	0.0087
Giardia lamblia	Kinase, NEK	0.0019	0.0087	1
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.1068	1	1
Leishmania major	hypothetical protein, conserved	0.0019	0.0087	0.0202
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Trypanosoma brucei	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Giardia lamblia	E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B	0.0019	0.0087	1
Loa Loa (eye worm)	hypothetical protein	0.038	0.3496	0.3496
Brugia malayi	hypothetical protein	0.0019	0.0087	0.0087
Echinococcus granulosus	E3 ubiquitin protein ligase RNF146	0.0019	0.0087	0.007
Plasmodium vivax	E3 ubiquitin-protein ligase RNF5, putative	0.0019	0.0087	0.007
Toxoplasma gondii	hypothetical protein	0.0019	0.0087	0.007
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202
Entamoeba histolytica	zinc finger domain containing protein	0.0019	0.0087	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0087	0.0087
Giardia lamblia	Hypothetical protein	0.0019	0.0087	1
Echinococcus multilocularis	ring finger protein 170	0.0019	0.0087	0.007
Schistosoma mansoni	ATP-binding cassette sub-family g2 (white protein) (abcg2)	0.0012	0.0017	0.0017
Leishmania major	hypothetical protein, conserved	0.0019	0.0087	0.0202
Brugia malayi	RING zinc finger protein	0.0019	0.0087	0.0087
Leishmania major	hypothetical protein	0.0019	0.0087	0.0202
Schistosoma mansoni	hypothetical protein	0.0019	0.0087	0.0087
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.1068	1	1
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0019	0.0087	0.0202

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.2 uM	Inhibition of ABCG2-mediated mitoxantrone efflux in HEK293 cells by flow cytometry	ChEMBL.	22165858
Inhibition (binding)	= -21.87 %	Inhibition of P-glycoprotein/ABCB1-mediated mitoxantrone efflux in HEK293 cells at 5 uM by flow cytometry relative to 5 uM of GF120918	ChEMBL.	22165858
Inhibition (binding)	= -4.29 %	Inhibition of P-glycoprotein/ABCB1-mediated mitoxantrone efflux in HEK293 cells at 1 uM by flow cytometry relative to 5 uM of GF120918	ChEMBL.	22165858
Inhibition (binding)	= 1.13 %	Inhibition of MRP1/ABCC1-mediated calcein efflux in HEK293 cells at 1 uM by flow cytometry relative to untreated control	ChEMBL.	22165858
Inhibition (binding)	= 3.09 %	Inhibition of P-MRP1/ABCC1-mediated mitoxantrone efflux in HEK293 cells at 5 uM by flow cytometry relative to untreated control	ChEMBL.	22165858

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2011289

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1640698