Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0728 | 1 | 1 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0728 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0259 | 0.3438 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.3438 | 0.3438 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0728 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0259 | 0.3438 | 0.3438 |
Onchocerca volvulus | 0.0728 | 1 | 1 | |
Giardia lamblia | Kinase, NEK | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0728 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0259 | 0.3438 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0259 | 0.3438 | 0.5 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0728 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0259 | 0.3438 | 1 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0728 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0259 | 0.3438 | 0.3438 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0259 | 0.3438 | 0.3438 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0259 | 0.3438 | 0.3438 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0728 | 1 | 1 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0259 | 0.3438 | 0.3438 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0259 | 0.3438 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.3438 | 0.3438 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0259 | 0.3438 | 1 |
Schistosoma mansoni | RNA binding protein | 0.0259 | 0.3438 | 0.3438 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0728 | 1 | 1 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0728 | 1 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.0259 | 0.3438 | 0.3438 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0259 | 0.3438 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0259 | 0.3438 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0259 | 0.3438 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0259 | 0.3438 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.3438 | 0.3438 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0728 | 1 | 1 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0728 | 1 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0259 | 0.3438 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0259 | 0.3438 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0728 | 1 | 1 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0259 | 0.3438 | 0.3438 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.3438 | 0.3438 |
Giardia lamblia | Ser/Thr protein kinase | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0728 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0259 | 0.3438 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0259 | 0.3438 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0728 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0728 | 1 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0728 | 1 | 1 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0259 | 0.3438 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0259 | 0.3438 | 0.3438 |
Loa Loa (eye worm) | brahma associated protein | 0.0728 | 1 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0728 | 1 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0728 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0259 | 0.3438 | 1 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.3438 | 0.3438 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0259 | 0.3438 | 0.5 |
Schistosoma mansoni | brg-1 associated factor | 0.0728 | 1 | 1 |
Giardia lamblia | Protein 21.1 | 0.0013 | 0 | 0.5 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0259 | 0.3438 | 0.5 |
Chlamydia trachomatis | SWIB complex protein | 0.0728 | 1 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.0728 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0728 | 1 | 1 |
Schistosoma mansoni | fusion | 0.0259 | 0.3438 | 0.3438 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0259 | 0.3438 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 56 nM | Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifearase reporter gene assay | ChEMBL. | 22525313 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.