Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Giardia lamblia | Ser/Thr protein kinase | 0.0012 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0669 | 1 | 0.5 |
Schistosoma mansoni | RNA binding protein | 0.0238 | 0.3438 | 0.3438 |
Leishmania major | hypothetical protein, conserved | 0.0238 | 0.3438 | 1 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0238 | 0.3438 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0669 | 1 | 1 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0238 | 0.3438 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0238 | 0.3438 | 0.3438 |
Leishmania major | hypothetical protein, conserved | 0.0238 | 0.3438 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0238 | 0.3438 | 0.5 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0238 | 0.3438 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0669 | 1 | 1 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0238 | 0.3438 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0669 | 1 | 1 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0238 | 0.3438 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0669 | 1 | 1 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0669 | 1 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0669 | 1 | 0.5 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0669 | 1 | 1 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0238 | 0.3438 | 0.5 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0238 | 0.3438 | 0.3438 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0238 | 0.3438 | 0.5 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0669 | 1 | 1 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | brg-1 associated factor | 0.0669 | 1 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0669 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0238 | 0.3438 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Chlamydia trachomatis | SWIB complex protein | 0.0669 | 1 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0669 | 1 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0669 | 1 | 1 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0238 | 0.3438 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.0669 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0238 | 0.3438 | 1 |
Giardia lamblia | Kinase, NEK | 0.0012 | 0 | 0.5 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0669 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0669 | 1 | 1 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.3438 | 0.3438 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | fusion | 0.0238 | 0.3438 | 0.3438 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0238 | 0.3438 | 0.3438 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0238 | 0.3438 | 0.5 |
Brugia malayi | YY1-associated factor 2 | 0.0238 | 0.3438 | 0.3438 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0238 | 0.3438 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0238 | 0.3438 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0238 | 0.3438 | 0.3438 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0669 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0669 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0669 | 1 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0238 | 0.3438 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0238 | 0.3438 | 0.3438 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.3438 | 0.3438 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0669 | 1 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0669 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.3438 | 0.3438 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0238 | 0.3438 | 0.3438 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.3438 | 0.3438 |
Loa Loa (eye worm) | brahma associated protein | 0.0669 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0238 | 0.3438 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Onchocerca volvulus | 0.0669 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.3438 | 0.3438 |
Schistosoma mansoni | hypothetical protein | 0.0238 | 0.3438 | 0.3438 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0238 | 0.3438 | 0.5 |
Giardia lamblia | Protein 21.1 | 0.0012 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 330 nM | Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifearase reporter gene assay | ChEMBL. | 22525313 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.