Detailed information for compound 1643298

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 5832.86 | Formula: C188H237N75O108P18
  • H donors: 44 H acceptors: 78 LogP: -36.23 Rotable bonds: 111
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@@H](OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(CC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1O)n1cc(C)c(=O)[nH]c1=O)O)n1ccc(nc1=O)N)O)n1cc(C)c(=O)[nH]c1=O)O)n1ccc(nc1=O)N)O)n1cc(C)c(=O)[nH]c1=O)O)n1cnc2c1ncnc2N)O)n1cc(C)c(=O)[nH]c1=O)O)n1cnc2c1nc(N)[nH]c2=O)O)n1ccc(nc1=O)N)O)Cn1cnc2c1nc1nc(N)nc(c1c2)N)O)n1cnc2c1ncnc2N)O)n1cnc2c1ncnc2N)O)n1ccc(nc1=O)N)O)n1cc(C)c(nc1=O)N)O)n1cnc2c1nc(N)[nH]c2=O)O)n1cnc2c1nc(N)[nH]c2=O)O)n1cnc2c1ncnc2N)O)n1cnc2c1ncnc2N)O)n1cnc2c1nc(N)[nH]c2=O
  • InChi: 1S/C188H237N75O108P18/c1-74-35-250(184(278)230-149(74)193)128-25-91(108(343-128)49-329-385(309,310)370-99-33-138(262-72-223-147-165(262)235-178(203)239-173(147)272)353-117(99)58-335-389(317,318)371-100-34-139(263-73-224-148-166(263)236-179(204)240-174(148)273)352-116(100)57-334-388(315,316)369-98-32-135(259-69-220-144-155(199)209-63-214-162(144)259)351-115(98)56-333-387(313,314)367-96-30-133(257-67-218-142-153(197)207-61-212-160(142)257)349-113(96)53-324-377(293,294)357-85-19-136(337-101(85)41-264)260-70-221-145-163(260)233-176(201)237-171(145)270)363-381(301,302)326-47-107-90(24-126(342-107)249-14-9-121(192)228-183(249)277)362-380(299,300)331-55-114-97(31-134(350-114)258-68-219-143-154(198)208-62-213-161(143)258)368-386(311,312)332-54-111-94(28-131(347-111)255-65-216-140-151(195)205-59-210-158(140)255)358-374(287,288)319-42-79(40-245-64-215-81-16-80-150(194)229-175(200)232-156(80)231-157(81)245)354-373(285,286)321-45-104-87(21-123(339-104)246-11-6-118(189)225-180(246)274)360-378(295,296)322-44-103-86(20-137(346-103)261-71-222-146-164(261)234-177(202)238-172(146)271)355-372(283,284)15-10-83-84(18-127(336-83)252-37-76(3)168(267)242-186(252)280)356-376(291,292)323-52-112-95(29-132(348-112)256-66-217-141-152(196)206-60-211-159(141)256)366-384(307,308)330-51-110-93(27-130(345-110)254-39-78(5)170(269)244-188(254)282)365-383(305,306)327-48-106-89(23-125(341-106)248-13-8-120(191)227-182(248)276)361-379(297,298)328-50-109-92(26-129(344-109)253-38-77(4)169(268)243-187(253)281)364-382(303,304)325-46-105-88(22-124(340-105)247-12-7-119(190)226-181(247)275)359-375(289,290)320-43-102-82(265)17-122(338-102)251-36-75(2)167(266)241-185(251)279/h6-9,11-14,16,35-39,59-73,79,82-117,122-139,264-265H,10,15,17-34,40-58H2,1-5H3,(H,283,284)(H,285,286)(H,287,288)(H,289,290)(H,291,292)(H,293,294)(H,295,296)(H,297,298)(H,299,300)(H,301,302)(H,303,304)(H,305,306)(H,307,308)(H,309,310)(H,311,312)(H,313,314)(H,315,316)(H,317,318)(H2,189,225,274)(H2,190,226,275)(H2,191,227,276)(H2,192,228,277)(H2,193,230,278)(H2,195,205,210)(H2,196,206,211)(H2,197,207,212)(H2,198,208,213)(H2,199,209,214)(H,241,266,279)(H,242,267,280)(H,243,268,281)(H,244,269,282)(H3,201,233,237,270)(H3,202,234,238,271)(H3,203,235,239,272)(H3,204,236,240,273)(H4,194,200,229,231,232)/t79-,82-,83+,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101+,102+,103+,104+,105+,106+,107+,108+,109+,110+,111+,112+,113+,114+,115+,116+,117+,122+,123+,124+,125+,126+,127+,128+,129+,130+,131+,132+,133+,134+,135+,136+,137+,138+,139+/m0/s1
  • InChiKey: GMVCHNXWIQKYJQ-DRKBCLBVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.008 0.0905 0.1024
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0072 0.0058
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0022 0.0072 0.0075
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0022 0.0061 0.0061
Trichomonas vaginalis histone deacetylase, putative 0.0042 0.036 0.0391
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0072 0.0786 0.091
Schistosoma mansoni ap endonuclease 0.0019 0.0022 0.0026
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0022 0.0072 0.0058
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0022 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0617 0.8612 0.8897
Toxoplasma gondii histone deacetylase HDAC1 0.0141 0.1775 0.2055
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0219 0.2903 0.2903
Schistosoma mansoni hypothetical protein 0.0072 0.0786 0.091
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0061 0.0061
Echinococcus multilocularis dro:myosuppressin receptor 0.0072 0.0786 0.0786
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0022 0.0072 0.0072
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0058 0.0584 1
Loa Loa (eye worm) hypothetical protein 0.0219 0.2903 0.2999
Toxoplasma gondii ran binding protein 0.0219 0.2903 0.336
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0022 0.0061 0.0071
Trichomonas vaginalis histone deacetylase, putative 0.0042 0.036 0.0391
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.008 0.0905 0.1024
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0022 0.0061 0.0045
Echinococcus multilocularis neuropeptides capa receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis neuropeptide receptor 0.0072 0.0786 0.0786
Toxoplasma gondii hypothetical protein 0.0058 0.0584 0.0676
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0072 0.0058
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Echinococcus granulosus neuropeptide s receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0072 0.0786 0.0786
Echinococcus granulosus g protein coupled receptor 0.0072 0.0786 0.0786
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0072 0.0084
Echinococcus granulosus tm gpcr rhodopsin 0.0072 0.0786 0.0786
Brugia malayi G protein-coupled receptor 0.0072 0.0786 0.0786
Brugia malayi MAP kinase sur-1 0.0619 0.8639 0.8639
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0072 0.0786 0.091
Echinococcus multilocularis mitogen activated protein kinase 3 0.0619 0.8639 0.8639
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0072 0.0786 0.0786
Onchocerca volvulus 0.0617 0.8612 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0072 0.0786 0.0813
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0619 0.8639 1
Echinococcus multilocularis allatostatin A receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0022 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0691 0.9679 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0619 0.8639 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0089 0.103 0.103
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Trypanosoma cruzi hypothetical protein, conserved 0.0219 0.2903 0.3343
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Brugia malayi RE15519p 0.0072 0.0786 0.0786
Toxoplasma gondii histone deacetylase HDAC5 0.0042 0.036 0.0416
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0022 0.0072 0.0084
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0072 0.0084
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0022 0.0072 0.0058
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Onchocerca volvulus 0.0219 0.2903 0.3371
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.008 0.0905 0.1024
Echinococcus granulosus mitogen activated protein kinase 3 0.0619 0.8639 0.8639
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0089 0.103 0.1064
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.008 0.0905 0.1024
Toxoplasma gondii hypothetical protein 0.0058 0.0584 0.0676
Leishmania major hypothetical protein, conserved 0.0022 0.0061 0.0045
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0084
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0022 0.0061 0.0045
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Echinococcus granulosus neuropeptide receptor 0.0599 0.8365 0.8365
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0022 0.0072 0.0072
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0072 0.0786 0.0786
Plasmodium vivax phosphodiesterase gamma, putative 0.0022 0.0072 0.0084
Echinococcus multilocularis SWI:SNF matrix associated 0.0617 0.8612 0.8612
Brugia malayi hypothetical protein 0.0072 0.0786 0.0786
Schistosoma mansoni hypothetical protein 0.0617 0.8612 0.9968
Schistosoma mansoni biogenic amine receptor 0.0072 0.0786 0.091
Schistosoma mansoni histone deacetylase hda2 0.0042 0.036 0.0416
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Trypanosoma cruzi histone deacetylase 1, putative 0.0042 0.036 0.0391
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0061 0.0061
Brugia malayi SWIB/MDM2 domain containing protein 0.0617 0.8612 0.8612
Leishmania major histone deacetylase, putative 0.0042 0.036 0.0391
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Trypanosoma cruzi WLM domain containing protein, putative 0.0219 0.2903 0.3343
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0042 0.036 0.0391
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0058 0.0584 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Loa Loa (eye worm) melatonin receptor type 1A 0.0072 0.0786 0.0813
Trichomonas vaginalis BRCA1-associated protein, putative 0.0022 0.0061 0.0045
Toxoplasma gondii histone deacetylase HDAC2 0.0042 0.036 0.0416
Mycobacterium leprae conserved hypothetical protein 0.0058 0.0584 0.5
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0058
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0072 0.0786 0.0786
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0022 0.0061 0.0071
Echinococcus multilocularis ring and YY1 binding protein 0.0219 0.2903 0.2903
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0072 0.0786 0.0786
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0022 0.0072 0.0058
Plasmodium vivax hypothetical protein, conserved 0.0617 0.8612 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0072 0.0786 0.0786
Echinococcus multilocularis g protein coupled receptor 0.0072 0.0786 0.0786
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0072 0.0786 0.0786
Brugia malayi Histone deacetylase family protein 0.0141 0.1775 0.1775
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0022 0.0072 0.0058
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0022 0.0072 0.0072
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0072 0.0786 0.0786
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0042 0.036 0.0391
Loa Loa (eye worm) neuropeptide F receptor 0.0072 0.0786 0.0813
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0219 0.2903 0.3343
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0022 0.0061 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0584 0.0652
Trypanosoma cruzi WLM domain containing protein, putative 0.0219 0.2903 0.3343
Echinococcus granulosus BRCA1 associated protein 0.0022 0.0061 0.0061
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0219 0.2903 0.2903
Trypanosoma cruzi hypothetical protein, conserved 0.0219 0.2903 0.3343
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0061 0.0063
Echinococcus granulosus neuropeptide receptor 0.0072 0.0786 0.0786
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0022 0.5
Onchocerca volvulus Histone deacetylase 10 homolog 0.0042 0.036 0.0418
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0022 0.0061 0.0045
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0042 0.036 0.0391
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Plasmodium falciparum histone deacetylase, putative 0.0141 0.1775 0.2061
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Plasmodium vivax histone deacetylase 1, putative 0.0042 0.036 0.0418
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0022 0.0061 0.0045
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.008 0.0905 0.1024
Brugia malayi hypothetical protein 0.0072 0.0786 0.0786
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0022 0.0061 0.0071
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0219 0.2903 0.3343
Plasmodium vivax histone deacetylase, putative 0.0042 0.036 0.0418
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0022 0.0072 0.0058
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0022 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Echinococcus granulosus SWI:SNF matrix associated 0.0617 0.8612 0.8612
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0022 0.0072 0.0084
Echinococcus multilocularis G protein coupled receptor 139 0.0599 0.8365 0.8365
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0022 0.0022
Schistosoma mansoni biogenic amine receptor 0.0072 0.0786 0.091
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0072 0.0058
Schistosoma mansoni hypothetical protein 0.0072 0.0786 0.091
Echinococcus multilocularis histone deacetylase 7 0.0141 0.1775 0.1775
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Schistosoma mansoni serine/threonine protein kinase 0.0619 0.8639 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0619 0.8639 1
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0617 0.8612 1
Schistosoma mansoni fusion 0.0219 0.2903 0.336
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.008 0.0905 0.1024
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.008 0.0905 0.1024
Loa Loa (eye worm) hypothetical protein 0.0219 0.2903 0.2999
Loa Loa (eye worm) histone deacetylase 7A 0.0141 0.1775 0.1834
Loa Loa (eye worm) TYRA-2 protein 0.0072 0.0786 0.0813
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Echinococcus granulosus fmrfamide receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis neuropeptide Y receptor 0.0072 0.0786 0.0786
Onchocerca volvulus 0.0219 0.2903 0.3371
Loa Loa (eye worm) hypothetical protein 0.0089 0.103 0.1064
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Brugia malayi hypothetical protein 0.0072 0.0786 0.0786
Brugia malayi follicle stimulating hormone receptor 0.0072 0.0786 0.0786
Trypanosoma brucei hypothetical protein, conserved 0.0219 0.2903 0.3343
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0072 0.0058
Leishmania major hypothetical protein, conserved 0.0022 0.0072 0.0058
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0061 0.0045
Schistosoma mansoni growth hormone secretagogue receptor 0.0072 0.0786 0.091
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0617 0.8612 0.9968
Trypanosoma cruzi histone deacetylase, putative 0.0141 0.1775 0.2034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0219 0.2903 0.336
Brugia malayi hypothetical protein 0.0072 0.0786 0.0786
Onchocerca volvulus 0.0219 0.2903 0.3371
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Brugia malayi hypothetical protein 0.0072 0.0786 0.0786
Schistosoma mansoni histamine h1 receptor 0.0072 0.0786 0.091
Echinococcus multilocularis neuropeptide s receptor 0.0072 0.0786 0.0786
Trichomonas vaginalis conserved hypothetical protein 0.0617 0.8612 0.9968
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0072 0.0786 0.0786
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0089 0.103 0.103
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0619 0.8639 0.8926
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0084
Trypanosoma brucei cAMP-specific phosphodiesterase 0.008 0.0905 0.1024
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0619 0.8639 1
Echinococcus granulosus histone deacetylase 7 0.0141 0.1775 0.1775
Leishmania major hypothetical protein, conserved 0.0022 0.0061 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Echinococcus granulosus hypothetical protein 0.0072 0.0786 0.0786
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0219 0.2903 0.3343
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0072 0.0786 0.091
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0072 0.0786 0.0786
Trichomonas vaginalis CMGC family protein kinase 0.0619 0.8639 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Echinococcus multilocularis neuropeptides capa receptor 0.0072 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0075
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0022 0.0061 0.0061
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0022 0.0072 0.0058
Echinococcus granulosus sodium and chloride dependent glycine 0.0089 0.103 0.103
Brugia malayi Tachykinin-like peptides receptor 99D 0.0072 0.0786 0.0786
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0786 0.091
Brugia malayi hypothetical protein 0.0072 0.0786 0.0786
Schistosoma mansoni hypothetical protein 0.0072 0.0786 0.091
Brugia malayi histone deacetylase 11 0.0042 0.036 0.036
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0022 0.0072 0.0058
Onchocerca volvulus 0.0072 0.0786 0.0913
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Echinococcus multilocularis fmrfamide receptor 0.0072 0.0786 0.0786
Brugia malayi ORL1-like opioid receptor 0.0072 0.0786 0.0786
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.008 0.0905 0.0905
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Loa Loa (eye worm) histone deacetylase 0.0141 0.1775 0.1834
Echinococcus granulosus 7tm_1 domain containing protein 0.0072 0.0786 0.0786
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0072 0.0058
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0617 0.8612 0.8612
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0022 0.0023
Schistosoma mansoni RNA binding protein 0.0219 0.2903 0.336
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0219 0.2903 0.2903
Brugia malayi hypothetical protein 0.0072 0.0786 0.0786
Leishmania major hypothetical protein, conserved 0.0219 0.2903 0.3343
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0584 0.0652
Echinococcus granulosus alpha 1A adrenergic receptor 0.0072 0.0786 0.0786
Schistosoma mansoni adenoreceptor 0.0072 0.0786 0.091
Trypanosoma cruzi histone deacetylase, putative 0.0042 0.036 0.0391
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0022 0.0072 0.0072
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.008 0.0905 0.1024
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0022 0.0072 0.0072
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.008 0.0905 0.1024
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0619 0.8639 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0042 0.036 0.0391
Echinococcus granulosus histone deacetylase 0.0141 0.1775 0.1775
Trypanosoma brucei histone deacetylase 2 0.0042 0.036 0.0391
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.008 0.0905 0.1024
Loa Loa (eye worm) hypothetical protein 0.0219 0.2903 0.2999
Brugia malayi Serotonin receptor 0.0072 0.0786 0.0786
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0219 0.2903 0.2903
Trypanosoma brucei histone deacetylase, putative 0.0141 0.1775 0.2034
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0619 0.8639 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0022 0.0061 0.0045
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0619 0.8639 1
Trypanosoma brucei histone deacetylase 4 0.0141 0.1775 0.2034
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0022 0.0061 0.0071
Echinococcus multilocularis neuropeptide receptor A26 0.0072 0.0786 0.0786
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0072 0.0084
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0022 0.0022
Echinococcus multilocularis histone deacetylase 3 0.0042 0.036 0.036
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0072 0.0786 0.0786
Schistosoma mansoni biogenic amine (5HT) receptor 0.0072 0.0786 0.091
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0072 0.0786 0.091
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0072 0.0786 0.091
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Trichomonas vaginalis histone deacetylase, putative 0.0042 0.036 0.0391
Trypanosoma brucei histone deacetylase 1 0.0042 0.036 0.0391
Schistosoma mansoni hypothetical protein 0.0617 0.8612 0.9968
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0061 0.0061
Giardia lamblia Hypothetical protein 0.0022 0.0061 0.0045
Echinococcus multilocularis mitogen activated protein kinase 0.0619 0.8639 0.8639
Schistosoma mansoni neuropeptide F-like receptor 0.0072 0.0786 0.091
Trichomonas vaginalis histone deacetylase, putative 0.0042 0.036 0.0391
Leishmania major hypothetical protein, conserved 0.0219 0.2903 0.3343
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0022 0.0072 0.0072
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.008 0.0905 0.1024
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Schistosoma mansoni TRABID protein (C64 family) 0.0219 0.2903 0.336
Echinococcus granulosus sex peptide receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0022 0.0022
Schistosoma mansoni histone deacetylase 4 5 0.0141 0.1775 0.2055
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Echinococcus granulosus histone deacetylase 1 0.0042 0.036 0.036
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0072 0.0786 0.0813
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0084
Echinococcus multilocularis zinc finger protein Ran binding 0.0219 0.2903 0.2903
Echinococcus multilocularis histone deacetylase 1 0.0042 0.036 0.036
Trypanosoma brucei protein kinase, putative 0.0619 0.8639 1
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0072 0.0058
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0072 0.0786 0.0813
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Leishmania major hypothetical protein, conserved 0.0022 0.0072 0.0058
Brugia malayi Histone deacetylase 1 0.0042 0.036 0.036
Plasmodium falciparum histone deacetylase 2 0.0141 0.1775 0.2061
Echinococcus granulosus histone deacetylase 6 0.0141 0.1775 0.1775
Onchocerca volvulus 0.0072 0.0786 0.0913
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0072 0.0786 0.0786
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0072 0.0786 0.0786
Loa Loa (eye worm) G-protein coupled receptor 0.0072 0.0786 0.0813
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0022 0.0061 0.0045
Entamoeba histolytica histone deacetylase, putative 0.0042 0.036 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0022 0.0072 0.0072
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.008 0.0905 0.1024
Plasmodium falciparum phosphodiesterase delta, putative 0.0022 0.0072 0.0084
Leishmania major histone deacetylase, putative 0.0042 0.036 0.0391
Schistosoma mansoni amine GPCR 0.0072 0.0786 0.091
Brugia malayi brahma associated protein 60 kDa 0.0617 0.8612 0.8612
Giardia lamblia Hypothetical protein 0.0022 0.0072 0.0058
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0072 0.0786 0.091
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Echinococcus multilocularis g protein coupled receptor 0.0072 0.0786 0.0786
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0584 0.0678
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0022 0.0061 0.0063
Echinococcus granulosus histone deacetylase 3 0.0042 0.036 0.036
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0617 0.8612 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0084
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.008 0.0905 0.1048
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0617 0.8612 1
Echinococcus granulosus neuropeptide Y receptor 0.0072 0.0786 0.0786
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0022 0.0072 0.0072
Trichomonas vaginalis CMGC family protein kinase 0.0619 0.8639 1
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0584 0.0652
Trichomonas vaginalis CMGC family protein kinase 0.0619 0.8639 1
Echinococcus granulosus tm gpcr rhodopsin 0.0072 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0219 0.2903 0.3343
Brugia malayi neuropeptide F receptor 0.0072 0.0786 0.0786
Echinococcus granulosus dro:myosuppressin receptor 0.0072 0.0786 0.0786
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0072 0.0084
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0058
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0022 0.0072 0.0072
Echinococcus granulosus 7TM GPCR rhodopsin 0.0072 0.0786 0.0786
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0713 1 1
Onchocerca volvulus 0.0072 0.0786 0.0913
Brugia malayi putative neuropeptide receptor 0.0072 0.0786 0.0786
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0058
Brugia malayi Melatonin receptor type 1A 0.0072 0.0786 0.0786
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0022 0.0061 0.0071
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0022 0.0072 0.0084
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Brugia malayi hypothetical protein 0.0072 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Echinococcus granulosus g protein coupled receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0072 0.0786 0.0786
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0022 0.0072 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0075
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0072 0.0786 0.0786
Schistosoma mansoni neuropeptide F-like receptor 0.0072 0.0786 0.091
Schistosoma mansoni histone deacetylase 1 2 3 0.0042 0.036 0.0416
Onchocerca volvulus 0.0072 0.0786 0.0913
Giardia lamblia Kinase, CMGC MAPK 0.0619 0.8639 1
Loa Loa (eye worm) PDE1B protein 0.0022 0.0072 0.0075
Echinococcus multilocularis neuropeptide FF receptor 2 0.0072 0.0786 0.0786
Onchocerca volvulus 0.0072 0.0786 0.0913
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0058
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0072 0.0786 0.091
Echinococcus multilocularis somatostatin receptor 0.0072 0.0786 0.0786
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0219 0.2903 0.3371
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0072 0.0786 0.0786
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Echinococcus granulosus peptide allatostatin:somatostatin 0.0072 0.0786 0.0786
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0022 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Echinococcus granulosus neuropeptides capa receptor 0.0072 0.0786 0.0786
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0022 0.0072 0.0072
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Loa Loa (eye worm) hypothetical protein 0.008 0.0905 0.0935
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.008 0.0905 0.0905
Leishmania major hypothetical protein, conserved 0.0219 0.2903 0.3343
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0072 0.0058
Echinococcus multilocularis SWI:SNF matrix associated 0.0617 0.8612 0.8612
Brugia malayi putative neuropeptide receptor NPR1 0.0072 0.0786 0.0786
Schistosoma mansoni opsin-like receptor 0.0072 0.0786 0.091
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0063 0.0651 0.0651
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0061 0.0045
Trypanosoma cruzi histone deacetylase, putative 0.0141 0.1775 0.2034
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0022 0.0061 0.0045
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0061 0.0045
Schistosoma mansoni myosin xvIII 0.0072 0.0786 0.091
Loa Loa (eye worm) hypothetical protein 0.0633 0.8846 0.914
Echinococcus multilocularis g protein coupled receptor 0.0072 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0089 0.103 0.1064
Onchocerca volvulus 0.0072 0.0786 0.0913
Echinococcus granulosus orexin receptor type 2 0.0072 0.0786 0.0786
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0022 0.0026
Brugia malayi G protein-coupled receptor F59B2.13 0.0072 0.0786 0.0786
Brugia malayi Dopamine receptor protein 1 0.0072 0.0786 0.0786
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0219 0.2903 0.3371
Loa Loa (eye worm) histone deacetylase 3 0.0042 0.036 0.0372
Schistosoma mansoni opsin-like receptor 0.0072 0.0786 0.091
Brugia malayi Dopamine receptor 0.0072 0.0786 0.0786
Toxoplasma gondii GAF domain-containing protein 0.0058 0.0584 0.0676
Schistosoma mansoni ap endonuclease 0.0019 0.0022 0.0026
Schistosoma mansoni histone deacetylase 0.0042 0.036 0.0416
Echinococcus granulosus tm gpcr rhodopsin 0.0072 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0219 0.2903 0.2999
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0022 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0042 0.036 0.0372
Echinococcus granulosus biogenic amine 5HT receptor 0.0072 0.0786 0.0786
Chlamydia trachomatis SWIB complex protein 0.0617 0.8612 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0072 0.0084
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Onchocerca volvulus 0.0072 0.0786 0.0913
Schistosoma mansoni opsin-like receptor 0.0072 0.0786 0.091
Brugia malayi Protein kinase domain containing protein 0.0063 0.0651 0.0651
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0786 0.091
Loa Loa (eye worm) brahma associated protein 0.0617 0.8612 0.8897
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0072 0.0058
Leishmania major histone deacetylase, putative 0.0141 0.1775 0.2034
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0072 0.0058
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0022 0.0061 0.0071
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0072 0.0786 0.0786
Onchocerca volvulus 0.0072 0.0786 0.0913
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0022 0.0061 0.0071
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Brugia malayi hypothetical protein 0.0072 0.0786 0.0786
Schistosoma mansoni zinc finger protein 0.0219 0.2903 0.336
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0219 0.2903 0.3343
Brugia malayi hypothetical protein 0.0072 0.0786 0.0786
Brugia malayi larval opioid receptor 0.0072 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Onchocerca volvulus 0.0072 0.0786 0.0913
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0022 0.0061 0.1154
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0219 0.2903 0.3343
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0072 0.0786 0.091
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.0022 0.0061 0.0071
Mycobacterium ulcerans putative regulatory protein 0.0058 0.0584 1
Brugia malayi G-protein coupled receptor 0.0072 0.0786 0.0786
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0072 0.0058
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0713 1 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0084
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0022 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0219 0.2903 0.2999
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0022 0.0072 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0072 0.0058
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.008 0.0905 0.1024
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Brugia malayi G-protein coupled receptor 0.0072 0.0786 0.0786
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0072 0.0786 0.091
Trypanosoma cruzi histone deacetylase, putative 0.0042 0.036 0.0391
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Brugia malayi YY1-associated factor 2 0.0219 0.2903 0.2903
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0022 0.0072 0.0058
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0058
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0061 0.0063
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0022 0.0072 0.0072
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0058
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Echinococcus granulosus histone deacetylase 6 0.0141 0.1775 0.1775
Echinococcus multilocularis neuropeptide receptor 0.0599 0.8365 0.8365
Echinococcus granulosus neuropeptide receptor A26 0.0072 0.0786 0.0786
Schistosoma mansoni brca1-associated protein (brap2) 0.0022 0.0061 0.0071
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0786 0.091
Plasmodium falciparum GAF domain-related protein, putative 0.0058 0.0584 0.0678
Brugia malayi AKH receptor 0.0072 0.0786 0.0786
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0786 0.091
Brugia malayi BRCA1-associated protein 2 containing protein 0.0022 0.0061 0.0061
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0219 0.2903 0.2903
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0022 0.0061 0.0071
Echinococcus multilocularis g-protein coupled receptor 0.0072 0.0786 0.0786
Brugia malayi brahma associated protein 60 kDa 0.0617 0.8612 0.8612
Echinococcus multilocularis neuropeptide Y receptor 0.0072 0.0786 0.0786
Echinococcus granulosus sodium and chloride dependent glycine 0.0089 0.103 0.103
Brugia malayi Histone deacetylase family protein 0.0141 0.1775 0.1775
Onchocerca volvulus 0.0072 0.0786 0.0913
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0022 0.0061 0.0071
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0063 0.0651 0.0672
Echinococcus granulosus somatostatin receptor 0.0072 0.0786 0.0786
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0786 0.091
Onchocerca volvulus 0.0072 0.0786 0.0913
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0022 0.0072 0.0058
Trypanosoma brucei hypothetical protein, conserved 0.0219 0.2903 0.3343
Trichomonas vaginalis histone deacetylase, putative 0.0042 0.036 0.0391
Mycobacterium ulcerans putative regulatory protein 0.0058 0.0584 1
Leishmania major hypothetical protein, conserved 0.0219 0.2903 0.3343
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Plasmodium vivax histone deacetylase 2, putative 0.0141 0.1775 0.2061
Onchocerca volvulus 0.0072 0.0786 0.0913
Onchocerca volvulus 0.0072 0.0786 0.0913
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Trichomonas vaginalis brca1-associated protein, putative 0.0022 0.0061 0.0045
Loa Loa (eye worm) hypothetical protein 0.0099 0.1167 0.1205
Loa Loa (eye worm) neuropeptide F receptor 0.0072 0.0786 0.0813
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0022 0.0061 0.0045
Plasmodium falciparum histone deacetylase 1 0.0042 0.036 0.0418
Toxoplasma gondii exonuclease III APE 0.0019 0.0022 0.0026
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Schistosoma mansoni hypothetical protein 0.0219 0.2903 0.336
Plasmodium falciparum phosphodiesterase gamma, putative 0.0022 0.0072 0.0084
Echinococcus multilocularis histone deacetylase 0.0141 0.1775 0.1775
Trichomonas vaginalis histone deacetylase, putative 0.0042 0.036 0.0391
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0022 0.0061 0.1154
Echinococcus multilocularis BRCA1 associated protein 0.0022 0.0061 0.0061
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0072 0.0084
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0022 0.0026
Schistosoma mansoni amine GPCR 0.0072 0.0786 0.091
Brugia malayi Serotonin receptor 0.0072 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Giardia lamblia hypothetical protein 0.0022 0.0072 0.0058
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0072 0.0786 0.091
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0022 0.0061 0.0063
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0075
Schistosoma mansoni neuropeptide receptor 0.0072 0.0786 0.091
Chlamydia trachomatis DNA topoisomerase I 0.0617 0.8612 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0619 0.8639 1
Echinococcus multilocularis orexin receptor type 2 0.0072 0.0786 0.0786
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0584 0.0652
Trypanosoma cruzi hypothetical protein, conserved 0.0219 0.2903 0.3343
Echinococcus multilocularis serotonin receptor 0.0072 0.0786 0.0786
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0061 0.0063
Echinococcus granulosus neuropeptide FF receptor 2 0.0072 0.0786 0.0786
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.008 0.0905 0.1048
Echinococcus granulosus Zinc finger RanBP2 type 0.0219 0.2903 0.2903
Giardia lamblia Histone deacetylase 0.0042 0.036 0.0391
Brugia malayi sulfakinin receptor protein 0.0072 0.0786 0.0786
Schistosoma mansoni histone deacetylase hda2 0.0162 0.2085 0.2414
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0061 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0905 0.1024
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0022 0.0061 0.0071
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis histone deacetylase 8 0.0042 0.036 0.036
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0072 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Plasmodium vivax histone deacetylase, putative 0.0141 0.1775 0.2061
Echinococcus granulosus mitogen activated protein kinase 0.0619 0.8639 0.8639
Schistosoma mansoni biogenic amine receptor 0.0072 0.0786 0.091
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.008 0.0905 0.1024
Leishmania major histone deacetylase, putative 0.0141 0.1775 0.2034
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0072 0.0786 0.0786
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0072 0.0058
Echinococcus granulosus histone deacetylase 6 0.0162 0.2085 0.2085
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0022 0.0072 0.0058
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Schistosoma mansoni biogenic amine (5HT) receptor 0.0072 0.0786 0.091
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.008 0.0905 0.0905
Echinococcus multilocularis fmrfamide receptor 0.0072 0.0786 0.0786
Brugia malayi histone deacetylase 1 (HD1) 0.0042 0.036 0.036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0786 0.091
Echinococcus granulosus ring and YY1 binding protein 0.0219 0.2903 0.2903
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0786 0.091
Echinococcus granulosus serotonin receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis sodium and chloride dependent glycine 0.0089 0.103 0.103
Trypanosoma brucei cAMP-specific phosphodiesterase 0.008 0.0905 0.1024
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0072 0.0786 0.0786
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0072 0.0786 0.0913
Echinococcus granulosus biogenic amine 5HT receptor 0.0072 0.0786 0.0786
Trichomonas vaginalis CMGC family protein kinase 0.0619 0.8639 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.0022 0.0072 0.0058
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0022 0.0061 0.0071
Loa Loa (eye worm) G-protein coupled receptor 0.0072 0.0786 0.0813
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0072 0.0786 0.0813
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0617 0.8612 0.8612
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Schistosoma mansoni hypothetical protein 0.0072 0.0786 0.091
Echinococcus granulosus histone deacetylase 8 0.0042 0.036 0.036
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Schistosoma mansoni neuropeptide receptor 0.0599 0.8365 0.9683
Onchocerca volvulus Neuropeptide F receptor homolog 0.0072 0.0786 0.0913
Echinococcus multilocularis SWI:SNF matrix associated 0.0617 0.8612 0.8612
Echinococcus multilocularis histone deacetylase 6 0.0141 0.1775 0.1775
Loa Loa (eye worm) hypothetical protein 0.012 0.1477 0.1526
Loa Loa (eye worm) histone deacetylase 1 0.0042 0.036 0.0372
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0786 0.091
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0072 0.0786 0.091
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0072 0.0786 0.091
Echinococcus multilocularis serotonin receptor 0.0072 0.0786 0.0786
Echinococcus granulosus zinc finger protein Ran binding 0.0219 0.2903 0.2903
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0072 0.0786 0.091
Echinococcus multilocularis histone deacetylase 6 0.0141 0.1775 0.1775
Schistosoma mansoni sodium/chloride dependent transporter 0.0095 0.1112 0.1288
Schistosoma mansoni amine GPCR 0.0072 0.0786 0.091
Trypanosoma brucei histone deacetylase 3 0.0141 0.1775 0.2034
Echinococcus multilocularis G-protein coupled receptor, putative 0.0072 0.0786 0.0786
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0072 0.0786 0.0786
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0072 0.0786 0.0786
Brugia malayi neuropeptide F receptor 0.0072 0.0786 0.0786
Schistosoma mansoni brca1-associated protein (brap2) 0.0022 0.0061 0.0071
Echinococcus granulosus allatostatin A receptor 0.0072 0.0786 0.0786
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Toxoplasma gondii histone deacetylase HDAC3 0.0042 0.036 0.0416
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0061 0.0045
Echinococcus granulosus g-protein coupled receptor 0.0072 0.0786 0.0786
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0072 0.0786 0.0813
Brugia malayi GnHR receptor homolog 0.0072 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0042 0.036 0.0372
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Schistosoma mansoni histone deacetylase 4 5 0.0141 0.1775 0.2055
Schistosoma mansoni brg-1 associated factor 0.0617 0.8612 0.9968
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0072 0.0084
Brugia malayi Dopamine receptor protein 2 0.0072 0.0786 0.0786
Schistosoma mansoni hypothetical protein 0.0617 0.8612 0.9968
Schistosoma mansoni neuropeptide receptor 0.0072 0.0786 0.091
Brugia malayi histone deacetylase 3 (HD3) 0.0042 0.036 0.036
Schistosoma mansoni neuropeptide f receptor 76f 0.0072 0.0786 0.091
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0022 0.0061 0.0061
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0022 0.0072 0.0072
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0022 0.0072 0.0058
Echinococcus granulosus g protein coupled receptor 0.0072 0.0786 0.0786
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.008 0.0905 0.1024
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0061 0.0045
Echinococcus granulosus neuropeptide Y receptor 0.0072 0.0786 0.0786
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0219 0.2903 0.2903
Onchocerca volvulus 0.0219 0.2903 0.3371
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0072 0.0786 0.0786
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0786 0.091
Echinococcus granulosus neuropeptides capa receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis histone deacetylase 6 0.0162 0.2085 0.2085
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0219 0.2903 0.3343
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0022 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0089 0.103 0.1192
Schistosoma mansoni alpha-1 adrenergic receptor 0.0072 0.0786 0.091
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0022 0.0061 0.1154
Schistosoma mansoni amine GPCR 0.0072 0.0786 0.091
Onchocerca volvulus 0.0072 0.0786 0.0913
Loa Loa (eye worm) histone deacetylase 11 0.0042 0.036 0.0372
Schistosoma mansoni histone deacetylase 0.0042 0.036 0.0416
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0022 0.0061 0.0045
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0063 0.0656 0.0656
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Onchocerca volvulus 0.0072 0.0786 0.0913
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Toxoplasma gondii histone deacetylase HDAC4 0.0042 0.036 0.0416
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0022 0.0072 0.0058
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0022 0.0072 0.0084
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0058 0.0584 1
Leishmania major hypothetical protein, conserved 0.0219 0.2903 0.3343
Trypanosoma cruzi histone deacetylase, putative 0.0141 0.1775 0.2034
Schistosoma mansoni neuropeptide receptor 0.0072 0.0786 0.091
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0617 0.8612 0.9968
Echinococcus granulosus G protein coupled receptor 139 0.0072 0.0786 0.0786
Echinococcus multilocularis sex peptide receptor 0.0072 0.0786 0.0786
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Schistosoma mansoni amine GPCR 0.0072 0.0786 0.091
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Onchocerca volvulus 0.0072 0.0786 0.0913
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0219 0.2903 0.2903
Onchocerca volvulus 0.0072 0.0786 0.0913
Toxoplasma gondii hypothetical protein 0.0058 0.0584 0.0676
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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