Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sigma non-opioid intracellular receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | C-8 sterol isomerase-like protein | 0.064 | 0.7843 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0285 | 0.3113 | 0.3113 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0285 | 0.3113 | 0.3113 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0285 | 0.3113 | 0.3113 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0104 | 0.07 | 0.07 |
Schistosoma mansoni | RNA binding protein | 0.0285 | 0.3113 | 0.3113 |
Schistosoma mansoni | hypothetical protein | 0.0285 | 0.3113 | 0.3113 |
Schistosoma mansoni | zinc finger protein | 0.0285 | 0.3113 | 0.3113 |
Chlamydia trachomatis | SWIB complex protein | 0.0802 | 1 | 0.5 |
Schistosoma mansoni | brg-1 associated factor | 0.0802 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0104 | 0.07 | 0.07 |
Plasmodium vivax | hypothetical protein, conserved | 0.0802 | 1 | 0.5 |
Onchocerca volvulus | 0.0285 | 0.3113 | 0.3113 | |
Onchocerca volvulus | 0.0285 | 0.3113 | 0.3113 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0104 | 0.07 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.064 | 0.7843 | 0.7843 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.064 | 0.7843 | 1 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0285 | 0.3113 | 0.3113 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.3113 | 0.3113 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0285 | 0.3113 | 0.3113 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0802 | 1 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0802 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0802 | 1 | 1 |
Onchocerca volvulus | 0.0285 | 0.3113 | 0.3113 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0104 | 0.07 | 0.07 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0285 | 0.3113 | 0.3113 |
Schistosoma mansoni | hypothetical protein | 0.0802 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0379 | 0.4365 | 0.4365 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0802 | 1 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0802 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0379 | 0.4365 | 0.4365 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0802 | 1 | 0.5 |
Schistosoma mansoni | fusion | 0.0285 | 0.3113 | 0.3113 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0802 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0285 | 0.3113 | 0.3113 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0802 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.3113 | 0.3113 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0285 | 0.3113 | 0.3113 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0104 | 0.07 | 0.07 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0104 | 0.07 | 0.07 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0285 | 0.3113 | 0.3113 |
Echinococcus multilocularis | geminin | 0.0379 | 0.4365 | 0.4365 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.3113 | 0.3113 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0285 | 0.3113 | 0.3113 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.064 | 0.7843 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0802 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0104 | 0.07 | 0.07 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0104 | 0.07 | 0.07 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0802 | 1 | 1 |
Onchocerca volvulus | 0.0802 | 1 | 1 | |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0285 | 0.3113 | 0.3113 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.3113 | 0.3113 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0802 | 1 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0802 | 1 | 1 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0802 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0802 | 1 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.0285 | 0.3113 | 0.3113 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.064 | 0.7843 | 0.7843 |
Schistosoma mansoni | hypothetical protein | 0.0379 | 0.4365 | 0.4365 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0802 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0104 | 0.07 | 0.07 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0285 | 0.3113 | 0.3113 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.3113 | 0.3113 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0802 | 1 | 1 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0285 | 0.3113 | 0.3113 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.3671 | 0.3671 |
Onchocerca volvulus | 0.0285 | 0.3113 | 0.3113 | |
Loa Loa (eye worm) | brahma associated protein | 0.0802 | 1 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0802 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0802 | 1 | 1 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0285 | 0.3113 | 0.3113 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Analgesic activity against formalin-induced neuropathic pain in paclitaxel treated CD1 mouse assessed as decrease of time spent in paw licking at 100 mg/kg, po administered 14 days post paclitaxel dosing and 1 hr prior formalin challenge measured for 0 to 5 mins post formalin challenge | ChEMBL. | 22512908 | |
Activity (ADMET) | Toxicity in CD1 mouse assessed as weight loss at 40 mg/kg, ip after 3 to 4 weeks chronic treatment | ChEMBL. | 22512908 | |
Activity (functional) | Analgesic activity against formalin-induced neuropathic pain in paclitaxel treated CD1 mouse assessed as decrease of time spent in paw licking at 100 mg/kg, po administered 14 days post paclitaxel dosing and 1 hr prior formalin challenge measured for 35 to 40 mins post formalin challenge | ChEMBL. | 22512908 | |
Activity (ADMET) | Toxicity in SCID mouse assessed as weight loss at 40 mg/kg, ip after 3 to 4 weeks chronic treatment | ChEMBL. | 22512908 | |
Activity (ADMET) | Toxicity in SCID mouse assessed as mortality at 40 mg/kg, ip after 3 to 4 weeks chronic treatment | ChEMBL. | 22512908 | |
Activity (ADMET) | Toxicity in CD1 mouse assessed as mortality at 40 mg/kg, ip after 3 to 4 weeks chronic treatment | ChEMBL. | 22512908 | |
GI50 (functional) | = 4.92 uM | Growth inhibition of human HCT116 cells after 48 hrs by SRB assay | ChEMBL. | 22512908 |
IC50 (binding) | = 3.2 nM | Displacement of [3H](+)pentazocine from sigma-1 receptor expressed in human Jurkat cell membranes after 2 hrs by liquid scintillation spectroscopy | ChEMBL. | 22512908 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.