Detailed information for compound 1643398

Basic information

Technical information
  • TDR Targets ID: 1643398
  • Name: 7-chloro-N-[(5-nitrofuran-2-yl)methylideneami no]quinolin-4-amine
  • MW: 316.699 | Formula: C14H9ClN4O3
  • H donors: 1 H acceptors: 3 LogP: 4 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)nccc2N/N=C/c1ccc(o1)[N+](=O)[O-]
  • InChi: 1S/C14H9ClN4O3/c15-9-1-3-11-12(5-6-16-13(11)7-9)18-17-8-10-2-4-14(22-10)19(20)21/h1-8H,(H,16,18)/b17-8+
  • InChiKey: CSWFEWOOMWPWKL-CAOOACKPSA-N  


Substructure search Similarity search

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Synonyms

  • 7-chloro-N-[(5-nitro-2-furyl)methyleneamino]quinolin-4-amine
  • 7-chloro-N-[(5-nitro-2-furyl)methyleneamino]-4-quinolinamine
  • (7-chloro-4-quinolyl)-[(5-nitro-2-furyl)methyleneamino]amine
  • T0508-4964

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens EYA transcriptional coactivator and phosphatase 2 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Trypanosoma brucei gambiense phosphoglycerate kinase, putative No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references
Homo sapiens microphthalmia-associated transcription factor Starlite/ChEMBL No references
Trypanosoma brucei phosphoglycerate kinase Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Babesia bovis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium leprae Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Treponema pallidum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Chlamydia trachomatis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133408 All targets in OG5_133408
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis transcription factor eb Get druggable targets OG5_133408 All targets in OG5_133408
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Helix-loop-helix DNA-binding domain containing protein Get druggable targets OG5_133408 All targets in OG5_133408
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni eyes absent homolog Get druggable targets OG5_129664 All targets in OG5_129664
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Theileria parva phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii phosphoglycerate kinase PGKI Get druggable targets OG5_126776 All targets in OG5_126776
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii phosphoglycerate kinase PGKII Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Mycobacterium ulcerans phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K01104 protein-tyrosine phosphatase [EC3.1.3.48], putative Get druggable targets OG5_129664 All targets in OG5_129664
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus transcription factor eb Get druggable targets OG5_133408 All targets in OG5_133408
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein Get druggable targets OG5_133408 All targets in OG5_133408
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum Phosphoglycerate kinase (EC 2.7.2.3), related Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Entamoeba histolytica phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Leishmania major phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Leishmania major phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Leishmania infantum phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Brugia malayi Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania braziliensis PGKC, phosphoglycerate kinase C Get druggable targets OG5_126776 All targets in OG5_126776
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium falciparum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0695 1 1
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0206 0.2585 0.5
Schistosoma mansoni RNA binding protein 0.0247 0.3217 0.3217
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0247 0.3217 1
Echinococcus granulosus phosphoglycerate kinase 1 0.0206 0.2585 0.2585
Schistosoma mansoni hypothetical protein 0.0695 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0695 1 1
Echinococcus multilocularis muscleblind protein 0.018 0.2205 0.2205
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0695 1 1
Echinococcus granulosus muscleblind protein 0.018 0.2205 0.2205
Loa Loa (eye worm) hypothetical protein 0.0247 0.3217 0.3217
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0247 0.3217 1
Trypanosoma cruzi WLM domain containing protein, putative 0.0247 0.3217 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0084 0.0014
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0615 0.1735
Mycobacterium ulcerans phosphoglycerate kinase 0.0206 0.2585 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0247 0.3217 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.2585 0.7992
Schistosoma mansoni hypothetical protein 0.0205 0.2572 0.2572
Giardia lamblia Phosphoglycerate kinase 0.0206 0.2585 0.5
Treponema pallidum phosphoglycerate kinase 0.0206 0.2585 0.5
Loa Loa (eye worm) hypothetical protein 0.0106 0.1084 0.1084
Schistosoma mansoni eyes absent homolog 0.0106 0.1084 0.1084
Chlamydia trachomatis SWIB complex protein 0.0695 1 1
Loa Loa (eye worm) hypothetical protein 0.0247 0.3217 0.3217
Trypanosoma brucei phosphoglycerate kinase 0.0075 0.0615 0.1912
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0695 1 1
Loa Loa (eye worm) brahma associated protein 0.0695 1 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0247 0.3217 1
Brugia malayi hypothetical protein 0.0106 0.1084 0.1084
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0377 0.0377
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0615 0.1735
Leishmania major hypothetical protein, conserved 0.0247 0.3217 1
Loa Loa (eye worm) hypothetical protein 0.018 0.2205 0.2205
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.013 0.1437 0.1437
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0069 0.0215
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.013 0.1447 0.1447
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0075 0.0615 0.1735
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0247 0.3217 1
Echinococcus granulosus geminin 0.0205 0.2572 0.2572
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0206 0.2585 0.5
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0206 0.2585 0.2585
Loa Loa (eye worm) hypothetical protein 0.018 0.2205 0.2205
Echinococcus granulosus Zinc finger RanBP2 type 0.0247 0.3217 0.3217
Echinococcus multilocularis SWI:SNF matrix associated 0.0695 1 1
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0695 1 1
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0206 0.2585 0.5
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0247 0.3217 0.3217
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0131 0.0131
Brugia malayi brahma associated protein 60 kDa 0.0695 1 1
Toxoplasma gondii ran binding protein 0.0247 0.3217 0.3217
Schistosoma mansoni brg-1 associated factor 0.0695 1 1
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.2585 0.2534
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0069 0.0069
Brugia malayi Muscleblind-like protein 0.018 0.2205 0.2205
Schistosoma mansoni TRABID protein (C64 family) 0.0247 0.3217 0.3217
Echinococcus granulosus tumor protein p63 0.0408 0.5652 0.5652
Echinococcus multilocularis tumor protein p63 0.0408 0.5652 0.5652
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.2585 0.2585
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0247 0.3217 0.3217
Trypanosoma brucei hypothetical protein, conserved 0.0247 0.3217 1
Onchocerca volvulus 0.0247 0.3217 0.2952
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0131 0.0131
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0695 1 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0695 1 1
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0247 0.3217 0.3217
Onchocerca volvulus 0.0247 0.3217 0.2952
Echinococcus multilocularis ring and YY1 binding protein 0.0247 0.3217 0.3217
Leishmania major phosphoglycerate kinase B, cytosolic 0.0206 0.2585 0.7992
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0615 0.1735
Schistosoma mansoni hypothetical protein 0.0247 0.3217 0.3217
Brugia malayi hypothetical protein 0.0043 0.0131 0.0131
Schistosoma mansoni zinc finger protein 0.0247 0.3217 0.3217
Schistosoma mansoni hypothetical protein 0.0205 0.2572 0.2572
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0615 0.1735
Loa Loa (eye worm) hypothetical protein 0.013 0.1437 0.1437
Echinococcus granulosus expressed protein 0.004 0.0084 0.0084
Brugia malayi Phosphoglycerate kinase 0.0206 0.2585 0.2585
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0247 0.3217 0.2952
Entamoeba histolytica hypothetical protein 0.0043 0.0131 0.0244
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0247 0.3217 0.3217
Loa Loa (eye worm) hypothetical protein 0.006 0.0377 0.0377
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.2585 0.2534
Loa Loa (eye worm) hypothetical protein 0.0365 0.5 0.5
Echinococcus granulosus snurportin 1 0.0372 0.5102 0.5102
Brugia malayi SWIB/MDM2 domain containing protein 0.0695 1 1
Entamoeba histolytica hypothetical protein 0.0043 0.0131 0.0244
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0247 0.3217 0.3217
Loa Loa (eye worm) hypothetical protein 0.0247 0.3217 0.3217
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.2585 0.8035
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.2585 0.8035
Echinococcus granulosus ring and YY1 binding protein 0.0247 0.3217 0.3217
Echinococcus granulosus transcription factor eb 0.013 0.1447 0.1447
Schistosoma mansoni hypothetical protein 0.0043 0.0131 0.0131
Entamoeba histolytica hypothetical protein 0.0043 0.0131 0.0244
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0247 0.3217 0.3217
Schistosoma mansoni hypothetical protein 0.0695 1 1
Chlamydia trachomatis DNA topoisomerase I 0.0695 1 1
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0695 1 1
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0084 0.0084
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0084 0.0084
Brugia malayi hypothetical protein 0.0365 0.5 0.5
Brugia malayi Phosphoglycerate kinase 0.0075 0.0615 0.0615
Schistosoma mansoni rotamase 0.004 0.0084 0.0084
Brugia malayi RNA, U transporter 1 0.0099 0.0972 0.0972
Plasmodium falciparum phosphoglycerate kinase 0.0206 0.2585 0.2585
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0206 0.2585 0.2585
Brugia malayi YY1-associated factor 2 0.0247 0.3217 0.3217
Trypanosoma cruzi hypothetical protein, conserved 0.0247 0.3217 1
Leishmania major hypothetical protein, conserved 0.0247 0.3217 1
Echinococcus multilocularis snurportin 1 0.0372 0.5102 0.5102
Onchocerca volvulus 0.0695 1 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0695 1 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0615 0.1735
Echinococcus granulosus zinc finger protein Ran binding 0.0247 0.3217 0.3217
Onchocerca volvulus 0.0247 0.3217 0.2952
Trypanosoma cruzi hypothetical protein, conserved 0.0247 0.3217 1
Entamoeba histolytica phosphoglycerate kinase, putative 0.0206 0.2585 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0247 0.3217 0.3217
Plasmodium vivax hypothetical protein, conserved 0.0695 1 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0247 0.3217 1
Schistosoma mansoni hypothetical protein 0.0372 0.5102 0.5102
Echinococcus multilocularis expressed protein 0.004 0.0084 0.0084
Echinococcus multilocularis phosphoglycerate kinase 1 0.0206 0.2585 0.2585
Echinococcus multilocularis geminin 0.0205 0.2572 0.2572
Trypanosoma cruzi WLM domain containing protein, putative 0.0247 0.3217 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.2585 0.7992
Trypanosoma brucei phosphoglycerate kinase, putative 0.0075 0.0615 0.1912
Echinococcus multilocularis muscleblind protein 1 0.018 0.2205 0.2205
Echinococcus multilocularis zinc finger protein Ran binding 0.0247 0.3217 0.3217
Onchocerca volvulus 0.0365 0.5 0.4804
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0695 1 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0247 0.3217 1
Echinococcus multilocularis transcription factor eb 0.013 0.1447 0.1447
Entamoeba histolytica hypothetical protein 0.0043 0.0131 0.0244
Leishmania major hypothetical protein, conserved 0.0247 0.3217 1
Echinococcus granulosus SWI:SNF matrix associated 0.0695 1 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0695 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0131 0.0131
Trichomonas vaginalis rotamase, putative 0.004 0.0084 0.0014
Loa Loa (eye worm) hypothetical protein 0.0247 0.3217 0.3217
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0247 0.3217 0.3217
Onchocerca volvulus 0.0247 0.3217 0.2952
Schistosoma mansoni fusion 0.0247 0.3217 0.3217
Loa Loa (eye worm) hypothetical protein 0.0247 0.3217 0.3217
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.2585 0.2585
Plasmodium vivax phosphoglycerate kinase, putative 0.0206 0.2585 0.2585
Loa Loa (eye worm) hypothetical protein 0.0106 0.1084 0.1084
Loa Loa (eye worm) hypothetical protein 0.0206 0.2585 0.2585
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.5102 0.5102
Trypanosoma brucei hypothetical protein, conserved 0.0247 0.3217 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0695 1 1
Leishmania major phosphoglycerate kinase C, glycosomal 0.0206 0.2585 0.7992
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0247 0.3217 1
Leishmania major hypothetical protein, conserved 0.0247 0.3217 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0247 0.3217 0.3217
Leishmania major hypothetical protein, conserved 0.0247 0.3217 1

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 15.296 uM PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
AC50 (functional) = 15.296 uM PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
AC50 (functional) = 15.296 uM PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
GI (functional) = 24.1 % Cytotoxicity against Homo sapiens (human) HCT8 cells assessed as growth inhibition at 25 ug/ml after 72 hr by MTT assay ChEMBL. No reference
Potency (functional) 2.0546 uM PUBCHEM_BIOASSAY: qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540272] ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6626 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.2604 uM PUBCHEM_BIOASSAY: qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation in HepG2 cytotox. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540272] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (binding) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 116.2157 uM PUBCHEM_BIOASSAY: Inhibitors of Eya2ED: Hit Confirmation in Primary Screen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488837, AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Giardia lamblia
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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