Detailed information for compound 1643454

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 5832.86 | Formula: C188H237N75O108P18
  • H donors: 44 H acceptors: 78 LogP: -36.23 Rotable bonds: 111
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@@H](OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(CC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1O)n1cc(C)c(=O)[nH]c1=O)O)n1ccc(nc1=O)N)O)n1cc(C)c(=O)[nH]c1=O)O)n1ccc(nc1=O)N)O)n1cc(C)c(=O)[nH]c1=O)O)n1cnc2c1ncnc2N)O)n1cc(C)c(=O)[nH]c1=O)O)n1cnc2c1nc(N)[nH]c2=O)O)Cn1cnc2c1nc1nc(N)nc(c1c2)N)O)n1ccc(nc1=O)N)O)n1cnc2c1ncnc2N)O)n1cnc2c1ncnc2N)O)n1ccc(nc1=O)N)O)n1cc(C)c(nc1=O)N)O)n1cnc2c1nc(N)[nH]c2=O)O)n1cnc2c1nc(N)[nH]c2=O)O)n1cnc2c1ncnc2N)O)n1cnc2c1ncnc2N)O)n1cnc2c1nc(N)[nH]c2=O
  • InChi: 1S/C188H237N75O108P18/c1-74-35-250(184(278)230-149(74)193)128-25-91(108(343-128)49-329-385(309,310)370-99-33-138(262-72-223-147-165(262)235-178(203)239-173(147)272)353-117(99)58-335-389(317,318)371-100-34-139(263-73-224-148-166(263)236-179(204)240-174(148)273)352-116(100)57-334-388(315,316)369-98-32-135(259-69-220-144-155(199)209-63-214-162(144)259)351-115(98)56-332-386(311,312)367-95-29-132(256-66-217-141-152(196)206-60-211-159(141)256)348-112(95)53-323-377(293,294)357-85-19-136(337-101(85)41-264)260-70-221-145-163(260)233-176(201)237-171(145)270)362-380(299,300)325-47-107-90(24-126(342-107)249-14-9-121(192)228-183(249)277)361-379(297,298)331-54-113-97(31-134(349-113)258-68-219-143-154(198)208-62-213-161(143)258)368-387(313,314)333-55-114-96(30-133(350-114)257-67-218-142-153(197)207-61-212-160(142)257)365-383(305,306)327-45-104-87(21-123(339-104)246-11-6-118(189)225-180(246)274)358-374(287,288)319-42-79(40-245-64-215-81-16-80-150(194)229-175(200)232-156(80)231-157(81)245)354-373(285,286)321-44-103-86(20-137(346-103)261-71-222-146-164(261)234-177(202)238-172(146)271)355-372(283,284)15-10-83-84(18-127(336-83)252-37-76(3)168(267)242-186(252)280)356-376(291,292)322-52-111-94(28-131(347-111)255-65-216-140-151(195)205-59-210-158(140)255)366-384(307,308)330-51-110-93(27-130(345-110)254-39-78(5)170(269)244-188(254)282)364-382(303,304)326-48-106-89(23-125(341-106)248-13-8-120(191)227-182(248)276)360-378(295,296)328-50-109-92(26-129(344-109)253-38-77(4)169(268)243-187(253)281)363-381(301,302)324-46-105-88(22-124(340-105)247-12-7-119(190)226-181(247)275)359-375(289,290)320-43-102-82(265)17-122(338-102)251-36-75(2)167(266)241-185(251)279/h6-9,11-14,16,35-39,59-73,79,82-117,122-139,264-265H,10,15,17-34,40-58H2,1-5H3,(H,283,284)(H,285,286)(H,287,288)(H,289,290)(H,291,292)(H,293,294)(H,295,296)(H,297,298)(H,299,300)(H,301,302)(H,303,304)(H,305,306)(H,307,308)(H,309,310)(H,311,312)(H,313,314)(H,315,316)(H,317,318)(H2,189,225,274)(H2,190,226,275)(H2,191,227,276)(H2,192,228,277)(H2,193,230,278)(H2,195,205,210)(H2,196,206,211)(H2,197,207,212)(H2,198,208,213)(H2,199,209,214)(H,241,266,279)(H,242,267,280)(H,243,268,281)(H,244,269,282)(H3,201,233,237,270)(H3,202,234,238,271)(H3,203,235,239,272)(H3,204,236,240,273)(H4,194,200,229,231,232)/t79-,82-,83+,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101+,102+,103+,104+,105+,106+,107+,108+,109+,110+,111+,112+,113+,114+,115+,116+,117+,122+,123+,124+,125+,126+,127+,128+,129+,130+,131+,132+,133+,134+,135+,136+,137+,138+,139+/m0/s1
  • InChiKey: DDUOYLJTXLZYSV-DRKBCLBVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Onchocerca volvulus 0.0072 0.0786 0.0913
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0786 0.091
Echinococcus granulosus somatostatin receptor 0.0072 0.0786 0.0786
Mycobacterium ulcerans putative regulatory protein 0.0058 0.0584 1
Leishmania major hypothetical protein, conserved 0.0219 0.2903 0.3343
Trichomonas vaginalis histone deacetylase, putative 0.0042 0.036 0.0391
Trypanosoma brucei hypothetical protein, conserved 0.0219 0.2903 0.3343
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0022 0.0072 0.0058
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0063 0.0651 0.0672
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0022 0.0061 0.0071
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0219 0.2903 0.2903
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0786 0.091
Brugia malayi BRCA1-associated protein 2 containing protein 0.0022 0.0061 0.0061
Onchocerca volvulus 0.0072 0.0786 0.0913
Brugia malayi Histone deacetylase family protein 0.0141 0.1775 0.1775
Echinococcus granulosus sodium and chloride dependent glycine 0.0089 0.103 0.103
Echinococcus multilocularis neuropeptide Y receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis g-protein coupled receptor 0.0072 0.0786 0.0786
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0022 0.0061 0.0071
Brugia malayi brahma associated protein 60 kDa 0.0617 0.8612 0.8612
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0022 0.0026
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0072 0.0084
Brugia malayi Serotonin receptor 0.0072 0.0786 0.0786
Schistosoma mansoni amine GPCR 0.0072 0.0786 0.091
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Toxoplasma gondii exonuclease III APE 0.0019 0.0022 0.0026
Echinococcus multilocularis BRCA1 associated protein 0.0022 0.0061 0.0061
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0022 0.0061 0.1154
Echinococcus multilocularis histone deacetylase 0.0141 0.1775 0.1775
Trichomonas vaginalis histone deacetylase, putative 0.0042 0.036 0.0391
Plasmodium falciparum phosphodiesterase gamma, putative 0.0022 0.0072 0.0084
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Schistosoma mansoni hypothetical protein 0.0219 0.2903 0.336
Trichomonas vaginalis brca1-associated protein, putative 0.0022 0.0061 0.0045
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0022 0.0061 0.0045
Plasmodium falciparum histone deacetylase 1 0.0042 0.036 0.0418
Loa Loa (eye worm) hypothetical protein 0.0099 0.1167 0.1205
Loa Loa (eye worm) neuropeptide F receptor 0.0072 0.0786 0.0813
Onchocerca volvulus 0.0072 0.0786 0.0913
Onchocerca volvulus 0.0072 0.0786 0.0913
Plasmodium vivax histone deacetylase 2, putative 0.0141 0.1775 0.2061
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Trypanosoma cruzi histone deacetylase, putative 0.0042 0.036 0.0391
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0072 0.0786 0.091
Brugia malayi G-protein coupled receptor 0.0072 0.0786 0.0786
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0022 0.0072 0.0058
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.008 0.0905 0.1024
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0072 0.0058
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0072 0.0786 0.091
Loa Loa (eye worm) hypothetical protein 0.0219 0.2903 0.2999
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0713 1 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0084
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0022 0.0072 0.0072
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0072 0.0058
Brugia malayi G-protein coupled receptor 0.0072 0.0786 0.0786
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.0022 0.0061 0.0071
Mycobacterium ulcerans putative regulatory protein 0.0058 0.0584 1
Onchocerca volvulus 0.0072 0.0786 0.0913
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Brugia malayi larval opioid receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0219 0.2903 0.3343
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0022 0.0061 0.1154
Brugia malayi AKH receptor 0.0072 0.0786 0.0786
Plasmodium falciparum GAF domain-related protein, putative 0.0058 0.0584 0.0678
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0786 0.091
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0058
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Schistosoma mansoni brca1-associated protein (brap2) 0.0022 0.0061 0.0071
Echinococcus granulosus neuropeptide receptor A26 0.0072 0.0786 0.0786
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Echinococcus multilocularis neuropeptide receptor 0.0599 0.8365 0.8365
Echinococcus granulosus histone deacetylase 6 0.0141 0.1775 0.1775
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0058
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0022 0.0072 0.0058
Brugia malayi YY1-associated factor 2 0.0219 0.2903 0.2903
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0022 0.0072 0.0072
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0061 0.0063
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0072 0.0084
Chlamydia trachomatis SWIB complex protein 0.0617 0.8612 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Loa Loa (eye worm) hypothetical protein 0.0042 0.036 0.0372
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0022 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Echinococcus granulosus biogenic amine 5HT receptor 0.0072 0.0786 0.0786
Schistosoma mansoni histone deacetylase 0.0042 0.036 0.0416
Loa Loa (eye worm) hypothetical protein 0.0219 0.2903 0.2999
Echinococcus granulosus tm gpcr rhodopsin 0.0072 0.0786 0.0786
Brugia malayi Dopamine receptor 0.0072 0.0786 0.0786
Schistosoma mansoni ap endonuclease 0.0019 0.0022 0.0026
Toxoplasma gondii GAF domain-containing protein 0.0058 0.0584 0.0676
Brugia malayi hypothetical protein 0.0072 0.0786 0.0786
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0219 0.2903 0.3343
Brugia malayi hypothetical protein 0.0072 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0022 0.0061 0.0071
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0072 0.0786 0.0786
Onchocerca volvulus 0.0072 0.0786 0.0913
Schistosoma mansoni zinc finger protein 0.0219 0.2903 0.336
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0072 0.0058
Loa Loa (eye worm) brahma associated protein 0.0617 0.8612 0.8897
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0022 0.0061 0.0071
Leishmania major histone deacetylase, putative 0.0141 0.1775 0.2034
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0072 0.0058
Schistosoma mansoni opsin-like receptor 0.0072 0.0786 0.091
Brugia malayi Protein kinase domain containing protein 0.0063 0.0651 0.0651
Onchocerca volvulus 0.0072 0.0786 0.0913
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0786 0.091
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Leishmania major hypothetical protein, conserved 0.0219 0.2903 0.3343
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.008 0.0905 0.0905
Loa Loa (eye worm) hypothetical protein 0.008 0.0905 0.0935
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0072 0.0058
Echinococcus granulosus neuropeptides capa receptor 0.0072 0.0786 0.0786
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0022 0.0072 0.0072
Echinococcus granulosus peptide allatostatin:somatostatin 0.0072 0.0786 0.0786
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0022 0.0072 0.0072
Echinococcus multilocularis neuropeptide FF receptor 2 0.0072 0.0786 0.0786
Giardia lamblia Kinase, CMGC MAPK 0.0619 0.8639 1
Loa Loa (eye worm) PDE1B protein 0.0022 0.0072 0.0075
Schistosoma mansoni histone deacetylase 1 2 3 0.0042 0.036 0.0416
Onchocerca volvulus 0.0072 0.0786 0.0913
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0072 0.0786 0.0786
Echinococcus multilocularis somatostatin receptor 0.0072 0.0786 0.0786
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0219 0.2903 0.3371
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0072 0.0786 0.091
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Onchocerca volvulus 0.0072 0.0786 0.0913
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0058
Loa Loa (eye worm) histone deacetylase 3 0.0042 0.036 0.0372
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0219 0.2903 0.3371
Schistosoma mansoni opsin-like receptor 0.0072 0.0786 0.091
Brugia malayi G protein-coupled receptor F59B2.13 0.0072 0.0786 0.0786
Brugia malayi Dopamine receptor protein 1 0.0072 0.0786 0.0786
Onchocerca volvulus 0.0072 0.0786 0.0913
Echinococcus multilocularis g protein coupled receptor 0.0072 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0633 0.8846 0.914
Loa Loa (eye worm) hypothetical protein 0.0089 0.103 0.1064
Schistosoma mansoni myosin xvIII 0.0072 0.0786 0.091
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0061 0.0045
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0022 0.0026
Echinococcus granulosus orexin receptor type 2 0.0072 0.0786 0.0786
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0063 0.0651 0.0651
Schistosoma mansoni opsin-like receptor 0.0072 0.0786 0.091
Brugia malayi putative neuropeptide receptor NPR1 0.0072 0.0786 0.0786
Echinococcus multilocularis SWI:SNF matrix associated 0.0617 0.8612 0.8612
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0022 0.0061 0.0045
Trypanosoma cruzi histone deacetylase, putative 0.0141 0.1775 0.2034
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0061 0.0045
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0022 0.0072 0.0058
Toxoplasma gondii histone deacetylase HDAC4 0.0042 0.036 0.0416
Trypanosoma cruzi histone deacetylase, putative 0.0141 0.1775 0.2034
Leishmania major hypothetical protein, conserved 0.0219 0.2903 0.3343
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0058 0.0584 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0022 0.0072 0.0084
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0063 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Onchocerca volvulus 0.0072 0.0786 0.0913
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0022 0.0061 0.0045
Loa Loa (eye worm) histone deacetylase 11 0.0042 0.036 0.0372
Onchocerca volvulus 0.0072 0.0786 0.0913
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0022 0.0061 0.1154
Schistosoma mansoni amine GPCR 0.0072 0.0786 0.091
Schistosoma mansoni histone deacetylase 0.0042 0.036 0.0416
Onchocerca volvulus 0.0072 0.0786 0.0913
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Onchocerca volvulus 0.0072 0.0786 0.0913
Toxoplasma gondii hypothetical protein 0.0058 0.0584 0.0676
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0219 0.2903 0.2903
Echinococcus multilocularis sex peptide receptor 0.0072 0.0786 0.0786
Schistosoma mansoni amine GPCR 0.0072 0.0786 0.091
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Echinococcus granulosus G protein coupled receptor 139 0.0072 0.0786 0.0786
Schistosoma mansoni neuropeptide receptor 0.0072 0.0786 0.091
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0617 0.8612 0.9968
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0072 0.0084
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Schistosoma mansoni brg-1 associated factor 0.0617 0.8612 0.9968
Brugia malayi histone deacetylase 3 (HD3) 0.0042 0.036 0.036
Schistosoma mansoni neuropeptide receptor 0.0072 0.0786 0.091
Brugia malayi Dopamine receptor protein 2 0.0072 0.0786 0.0786
Schistosoma mansoni hypothetical protein 0.0617 0.8612 0.9968
Brugia malayi GnHR receptor homolog 0.0072 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0042 0.036 0.0372
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0072 0.0786 0.0813
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Schistosoma mansoni histone deacetylase 4 5 0.0141 0.1775 0.2055
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0061 0.0045
Toxoplasma gondii histone deacetylase HDAC3 0.0042 0.036 0.0416
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Echinococcus granulosus g-protein coupled receptor 0.0072 0.0786 0.0786
Brugia malayi neuropeptide F receptor 0.0072 0.0786 0.0786
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0072 0.0786 0.0786
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0072 0.0786 0.0786
Echinococcus multilocularis G-protein coupled receptor, putative 0.0072 0.0786 0.0786
Trypanosoma brucei histone deacetylase 3 0.0141 0.1775 0.2034
Schistosoma mansoni brca1-associated protein (brap2) 0.0022 0.0061 0.0071
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Echinococcus granulosus allatostatin A receptor 0.0072 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Echinococcus multilocularis histone deacetylase 6 0.0162 0.2085 0.2085
Schistosoma mansoni alpha-1 adrenergic receptor 0.0072 0.0786 0.091
Schistosoma mansoni sodium/chloride dependent transporter 0.0089 0.103 0.1192
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0022 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0219 0.2903 0.3343
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0786 0.091
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Onchocerca volvulus 0.0219 0.2903 0.3371
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0072 0.0786 0.0786
Echinococcus granulosus neuropeptides capa receptor 0.0072 0.0786 0.0786
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0061 0.0045
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.008 0.0905 0.1024
Echinococcus granulosus g protein coupled receptor 0.0072 0.0786 0.0786
Echinococcus granulosus neuropeptide Y receptor 0.0072 0.0786 0.0786
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0219 0.2903 0.2903
Schistosoma mansoni neuropeptide f receptor 76f 0.0072 0.0786 0.091
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0022 0.0072 0.0058
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0022 0.0072 0.0072
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0022 0.0061 0.0061
Loa Loa (eye worm) G-protein coupled receptor 0.0072 0.0786 0.0813
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0022 0.0061 0.0071
Leishmania major cAMP-specific phosphodiesterase, putative 0.0022 0.0072 0.0058
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0617 0.8612 0.8612
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0072 0.0786 0.0813
Echinococcus granulosus biogenic amine 5HT receptor 0.0072 0.0786 0.0786
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0072 0.0786 0.0913
Trichomonas vaginalis CMGC family protein kinase 0.0619 0.8639 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0089 0.103 0.103
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0072 0.0786 0.0786
Trypanosoma brucei cAMP-specific phosphodiesterase 0.008 0.0905 0.1024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0786 0.091
Echinococcus granulosus serotonin receptor 0.0072 0.0786 0.0786
Echinococcus granulosus ring and YY1 binding protein 0.0219 0.2903 0.2903
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0786 0.091
Brugia malayi histone deacetylase 1 (HD1) 0.0042 0.036 0.036
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0072 0.0786 0.091
Echinococcus multilocularis serotonin receptor 0.0072 0.0786 0.0786
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0072 0.0786 0.091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0786 0.091
Loa Loa (eye worm) histone deacetylase 1 0.0042 0.036 0.0372
Schistosoma mansoni amine GPCR 0.0072 0.0786 0.091
Echinococcus multilocularis histone deacetylase 6 0.0141 0.1775 0.1775
Schistosoma mansoni sodium/chloride dependent transporter 0.0095 0.1112 0.1288
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0072 0.0786 0.091
Echinococcus granulosus zinc finger protein Ran binding 0.0219 0.2903 0.2903
Loa Loa (eye worm) hypothetical protein 0.012 0.1477 0.1526
Echinococcus multilocularis histone deacetylase 6 0.0141 0.1775 0.1775
Schistosoma mansoni neuropeptide receptor 0.0599 0.8365 0.9683
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Onchocerca volvulus Neuropeptide F receptor homolog 0.0072 0.0786 0.0913
Echinococcus multilocularis SWI:SNF matrix associated 0.0617 0.8612 0.8612
Schistosoma mansoni hypothetical protein 0.0072 0.0786 0.091
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Echinococcus granulosus histone deacetylase 8 0.0042 0.036 0.036
Brugia malayi sulfakinin receptor protein 0.0072 0.0786 0.0786
Giardia lamblia Histone deacetylase 0.0042 0.036 0.0391
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0061 0.0071
Schistosoma mansoni histone deacetylase hda2 0.0162 0.2085 0.2414
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0061 0.0063
Echinococcus multilocularis serotonin receptor 0.0072 0.0786 0.0786
Echinococcus granulosus Zinc finger RanBP2 type 0.0219 0.2903 0.2903
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.008 0.0905 0.1048
Echinococcus granulosus neuropeptide FF receptor 2 0.0072 0.0786 0.0786
Trypanosoma cruzi hypothetical protein, conserved 0.0219 0.2903 0.3343
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0584 0.0652
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0072 0.0786 0.091
Giardia lamblia hypothetical protein 0.0022 0.0072 0.0058
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Echinococcus multilocularis orexin receptor type 2 0.0072 0.0786 0.0786
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0619 0.8639 1
Chlamydia trachomatis DNA topoisomerase I 0.0617 0.8612 1
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0022 0.0061 0.0063
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0075
Schistosoma mansoni neuropeptide receptor 0.0072 0.0786 0.091
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0022 0.0072 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0072 0.0058
Echinococcus granulosus histone deacetylase 6 0.0162 0.2085 0.2085
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0072 0.0786 0.0786
Echinococcus multilocularis fmrfamide receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.008 0.0905 0.0905
Schistosoma mansoni biogenic amine (5HT) receptor 0.0072 0.0786 0.091
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.008 0.0905 0.1024
Echinococcus granulosus mitogen activated protein kinase 0.0619 0.8639 0.8639
Schistosoma mansoni biogenic amine receptor 0.0072 0.0786 0.091
Plasmodium vivax histone deacetylase, putative 0.0141 0.1775 0.2061
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Leishmania major histone deacetylase, putative 0.0141 0.1775 0.2034
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0072 0.0786 0.0786
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0022 0.0061 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0905 0.1024
Echinococcus multilocularis histone deacetylase 8 0.0042 0.036 0.036
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0022 0.0072 0.0072
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0022 0.0072 0.0058
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0022 0.0022
Echinococcus granulosus SWI:SNF matrix associated 0.0617 0.8612 0.8612
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Echinococcus multilocularis G protein coupled receptor 139 0.0599 0.8365 0.8365
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0022 0.0072 0.0084
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0219 0.2903 0.3343
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0022 0.0061 0.0071
Plasmodium vivax histone deacetylase, putative 0.0042 0.036 0.0418
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0022 0.0061 0.0045
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Plasmodium falciparum histone deacetylase, putative 0.0141 0.1775 0.2061
Plasmodium vivax histone deacetylase 1, putative 0.0042 0.036 0.0418
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.008 0.0905 0.1024
Brugia malayi hypothetical protein 0.0072 0.0786 0.0786
Onchocerca volvulus Histone deacetylase 10 homolog 0.0042 0.036 0.0418
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0022 0.5
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0022 0.0061 0.0045
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0042 0.036 0.0391
Loa Loa (eye worm) hypothetical protein 0.0089 0.103 0.1064
Onchocerca volvulus 0.0219 0.2903 0.3371
Echinococcus multilocularis neuropeptide Y receptor 0.0072 0.0786 0.0786
Echinococcus granulosus fmrfamide receptor 0.0072 0.0786 0.0786
Trypanosoma brucei hypothetical protein, conserved 0.0219 0.2903 0.3343
Brugia malayi follicle stimulating hormone receptor 0.0072 0.0786 0.0786
Brugia malayi hypothetical protein 0.0072 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Loa Loa (eye worm) hypothetical protein 0.0219 0.2903 0.2999
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.008 0.0905 0.1024
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.008 0.0905 0.1024
Loa Loa (eye worm) TYRA-2 protein 0.0072 0.0786 0.0813
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Loa Loa (eye worm) histone deacetylase 7A 0.0141 0.1775 0.1834
Schistosoma mansoni serine/threonine protein kinase 0.0619 0.8639 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Echinococcus multilocularis histone deacetylase 7 0.0141 0.1775 0.1775
Schistosoma mansoni hypothetical protein 0.0072 0.0786 0.091
Schistosoma mansoni fusion 0.0219 0.2903 0.336
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0617 0.8612 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0619 0.8639 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0072 0.0058
Schistosoma mansoni biogenic amine receptor 0.0072 0.0786 0.091
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0022 0.0072 0.0058
Brugia malayi Histone deacetylase family protein 0.0141 0.1775 0.1775
Echinococcus multilocularis ring and YY1 binding protein 0.0219 0.2903 0.2903
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0022 0.0061 0.0071
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0072 0.0786 0.0786
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0072 0.0786 0.0786
Echinococcus multilocularis g protein coupled receptor 0.0072 0.0786 0.0786
Plasmodium vivax hypothetical protein, conserved 0.0617 0.8612 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0072 0.0786 0.0786
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0072 0.0786 0.0786
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0022 0.0072 0.0058
Toxoplasma gondii histone deacetylase HDAC2 0.0042 0.036 0.0416
Trichomonas vaginalis BRCA1-associated protein, putative 0.0022 0.0061 0.0045
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0072 0.0786 0.0786
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0058
Mycobacterium leprae conserved hypothetical protein 0.0058 0.0584 0.5
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Loa Loa (eye worm) melatonin receptor type 1A 0.0072 0.0786 0.0813
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0042 0.036 0.0391
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0058 0.0584 1
Trypanosoma cruzi WLM domain containing protein, putative 0.0219 0.2903 0.3343
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Echinococcus granulosus neuropeptide receptor 0.0072 0.0786 0.0786
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0061 0.0063
Trypanosoma cruzi hypothetical protein, conserved 0.0219 0.2903 0.3343
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0219 0.2903 0.2903
Echinococcus granulosus BRCA1 associated protein 0.0022 0.0061 0.0061
Trypanosoma cruzi WLM domain containing protein, putative 0.0219 0.2903 0.3343
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0022 0.0061 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0584 0.0652
Loa Loa (eye worm) neuropeptide F receptor 0.0072 0.0786 0.0813
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0042 0.036 0.0391
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0072 0.0786 0.0786
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0022 0.0072 0.0072
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0219 0.2903 0.3343
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0089 0.103 0.1064
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.008 0.0905 0.1024
Toxoplasma gondii hypothetical protein 0.0058 0.0584 0.0676
Onchocerca volvulus 0.0219 0.2903 0.3371
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Echinococcus granulosus mitogen activated protein kinase 3 0.0619 0.8639 0.8639
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.008 0.0905 0.1024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Toxoplasma gondii histone deacetylase HDAC5 0.0042 0.036 0.0416
Brugia malayi RE15519p 0.0072 0.0786 0.0786
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0022 0.0072 0.0058
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0072 0.0084
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0022 0.0072 0.0084
Trypanosoma cruzi hypothetical protein, conserved 0.0219 0.2903 0.3343
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Echinococcus multilocularis sodium and chloride dependent glycine 0.0089 0.103 0.103
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Leishmania major histone deacetylase, putative 0.0042 0.036 0.0391
Brugia malayi SWIB/MDM2 domain containing protein 0.0617 0.8612 0.8612
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0061 0.0061
Brugia malayi hypothetical protein 0.0072 0.0786 0.0786
Trypanosoma cruzi histone deacetylase 1, putative 0.0042 0.036 0.0391
Schistosoma mansoni histone deacetylase hda2 0.0042 0.036 0.0416
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Schistosoma mansoni biogenic amine receptor 0.0072 0.0786 0.091
Schistosoma mansoni hypothetical protein 0.0617 0.8612 0.9968
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0022 0.0072 0.0072
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis SWI:SNF matrix associated 0.0617 0.8612 0.8612
Plasmodium vivax phosphodiesterase gamma, putative 0.0022 0.0072 0.0084
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0022 0.0061 0.0045
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0084
Leishmania major hypothetical protein, conserved 0.0022 0.0061 0.0045
Echinococcus granulosus neuropeptide receptor 0.0599 0.8365 0.8365
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0058 0.0584 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0022 0.0072 0.0072
Trichomonas vaginalis histone deacetylase, putative 0.0042 0.036 0.0391
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0022 0.0061 0.0071
Loa Loa (eye worm) hypothetical protein 0.0219 0.2903 0.2999
Toxoplasma gondii ran binding protein 0.0219 0.2903 0.336
Schistosoma mansoni hypothetical protein 0.0072 0.0786 0.091
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0061 0.0061
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0219 0.2903 0.2903
Toxoplasma gondii histone deacetylase HDAC1 0.0141 0.1775 0.2055
Echinococcus multilocularis dro:myosuppressin receptor 0.0072 0.0786 0.0786
Schistosoma mansoni ap endonuclease 0.0019 0.0022 0.0026
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0072 0.0786 0.091
Trichomonas vaginalis histone deacetylase, putative 0.0042 0.036 0.0391
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0022 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0617 0.8612 0.8897
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0022 0.0072 0.0072
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0022 0.0072 0.0058
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0022 0.0072 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0072 0.0058
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.008 0.0905 0.1024
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0619 0.8639 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0072 0.0786 0.0813
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0619 0.8639 1
Loa Loa (eye worm) hypothetical protein 0.0691 0.9679 1
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0022 0.0061 0.0061
Echinococcus multilocularis allatostatin A receptor 0.0072 0.0786 0.0786
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0072 0.0786 0.0786
Brugia malayi MAP kinase sur-1 0.0619 0.8639 0.8639
Brugia malayi G protein-coupled receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis mitogen activated protein kinase 3 0.0619 0.8639 0.8639
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0072 0.0786 0.091
Onchocerca volvulus 0.0617 0.8612 1
Echinococcus granulosus neuropeptide s receptor 0.0072 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0072 0.0058
Echinococcus granulosus tm gpcr rhodopsin 0.0072 0.0786 0.0786
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0072 0.0084
Echinococcus granulosus g protein coupled receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0072 0.0786 0.0786
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0022 0.0061 0.0045
Echinococcus multilocularis neuropeptides capa receptor 0.0072 0.0786 0.0786
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.008 0.0905 0.1024
Toxoplasma gondii hypothetical protein 0.0058 0.0584 0.0676
Echinococcus multilocularis neuropeptide receptor 0.0072 0.0786 0.0786
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0058
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0022 0.0072 0.0084
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0022 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Trichomonas vaginalis CMGC family protein kinase 0.0619 0.8639 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Echinococcus granulosus tm gpcr rhodopsin 0.0072 0.0786 0.0786
Echinococcus granulosus dro:myosuppressin receptor 0.0072 0.0786 0.0786
Brugia malayi neuropeptide F receptor 0.0072 0.0786 0.0786
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0219 0.2903 0.3343
Trichomonas vaginalis CMGC family protein kinase 0.0619 0.8639 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0022 0.0072 0.0072
Echinococcus granulosus neuropeptide Y receptor 0.0072 0.0786 0.0786
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0584 0.0652
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0617 0.8612 1
Echinococcus granulosus histone deacetylase 3 0.0042 0.036 0.036
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0584 0.0678
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0022 0.0061 0.0063
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0617 0.8612 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.008 0.0905 0.1048
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0084
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0022 0.0072 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0075
Schistosoma mansoni neuropeptide F-like receptor 0.0072 0.0786 0.091
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0072 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Brugia malayi hypothetical protein 0.0072 0.0786 0.0786
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0072 0.0786 0.0786
Echinococcus granulosus g protein coupled receptor 0.0072 0.0786 0.0786
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0022 0.0072 0.0084
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0022 0.0061 0.0071
Brugia malayi Melatonin receptor type 1A 0.0072 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Onchocerca volvulus 0.0072 0.0786 0.0913
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0713 1 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0072 0.0786 0.0786
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0058
Brugia malayi putative neuropeptide receptor 0.0072 0.0786 0.0786
Echinococcus granulosus sex peptide receptor 0.0072 0.0786 0.0786
Schistosoma mansoni TRABID protein (C64 family) 0.0219 0.2903 0.336
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.008 0.0905 0.1024
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Leishmania major hypothetical protein, conserved 0.0219 0.2903 0.3343
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0022 0.0072 0.0072
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Schistosoma mansoni histone deacetylase 4 5 0.0141 0.1775 0.2055
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0022 0.0022
Echinococcus multilocularis mitogen activated protein kinase 0.0619 0.8639 0.8639
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0061 0.0061
Giardia lamblia Hypothetical protein 0.0022 0.0061 0.0045
Trichomonas vaginalis histone deacetylase, putative 0.0042 0.036 0.0391
Schistosoma mansoni neuropeptide F-like receptor 0.0072 0.0786 0.091
Trypanosoma brucei histone deacetylase 1 0.0042 0.036 0.0391
Trichomonas vaginalis histone deacetylase, putative 0.0042 0.036 0.0391
Schistosoma mansoni hypothetical protein 0.0617 0.8612 0.9968
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0072 0.0786 0.091
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0072 0.0786 0.091
Giardia lamblia Hypothetical protein 0.0022 0.0072 0.0058
Plasmodium falciparum phosphodiesterase delta, putative 0.0022 0.0072 0.0084
Leishmania major histone deacetylase, putative 0.0042 0.036 0.0391
Schistosoma mansoni amine GPCR 0.0072 0.0786 0.091
Brugia malayi brahma associated protein 60 kDa 0.0617 0.8612 0.8612
Echinococcus multilocularis g protein coupled receptor 0.0072 0.0786 0.0786
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0072 0.0786 0.091
Loa Loa (eye worm) G-protein coupled receptor 0.0072 0.0786 0.0813
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0072 0.0786 0.0786
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0022 0.0072 0.0072
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.008 0.0905 0.1024
Entamoeba histolytica histone deacetylase, putative 0.0042 0.036 1
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0022 0.0061 0.0045
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Leishmania major hypothetical protein, conserved 0.0022 0.0072 0.0058
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Onchocerca volvulus 0.0072 0.0786 0.0913
Echinococcus granulosus histone deacetylase 6 0.0141 0.1775 0.1775
Plasmodium falciparum histone deacetylase 2 0.0141 0.1775 0.2061
Brugia malayi Histone deacetylase 1 0.0042 0.036 0.036
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0072 0.0058
Echinococcus multilocularis zinc finger protein Ran binding 0.0219 0.2903 0.2903
Trypanosoma brucei protein kinase, putative 0.0619 0.8639 1
Echinococcus multilocularis histone deacetylase 1 0.0042 0.036 0.036
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0072 0.0786 0.0813
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0084
Echinococcus granulosus histone deacetylase 1 0.0042 0.036 0.036
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0072 0.0786 0.0813
Leishmania major hypothetical protein, conserved 0.0219 0.2903 0.3343
Brugia malayi hypothetical protein 0.0072 0.0786 0.0786
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0219 0.2903 0.2903
Schistosoma mansoni RNA binding protein 0.0219 0.2903 0.336
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0022 0.0023
Echinococcus granulosus alpha 1A adrenergic receptor 0.0072 0.0786 0.0786
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0584 0.0652
Loa Loa (eye worm) histone deacetylase 0.0141 0.1775 0.1834
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0072 0.0058
Echinococcus granulosus 7tm_1 domain containing protein 0.0072 0.0786 0.0786
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0617 0.8612 0.8612
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Onchocerca volvulus 0.0072 0.0786 0.0913
Brugia malayi ORL1-like opioid receptor 0.0072 0.0786 0.0786
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.008 0.0905 0.0905
Echinococcus multilocularis fmrfamide receptor 0.0072 0.0786 0.0786
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0072 0.0786 0.091
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Brugia malayi Tachykinin-like peptides receptor 99D 0.0072 0.0786 0.0786
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0022 0.0072 0.0058
Brugia malayi histone deacetylase 11 0.0042 0.036 0.036
Schistosoma mansoni hypothetical protein 0.0072 0.0786 0.091
Brugia malayi hypothetical protein 0.0072 0.0786 0.0786
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0022 0.0022
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0022 0.0072 0.0084
Schistosoma mansoni biogenic amine (5HT) receptor 0.0072 0.0786 0.091
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0072 0.0786 0.0786
Echinococcus multilocularis histone deacetylase 3 0.0042 0.036 0.036
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0022 0.0061 0.0045
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0619 0.8639 1
Echinococcus multilocularis neuropeptide receptor A26 0.0072 0.0786 0.0786
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0022 0.0061 0.0071
Trypanosoma brucei histone deacetylase 4 0.0141 0.1775 0.2034
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0619 0.8639 1
Brugia malayi Serotonin receptor 0.0072 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0219 0.2903 0.2999
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.008 0.0905 0.1024
Trypanosoma brucei histone deacetylase 2 0.0042 0.036 0.0391
Echinococcus granulosus histone deacetylase 0.0141 0.1775 0.1775
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0219 0.2903 0.2903
Trypanosoma brucei histone deacetylase, putative 0.0141 0.1775 0.2034
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0022 0.0072 0.0072
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.008 0.0905 0.1024
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.008 0.0905 0.1024
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0022 0.0072 0.0072
Trypanosoma cruzi histone deacetylase, putative 0.0042 0.036 0.0391
Schistosoma mansoni adenoreceptor 0.0072 0.0786 0.091
Trypanosoma cruzi histone deacetylase 1, putative 0.0042 0.036 0.0391
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0619 0.8639 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0619 0.8639 0.8926
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0089 0.103 0.103
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Schistosoma mansoni histamine h1 receptor 0.0072 0.0786 0.091
Brugia malayi hypothetical protein 0.0072 0.0786 0.0786
Onchocerca volvulus 0.0219 0.2903 0.3371
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0072 0.0786 0.0786
Trichomonas vaginalis conserved hypothetical protein 0.0617 0.8612 0.9968
Echinococcus multilocularis neuropeptide s receptor 0.0072 0.0786 0.0786
Echinococcus multilocularis rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Brugia malayi hypothetical protein 0.0072 0.0786 0.0786
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0219 0.2903 0.336
Schistosoma mansoni growth hormone secretagogue receptor 0.0072 0.0786 0.091
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0022 0.0061 0.0045
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0022 0.0072 0.0058
Leishmania major hypothetical protein, conserved 0.0022 0.0072 0.0058
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Trypanosoma cruzi histone deacetylase, putative 0.0141 0.1775 0.2034
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0022 0.0072 0.0084
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0617 0.8612 0.9968
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0022 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0075
Echinococcus granulosus sodium and chloride dependent glycine 0.0089 0.103 0.103
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0022 0.0072 0.0058
Trichomonas vaginalis CMGC family protein kinase 0.0619 0.8639 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0072 0.0786 0.091
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0072 0.0786 0.0786
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0219 0.2903 0.3343
Echinococcus granulosus hypothetical protein 0.0072 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0072 0.0786 0.0813
Echinococcus multilocularis neuropeptides capa receptor 0.0072 0.0786 0.0786
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0905 0.1024
Echinococcus granulosus rhodopsin orphan GPCR 0.0072 0.0786 0.0786
Leishmania major hypothetical protein, conserved 0.0022 0.0061 0.0045
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0619 0.8639 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.008 0.0905 0.1024
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0022 0.0072 0.0084
Echinococcus granulosus histone deacetylase 7 0.0141 0.1775 0.1775

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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