Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alcohol dehydrogenase | 0.0157 | 1 | 1 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase | 0.0019 | 0.096 | 0.3834 |
Mycobacterium tuberculosis | Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) | 0.0019 | 0.096 | 0.0812 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0019 | 0.096 | 0.5 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0019 | 0.096 | 0.0812 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0978 | 0.083 |
Mycobacterium ulcerans | oxidoreductase | 0.0012 | 0.0503 | 0.0347 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase AdhC | 0.0019 | 0.096 | 0.0812 |
Schistosoma mansoni | zinc binding dehydrogenase | 0.0019 | 0.096 | 0.0812 |
Echinococcus multilocularis | hypothetical protein | 0.0008 | 0.0237 | 0.0321 |
Mycobacterium tuberculosis | S-nitrosomycothiol reductase MscR | 0.0019 | 0.096 | 0.0812 |
Wolbachia endosymbiont of Brugia malayi | NADPH:quinone reductase | 0.0019 | 0.096 | 0.5 |
Mycobacterium tuberculosis | Probable NADP-dependent alcohol dehydrogenase AdhC | 0.0019 | 0.096 | 0.0812 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.096 | 0.0812 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0043 | 0.2503 | 0.9995 |
Mycobacterium tuberculosis | Possible dehydrogenase | 0.0019 | 0.096 | 0.0812 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0019 | 0.096 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0019 | 0.096 | 0.0812 |
Toxoplasma gondii | Zn-containing alcohol dehydrogenase | 0.0157 | 1 | 1 |
Onchocerca volvulus | Putative alcohol dehydrogenase | 0.0157 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0043 | 0.2504 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0012 | 0.0503 | 0.0347 |
Mycobacterium ulcerans | oxidoreductase | 0.0019 | 0.096 | 0.0812 |
Onchocerca volvulus | 0.0012 | 0.0503 | 0.0273 | |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0019 | 0.096 | 0.0812 |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.0237 | 0.0076 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0019 | 0.096 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0446 | 0.0289 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0019 | 0.096 | 0.0812 |
Echinococcus granulosus | semaphorin 5B | 0.0008 | 0.0237 | 0.0321 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0019 | 0.096 | 0.3834 |
Mycobacterium ulcerans | short-chain dehydrogenase | 0.0019 | 0.096 | 0.0812 |
Mycobacterium leprae | Probable S-nitrosomycothiol reductase MscR | 0.0157 | 1 | 1 |
Mycobacterium tuberculosis | Possible dehydrogenase | 0.0019 | 0.096 | 0.0812 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0043 | 0.2504 | 0.2381 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0019 | 0.096 | 0.5 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0019 | 0.096 | 1 |
Leishmania major | zinc-binding dehydrogenase-like protein | 0.0012 | 0.0503 | 0.4279 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0019 | 0.096 | 1 |
Mycobacterium tuberculosis | Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) | 0.0019 | 0.096 | 0.0812 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0019 | 0.096 | 0.0812 |
Onchocerca volvulus | 0.0019 | 0.0978 | 0.0759 | |
Entamoeba histolytica | protein kinase, putative | 0.0043 | 0.2504 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0019 | 0.096 | 1 |
Trypanosoma brucei | Trans-2-enoyl-ACP reductase 2, putative | 0.0012 | 0.0503 | 0.4279 |
Entamoeba histolytica | protein kinase, putative | 0.0043 | 0.2504 | 1 |
Trypanosoma brucei | oxidoreductase, putative | 0.0019 | 0.096 | 1 |
Leishmania major | oxidoreductase-like protein | 0.0019 | 0.096 | 1 |
Leishmania major | zinc binding dehydrogenase-like protein | 0.0019 | 0.096 | 1 |
Echinococcus granulosus | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0019 | 0.096 | 0.3409 |
Mycobacterium tuberculosis | Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) | 0.0019 | 0.096 | 0.0812 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.096 | 0.0812 |
Schistosoma mansoni | plexin | 0.0011 | 0.0446 | 0.0289 |
Leishmania major | nuclear receptor binding factor-like protein | 0.0012 | 0.0503 | 0.4279 |
Mycobacterium ulcerans | quinone reductase Qor | 0.0019 | 0.096 | 0.0812 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0019 | 0.096 | 0.0812 |
Leishmania major | d-xylulose reductase, putative | 0.0019 | 0.096 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.096 | 0.0812 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0237 | 0.0076 |
Mycobacterium tuberculosis | Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0138 | 0.8745 | 0.8724 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0019 | 0.096 | 0.0812 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0019 | 0.096 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0237 | 0.0076 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0019 | 0.096 | 1 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase | 0.0157 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0019 | 0.096 | 0.0812 |
Mycobacterium tuberculosis | Probable alcohol dehydrogenase Adh | 0.0019 | 0.096 | 0.0812 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0019 | 0.096 | 1 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD-dependent AdhB | 0.0157 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.0237 | 0.0076 |
Trypanosoma brucei | oxidoreductase, putative | 0.0019 | 0.096 | 1 |
Brugia malayi | plexin A | 0.0023 | 0.1211 | 0.1066 |
Mycobacterium ulcerans | zinc-type alcohol dehydrogenase AdhD | 0.0157 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0503 | 0.0347 |
Brugia malayi | Sema domain containing protein | 0.0008 | 0.0237 | 0.0076 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 | 0.0138 | 0.8745 | 0.8724 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0446 | 0.0289 |
Toxoplasma gondii | quinone oxidoreductase, putative | 0.0019 | 0.096 | 0.0812 |
Echinococcus multilocularis | plexin a4 | 0.0023 | 0.1211 | 0.448 |
Echinococcus granulosus | serine:threonine protein kinase Chk2 | 0.0043 | 0.2504 | 1 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0008 | 0.0237 | 0.0076 |
Leishmania major | oxidoreductase, putative | 0.0019 | 0.096 | 1 |
Mycobacterium ulcerans | NADPH quinone oxidoreductase FadB4 | 0.0019 | 0.096 | 0.0812 |
Schistosoma mansoni | semaphorin 5-related | 0.0008 | 0.0237 | 0.0076 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0019 | 0.096 | 0.0812 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0019 | 0.096 | 1 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0012 | 0.0503 | 0.4279 |
Schistosoma mansoni | plexin | 0.0019 | 0.0978 | 0.083 |
Echinococcus multilocularis | semaphorin 5B | 0.0008 | 0.0237 | 0.0321 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) | 0.0157 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0237 | 0.0076 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0012 | 0.0503 | 0.0347 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0157 | 1 | 1 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase Adh | 0.0019 | 0.096 | 0.0812 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0019 | 0.096 | 0.0812 |
Echinococcus granulosus | plexin a4 | 0.0023 | 0.1211 | 0.448 |
Mycobacterium tuberculosis | Probable alcohol dehydrogenase AdhA | 0.0019 | 0.096 | 0.0812 |
Mycobacterium ulcerans | NADP-dependent oxidoreductase | 0.0012 | 0.0503 | 0.0347 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0019 | 0.096 | 0.0812 |
Loa Loa (eye worm) | alcohol dehydrogenase class III | 0.0157 | 1 | 1 |
Brugia malayi | Sema domain containing protein | 0.0008 | 0.0237 | 0.0076 |
Echinococcus multilocularis | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0019 | 0.096 | 0.3409 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase AdhE2 | 0.0157 | 1 | 1 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0012 | 0.0503 | 0.0273 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0237 | 0.0076 |
Leishmania major | NADP-dependent alcohol dehydrogenase, putative | 0.0019 | 0.096 | 1 |
Brugia malayi | hypothetical protein | 0.0008 | 0.0237 | 0.0076 |
Echinococcus granulosus | semaphorin 1A | 0.0008 | 0.0237 | 0.0321 |
Leishmania major | quinone oxidoreductase, putative | 0.0019 | 0.096 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0237 | 0.0076 |
Mycobacterium ulcerans | Zn-dependent alcohol dehydrogenase, AdhX | 0.0019 | 0.096 | 0.0812 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0237 | 0.0076 |
Brugia malayi | hypothetical protein | 0.0008 | 0.0237 | 0.0076 |
Mycobacterium ulcerans | dehydrogenase | 0.0019 | 0.096 | 0.0812 |
Loa Loa (eye worm) | plexin A | 0.0023 | 0.1211 | 0.1066 |
Mycobacterium tuberculosis | Possible oxidoreductase FadB5 | 0.0019 | 0.096 | 0.0812 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0019 | 0.096 | 0.0812 |
Brugia malayi | Plexin repeat family protein | 0.0019 | 0.0978 | 0.083 |
Mycobacterium ulcerans | oxidoreductase FadB5 | 0.0019 | 0.096 | 0.0812 |
Mycobacterium ulcerans | polyketide synthase | 0.0019 | 0.096 | 0.0812 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0019 | 0.096 | 0.3834 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0008 | 0.0237 | 0.0076 |
Onchocerca volvulus | 0.0019 | 0.096 | 0.0741 | |
Loa Loa (eye worm) | acyl carrier protein | 0.0012 | 0.0503 | 0.0347 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0019 | 0.096 | 0.0812 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0019 | 0.096 | 0.0812 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0019 | 0.096 | 0.0812 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0043 | 0.2503 | 0.9995 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.