TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 263.311 | Formula: C10H17NO5S
H donors: 4 H acceptors: 5 LogP: -1.83 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OS(=O)(=O)O.CNC(Cc1ccc(cc1)O)C
InChi: 1S/C10H15NO.H2O4S/c1-8(11-2)7-9-3-5-10(12)6-4-9;1-5(2,3)4/h3-6,8,11-12H,7H2,1-2H3;(H2,1,2,3,4)
InChiKey: PFBFUZCCJVXPKX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.014	0.1749
Brugia malayi	Importin beta-1 subunit	0.0028	0.0062	0.0061
Brugia malayi	Pre-SET motif family protein	0.0205	0.0696	0.0695
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.014	0.0139
Onchocerca volvulus		0.0149	0.0493	0.6179
Schistosoma mansoni	cpg binding protein	0.0028	0.0061	0.0061
Onchocerca volvulus		0.0041	0.0108	0.1348
Brugia malayi	Pre-SET motif family protein	0.003	0.0068	0.0067
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.0128	0.0128
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.005	0.014	1
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0098	0.1223
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0061	0.0061
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0075	0.3349
Brugia malayi	jmjC domain containing protein	0.0036	0.009	0.009
Plasmodium vivax	hypothetical protein, conserved	0.0011	0	0.0064
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0063	0.4025
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0134	0.0439	0.0439
Echinococcus granulosus	microtubule associated protein 2	0.0679	0.2391	0.2391
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0172	0.0172
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0062	0.0061
Onchocerca volvulus		0.0028	0.0061	0.0766
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0016	0.0015
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0013	0.0006	0.0006
Echinococcus granulosus	snurportin 1	0.0303	0.1045	0.1044
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0016	0.0015
Schistosoma mansoni	jumonji domain containing protein	0.0075	0.0227	0.0227
Brugia malayi	Heterochromatin protein 1	0.0069	0.0206	0.0205
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0032	0.0075	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0016	0.0015
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.0128	0.0128
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0023	0.0288
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.005	0.014	1
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.014	0.1749
Brugia malayi	jmjC domain containing protein	0.0094	0.0297	0.0296
Schistosoma mansoni	hypothetical protein	0.0016	0.0016	0.0015
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0124	0.0404	0.0403
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0206	0.0205
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0098	0.1223
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0108	0.1354
Echinococcus multilocularis	expressed protein	0.0033	0.0078	0.0077
Brugia malayi	hypothetical protein	0.0149	0.0493	0.0492
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.014	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0128	0.0128
Schistosoma mansoni	hypothetical protein	0.0303	0.1045	0.1044
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.0128	0.0128
Trypanosoma brucei	protein kinase, putative	0.005	0.014	1
Loa Loa (eye worm)	CHromoDomain protein family member	0.0013	0.0006	0.0006
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.0152	0.0151
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0043	0.053
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.014	0.1749
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.005	0.014	1
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.005	0.014	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0023	0.0288
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0013	0.0006	0.0006
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0013	0.0006	0.0006
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0033	0.0078	0.0077
Echinococcus multilocularis	cpg binding protein	0.003	0.0067	0.0067
Echinococcus granulosus	bifunctional protein NCOAT	0.2804	1	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.014	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0303	0.1045	0.1044
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0068	0.0067
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0062	0.0061
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0063	0.4025
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0016	0.0015
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0023	0.0288
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0206	0.2577
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.014	0.8968
Loa Loa (eye worm)	hypothetical protein	0.003	0.0068	0.0067
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.0128	0.0128
Schistosoma mansoni	thyroid hormone receptor	0.0134	0.0439	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0149	0.0493	0.0492
Plasmodium falciparum	heterochromatin protein 1	0.0011	0	0.0069
Loa Loa (eye worm)	hyaluronidase	0.2804	1	1
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0062	0.9143
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0068	0.0067
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0124	0.0404	0.0403
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0015	0.0013	0.0154
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0063	0.0063
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0128	0.0128
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0094	0.0297	0.0296
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0011	0	0.0069
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0068	0.0067
Schistosoma mansoni	hypothetical protein	0.0016	0.0016	0.0015
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0023	0.0288
Echinococcus granulosus	cpg binding protein	0.003	0.0067	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0063	0.0063
Brugia malayi	SET domain containing protein	0.0013	0.0007	0.0006
Schistosoma mansoni	thyroid hormone receptor	0.0134	0.0439	0.0439
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0011	0.0133
Plasmodium vivax	SET domain protein, putative	0.003	0.0068	1
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0063	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0136	0.0136
Trichomonas vaginalis	rotamase, putative	0.0032	0.0075	0.0938
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0043	0.053
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0136	0.0135
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.014	0.0139
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.014	1
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.0152	0.0151
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0016	0.0015
Trichomonas vaginalis	set domain proteins, putative	0.0234	0.0797	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0023	0.0288
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0023	0.0288
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0166	0.0556	0.0556
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0023	0.0288
Schistosoma mansoni	hypothetical protein	0.0029	0.0063	0.0063
Echinococcus granulosus	chromobox protein 1	0.0069	0.0206	0.0205
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0103	0.0103
Schistosoma mansoni	importin beta-1	0.0028	0.0062	0.0061
Brugia malayi	mbt repeat family protein	0.0047	0.0128	0.0128
Brugia malayi	RNA, U transporter 1	0.0081	0.0249	0.0249
Schistosoma mansoni	cpg binding protein	0.003	0.0067	0.0067
Schistosoma mansoni	hypothetical protein	0.0034	0.008	0.008
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0068	0.0067
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0179	0.0178
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0061	0.0061
Schistosoma mansoni	aminopeptidase P homologue (M24 family)	0.2804	1	1
Echinococcus granulosus	dnaJ subfamily B	0.0402	0.1401	0.1401
Onchocerca volvulus		0.0234	0.0797	1
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0108	0.1354
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0136	0.0135
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0023	0.0288
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0206	0.0205
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.0085	0.0084
Loa Loa (eye worm)	hypothetical protein	0.1191	0.4225	0.4225
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0016	0.0015
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.0128	0.0128
Schistosoma mansoni	Hyaluronidase	0.2804	1	1
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0206	0.2577
Onchocerca volvulus		0.0011	0	0.000000055302
Echinococcus granulosus	peregrin	0.0029	0.0063	0.0063
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0068	0.0067
Echinococcus multilocularis	bifunctional protein NCOAT	0.2804	1	1
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.0152	0.0151
Brugia malayi	F/Y-rich N-terminus family protein	0.0019	0.0029	0.0028
Loa Loa (eye worm)	hypothetical protein	0.02	0.0676	0.0676
Onchocerca volvulus		0.0047	0.0128	0.1605
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.003	0.0068	0.0068
Echinococcus multilocularis	peregrin	0.0029	0.0063	0.0063
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0068	0.4325
Brugia malayi	MAP kinase sur-1	0.005	0.014	0.0139
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.009	0.009
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0078	0.0973
Brugia malayi	Bromodomain containing protein	0.0029	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0034	0.008	0.008
Plasmodium vivax	hypothetical protein, conserved	0.0011	0	0.0064
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0032	0.0075	0.3349
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.0152	0.0151
Brugia malayi	chromobox protein homolog 3	0.0038	0.0098	0.0097
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0017	0.0023	0.0022
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0011	0	0.0069
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0032	0.0075	0.1709
Loa Loa (eye worm)	MBCTL1	0.0053	0.0152	0.0151
Echinococcus granulosus	Chromobox protein 3	0.0011	0	0.0000000044044
Onchocerca volvulus		0.003	0.0068	0.085
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0156	1
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0098	0.1223
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0033	0.0078	0.0077
Toxoplasma gondii	peptidylprolyl isomerase	0.0032	0.0075	0.4809
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.009	0.009
Schistosoma mansoni	chromobox protein	0.0069	0.0206	0.0205
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0185	0.0622	0.0622
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0166	0.0556	0.0556
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0103	0.0103
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.014	0.1749
Loa Loa (eye worm)	heterochromatin protein 1	0.0069	0.0206	0.0205
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.014	0.0139
Schistosoma mansoni	hypothetical protein	0.0016	0.0016	0.0015
Schistosoma mansoni	cpg binding protein	0.003	0.0067	0.0067
Echinococcus multilocularis	snurportin 1	0.0303	0.1045	0.1044
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.014	0.0139
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0205	0.0696	0.0695
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0016	0.0015
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0043	0.053
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0094	0.0297	0.0296
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.0152	0.0151
Brugia malayi	CHD4 protein	0.0013	0.0006	0.0006
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.0128	0.0128
Plasmodium vivax	heterochromatin protein 1, putative	0.0011	0	0.0064
Echinococcus multilocularis	dnaJ subfamily B	0.0402	0.1401	0.1401
Schistosoma mansoni	hypothetical protein	0.0016	0.0016	0.0015
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0058	0.0719
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0058	0.0719
Echinococcus granulosus	lysine specific demethylase 5A	0.0036	0.009	0.009
Echinococcus granulosus	chromobox protein 1	0.0069	0.0206	0.0205
Giardia lamblia	Kinase, CMGC MAPK	0.005	0.014	1
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0063	0.931
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.0152	0.0151
Schistosoma mansoni	hypothetical protein	0.0402	0.1401	0.1401
Entamoeba histolytica	hypothetical protein	0.0023	0.0043	0.5647
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0098	0.0097
Schistosoma mansoni	hypothetical protein	0.0124	0.0404	0.0403
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0013	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0152	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0062	0.0061
Brugia malayi	mbt repeat family protein	0.0047	0.0128	0.0128
Schistosoma mansoni	microtubule-associated protein tau	0.0679	0.2391	0.2391
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.02	0.0676	0.0676
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.008	0.008
Brugia malayi	PHD-finger family protein	0.0029	0.0063	0.0063
Schistosoma mansoni	chromobox protein	0.0069	0.0206	0.0205
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0075	0.3349
Echinococcus multilocularis	Chromobox protein 3	0.0011	0	0.0000000044044
Schistosoma mansoni	hypothetical protein	0.0285	0.0982	0.0981
Echinococcus granulosus	GPCR family 2	0.0016	0.0016	0.0015
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0185	0.0622	0.0622
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0063	0.0063
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.005	0.014	1
Trichomonas vaginalis	rotamase, putative	0.0033	0.0078	0.0973
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0062	0.3952
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0068	0.0067
Plasmodium falciparum	importin beta, putative	0.0028	0.0062	0.9821
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0108	0.1354
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.014	0.0139
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0041	0.0108	0.0107
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.009	0.009
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.0128	0.1605
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0063	0.0063
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0128	0.0128
Onchocerca volvulus	Alhambra homolog	0.0029	0.0063	0.0785
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0062	0.0061
Echinococcus granulosus	expressed protein	0.0033	0.0078	0.0077
Schistosoma mansoni	rotamase	0.0033	0.0078	0.0077
Echinococcus multilocularis	microtubule associated protein 2	0.0679	0.2391	0.2391

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2000922

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1648153